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Drug metabolism and disposition, ISSN 1521-009X, 2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
American journal of physiology. Regulatory, integrative and comparative physiology, ISSN 0363-6119, 01/2013, Volume 304, Issue 1, pp. R23 - R32
The interaction between adenosine and soluble epoxide hydrolase (sEH) in vascular response is not known. Therefore, we hypothesized that lack of sEH in mice... 
Relaxation | CYP2J5-epoxgenase;ω-hydroxylase | receptor | Soluble epoxide hydrolase | Contraction | Adenosine A | Epoxide Hydrolases - physiology | Adenosine-5'-(N-ethylcarboxamide) - pharmacology | Butyrates - pharmacology | Male | Receptor, Adenosine A2A - physiology | Lauric Acids - pharmacology | Vasodilation - genetics | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Adenosine A2 Receptor Agonists - pharmacology | Urea - analogs & derivatives | Female | Benzamides - pharmacology | Oxygenases - physiology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | Adamantane - analogs & derivatives | NG-Nitroarginine Methyl Ester - pharmacology | Adamantane - pharmacology | Triazines - pharmacology | Phenethylamines - pharmacology | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Gene Silencing | Adenosine - pharmacology | Pyrimidines - pharmacology | Epoxide Hydrolases - genetics | Triazoles - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | PPAR gamma - physiology | Animals | Adenosine - analogs & derivatives | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Vasodilation - drug effects | Urea - pharmacology | adenosine A2a receptor | CYP2J5-epoxgenase | ω-hydroxylase | relaxation | contraction | Cardiovascular and Renal Integration | soluble epoxide hydrolase | adenosine A1 receptor
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2010, Volume 68, Issue 1, pp. 113 - 126
Endocannabinoids and their receptor CB1 play key roles in brain function. Astrocytes express CB1Rs that are activated by endocannabinoids released by neurons.... 
ENDOGENOUS CANNABINOIDS | ACTIVATION | CA1 PYRAMIDAL CELLS | EXCITATORY SYNAPSES | NEURONS | LONG-TERM POTENTIATION | GLIAL-CELLS | NEUROSCIENCES | MODULATION | HIPPOCAMPAL SYNAPSES | PLASTICITY | Cannabinoid Receptor Modulators - metabolism | Cannabinoid Receptor Modulators - pharmacology | Glycine - analogs & derivatives | Synaptic Transmission - physiology | Synaptic Transmission - genetics | Calcium - metabolism | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Resorcinols - pharmacology | Drug Interactions | Photolysis | Piperidines - pharmacology | Pyramidal Cells - physiology | Egtazic Acid - analogs & derivatives | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Electric Stimulation - methods | Endocannabinoids | Excitatory Postsynaptic Potentials - genetics | Pyrazoles - pharmacology | Animals, Newborn | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Chelating Agents - pharmacology | Hippocampus - cytology | Mice, Knockout | Astrocytes - physiology | Animals | Egtazic Acid - pharmacology | Glycine - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Benzoates - pharmacology | Thapsigargin - pharmacology | Mice | Pyridines - pharmacology | Receptor, Cannabinoid, CB1 - deficiency | In Vitro Techniques | Glutamate | Neurons | Studies | Retina | Transmitters | Potentiation | Brain | Neurotransmitter release | Astrocytes | Glutamic acid receptors | Cannabinoid CB1 receptors | synaptic depression | Calcium signalling | Pyramidal cells | Synaptic transmission | Endogenous stimuli | Receptor mechanisms | Glutamic acid receptors (metabotropic) | Hippocampus | Neurotransmission
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2008, Volume 73, Issue 3, pp. 789 - 800
In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human immunodeficiency virus (HIV). A... 
AMINO-TERMINAL DOMAIN | PROTEIN | ENTRY | CORECEPTOR | RECEPTOR ANTAGONISTS | IMMUNODEFICIENCY-VIRUS TYPE-1 | ANTI-HIV-1 ACTIVITY | PHARMACOLOGY & PHARMACY | HIGHLY POTENT | INHIBITOR | BINDING | Anti-HIV Agents - pharmacology | Benzoates - metabolism | Humans | Receptors, CCR5 - genetics | Piperazines - chemistry | Pyrimidines - metabolism | Receptors, CCR5 - metabolism | Piperidines - pharmacology | Amides - metabolism | Anti-HIV Agents - metabolism | Radioligand Assay | Binding Sites | Amides - pharmacology | Anti-HIV Agents - classification | Amino Acid Sequence | Piperidines - metabolism | Models, Molecular | Pyrimidines - pharmacology | HIV Fusion Inhibitors - pharmacology | Piperazines - pharmacology | Triazoles - metabolism | Anti-HIV Agents - chemistry | Amides - chemistry | Benzoates - pharmacology | Hydrophobic and Hydrophilic Interactions | Receptors, CCR5 - chemistry | Quaternary Ammonium Compounds - pharmacology | Cricetulus | Triazoles - chemistry | Benzoates - chemistry | Cyclohexanes - pharmacology | Molecular Sequence Data | Piperazines - metabolism | Quaternary Ammonium Compounds - chemistry | Pyrimidines - chemistry | Cyclohexanes - metabolism | Transfection | Inhibitory Concentration 50 | Cyclohexanes - chemistry | Molecular Structure | Membrane Fusion - drug effects | Spiro Compounds - chemistry | CCR5 Receptor Antagonists | CHO Cells | Protein Structure, Tertiary | Cricetinae | Piperidines - chemistry | Mutagenesis, Site-Directed | Protein Structure, Secondary | HIV-1 - drug effects | Static Electricity | Sequence Homology, Amino Acid | Triazoles - pharmacology | Animals | Quaternary Ammonium Compounds - metabolism | Spiro Compounds - pharmacology | Spiro Compounds - metabolism
Journal Article
Nature neuroscience, ISSN 1546-1726, 2013, Volume 16, Issue 8, pp. 1154 - 1161
Journal Article
Journal Article
by Hou, L
The Journal of neuroscience, ISSN 1529-2401, 2004, Volume 24, Issue 28, pp. 6352 - 6361
Hippocampal long-term depression (LTD) is a long-lasting decrease in synaptic strength that is most commonly studied at glutamatergic inputs to pyramidal cells... 
CA1 | Phosphorylation | Protein kinase | Hippocampus | Synaptic plasticity | Translation initiation | MAMMALIAN TARGET | MESSENGER-RNA TRANSLATION | hippocampus | PHOSPHATIDYLINOSITOL 3-KINASE | translation initiation | HIPPOCAMPAL CA1 REGION | AREA CA1 | NEUROSCIENCES | protein kinase | X MENTAL-RETARDATION | PROTEIN-KINASE B | P70 S6 KINASE | synaptic plasticity | phosphorylation | DHPG-INDUCED LTD | Glycine - analogs & derivatives | Pyramidal Cells - metabolism | Synaptosomes - drug effects | Receptors, Metabotropic Glutamate - physiology | Male | Tacrolimus - analogs & derivatives | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Resorcinols - pharmacology | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Tacrolimus - pharmacology | Receptor, Metabotropic Glutamate 5 | Pyramidal Cells - drug effects | Phosphorylation - drug effects | Chromones - pharmacology | Pyramidal Cells - ultrastructure | 3-Phosphoinositide-Dependent Protein Kinases | Dendrites - drug effects | Dendrites - metabolism | Long-Term Synaptic Depression - physiology | Protein Kinases - drug effects | Protein-Serine-Threonine Kinases - physiology | Synaptosomes - physiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Hippocampus - cytology | Sirolimus - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Androstadienes - pharmacology | Glycine - pharmacology | Signal Transduction - drug effects | Protein Kinases - physiology | Wortmannin | Proto-Oncogene Proteins - physiology | Benzoates - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Mice | Pyridines - pharmacology | TOR Serine-Threonine Kinases | Hippocampus - physiology | Receptors, Metabotropic Glutamate - agonists | Cellular | Molecular
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 1/2013, Volume 81, Issue 1, pp. 27 - 40
Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme... 
Life Sciences | Biochemistry, general | Plant Pathology | α - Amy2/54 gene expression | Nitric oxide | Heme oxygenase-1 | cGMP | Aleurone layers | Plant Sciences | Triticum aestivum | α-Amy2/54 gene expression | ARABIDOPSIS-THALIANA | SEED-GERMINATION | ADVENTITIOUS ROOTING PROCESS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GUANYLYL CYCLASE ACTIVITY | GIBBERELLIN-RESPONSE MUTANT | BARLEY ALEURONE | PLANT SCIENCES | PROGRAMMED CELL-DEATH | INHIBITS APOPTOSIS | alpha-Amy2/54 gene expression | ABSCISIC-ACID | Cyclic GMP - pharmacology | Heme Oxygenase-1 - metabolism | Gene Expression - drug effects | Nitric Oxide - pharmacology | Protoporphyrins - pharmacology | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | alpha-Amylases - genetics | Heme Oxygenase-1 - genetics | Carbon Monoxide - pharmacology | Cyclic GMP - analogs & derivatives | Plant Proteins - antagonists & inhibitors | Plant Proteins - metabolism | Nitric Oxide Donors - pharmacology | Triticum - enzymology | Aminoquinolines - pharmacology | Genes, Plant - drug effects | Spermine - analogs & derivatives | Signal Transduction | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | alpha-Amylases - metabolism | Heme Oxygenase-1 - antagonists & inhibitors | Triticum - genetics | Plant Proteins - genetics | Spermine - pharmacology | Benzoates - pharmacology | Gibberellins - pharmacology | Nitric Oxide - metabolism | Plant Growth Regulators - pharmacology | Triticum - drug effects
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 12/2005, Volume 94, Issue 6, pp. 4281 - 4289
Long-term depression (LTD) of the parallel fiber-Purkinje cell synapse in the cerebellum is a cellular model system that has been suggested to underlie certain... 
PURKINJE NEURONS | AMPA-RECEPTOR | PHYSIOLOGY | RAT CEREBELLUM | D-ASPARTATE RECEPTORS | NITRIC-OXIDE | METABOTROPIC GLUTAMATE RECEPTORS | NO SYNTHASE | PRESYNAPTIC NMDA | NEUROSCIENCES | CELL SYNAPSE | SYNAPTIC DEPRESSION | Electric Stimulation | 2-Amino-5-phosphonovalerate - pharmacology | Cerebellum - physiology | Purkinje Cells - physiology | N-Methylaspartate - pharmacology | Drug Interactions | Nerve Fibers - physiology | Long-Term Potentiation - drug effects | Time Factors | Long-Term Potentiation - physiology | Cadmium Chloride - pharmacology | Purkinje Cells - radiation effects | Animals, Newborn | Baclofen - pharmacology | Nerve Tissue Proteins - physiology | Synapses - physiology | Enzyme Inhibitors - pharmacology | Nerve Tissue Proteins - radiation effects | Rats | Excitatory Amino Acid Antagonists - pharmacology | Imidazoles - pharmacology | Magnesium - pharmacology | Long-Term Potentiation - radiation effects | Nerve Tissue Proteins - drug effects | Rats, Sprague-Dawley | Receptors, N-Methyl-D-Aspartate - physiology | GABA Antagonists - pharmacology | Nitroarginine - pharmacology | Animals | Phosphinic Acids - pharmacology | Cerebellum - cytology | GABA Agonists - pharmacology | Benzoates - pharmacology | Models, Neurological | In Vitro Techniques | Nitric Oxide - metabolism | Propanolamines - pharmacology | Dose-Response Relationship, Radiation
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 06/2009, Volume 329, Issue 3, pp. 928 - 937
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2009, Volume 157, Issue 5, pp. 781 - 795
Background and purpose:  In endothelial dysfunction, signalling by nitric oxide (NO) is impaired because of the oxidation and subsequent loss of the soluble... 
haem | HMR 1766 | nitric oxide | soluble guanylyl cyclase | cGMP | BAY 41-2272 | BAY 58-2667 | oxidative stress | BAY 58‐2667 | BAY 41‐2272 | Oxidative stress | Haem | Nitric oxide | Soluble guanylyl cyclase | Cgmp | SPONTANEOUSLY HYPERTENSIVE-RATS | DOWN-REGULATION | BINDING HEME | IDENTIFICATION | NO-INDEPENDENT STIMULATORS | CYCLIC-GMP | PROTOPORPHYRIN-IX | NITRATE TOLERANCE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | MEMBRANE ASSOCIATION | Enzyme Activators - pharmacology | Heme - metabolism | ortho-Aminobenzoates - pharmacology | Cricetulus | Protoporphyrins - pharmacology | Enzyme Activators - metabolism | Structure-Activity Relationship | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Transfection | Oxadiazoles - pharmacology | Swine | Enzyme Activators - chemistry | Molecular Structure | Aequorin - genetics | Binding Sites | Cyclic AMP - metabolism | Genes, Reporter | CHO Cells | Pyrazoles - pharmacology | Binding, Competitive | Cricetinae | Oxidation-Reduction | Cyclic Nucleotide-Gated Cation Channels - genetics | Enzyme Inhibitors - pharmacology | Enzyme Stability | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - genetics | Sulfonamides - pharmacology | Animals | Benzoates - pharmacology | Guanylate Cyclase - genetics | Pyridines - pharmacology | Enzyme Activation | Mutation | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Research Papers
Journal Article
Journal Article
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