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1. Full Text Behavioral Toxicity Revisited: Iatrogenic Comorbidity in Psychiatric Evaluation and Treatment
by Fava, Giovanni A and Cosci, Fiammetta and Offidani, Emanuela and Guidi, Jenny
Journal of Clinical Psychopharmacology, ISSN 0271-0749, 09/2016, Volume 36, Issue 6, pp. 550 - 553
In 1968, DiMascio and Shader provided a conceptual framework for behavioral toxicity of psychotropic drugs (ie, the pharmacological actions of a drug that,... 
switching | behavioral toxicity | antidepressant drugs | PSYCHIATRY | MAJOR-DEPRESSIVE DISORDER | iatrogenic comorbidity | ANTIDEPRESSANT TREATMENT | PSYCHOTHERAPY | RISK | withdrawal | BENZODIAZEPINES | TRENDS | MENTAL-DISORDERS | DRUGS | PERSPECTIVES | PHARMACOLOGY & PHARMACY | ANXIETY DISORDERS | Psychotropic Drugs - adverse effects | Mental Disorders - chemically induced | Comorbidity | Mental Disorders - drug therapy | Humans | Iatrogenic Disease - epidemiology | Mental Disorders - diagnosis
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2. Benzodiazepine dependence, toxicity, and abuse
: a task force report of the American Psychiatric Association
American Psychiatric Association
1990, ISBN 0890422281, vii, 116
Toxicology | pharmacology | Substance Dependence | Prescriptions, Drug | Drug Utilization | Physiological effect | Benzodiazepine abuse | Benzodiazepines
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3. Full Text Separating host and microbiome contributions to drug pharmacokinetics and toxicity
by Zimmermann, Michael and Zimmermann-Kogadeeva, Maria and Wegmann, Rebekka and Goodman, Andrew L
Science, ISSN 0036-8075, 02/2019, Volume 363, Issue 6427, pp. 600 - 600
The gut microbiota is implicated in the metabolism of many medical drugs, with consequences for interpersonal variation in drug efficacy and toxicity. However,... 
5-FLUOROURACIL | CATABOLISM | INTESTINAL MICROFLORA | CLONAZEPAM | MECHANISM | DIHYDROPYRIMIDINE DEHYDROGENASE | MULTIDISCIPLINARY SCIENCES | (E)-5-(2-BROMOVINYL)URACIL | HUMAN GUT SYMBIONT | SORIVUDINE | EXPRESSION | Drugs | Microbiota (Symbiotic organisms) | Physiological aspects | Transformation | Animal models | Physiological effects | Toxicity | Medical services | Microbiomes | Microorganisms | Microbiota | Absorption | Metabolites | Antidepressants | Intestine | Compartments | Animal tissues | Drug metabolism | Genetics | Biocompatibility | Oxidation | Xenobiotics | Digestive tract | Food | Enzymes | Gnotobiotics | Effectiveness | Computer simulation | Digestive system | Exposure | Pharmacology | Bioavailability | Clonazepam | Metabolism | Conversion | Benzodiazepines | Organic chemistry | Computer applications | Nucleosides | Transformations | In vivo methods and tests | Mice | Kinetics | Pharmacokinetics | Variation | Nucleoside analogs
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4. Full Text Case series: toxicity from 25B-NBOMe - a cluster of N-bomb cases
by Gee, Paul and Schep, Leo J and Jensen, Berit P and Moore, Grant and Barrington, Stuart
Clinical Toxicology, ISSN 1556-3650, 02/2016, Volume 54, Issue 2, pp. 141 - 146
Background A new class of hallucinogens called NBOMes has emerged. This class includes analogues 25I-NBOMe, 25C-NBOMe and 25B-NBOMe. Case reports and judicial... 
NBOMe | N-bomb | novel psychoactive substances | substituted phenylethylamines | 25B-NBOMe | EXPOSURES | TOXICOLOGY | 25I-NBOME | 5-HT2A | INTOXICATION | Dimethoxyphenylethylamine - analogs & derivatives | Phenethylamines - toxicity | Dimethoxyphenylethylamine - toxicity | Hallucinogens - toxicity | Humans | Bombs | Hallucinations - chemically induced | Male | Young Adult | Tandem Mass Spectrometry | Anisoles - toxicity | Benzodiazepines - toxicity | Chromatography, Liquid | Adult | Female | Hallucinations - pathology | Cluster Analysis | Index Medicus | Abridged Index Medicus
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5. Full Text Diazepam Toxicity Presenting as a Dementia Disorder
by Kurlawala, Zimple and Roberts, Jeffrey A and McMillan, Joseph D and Friedland, Robert P
Journal of Alzheimer's Disease, ISSN 1387-2877, 2018, Volume 66, Issue 3, pp. 935 - 938
The toxicity associated with long-standing benzodiazepine use in older persons is a critical issue. Several epidemiological reports have studied correlation... 
dementia | diazepam | Alzheimer's disease | benzodiazepine | COGNITIVE DECLINE | MANAGEMENT | EVENTS | NEUROSCIENCES | BENZODIAZEPINE USE | POLYPHARMACY | Toxicity | Cortex | Cognitive ability | Cognition | Epidemiology | Benzodiazepines | Atrophy | Magnetic resonance imaging | Correlation analysis | Dementia disorders | Elderly | Age | Diazepam | Dementia
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6. Full Text Relative toxicity of benzodiazepines and hypnotics commonly used for self-poisoning: An epidemiological study of fatal toxicity and case fatality
by Geulayov, Galit and Ferrey, Anne and Casey, Deborah and Wells, Claudia and Fuller, Alice and Bankhead, Clare and Gunnell, David and Clements, Caroline and Kapur, Navneet and Ness, Jennifer and Waters, Keith and Hawton, Keith
Journal of Psychopharmacology, ISSN 0269-8811, 6/2018, Volume 32, Issue 6, pp. 654 - 662
The relative toxicity of anxiolytic and hypnotic drugs commonly used for self-poisoning was assessed using data on suicides, prescriptions and non-fatal... 
Minor tranquilisers | self-poisoning | relative toxicity | self-harm | sedatives | suicide | INSOMNIA | PSYCHIATRY | OVERDOSE | DISORDERS | RISK | TIME | NEUROSCIENCES | CLINICAL NEUROLOGY | HARM | PHARMACOLOGY & PHARMACY | ENGLAND | Drugs | Toxicity | Pharmacology | Hypnotics | Fatal | Suicide | Epidemiology | Benzodiazepines | Alcohols | Confidence intervals | Zopiclone | Temazepam | Zolpidem | Fatalities | Poisoning | Overdose | Diazepam
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7. Full Text A Case Report: Anti-Psychotic Agents Related Ocular Toxicity
by Choy, Bonnie Nga Kwan and Ng, Alex Lap Ki and Shum, Jennifer Wei Huen and Fan, Michelle Ching Yim and Lai, Jimmy Shiu Ming
Medicine (United States), ISSN 0025-7974, 04/2016, Volume 95, Issue 15, p. e3360
Chlorpromazine is known to cause ocular pigmentary deposits. However, delayed presentation after cessation of chlorpromazine has not been reported. There are... 
SKIN PIGMENTATION | CORNEAL | CLOZAPINE | MEDICINE, GENERAL & INTERNAL | CHLORPROMAZINE | THERAPY | LENS OPACITIES | Chlorpromazine - therapeutic use | Eye Diseases - chemically induced | Antipsychotic Agents - therapeutic use | Antipsychotic Agents - adverse effects | Humans | Female | Aged | Benzodiazepines - adverse effects | Schizophrenia - drug therapy | Benzodiazepines - therapeutic use | Chlorpromazine - adverse effects | Ocular toxicology | Usage | Dosage and administration | Research | Chlorpromazine
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8. Full Text Modulating therapeutic activity and toxicity of pyrrolobenzodiazepine antibody-drug conjugates with self-immolative disulfide linkers
by Pillow, Thomas H and Schutten, Melissa and Yu, Shang-Fan and Ohri, Rachana and Sadowsky, Jack and Poon, Kirsten Achilles and Solis, Willy and Zhong, Fiona and Del Rosario, Geoffrey and Go, Mary Ann T and Lau, Jeffrey and Yee, Sharon and He, Jintang and Liu, Luna and Ng, Carl and Xu, Keyang and Leipold, Douglas D and Kamath, Amrita V and Zhang, Donglu and Masterson, Luke and Gregson, Stephen J and Howard, Philip W and Fang, Fan and Chen, Jinhua and Gunzner-Toste, Janet and Kozak, Katherine K and Spencer, Susan and Polakis, Paul and Polson, Andrew G and Flygare, John A and Junutula, Jagath R
Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 871 - 878
A novel disulfide linker was designed to enable a direct connection between cytotoxic pyrrolobenzodiazepine (PBD) drugs and the cysteine on a targeting... 
TARGETED TREATMENT | DESIGN | ONCOLOGY | STABILITY | IN-VIVO | BIOLOGICAL EVALUATION | CHEMISTRY | LYMPHOMA | SELECTION | CANCER-THERAPY | DELIVERY | Antibodies - chemistry | Humans | Antineoplastic Agents - administration & dosage | Immunoconjugates - administration & dosage | Pyrroles - immunology | Disulfides - chemistry | Pyrroles - administration & dosage | Antibodies - immunology | Cell Survival - drug effects | Antineoplastic Agents - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Neoplasms - drug therapy | Benzodiazepines - immunology | Xenograft Model Antitumor Assays | Antibodies - administration & dosage | Animals | Disulfides - immunology | Neoplasms - immunology | Benzodiazepines - chemistry | Cell Line, Tumor | Pyrroles - chemistry | Benzodiazepines - administration & dosage | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Drugs | Conjugates | Cysteine | Effectiveness | Toxicity | Xenografts | Rats | Cytotoxicity | Safety | Cancer
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9. Full Text Treatment of caffeine toxicity with metoprolol
by Li, Siu Fai and Edwards, Lindsey and Nguyen, Vincent
American Journal of Emergency Medicine, ISSN 0735-6757, 03/2019, Volume 37, Issue 3, pp. 562.e5 - 562.e10
A 27-year-old man presented with an intentional overdose of concentrated caffeine powder that he bought over the internet. The patient received benzodiazepines... 
Adenosine | Toxicology | Metoprolol | Supraventricular tachycardia | Suicide | Caffeine | METAANALYSIS | EFFICACY | EMERGENCY MEDICINE | INGESTION | ESMOLOL | ATRIAL-FIBRILLATION | Tachycardia | Care and treatment | Emergency medicine | Cardiac arrhythmia | Toxicity | Coffee | Patients | Benzodiazepines | Powder | Heart rate | Sinuses | Monitoring systems | Suicides & suicide attempts | Overdose | Blood pressure | Internet | Potassium | Emergency medical services
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10. Full Text Toxicity of Bupropion Overdose Compared With Selective Serotonin Reuptake Inhibitors
by Overberg, A and Morton, S and Wagner, E and Froberg, B
PEDIATRICS, ISSN 0031-4005, 08/2019, Volume 144, Issue 2, p. e20183295
OBJECTIVES: Adolescent depression and attempted and completed suicide are increasing in the United States. Because suicide is often impulsive, the means of... 
ANTIDEPRESSANTS | SEIZURES | AMERICAN ASSOCIATION | ADOLESCENTS | PEDIATRICS | SUICIDE | ONSET | Usage | Depression, Mental | Youth | Serotonin uptake inhibitors | Pediatric research | Psychological aspects | Complications and side effects | Bupropion | Analysis | Teenagers | Dosage and administration | Comparative analysis | Drug therapy | Health risk assessment | Health aspects | Adolescence | Self-injury | Demography | Serotonin | Toxicity | Fluoxetine | Exposure | Mental depression | Suicide | Sertraline | Self destructive behavior | Benzodiazepines | Morbidity | Citalopram | Demographics | Inhibitors | Antidepressants | Hallucinations | Overdose | Intubation | Resuscitation | Seizures | Index Medicus | Abridged Index Medicus
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11. Full Text Neurosteroids for the potential protection of humans against organophosphate toxicity
by Reddy, Doodipala Samba
Annals of the New York Academy of Sciences, ISSN 0077-8923, 08/2016, Volume 1378, Issue 1, pp. 25 - 32
This article describes the therapeutic potential of neurosteroids as anticonvulsant antidotes for chemical intoxication caused by organophosphate pesticides... 
organophosphate | nerve agent | benzodiazepine | neurosteroid | neuroactive steroid | NERVOUS-SYSTEM | EXTRASYNAPTIC GABA(A) RECEPTORS | STATUS EPILEPTICUS | DELTA-SUBUNIT | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ANTICONVULSANT ACTIVITY | SUBWAY SARIN ATTACK | TOKYO SUBWAY | NEUROACTIVE STEROIDS | AGENT-INDUCED SEIZURES | TOXICOLOGY | CHEMISTRY, APPLIED | TONIC INHIBITION | Neuroprotective Agents - therapeutic use | Status Epilepticus - diagnosis | Animals | Neurotransmitter Agents - therapeutic use | Organophosphate Poisoning - diagnosis | Humans | Status Epilepticus - chemically induced | Status Epilepticus - prevention & control | Anticonvulsants - therapeutic use | Organophosphate Poisoning - prevention & control | Organophosphates - toxicity | Brain | Nerve gas | Seizures (Medicine) | Epilepsy | Injuries | Benzodiazepines | Convulsions & seizures | Traumatic brain injury | Toxicity | Biological & chemical weapons
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12. Full Text An index of fatal toxicity for new psychoactive substances
by King, Leslie A and Corkery, John M
Journal of Psychopharmacology, ISSN 0269-8811, 7/2018, Volume 32, Issue 7, pp. 793 - 801
An index of fatal toxicity for new psychoactive substances has been developed based solely on information provided on death certificates. An updated index of... 
prevalence | availability | legal highs | new psychoactive substances | drug users | Mortality statistics | PSYCHIATRY | PHARMACOLOGY & PHARMACY | NEUROSCIENCES | CLINICAL NEUROLOGY | Interpolation | Cannabis | Amphetamine | Toxicity | Mathematical analysis | Butyrolactone | Fatalities | Cocaine | Fatal | Heroin | Benzodiazepines | Seizures
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13. Full Text Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity
by Häussinger, Dieter and Görg, Boris
Current Opinion in Clinical Nutrition and Metabolic Care, ISSN 1363-1950, 01/2010, Volume 13, Issue 1, pp. 87 - 92
PURPOSE OF REVIEWDescription of the role of oxidative stress in the pathogenesis of cerebral ammonia toxicity and hepatic encephalopathy. RECENT... 
Astrocytes | Protein tyrosine nitration | NADPH oxidase | Hepatic encephalopathy | RNA oxidation | ACUTE LIVER-FAILURE | CULTURED RAT ASTROCYTES | BENZODIAZEPINE-RECEPTOR | MITOCHONDRIAL PERMEABILITY TRANSITION | PORTACAVAL ANASTOMOSIS | NUTRITION & DIETETICS | PROTEIN-TYROSINE NITRATION | hepatic encephalopathy | IN-VIVO | ENDOCRINOLOGY & METABOLISM | GLUTAMINE-SYNTHETASE | astrocytes | HEPATIC-ENCEPHALOPATHY | protein tyrosine nitration | Astrocytes - drug effects | Gene Expression | Brain Edema - metabolism | Hepatic Encephalopathy - metabolism | Oxidative Stress | Zinc - metabolism | Humans | Astrocytes - pathology | Ammonia - toxicity | Mitochondria - metabolism | Hepatic Encephalopathy - complications | Nitrosation | Brain - metabolism | Hepatic Encephalopathy - chemically induced | Tyrosine - metabolism | Animals | Brain Edema - chemically induced | Proteins - metabolism | RNA - metabolism | Index Medicus
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14. Full Text Brain targeting of olanzapine via intranasal delivery of core–shell difunctional block copolymer mixed nanomicellar carriers: In vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies
by Abdelbary, Ghada Ahmed and Tadros, Mina Ibrahim
International Journal of Pharmaceutics, ISSN 0378-5173, 08/2013, Volume 452, Issue 1-2, pp. 300 - 310
(1) Olanzapine (OZ)-loaded micellar nanocarriers (F11), (2) histopathological assessment of the local toxicity on the sheep nasal mucosa, (3) minor changes in... 
Polymeric mixed micelles | Radiolabeling | Olanzapine | Nose-to-brain delivery | In vivo biodistribution | SYSTEM | DRUG-DELIVERY | VESICLES | RELEVANCE | PHARMACOLOGY & PHARMACY | POLYMERIC MICELLES | Nanoparticles - chemistry | Rats, Wistar | Drug Carriers - administration & dosage | Male | Drug Carriers - chemistry | Brain - metabolism | Tissue Distribution | Micelles | Nasal Mucosa - anatomy & histology | Nasal Mucosa - drug effects | Poloxamer - chemistry | Rats | Benzodiazepines - pharmacokinetics | Antipsychotic Agents - pharmacokinetics | Administration, Intranasal | Antipsychotic Agents - administration & dosage | Animals | Antipsychotic Agents - chemistry | Benzodiazepines - chemistry | Hydrophobic and Hydrophilic Interactions | Benzodiazepines - administration & dosage | Sheep | Drug Carriers - pharmacokinetics | Nanoparticles - administration & dosage | Poloxalene - chemistry | Index Medicus
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15. Full Text Mouse Precision-Cut Liver Slices as an ex Vivo Model To Study Idiosyncratic Drug-Induced Liver Injury
by Hadi, Mackenzie and Chen, Yixi and Starokozhko, Viktoriia and Merema, Marjolijn T and Groothuis, Geny M.M
Chemical Research in Toxicology, ISSN 0893-228X, 09/2012, Volume 25, Issue 9, pp. 1938 - 1947
Idiosyncratic drug-induced liver injury (IDILI) has been the top reason for withdrawing drugs from the market or for black box warnings. IDILI may arise from... 
RAT-LIVER | CHEMISTRY, MEDICINAL | NECROSIS-FACTOR-ALPHA | CHEMISTRY, MULTIDISCIPLINARY | MICROARRAY ANALYSIS | METABOLISM | INFLAMMATORY STRESS | ANIMAL-MODELS | KUPFFER CELLS | TOXICOLOGY | TNF-ALPHA | BACTERIAL-ENDOTOXIN | INDUCED HEPATOTOXICITY | Glutathione - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Triazoles - chemistry | Thiazolidinediones - toxicity | Diclofenac - toxicity | Thiazolidinediones - chemistry | Diclofenac - chemistry | Pyrimidines - chemistry | Carbamazepine - chemistry | Pyrimidines - toxicity | Triazoles - toxicity | Clozapine - chemistry | Voriconazole | Carbamazepine - toxicity | Female | Chemical and Drug Induced Liver Injury - pathology | Nitrogen Oxides - metabolism | Chromans - chemistry | Granulocyte Colony-Stimulating Factor - metabolism | Biomarkers - metabolism | Cell Survival - drug effects | Ketoconazole - toxicity | Lipopolysaccharides - toxicity | Cytokines - metabolism | Mice, Inbred C57BL | Ketoconazole - chemistry | Drug Synergism | Animals | Benzodiazepines - toxicity | Chemical and Drug Induced Liver Injury - metabolism | Benzodiazepines - chemistry | Clozapine - toxicity | Chemokines - metabolism | Mice | Chromans - toxicity | In Vitro Techniques | Index Medicus
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16. Full Text Acute Toxicity Associated With the Recreational Use of the Novel Psychoactive Benzofuran N -methyl-5-(2 aminopropyl)benzofuran
by Hofer, Katharina E., MD and Faber, Katrin, MD and Müller, Daniel M., MSC and Hauffe, Till, MD and Wenger, Urs, MD and Kupferschmidt, Hugo, MD and Rauber-Lüthy, Christine, MD
Annals of Emergency Medicine, ISSN 0196-0644, 2016, Volume 69, Issue 1, pp. 79 - 82
N -methyl-5-(2 aminopropyl)benzofuran (5-MAPB) is a novel psychoactive benzofuran, created by N -methylation of 5-(2-aminopropyl)benzofuran (5-APB), which... 
Emergency | 5-APB | METABOLISM | EMERGENCY MEDICINE | ANALOGS | AMPHETAMINE | Benzofurans - toxicity | Young Adult | Designer Drugs - toxicity | Glasgow Coma Scale | Methamphetamine - toxicity | Humans | Hallucinations - chemically induced | Male | Psychotropic Drugs - toxicity | Methamphetamine - analogs & derivatives | Akathisia, Drug-Induced - etiology | Hypertension | Creatine kinase | Electrocardiogram | Ecstasy (Drug) | Electrocardiography | Liquid chromatography | Methylation | Creatine | Mass spectrometry | Hyperthermia | Fever | Benzodiazepines | Index Medicus | Abridged Index Medicus
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17. Full Text Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
by Wood, David M and Davies, Susannah and Puchnarewicz, Malgorzata and Johnston, Atholl and Dargan, Paul I
European Journal of Clinical Pharmacology, ISSN 0031-6970, 5/2012, Volume 68, Issue 5, pp. 853 - 856
Long-term regular use of ketamine has been reported to be associated with severe symptomatic urinary tract problems. Methoxetamine, an arylcyclohexylamine... 
Methoxetamine | Biomedicine | Ketamine | Pharmacology/Toxicology | Acute toxicity | Recreational drug | PHARMACOLOGY & PHARMACY | BLADDER DYSFUNCTION | LEGAL HIGHS | Cyclohexylamines - toxicity | Humans | Hypnotics and Sedatives - administration & dosage | Anticonvulsants - administration & dosage | Male | Hypnotics and Sedatives - therapeutic use | Tachycardia - etiology | Neurotoxicity Syndromes - drug therapy | Hypertension - etiology | Cyclohexylamines - administration & dosage | Emergency Treatment | Neurotoxicity Syndromes - therapy | Adult | Akathisia, Drug-Induced - etiology | Administration, Oral | Cyclohexanones - toxicity | Administration, Inhalation | Anticonvulsants - therapeutic use | Treatment Outcome | Cyclohexanones - administration & dosage | Seizures, Febrile - etiology | Hallucinations - etiology | Cyclohexylamines - blood | Catatonia - etiology | Confusion - etiology | Neurotoxicity Syndromes - physiopathology | Street Drugs - blood | Cyclohexanones - blood | Street Drugs - toxicity | Hypertension | Medical colleges | Tachycardia | Mass spectrometry | Antianxiety agents | Benzodiazepines | Pharmacology | Toxicity | Epidemiology | Drug use | Index Medicus
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