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Nature biotechnology, ISSN 1546-1696, 2009, Volume 28, Issue 1, pp. 63 - 70
Phosphodiesterase 4 (PDE4), the primary cAMP-hydrolyzing enzyme in cells, is a promising drug target for a wide range of conditions. Here we present seven... 
CAMP-SPECIFIC PHOSPHODIESTERASE | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN-KINASE | GENE COMPOSER | SUNCUS-MURINUS | AMP-SPECIFIC PHOSPHODIESTERASE | INHIBITORS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | ROLIPRAM BINDING | ANTIDEPRESSANT DRUGS | Phosphodiesterase Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - adverse effects | Humans | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Benzhydryl Compounds - chemistry | Benzhydryl Compounds - adverse effects | Phenylurea Compounds - adverse effects | Phenylurea Compounds - chemistry | Drug Design | Phosphodiesterase 4 Inhibitors | Behavior, Animal - drug effects | Biological Assay | Phosphodiesterase Inhibitors - chemistry | Benzhydryl Compounds - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Disease Models, Animal | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Catalytic Domain | Models, Molecular | Phenylurea Compounds - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Vomiting - drug therapy | Cognition - drug effects | Animals | Benzhydryl Compounds - pharmacology | Mice | Phenylurea Compounds - pharmacology | Kinetics | Care and treatment | Schizophrenia | Physiological aspects | Genetic aspects | Cellular signal transduction | Cyclic adenylic acid | Research | Phosphodiesterases | Enzymes | Biotechnology | Cellular biology | Molecular biology | Cognitive ability | Crystal structure | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 236, Issue 1, pp. 85 - 96
Several anthropogenous and naturally occurring substances, referred to as estrogen active compounds (EACs... 
Endocrine active compound | Estrogen receptor | Gene expression | Ishikawa cells | Illumina | TRANSCRIPTIONAL ACTIVATION | REPRODUCTIVE TOXICITY | RESVERATROL ACTS | RECEPTOR-ALPHA | ER-ALPHA | BREAST-CANCER | SIGNAL-TRANSDUCTION | IN-VITRO | PHARMACOLOGY & PHARMACY | DIETARY BISPHENOL-A | TOXICOLOGY | MOLECULAR-MECHANISMS | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Estrogens - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Endometrial Neoplasms - metabolism | Estrogen Antagonists - pharmacology | Stilbenes - pharmacology | RNA, Messenger - metabolism | Diethylstilbestrol - pharmacology | Endocrine Disruptors - pharmacology | Endometrial Neoplasms - genetics | Time Factors | Polymerase Chain Reaction | Female | Gene Expression Regulation, Neoplastic - drug effects | Estradiol - pharmacology | Phytoestrogens - pharmacology | Phenols - pharmacology | Reproducibility of Results | Receptors, Estrogen - genetics | Benzhydryl Compounds | Risk Assessment | Gene Expression Profiling - methods | Estrogens - toxicity | Endocrine Disruptors - toxicity | DDT - pharmacology | Receptors, Estrogen - drug effects | Genistein - pharmacology | Cell Line, Tumor | Cluster Analysis | Zearalenone - pharmacology | Endometrial cancer | Bisphenol-A | Resveratrol | Genetic research | Phenols | Diethylstilbestrol | Angiogenesis inhibitors | Hormones | Persistent organic pollutants | Isoflavones | Index Medicus | ESTROGENS | NEOPLASMS | DDT | DOSES | GENES | SCREENING | GENE REGULATION | RECEPTORS | 60 APPLIED LIFE SCIENCES
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2014, Volume 40, Issue 4, pp. 477 - 489
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including... 
PATHWAYS | TARGET GENES | FOXP3 OCCUPANCY | T(H)17 | REGULATORY NETWORK | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | PSORIASIS | ANTI-INTERLEUKIN-17 MONOCLONAL-ANTIBODY | TH17 CELLS | Myelin-Oligodendrocyte Glycoprotein - immunology | T-Lymphocyte Subsets - immunology | Transcription, Genetic - drug effects | Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Encephalomyelitis, Autoimmune, Experimental - immunology | Structure-Activity Relationship | Gene Regulatory Networks - drug effects | Cell Lineage - drug effects | Systems Biology | Benzhydryl Compounds - chemistry | Heterocyclic Compounds, 4 or More Rings - pharmacology | Th17 Cells - drug effects | T-Lymphocyte Subsets - drug effects | Peptide Fragments - immunology | Protein Binding - drug effects | Benzeneacetamides - chemistry | Benzeneacetamides - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Heterocyclic Compounds, 4 or More Rings - chemistry | Digoxin - chemistry | Digoxin - pharmacology | Mice, Knockout | Animals | Androstenols - chemistry | Cell Differentiation - drug effects | Cell Line, Tumor | Multiple Sclerosis - immunology | Th17 Cells - immunology | Benzhydryl Compounds - pharmacology | Mice | Multiple Sclerosis - drug therapy
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 7, p. e0131428
The aim of the present study was to evaluate the immunological effects on human macrophages of four endocrine disruptor compounds (EDCs... 
MIXTURES | IMMUNE-RESPONSE | IN-VITRO | 4-NONYLPHENOL | CHEMICALS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | BLOOD-SERUM | BISPHENOL-A | DIFFERENTIATION | EXPOSURE | Receptors, Estrogen - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Interleukin-1beta - agonists | Interleukin-8 - agonists | Tumor Necrosis Factor-alpha - agonists | Dose-Response Relationship, Drug | Endocrine Disruptors - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Interleukin-8 - secretion | Phosphorylation - drug effects | Phenols - pharmacology | Interleukin-1beta - secretion | Cell Line | Phagocytosis - drug effects | Receptors, Estrogen - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - secretion | Gene Expression Regulation | Macrophages - cytology | Macrophages - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Macrophages - drug effects | Benzhydryl Compounds - pharmacology | Diethylhexyl Phthalate - pharmacology | Dibutyl Phthalate - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Bisphenol-A | Cytokines | Macrophages | Estrogen | Octylphenol | Phosphorylation | Tert-octylphenol | Low concentrations | Estrogens | Dibutyl phthalate | Estrogen receptors | Kinases | Receptors | Immunology | Interleukin 1 | Interleukin 8 | Immune system | Immune response | Pesticides | Extracellular signal-regulated kinase | Zebrafish | MAP kinase | Tumor necrosis factor-α | Secretions | Bisphenol A | Phenols | Combined treatment | Human behavior | Phagocytosis | Life Sciences | Toxicology
Journal Article
Journal Article
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2017, Volume 333, pp. 43 - 50
Dipeptidyl peptidase-4 inhibitor (vildagliptin) has been shown to exert beneficial effects on insulin sensitivity and neuroprotection in obese-insulin... 
Obese-insulin resistance | Vildagliptin | Cognitive function | Mitochondrial function | Dapagliflozin | Synaptic plasticity | METFORMIN | OXIDATIVE STRESS | HOMEOSTASIS | COGNITION | DENSITY | PLASMA | CANAGLIFLOZIN | GLUCOSE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RECEPTOR FUNCTION | Memory - drug effects | Neuroprotective Agents - therapeutic use | Reactive Oxygen Species - metabolism | Insulin - physiology | Nitriles - pharmacology | Obesity - drug therapy | Rats, Wistar | Apoptosis - drug effects | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Cognition Disorders - metabolism | Male | Membrane Potential, Mitochondrial - drug effects | Brain - physiology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Brain - metabolism | Neuroprotective Agents - pharmacology | Long-Term Potentiation - drug effects | Diet, High-Fat | Malondialdehyde - blood | Adamantane - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Glucosides - therapeutic use | Benzhydryl Compounds - therapeutic use | Adamantane - analogs & derivatives | Malondialdehyde - metabolism | Adamantane - pharmacology | Cognition Disorders - physiopathology | Glucosides - pharmacology | Anti-Inflammatory Agents - pharmacology | Insulin Resistance | Obesity - physiopathology | Mitochondria - metabolism | Mitochondria - drug effects | Cognition Disorders - drug therapy | Maze Learning - drug effects | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Obesity - metabolism | Brain - drug effects | Animals | Benzhydryl Compounds - pharmacology | Oxidative Stress - drug effects | Mitochondria - physiology | Nitriles - therapeutic use | Obesity | Brain | Insulin resistance | Apoptosis | Analysis and chemistry | Low density lipoproteins | Cognition disorders | Glucose tolerance tests | Blood | High performance liquid chromatography | Neurophysiology | Index Medicus | INSULIN | APOPTOSIS | DRUGS | MITOCHONDRIA | RATS | SENSITIVITY | METABOLIC DISEASES | 60 APPLIED LIFE SCIENCES | BRAIN
Journal Article