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Drug metabolism and disposition, ISSN 1521-009X, 2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
Behavioural Pharmacology, ISSN 0955-8810, 10/2015, Volume 26, Issue 7 - Special Issue Pharmacological Approaches To The Study Of Social Behaviour - Part 2: Social Modulation Of Drug Effects, pp. 681 - 690
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 2, pp. 194 - 201
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2014, Volume 64, Issue 11, pp. 1128 - 1139
Abstract Background Non–vitamin K oral anticoagulants (NOACs) do not require routine laboratory monitoring. However, laboratory measurement may be desirable in... 
Cardiovascular | Internal Medicine | dabigatran | rivaroxaban | monitoring | laboratory | apixaban | MEASURING RIVAROXABAN | CARDIAC & CARDIOVASCULAR SYSTEMS | DIRECT THROMBIN INHIBITOR | DABIGATRAN CONCENTRATIONS | PROTHROMBIN TIME | PARTIAL THROMBOPLASTIN TIME | COAGULATION ASSAYS | IN-VITRO | FACTOR-XA INHIBITOR | PLASMA-CONCENTRATIONS | INTERNATIONAL NORMALIZED RATIO | Anticoagulants - administration & dosage | Humans | Antithrombins - administration & dosage | Thiophenes - administration & dosage | Dabigatran | Factor Xa Inhibitors - administration & dosage | Antithrombins - pharmacology | Pyridones - administration & dosage | Rivaroxaban | Benzimidazoles - administration & dosage | beta-Alanine - pharmacology | Factor Xa Inhibitors - pharmacology | beta-Alanine - analogs & derivatives | Pyrazoles - pharmacology | Administration, Oral | Morpholines - administration & dosage | beta-Alanine - administration & dosage | Morpholines - pharmacology | Thiophenes - pharmacology | Pyrazoles - administration & dosage | Partial Thromboplastin Time | Anticoagulants - pharmacology | Benzimidazoles - pharmacology | Drug Monitoring | Pyridones - pharmacology | Measurement | Anticoagulants (Medicine) | Vitamins | Studies | Anticoagulants | Plasma | Bibliographic literature | Laboratories | Drug therapy | Drug dosages | Bone surgery
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 03/2013, Volume 24, Issue 3, pp. 251 - 259
Journal Article
Cancer discovery, ISSN 2159-8290, 2014, Volume 4, Issue 7, pp. 816 - 827
Journal Article
Journal Article
Investigational new drugs, ISSN 1573-0646, 2014, Volume 32, Issue 5, pp. 825 - 837
The G1 restriction point is critical for regulating the cell cycle and is controlled by the Rb pathway (CDK4/6-cyclin D1-Rb-p16/ink4a). This pathway is... 
Medicine & Public Health | Cell cycle | Oncology | In vivo antitumor activity | Pharmacology/Toxicology | Combination therapy | LY2835219 | Kinase inhibitor | CDK4/6 inhibitor | Cdk4/6 inhibitor | LUNG | HUMAN BREAST | PHOSPHORYLATION | CANCER | DEPENDENT KINASE 4/6 | CONSTITUTIVELY ACTIVATED FLT3 | ONCOLOGY | BRAIN METASTASES | RESTRICTION POINT | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | EXPRESSION | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Neoplasms - metabolism | Humans | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | Deoxycytidine - therapeutic use | Aminopyridines - therapeutic use | Female | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Drug Therapy, Combination | Benzimidazoles - therapeutic use | Retinoblastoma Protein - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Protein Kinase Inhibitors - therapeutic use | Aminopyridines - pharmacology | Retinoblastoma Protein - antagonists & inhibitors | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Neoplasms - pathology | Deoxycytidine - analogs & derivatives | Dosage and administration | Research | Gemcitabine | Studies | Protein expression | Inhibitor drugs | Kinases | Cancer therapies | Analysis | CDK4 | Preclinical Studies | 6 inhibitor
Journal Article
The Journal of physiology, ISSN 0022-3751, 2016, Volume 594, Issue 23, pp. 7027 - 7047
Key points Candesartan, an inverse agonist of the type 1 angiotensin II receptor (AT1R), causes a concentration‐dependent inhibition of pressure‐dependent... 
type 1 angiotensin II receptor | cytoskeleton | mechanotransduction | actin stress fibres | vascular smooth muscle cell signalling | myogenic response | protein kinase C | RHO-ASSOCIATED KINASE | INTRAVASCULAR PRESSURE | PHYSIOLOGY | CEREBRAL PARENCHYMAL ARTERIOLES | RESISTANCE ARTERIES | PROTEIN-COUPLED RECEPTORS | MYOSIN PHOSPHORYLATION | STRETCH-ACTIVATION | CYTOSKELETON REORGANIZATION | NEUROSCIENCES | VASCULAR SMOOTH-MUSCLE | LIGHT-CHAIN PHOSPHORYLATION | Arterioles - physiology | Antihypertensive Agents - pharmacology | Receptor, Angiotensin, Type 1 - physiology | Tetrazoles - pharmacology | Captopril - pharmacology | Maleimides - pharmacology | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Muscle Development | Receptor, Angiotensin, Type 1 - genetics | Diglycerides - pharmacology | Indoles - pharmacology | Muscle Fibers, Skeletal - physiology | Vasoconstrictor Agents - pharmacology | Protein Kinase C - physiology | Abdominal Muscles - physiology | Cells, Cultured | Losartan - pharmacology | Imidazoles - pharmacology | Protein Kinase C - antagonists & inhibitors | Arterioles - drug effects | Pressure | Rats, Sprague-Dawley | Vasoconstriction - drug effects | Animals | Benzimidazoles - pharmacology | Pyridines - pharmacology | Actins - physiology | Atomic force microscopy | Actin | Angiotensin | Polymerization | Muscles | G proteins | Muscle proteins | Protein kinases | Arteries | Membrane proteins | Cardiovascular Physiology | Skeletal Muscle | Cardiovascular | Research Paper
Journal Article
Psychopharmacology (Berlin, Germany), ISSN 1432-2072, 2011, Volume 219, Issue 2, pp. 341 - 352
Impulsivity is associated with a number of psychiatric disorders, most notably attention deficit/hyperactivity disorder (ADHD). Drugs that augment... 
Neurosciences | Impulsivity | Sumanirole | Dopamine | Guanfacine | Quinpirole | GBR-12909 | Biomedicine | Atomoxetine | Pharmacology/Toxicology | Psychiatry | Noradrenaline | Five-choice serial reaction time task | Methylphenidate | TRAIT IMPULSIVITY | PSYCHIATRY | DEFICIT HYPERACTIVITY DISORDER | NEUROSCIENCES | REACTION-TIME-TASK | PREFRONTAL CORTEX | NUCLEUS-ACCUMBENS | DEFICIT/HYPERACTIVITY DISORDER | D2 RECEPTORS | MESSENGER-RNA | TERMINAL AUTORECEPTORS | PHARMACOLOGY & PHARMACY | Dopamine Agonists - therapeutic use | Adrenergic Agonists - pharmacology | Adrenergic Agonists - therapeutic use | Male | Reaction Time - drug effects | Atomoxetine Hydrochloride | Attention - drug effects | Serial Learning - drug effects | Animals, Outbred Strains | Benzimidazoles - therapeutic use | Dopamine Agonists - pharmacology | Choice Behavior - drug effects | Guanfacine - pharmacology | Rats | Guanfacine - therapeutic use | Methylphenidate - pharmacology | Piperazines - therapeutic use | Quinpirole - therapeutic use | Piperazines - pharmacology | Animals | Propylamines - therapeutic use | Methylphenidate - therapeutic use | Benzimidazoles - pharmacology | Impulsive Behavior - drug therapy | Propylamines - pharmacology | Quinpirole - pharmacology | Health aspects | Mental illness | Psychotropic drugs | Response time | Animal behavior | Attention Deficit Hyperactivity Disorder | Psychopharmacology | Rodents | Drugs | Mental disorders | Attention deficit hyperactivity disorder | impulsive behavior | Attention | Dopamine D3 receptors | Catecholamines | Reaction time task | quinpirole | Adrenergic receptors | Norepinephrine | Dopamine D2 receptors | Dopamine receptors | Original Investigation
Journal Article