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Drug Metabolism and Disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49701 - e49701
Paeoniflorin (PF), the principal component of Paeoniae Radix prescribed in traditional Chinese medicine, has been reported to exhibit many pharmacological... 
STROKE | ACTIVATION | PATHWAY | NEUROVASCULAR UNIT | MULTIDISCIPLINARY SCIENCES | FOCAL CEREBRAL-ISCHEMIA | INTRACEREBRAL HEMORRHAGE | NITRIC-OXIDE | MECHANISMS | EXPRESSION | NEUROPROTECTION | Microglia - metabolism | Tumor Necrosis Factor-alpha - blood | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Brain - metabolism | Inflammation - metabolism | Bridged-Ring Compounds - pharmacology | Monoterpenes | Neurons - metabolism | Disease Models, Animal | NF-kappa B - antagonists & inhibitors | bcl-2-Associated X Protein - metabolism | Rats | Brain - drug effects | Signal Transduction - drug effects | Brain Ischemia - drug therapy | Benzoates - pharmacology | Brain - pathology | Bridged-Ring Compounds - administration & dosage | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | Cerebral Infarction - drug therapy | Brain Ischemia - metabolism | Cytochromes c - genetics | Hippocampus - drug effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Interleukin-1beta - blood | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lipoxygenase - metabolism | Cerebral Infarction - metabolism | Inflammation - drug therapy | Neurons - drug effects | bcl-2-Associated X Protein - genetics | Cerebral Infarction - pathology | Astrocytes - drug effects | Glucosides - pharmacology | Microglia - drug effects | Cytochromes c - metabolism | Benzoates - administration & dosage | Gene Expression Regulation - drug effects | Animals | Glucosides - administration & dosage | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Cyclooxygenase 2 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Occlusion | Neuroprotection | Brain | Inflammatory response | Activation | Kinases | Carotid arteries | Signal transduction | Chinese medicine | Ischemia | Neurodegeneration | Cerebral blood flow | Rodents | Tumor necrosis factor-TNF | Inhibition | NF-κB protein | Stroke | Cytokines | Astrocytes | Traditional Chinese medicine | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Pharmacology | Inflammation | Tumor necrosis factor-α | IL-1β | Nitric-oxide synthase | Microglia | Signaling | Brain research | Liquid oxygen | Hypoxia | Brain damage | Cyclooxygenase-2 | Laboratory animals | Apoptosis | Veins & arteries | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2008, Volume 8, Issue 6, pp. 468 - 481
Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene,... 
HUMDISEASE | PATHOGENESIS | OBESITY | INSULIN-RESISTANCE | FOOD-INTAKE | GLUCOSE | LIVER | ENDOCRINOLOGY & METABOLISM | RECEPTOR | MICE | ADIPOSE-TISSUE | MELANOCORTIN SYSTEM | CELL BIOLOGY | RNA, Small Interfering - genetics | Peptides | Benzoates - chemistry | Benzoates - metabolism | Humans | Leptin - metabolism | Adipose Tissue, White - metabolism | Molecular Sequence Data | Male | RNA, Messenger - metabolism | Obesity - genetics | Benzylamines - metabolism | DNA-Binding Proteins - metabolism | DNA-Binding Proteins - agonists | Proteins - secretion | RNA Interference | Blood Proteins - genetics | Base Sequence | Liver X Receptors | Female | Orphan Nuclear Receptors | Amino Acid Sequence | Proteins - physiology | Fasting | Fatty Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Blood Proteins - secretion | Lipid Metabolism | Mice, Transgenic | Receptors, Cytoplasmic and Nuclear - agonists | Obesity - metabolism | Proteins - genetics | Benzylamines - chemistry | Animals | Energy Metabolism | Blood Proteins - physiology | Adipose Tissue, Brown - metabolism | Mice | RNA, Small Interfering - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Obesity | Physiological aspects | Homeostasis | Biological apparatus and supplies | Insulin resistance | Neuropeptides | Glucose | Diabetes | Universities and colleges | Dextrose | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, pp. e0145467 - e0145467
Alzheimer's disease (AD) is the major cause of dementia worldwide. The pharmacological activation of nuclear receptors (Liver X receptors: LXRs or Retinoid X... 
WILD-TYPE | AMYLOID BETA-PEPTIDE | ADULT NEUROGENESIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | SUBVENTRICULAR ZONE | TRANSGENIC MODEL | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | APOLIPOPROTEIN-E | Benzoates - therapeutic use | Cerebral Cortex - pathology | tau Proteins - metabolism | Cognition Disorders - metabolism | Male | Hippocampus - drug effects | Orphan Nuclear Receptors - metabolism | Apolipoproteins E - metabolism | Excitatory Postsynaptic Potentials - drug effects | ATP Binding Cassette Transporter 1 - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Gliosis - pathology | Dentate Gyrus - drug effects | Long-Term Potentiation - drug effects | Liver X Receptors | Amyloid beta-Peptides - metabolism | Female | Cerebral Cortex - drug effects | Biomarkers - metabolism | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Dentate Gyrus - metabolism | Orphan Nuclear Receptors - agonists | Neural Stem Cells - drug effects | Alzheimer Disease - drug therapy | Mice, Transgenic | Nuclear Proteins - metabolism | Hippocampus - pathology | Cognition Disorders - drug therapy | Gliosis - complications | Nerve Tissue Proteins - metabolism | Nestin - metabolism | Up-Regulation - drug effects | Hippocampus - metabolism | Cognition Disorders - complications | Animals | Alzheimer Disease - metabolism | Fluorescent Antibody Technique | Benzoates - pharmacology | Protein Biosynthesis - drug effects | Cell Proliferation - drug effects | Benzylamines - pharmacology | Benzylamines - therapeutic use | Dentate Gyrus - pathology | Neural Stem Cells - metabolism | Brain | Advertising executives | Cognition | Apolipoproteins | Alzheimer's disease | Liver | Amyloidogenesis | Peptides | Cognitive ability | Proteins | Receptors | Neurodegeneration | Physiology | Chemical synthesis | Neurodegenerative diseases | Cortex | Protein biosynthesis | Behavioral sciences | Metabolism | Retinoid X receptors | Nuclear receptors | Dentate gyrus | Gliosis | Molecular modelling | Tau protein | Protein synthesis | Stem cells | Ligands | ATP-binding protein | Hippocampus | Animal models | Cerebral cortex | Lipids | Kinases | Neurogenesis | ABCA1 protein | Reduction | Metabolites | Apolipoprotein E | Rodents | Dementia disorders | Liver X receptors | Neurons | Pharmacology | Cholesterol | Cortex (entorhinal) | Plasticity (synaptic) | Presenilin 1 | Laboratory animals | Alzheimers disease | Animal cognition | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2001, Volume 108, Issue 7, pp. 1001 - 1013
Journal Article
Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, ISSN 0003-6072, 12/2018, Volume 111, Issue 12, pp. 2293 - 2301
Journal Article
The Plant Journal, ISSN 0960-7412, 11/2012, Volume 72, Issue 3, pp. 411 - 422
Glucosinolates (GSLs) are nitrogen‐ and sulfur‐containing metabolites that contribute to human health and plant defense. The biological activities of these... 
glucosinolate | benzoate | sinapoylation | Arabidopsis | benzoylation | serine carboxypeptidase‐like acyltransferases | serine carboxypeptidase-like acyltransferases | SECONDARY METABOLISM | CARBOXYPEPTIDASE-LIKE PROTEIN | BENZOIC-ACID BIOSYNTHESIS | CELL-CULTURES | PLANT SCIENCES | SALICYLIC-ACID | GENE | THALIANA | SERINE CARBOXYPEPTIDASE | PETUNIA FLOWERS | ATTED-II | Arabidopsis - enzymology | Coenzyme A Ligases - genetics | Coumaric Acids - chemistry | Benzoates - chemistry | Benzoates - metabolism | Substrate Specificity | Glucosinolates - metabolism | Benzoylcholine - metabolism | Acyltransferases - metabolism | Glucosinolates - chemistry | Acyltransferases - genetics | Genetic Complementation Test | Propanols - metabolism | Coenzyme A Ligases - metabolism | Arabidopsis Proteins - metabolism | Propanols - chemistry | Cinnamates - metabolism | Glucosides - chemistry | Cinnamates - chemistry | Acyl Coenzyme A - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Glucosinolates - analysis | Seeds - metabolism | Seeds - genetics | Coumaric Acids - metabolism | Biosynthetic Pathways | Glucosides - metabolism | Carboxypeptidases | Esterification | Arabidopsis - metabolism | Arabidopsis - genetics | Phenotype | Benzoates - pharmacology | Kinetics | Mutation | Benzoylcholine - chemistry | Arabidopsis thaliana | Amino acids | Anopheles | Metabolites | Developmental biology | Transferases | Plant biology | Index Medicus
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 10/2013, Volume 455, Issue 1, pp. 75 - 85
The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to... 
DENGUE VECTOR | recombinant system | VECTOR AEDES-AEGYPTI | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | insecticide | IN-VITRO METABOLISM | ANOPHELES-GAMBIAE | resistance | mosquito | YEAST | MALARIA VECTOR | cytochrome P450 monooxygenase | metabolism | P450 | pyrethroid | Inactivation, Metabolic | Insecticides - chemistry | NADPH-Ferrihemoprotein Reductase - genetics | Saccharomyces cerevisiae - genetics | Benzoates - metabolism | Cytochrome P-450 Enzyme System - metabolism | Insecticide Resistance - genetics | NADPH-Ferrihemoprotein Reductase - chemistry | Saccharomyces cerevisiae - drug effects | Isoenzymes - chemistry | Pyrethrins - pharmacology | Insect Vectors - drug effects | Isoenzymes - metabolism | Insecticide Resistance - drug effects | Aedes - enzymology | Pyrethrins - metabolism | Insect Proteins - metabolism | Insect Vectors - enzymology | Insecticides - pharmacology | Benzaldehydes - chemistry | Escherichia coli - enzymology | NADPH-Ferrihemoprotein Reductase - metabolism | Oxidation-Reduction | Isoenzymes - genetics | Anopheles - drug effects | Insect Proteins - genetics | Benzaldehydes - pharmacology | Aedes - drug effects | Pyrethrins - chemistry | Anopheles - enzymology | Benzaldehydes - metabolism | Cytochrome P-450 Enzyme System - chemistry | Animals | Genetic Engineering | Insecticides - metabolism | Escherichia coli - genetics | Insect Proteins - chemistry | Cytochrome P-450 Enzyme System - genetics | Saccharomyces cerevisiae - enzymology | Molecular Docking Simulation | Index Medicus | AeCPR, Aedes aegypti CPR | 7-OH, 7-hydroxycoumarin | SRS, substrate recognition site | CPR, NADPH-cytochrome P450-reductase | Rt, retention time | Cyt b5, cytochrome b5 | PBAld, 3-phenoxybenzaldehyde | qPCR, quantitative real-time PCR | PBA, 3-phenoxybenzoic acid | PBAlc, 3-phenoxybenzoic alcohol | TFA, trifluoroacetic acid
Journal Article
American Journal of Hypertension, ISSN 0895-7061, 05/2008, Volume 21, Issue 5, pp. 576 - 581
Background Recently, some investigators have shown that telmisartan, an angiotensin II (Ang II)-receptor blocker (ARB), is a partial agonist of the peroxisome... 
METABOLIC SYNDROME | OXIDATIVE STRESS | SUPEROXIDE | NITRIC-OXIDE PRODUCTION | ENDOTHELIAL DYSFUNCTION | PROLIFERATOR-ACTIVATED RECEPTORS | CARDIAC-PERFORMANCE | TROGLITAZONE | PERIPHERAL VASCULAR DISEASE | ANGIOTENSIN-II | EPLERENONE | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Benzoates - therapeutic use | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Transforming Growth Factor beta1 - metabolism | NADPH Oxidases - metabolism | Hypertension - drug therapy | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | PPAR gamma - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Plasminogen Activator Inhibitor 1 - metabolism | rho-Associated Kinases - metabolism | Protein Kinase C - metabolism | Hypertension - chemically induced | Myocardium - metabolism | Superoxides - metabolism | Rats, Inbred Dahl | Benzimidazoles - therapeutic use | Disease Models, Animal | Collagen Type I - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - metabolism | Hypertrophy, Left Ventricular - prevention & control | Sodium Chloride, Dietary - adverse effects | Nitric Oxide Synthase Type III | Rats | Hypertension - metabolism | Myocardium - enzymology | Animals | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | PPAR gamma - agonists | Benzoates - pharmacology | Hypertension - complications | Benzimidazoles - pharmacology | Protein Kinase Inhibitors - pharmacology | Hypertrophy, Left Ventricular - physiopathology | Oxidative Stress - drug effects | Research Design | Ventricular Remodeling - drug effects | Nitric Oxide Synthase Type II - metabolism | Hypertension | Physiological aspects | Drug therapy | Cardiotonic agents | Telmisartan | Cardiac glycosides | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2015, Volume 112, Issue 2, pp. 536 - 541
Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits... 
Omega-3-derived epoxides | Obesity | Inflammation | Autophagy | Soluble epoxide hydrolase | PATHWAYS | autophagy | ER STRESS | OMEGA-3-FATTY-ACIDS | MULTIDISCIPLINARY SCIENCES | FATTY-ACIDS | soluble epoxide hydrolase | INDUCED INSULIN-RESISTANCE | EPOXYEICOSANOIDS | inflammation | DOCOSAHEXAENOIC ACID | EICOSAPENTAENOIC ACID | obesity | omega-3-derived epoxides | Epoxy Compounds - metabolism | Inflammation - pathology | Liver - pathology | Cadherins - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | Autophagy - physiology | Cytochrome P-450 CYP2E1 - metabolism | Adipose Tissue - metabolism | Inflammation - metabolism | Liver - drug effects | Mice, Mutant Strains | Female | Cadherins - genetics | Fatty Acid Desaturases - genetics | Fatty Acids, Omega-3 - metabolism | Fatty Acid Desaturases - metabolism | Liver - metabolism | Mice, Inbred C57BL | Adipose Tissue - pathology | Enzyme Inhibitors - pharmacology | Mice, Transgenic | 3T3-L1 Cells | Cytochrome P-450 CYP1A1 - metabolism | Obesity - metabolism | Obesity - pathology | Animals | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Adipose Tissue - drug effects | Epoxide Hydrolases - antagonists & inhibitors | Adipose tissues | Autophagy (Cytology) | Medical research | Liver | Epoxy compounds | Medicine, Experimental | Research | Health aspects | Tissue | Index Medicus | Obesitat | Liver diseases | Àcids grassos insaturats | Inflamació | Unsaturated fatty acids | Àcids grassos omega-3 | Teixit adipós | Malalties del fetge | Autofàgia | Omega-3 fatty acids | Biological Sciences | omega-3–derived epoxides
Journal Article
Journal of Experimental Botany, ISSN 0022-0957, 1/2011, Volume 62, Issue 11, pp. 3875 - 3884
In response to Fe-deficiency, various dicots increase their root branching which contributes to the enhancement of ferric-chelate reductase activity. Whether... 
Branching | Plant physiology | Plant roots | Oxides | Auxins | Nitrates | Plants | Root tips | Physiological regulation | Nutrient solutions | RESEARCH PAPER | NO synthase | nitric oxide<