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Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0149008 - e0149008
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 11/2017, Volume 109, pp. 21 - 30
The lipophilic phytocannabinoids cannabidiol (CBD) and Δ -tetrahydrocannabinol (THC) show therapeutic efficacy in various medical conditions. Both molecules... 
Cannabinoids | Oral bioavailability | Piperine | SNEDDS | First pass effect | RESVERATROL | CURCUMIN | P-GLYCOPROTEIN | UDP-GLUCURONOSYLTRANSFERASE | IN-VITRO | LIPID-BASED FORMULATIONS | METABOLISM | PHARMACOKINETICS | ENZYMES | PHARMACOLOGY & PHARMACY | Polyunsaturated Alkamides - chemistry | Emulsions | Stilbenes - administration & dosage | Cannabidiol - administration & dosage | Excipients - pharmacokinetics | Nanoparticles - chemistry | Rats, Wistar | Alkaloids - pharmacokinetics | Curcumin - chemistry | Biological Availability | Male | Stilbenes - chemistry | Benzodioxoles - administration & dosage | Curcumin - administration & dosage | Drug Delivery Systems | Lipids - chemistry | Excipients - chemistry | Benzodioxoles - pharmacokinetics | Piperidines - pharmacokinetics | Benzodioxoles - chemistry | Cannabidiol - pharmacokinetics | Cannabidiol - chemistry | Piperidines - administration & dosage | Piperidines - chemistry | Gastrointestinal Absorption | Administration, Oral | Curcumin - pharmacokinetics | Lipids - administration & dosage | Dronabinol - pharmacokinetics | Excipients - administration & dosage | Polyunsaturated Alkamides - administration & dosage | Animals | Lipids - pharmacokinetics | Stilbenes - pharmacokinetics | Alkaloids - administration & dosage | Nanoparticles - administration & dosage | Polyunsaturated Alkamides - pharmacokinetics | Dronabinol - administration & dosage | Dronabinol - chemistry | Alkaloids - chemistry | Index Medicus
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2008, Volume 130, Issue 39, pp. 13110 - 13119
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2017, Volume 27, Issue 2, pp. 176 - 179
(−)-Cubebin (CUB), isolated from seeds of , was used as starting material to obtain the derivatives (−)-hinokinin (HK) and (−)-O-benzyl cubebin (OBZ). Using... 
Anti-inflammatory activity | (−)-Hinokinin | Piper cubeba | (−)-Cubebin | (−)-O-benzylcubebin | CHEMISTRY, MEDICINAL | APPROXIMATION | (-)-Cubebin | LEAVES | CHEMISTRY, ORGANIC | (-)-Hinokinin | SWISS-MODEL | DENSITY | ZANTHOXYLUM-NARANJILLO | (-)-0-benzylcubebin | LIGNANS | ELECTROSTATICS | Rats, Wistar | Furans - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Benzodioxoles - administration & dosage | Cyclooxygenase 2 Inhibitors - chemistry | Dioxoles - chemical synthesis | Lignans - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyproheptadine - pharmacology | Polysorbates - pharmacology | Dextrans - pharmacology | Dioxoles - administration & dosage | Furans - chemistry | Computer Simulation | Dioxoles - pharmacology | 4-Butyrolactone - chemistry | Benzodioxoles - chemistry | Lignans - chemical synthesis | Rutaceae - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Benzodioxoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Dinoprostone - pharmacology | Catalytic Domain | Cyclooxygenase 2 Inhibitors - pharmacology | Lignans - chemistry | Cyclooxygenase 2 - chemistry | Cyclooxygenase 2 Inhibitors - administration & dosage | 4-Butyrolactone - pharmacology | 4-Butyrolactone - chemical synthesis | Dioxoles - chemistry | Indomethacin - pharmacology | Lignans - isolation & purification | Lignans - administration & dosage | Animals | 4-Butyrolactone - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Ligands | Mice | Molecular Docking Simulation | 4-Butyrolactone - analogs & derivatives | Edema - chemically induced | Furans - chemical synthesis | Benzodioxoles - pharmacology | Furans - administration & dosage | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 112 - 115
Protease-activated receptors ( PARs) are a family of G-proteincoupled receptors ( GPCRs) that are irreversibly activated by proteolytic cleavage of the N... 
PHENIX | ANTAGONIST | THROMBIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Allosteric Site - drug effects | Humans | Receptor, PAR-2 - metabolism | Imidazoles - chemistry | Models, Molecular | Crystallography, X-Ray | Antibodies, Blocking - pharmacology | Imidazoles - pharmacology | Benzimidazoles - chemistry | Receptor, PAR-2 - chemistry | Immunoglobulin Fab Fragments - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Signal Transduction - drug effects | Antibodies, Blocking - chemistry | Immunoglobulin Fab Fragments - chemistry | Benzyl Alcohols - pharmacology | Benzimidazoles - pharmacology | Ligands | Benzodioxoles - chemistry | Kinetics | Benzodioxoles - pharmacology | Physiological aspects | Cell receptors | Allosteric proteins | Cytochrome | Residues | G protein-coupled receptors | Peptides | Molecular structure | Hydrogen | Homology | Antagonists | Hydrophobicity | Hydrogen bonding | Optimization | Proteins | Lipophilic | Allosteric properties | Imidazole | Cleavage | Inhibition | Thromboembolism | Lysozyme | Hydrogen ion concentration | Deoxyribonucleic acid--DNA | Cultivation | Architecture | Fab | Crystals | Crystallization | Pharmacology | Inflammation | Glycosylation | Computer programs | Chemistry | Diffraction | Antagonist drugs | Lysine | Isoforms | Computer applications | Mutation | Internet | Receptor mechanisms | Binding sites | Glutamine | Cancer | Index Medicus
Journal Article
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 11/2014, Volume 79, Issue 21, pp. 10662 - 10668
Journal Article
Journal Article