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Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 545, Issue 7652, pp. 112 - 115
Protease-activated receptors ( PARs) are a family of G-proteincoupled receptors ( GPCRs) that are irreversibly activated by proteolytic cleavage of the N... 
PHENIX | THROMBIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Allosteric Site - drug effects | Humans | Receptor, PAR-2 - metabolism | Imidazoles - chemistry | Models, Molecular | Crystallography, X-Ray | Antibodies, Blocking - pharmacology | Imidazoles - pharmacology | Benzimidazoles - chemistry | Receptor, PAR-2 - chemistry | Immunoglobulin Fab Fragments - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Signal Transduction - drug effects | Antibodies, Blocking - chemistry | Immunoglobulin Fab Fragments - chemistry | Benzyl Alcohols - pharmacology | Benzimidazoles - pharmacology | Ligands | Benzodioxoles - chemistry | Kinetics | Benzodioxoles - pharmacology | Physiological aspects | Cell receptors | Allosteric proteins | Cytochrome | Residues | G protein-coupled receptors | Peptides | Molecular structure | Hydrogen | Homology | Antagonists | Hydrophobicity | Hydrogen bonding | Optimization | Proteins | Lipophilic | Allosteric properties | Imidazole | Cleavage | Inhibition | Thromboembolism | Lysozyme | Hydrogen ion concentration | Deoxyribonucleic acid--DNA | Cultivation | Architecture | Fab | Crystals | Crystallization | Pharmacology | Inflammation | Glycosylation | Computer programs | Chemistry | Diffraction | Antagonist drugs | Lysine | Isoforms | Computer applications | Mutation | Internet | Receptor mechanisms | Binding sites | Glutamine | Cancer
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 11, p. e0207605
Mycobacterial efflux pumps play a major role in the emergence of antimycobacterial drug resistance. Of particular interest is the proteinaceous multi-drug... 
TAP | RECOGNITION | WEB | MULTIDISCIPLINARY SCIENCES | PIPERINE | INHIBITORS | EFFICIENT | ISOLATE | Polyunsaturated Alkamides - chemistry | Bacterial Proteins - chemistry | Benzodioxoles - metabolism | Mycobacterium tuberculosis - drug effects | Thermodynamics | ATP-Binding Cassette Transporters - chemistry | Piperidines - pharmacology | ATP-Binding Cassette Transporters - metabolism | Alkaloids - metabolism | Benzodioxoles - chemistry | Binding Sites | Mycobacterium tuberculosis - metabolism | Principal Component Analysis | Protein Structure, Tertiary | Amino Acid Sequence | Piperidines - chemistry | Alkaloids - pharmacology | Piperidines - metabolism | Antitubercular Agents - pharmacology | Polyunsaturated Alkamides - metabolism | Verapamil - pharmacology | Molecular Dynamics Simulation | Verapamil - chemistry | Sequence Alignment | Hydrogen Bonding | Polyunsaturated Alkamides - pharmacology | Bacterial Proteins - metabolism | Molecular Docking Simulation | Drug Resistance, Multiple, Bacterial - genetics | Alkaloids - chemistry | Benzodioxoles - pharmacology | Verapamil - metabolism | Molecules | Usage | Mycobacterial infections | Models | Diagnosis | Research | Drug resistance | Risk factors | Molecular structure | Peptides | Hydrogen | Molecular dynamics | Homology | Lipids | Lipid bilayers | Proteins | Computational chemistry | Hydrogen bonds | Docking | Aminoglycoside antibiotics | Isoniazid | Bioinformatics | Efflux | Medical research | Open channels | Computer simulation | Substrate inhibition | Principal components analysis | Mode of action | Molecular modelling | Tuberculosis | Antibiotics | Simulation | Pharmacy | Affinity | Verapamil | Three dimensional models | Protein structure | Rifampin | Binding sites
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2008, Volume 130, Issue 39, pp. 13110 - 13119
Journal Article
Drug Delivery, ISSN 1071-7544, 09/2016, Volume 23, Issue 7, pp. 2608 - 2616
P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few... 
nanoparticles | PLGA | piperine | Breast cancer | P-glycoprotein efflux | oral bioavailability | chemosensitizer | rapamycin | NANOPRECIPITATION | RELEASE | P-GLYCOPROTEIN | PACLITAXEL | IN-VITRO | FORMULATION VARIABLES | BLACK PEPPER | PHARMACOLOGY & PHARMACY | ABSORPTION | MULTIDRUG-RESISTANCE | PLGA NANOPARTICLES | Polyunsaturated Alkamides - chemistry | Nanoparticles - chemistry | Drug Resistance, Multiple | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Biological Availability | ATP-Binding Cassette, Sub-Family B, Member 1 - pharmacology | Antineoplastic Agents - administration & dosage | Benzodioxoles - administration & dosage | Piperidines - pharmacology | Female | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Antineoplastic Agents - pharmacology | Benzodioxoles - chemistry | Piperidines - administration & dosage | Piperidines - chemistry | Alkaloids - pharmacology | Lactic Acid - chemistry | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Sirolimus - pharmacology | Polyunsaturated Alkamides - administration & dosage | Sirolimus - administration & dosage | Polyglycolic Acid - chemistry | Polyunsaturated Alkamides - pharmacology | Cell Line, Tumor | Alkaloids - administration & dosage | Sirolimus - chemistry | Alkaloids - chemistry | Benzodioxoles - pharmacology | Drug Resistance, Neoplasm - drug effects
Journal Article
Journal Article
Combinatorial chemistry & high throughput screening, ISSN 1386-2073, 2018, Volume 21, Issue 8, pp. 594 - 601
Journal Article
Journal of Emergency Medicine, ISSN 0736-4679, 2013, Volume 44, Issue 6, pp. 1108 - 1115
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2018, Volume 19, Issue 9, p. 2594
Natural products have an important role as prototypes in the synthesis of new anticancer drugs. Piperine is an alkaloid amide with antitumor activity and... 
toxicity | cancer | antitumor activity | piperine analogue | OXIDATIVE STRESS | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | NEUTROPHILS | CELL-CYCLE ARREST | PROLIFERATION | CHEMISTRY, MULTIDISCIPLINARY | INHIBITION | INFLAMMATION | GROWTH | Hemolysis - drug effects | Polyunsaturated Alkamides - chemistry | Polyunsaturated Alkamides - therapeutic use | Acetamides - pharmacology | Antineoplastic Agents - therapeutic use | Acetamides - therapeutic use | Piperidines - pharmacology | Female | Antineoplastic Agents - pharmacology | Benzodioxoles - chemistry | Benzodioxoles - therapeutic use | Th1-Th2 Balance - drug effects | Cell Survival - drug effects | Piperidines - chemistry | Alkaloids - pharmacology | Nitrobenzenes - chemistry | Immunomodulation | Carcinoma, Ehrlich Tumor - drug therapy | Antineoplastic Agents - chemistry | Erythrocytes - drug effects | Acetamides - chemistry | Animals | Piperidines - therapeutic use | Immune System - drug effects | Polyunsaturated Alkamides - pharmacology | Alkaloids - therapeutic use | RAW 264.7 Cells | Mice | Alkaloids - chemistry | Benzodioxoles - pharmacology | Reactive oxygen species | Toxicity | Erythrocytes | Cytotoxicity | Lymphocytes T | Immunosuppressive agents | Anticancer properties | Lethal dose | Interleukin 4 | Red blood cells | Antitumor agents | Lymphocytes | Biocompatibility | Immune system | Cytokines | Analogue | Interleukin 12 | Tumor necrosis factor-α | p-Nitrophenyl | Natural products | Nitric oxide | Interleukin 10 | Antitumor activity | Ascites | Acute toxicity | Flow cytometry | Nuclear magnetic resonance--NMR | Homeostasis | Metastasis | Angiogenesis | Cell cycle | Neutrophils | IL-1β | Potassium | Cancer | Apoptosis
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Journal Article
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