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1. Full Text Relative toxicity of benzodiazepines and hypnotics commonly used for self-poisoning: An epidemiological study of fatal toxicity and case fatality
by Geulayov, Galit and Ferrey, Anne and Casey, Deborah and Wells, Claudia and Fuller, Alice and Bankhead, Clare and Gunnell, David and Clements, Caroline and Kapur, Navneet and Ness, Jennifer and Waters, Keith and Hawton, Keith
Journal of psychopharmacology (Oxford), ISSN 0269-8811, 6/2018, Volume 32, Issue 6, pp. 654 - 662
Minor tranquilisers | self-poisoning | relative toxicity | self-harm | sedatives | suicide | Neurosciences | Clinical Neurology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Psychiatry | Science & Technology | Anti-Anxiety Agents - poisoning | Drug Overdose | England - epidemiology | Humans | Suicide, Attempted - statistics & numerical data | Female | Male | Hypnotics and Sedatives - poisoning | Benzodiazepines - poisoning | Suicide - statistics & numerical data | Drugs | Toxicity | Pharmacology | Hypnotics | Suicide | Epidemiology | Benzodiazepines | Alcohols | Confidence intervals | Zopiclone | Temazepam | Zolpidem | Fatalities | Poisoning | Overdose | Diazepam | Index Medicus
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2. Full Text Separating host and microbiome contributions to drug pharmacokinetics and toxicity
by Zimmermann, Michael and Zimmermann-Kogadeeva, Maria and Wegmann, Rebekka and Goodman, Andrew L
Science (American Association for the Advancement of Science), ISSN 0036-8075, 02/2019, Volume 363, Issue 6427, p. 600
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Bromodeoxyuridine - analogs & derivatives | Animals | Bacteroides thetaiotaomicron - enzymology | Biotransformation | Bromodeoxyuridine - pharmacokinetics | Gastrointestinal Microbiome | Germ-Free Life | Biological Availability | Bromodeoxyuridine - toxicity | Mice | Clonazepam - pharmacokinetics | Bacteroides thetaiotaomicron - genetics | Drug metabolism | Pharmacokinetics | Analysis | Drugs | Transformation | Animal models | Physiological effects | Toxicity | Health services | Microbiomes | Microorganisms | Microbiota | Absorption | Metabolites | Antidepressants | Intestine | Compartments | Animal tissues | Genetics | Biocompatibility | Oxidation | Intestinal microflora | Xenobiotics | Digestive tract | Food | Enzymes | Gnotobiotics | Effectiveness | Computer simulation | Digestive system | Exposure | Pharmacology | Bioavailability | Clonazepam | Metabolism | Conversion | Benzodiazepines | Organic chemistry | Computer applications | Nucleosides | In vivo methods and tests | Kinetics | Variation | Nucleoside analogs
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3. Full Text Acute Methylenedioxypyrovalerone Toxicity
by Froberg, Blake A and Froberg, Blake A and Levine, Michael and Levine, Michael and Beuhler, Michael C and Beuhler, Michael C and Judge, Bryan S and Judge, Bryan S and Moore, Philip W and Moore, Philip W and Engebretsen, Kristin M and Engebretsen, Kristin M and Mckeown, Nathanael J and Mckeown, Nathanael J and Rosenbaum, Christopher D and Rosenbaum, Christopher D and Young, Amy C and Young, Amy C and Rusyniak, Daniel E and Rusyniak, Daniel E and ACMT Toxicology Investigators Consortium (ToxIC) and On behalf of the ACMT Toxicology Investigators Consortium (ToxIC)
Journal of medical toxicology, ISSN 1556-9039, 6/2015, Volume 11, Issue 2, pp. 185 - 194
Poisons | Toxicology | Biomedicine | Drug effects | Central nervous system stimulants | Designer drugs | Pharmacology/Toxicology | Biomedicine general | Street drugs | Age Factors | Humans | Middle Aged | Psychomotor Agitation - psychology | Male | Pyrrolidines - poisoning | Treatment Outcome | Hypnotics and Sedatives - therapeutic use | Lorazepam - therapeutic use | Street Drugs | Young Adult | Substance-Related Disorders - epidemiology | Adolescent | Substance-Related Disorders - psychology | Adult | Female | Registries | Benzodioxoles - poisoning | Retrospective Studies | Substance-Related Disorders - diagnosis | Alkaloids - poisoning | Diagnosis, Dual (Psychiatry) | Drugs | Analysis | Methyl groups | Ephedrine | Clinical trials | Dosage and administration | Chemical properties | Health aspects | Drug abuse | Salts | Abuse | Toxicity | Complications | Spreadsheets | Medical records | Patients | Benzodiazepines | Case studies | Tachycardia | Acidosis | Index Medicus | Toxicology Investigation
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4. Full Text Case series: toxicity from 25B-NBOMe - a cluster of N-bomb cases
by Gee, Paul and Schep, Leo J and Jensen, Berit P and Moore, Grant and Barrington, Stuart
Clinical toxicology (Philadelphia, Pa.), ISSN 1556-3650, 02/2016, Volume 54, Issue 2, pp. 141 - 146
NBOMe | N-bomb | novel psychoactive substances | substituted phenylethylamines | 25B-NBOMe | Life Sciences & Biomedicine | Toxicology | Science & Technology | Dimethoxyphenylethylamine - analogs & derivatives | Phenethylamines - toxicity | Dimethoxyphenylethylamine - toxicity | Hallucinogens - toxicity | Humans | Bombs | Hallucinations - chemically induced | Male | Young Adult | Tandem Mass Spectrometry | Anisoles - toxicity | Benzodiazepines - toxicity | Chromatography, Liquid | Adult | Female | Hallucinations - pathology | Cluster Analysis | Index Medicus | Abridged Index Medicus
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5. Full Text Optimized Photo-Fenton degradation of psychoactive pharmaceuticals alprazolam and diazepam using a chemometric approach—Structure and toxicity of transformation products
by Mitsika, Elena E and Christophoridis, Christophoros and Kouinoglou, Nikolaos and Lazaridis, Nikolaos and Zacharis, Constantinos K and Fytianos, Konstantinos
Journal of hazardous materials, ISSN 0304-3894, 02/2021, Volume 403, pp. 123819 - 123819
Psychoactive | Transformation products | Central composite design | Photo-Fenton | LC–MS/MS | Benzodiazepines | Pharmaceuticals | Engineering | Engineering, Environmental | Life Sciences & Biomedicine | Technology | Environmental Sciences & Ecology | Science & Technology | Environmental Sciences | Alprazolam | Usage | Diazepam | Index Medicus
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6. Full Text COVID-19: Therapeutics and Their Toxicities
by Chary, Michael A and Barbuto, Alexander F and Izadmehr, Sudeh and Hayes, Bryan D and Burns, Michele M
Journal of medical toxicology, ISSN 1556-9039, 07/2020, Volume 16, Issue 3, pp. 284 - 294
Life Sciences & Biomedicine | Toxicology | Science & Technology | Hydroxychloroquine - therapeutic use | Chloroquine - toxicity | Pandemics | Antiviral Agents - therapeutic use | Antiviral Agents - toxicity | United States | Coronavirus Infections - drug therapy | Humans | Pneumonia, Viral - drug therapy | Betacoronavirus - drug effects | Chloroquine - therapeutic use | COVID-19 | SARS-CoV-2 | Hydroxychloroquine - toxicity | Epinephrine | Regulatory agencies | Toxicity | Pathogenesis | Chloroquine | Viral diseases | Genomes | Coronaviruses | Nucleic acids | Vaccines | Benzodiazepines | Severe acute respiratory syndrome coronavirus 2 | Hydroxychloroquine | Ibuprofen | Serum sickness | Ventricle | Mutation | Emergency medical services | Diazepam | Index Medicus
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7. Full Text Modulating therapeutic activity and toxicity of pyrrolobenzodiazepine antibody-drug conjugates with self-immolative disulfide linkers
by Pillow, Thomas H and Schutten, Melissa and Yu, Shang-Fan and Ohri, Rachana and Sadowsky, Jack and Poon, Kirsten Achilles and Solis, Willy and Zhong, Fiona and Del Rosario, Geoffrey and Go, Mary Ann T and Lau, Jeffrey and Yee, Sharon and He, Jintang and Liu, Luna and Ng, Carl and Xu, Keyang and Leipold, Douglas D and Kamath, Amrita V and Zhang, Donglu and Masterson, Luke and Gregson, Stephen J and Howard, Philip W and Fang, Fan and Chen, Jinhua and Gunzner-Toste, Janet and Kozak, Katherine K and Spencer, Susan and Polakis, Paul and Polson, Andrew G and Flygare, John A and Junutula, Jagath R
Molecular cancer therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 871 - 878
Life Sciences & Biomedicine | Oncology | Science & Technology | Antibodies - chemistry | Humans | Antineoplastic Agents - administration & dosage | Immunoconjugates - administration & dosage | Pyrroles - immunology | Disulfides - chemistry | Pyrroles - administration & dosage | Antibodies - immunology | Cell Survival - drug effects | Antineoplastic Agents - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Neoplasms - drug therapy | Benzodiazepines - immunology | Xenograft Model Antitumor Assays | Antibodies - administration & dosage | Animals | Disulfides - immunology | Neoplasms - immunology | Benzodiazepines - chemistry | Cell Line, Tumor | Pyrroles - chemistry | Benzodiazepines - administration & dosage | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Drugs | Conjugates | Cysteine | Effectiveness | Toxicity | Xenografts | Rats | Cytotoxicity | Safety | Cancer | Index Medicus
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8. Full Text Diazepam Toxicity Presenting as a Dementia Disorder
by Kurlawala, Zimple and Roberts, Jeffrey A and McMillan, Joseph D and Friedland, Robert P
Journal of Alzheimer's disease, ISSN 1387-2877, 2018, Volume 66, Issue 3, pp. 935 - 938
dementia | diazepam | Alzheimer's disease | benzodiazepine | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Toxicity | Cortex | Cognitive ability | Cognition | Epidemiology | Benzodiazepines | Atrophy | Magnetic resonance imaging | Correlation analysis | Older people | Dementia disorders | Age | Diazepam | Dementia | Index Medicus
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9. Full Text Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders
by Almeida, Antonia Amanda Cardoso de and Ferreira, Jose Roberto de Oliveira and de Carvalho, Rusbene Bruno Fonseca and Rizzo, Marcia dos Santos and Lopes, Luciano da Silva and Dittz, Dalton and Souza, Joao Marcelo de and Ferreira, Paulo Michel Pinheiro
Naunyn-Schmiedeberg's archives of pharmacology, ISSN 0028-1298, 12/2020, Volume 393, Issue 12, pp. 2301 - 2314
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Antioxidants | Evaluation | Alkaloids | Tranquilizing drugs | Nervous system diseases | Corticosteroids | Antidepressants | Poisoning | Seizures (Medicine) | Blood cells | Erythrocytes | Cytotoxicity | Adrenergic transmission | Leukocytes (mononuclear) | Inflammation | Benzodiazepines | Chronic exposure | Neurological diseases | Convulsions & seizures | Lysis | Peripheral blood mononuclear cells | Limonene | Picrotoxin | Reserpine | Seizures | Acute toxicity | Index Medicus
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10. Full Text Fatal Toxicity Indices for Medicine-Related Deaths in New Zealand, 2008-2013
by Fountain, John S and Tomlin, Andrew M and Reith, David M and Tilyard, Murray W
Drug safety, ISSN 0114-5916, 03/2020, Volume 43, Issue 3, pp. 223 - 232
Pharmacology & Pharmacy | Public, Environmental & Occupational Health | Toxicology | Life Sciences & Biomedicine | Science & Technology | Neuroleptics | Narcotics | Toxicity | Mortality | Clozapine | Methadone | Clomipramine | Benzodiazepines | Anxiolytics | Information systems | Psychotropic drugs | Medicine | Zopiclone | Databases | Antidepressants | Mathematical analysis | Risk assessment | Opioids | Population | Fatalities | Prescriptions | Drug dosages | Pharmaceuticals
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11. Full Text Treatment of cocaine cardiovascular toxicity: a systematic review
by Richards, John R and Garber, Dariush and Laurin, Erik G and Albertson, Timothy E and Derlet, Robert W and Amsterdam, Ezra A and Olson, Kent R and Ramoska, Edward A and Lange, Richard A
Clinical toxicology (Philadelphia, Pa.), ISSN 1556-3650, 05/2016, Volume 54, Issue 5, pp. 345 - 364
nitric oxide mediated vasodilators | benzodiazepines | cocaine | antipsychotics | alpha-adrenoceptor agonists | calcium channel blocking drugs | Alpha-adrenoceptor blocking drugs | beta-adrenoceptor blocking drugs | betaadrenoceptor blocking drugs | Life Sciences & Biomedicine | Toxicology | Science & Technology | Tachycardia - drug therapy | Vasodilator Agents - therapeutic use | Tachycardia - chemically induced | Humans | Calcium Channel Blockers - therapeutic use | Hypertension - drug therapy | Cardiovascular System - drug effects | Nitric Oxide - therapeutic use | Evidence-Based Medicine | Randomized Controlled Trials as Topic | Cocaine-Related Disorders - complications | Heart Rate - drug effects | Cardiovascular System - physiopathology | Cocaine - toxicity | Hypertension - chemically induced | Cocaine-Related Disorders - drug therapy | Benzodiazepines - therapeutic use | Cocaine abuse | Care and treatment | Analysis | Practice guidelines (Medicine) | Amiodarone | Dosage and administration | Management | Emergency medical services | Index Medicus | Abridged Index Medicus
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