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Neural plasticity, ISSN 2090-5904, 1/2016, Volume 2016, pp. 8501693 - 15
Journal Article
The New England journal of medicine, ISSN 1533-4406, 10/2018, Volume 379, Issue 17, pp. 1612 - 1620
.... The results indicate that among these patients, the use of VX-445-tezacaftor-ivacaftor to target Phe508del CFTR protein resulted in increased CFTR function in vitro... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Pyrazoles - therapeutic use | Forced Expiratory Volume - drug effects | Humans | Pyrrolidines - administration & dosage | Chloride Channel Agonists - therapeutic use | Male | Aminophenols - therapeutic use | Chloride Channel Agonists - adverse effects | Aminophenols - adverse effects | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Sweat - chemistry | Young Adult | Quinolones - adverse effects | Chlorides - metabolism | Quinolones - therapeutic use | Adult | Benzodioxoles - adverse effects | Female | Benzodioxoles - therapeutic use | Pyrazoles - pharmacology | Pyridines - therapeutic use | Pyridines - administration & dosage | Double-Blind Method | Genotype | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Chlorides - analysis | Pyrazoles - administration & dosage | Indoles - adverse effects | Cystic Fibrosis - genetics | Adolescent | Alleles | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Indoles - therapeutic use | Pyridines - pharmacology | Mutation | Cystic Fibrosis - drug therapy | Drug Combinations | Cystic fibrosis | Ivacaftor | Dosage and administration | Drug therapy | Statistical analysis | Writers | Epithelial cells | Chloride transport | Recovery of function | Patients | Design | Proteins | Genotype & phenotype | Chloride | Collaboration | Conductance | Cystic fibrosis transmembrane conductance regulator | Protein transport | Sweat | Pharmaceuticals | Index Medicus | Abridged Index Medicus
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2011, Volume 377, Issue 9773, pp. 1276 - 1287
... to the identification of novel therapeutic targets. Novel treatment strategies have been developed that aim to inhibit excessive bone resorption and increase bone formation... 
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Wnt Proteins - drug effects | Vitamin D Deficiency - complications | Calcium - metabolism | Bone Morphogenetic Proteins - immunology | Humans | Middle Aged | Osteoporosis - diagnosis | Osteoporosis, Postmenopausal - metabolism | Antibodies, Monoclonal - therapeutic use | Osteoporosis - drug therapy | Wnt Proteins - metabolism | Biphenyl Compounds - therapeutic use | Osteoporosis - etiology | Bone Remodeling - drug effects | Antibodies, Monoclonal, Humanized | Osteoporosis - metabolism | Vitamin D Deficiency - therapy | Aged, 80 and over | Bone Resorption - metabolism | Diphosphonates - therapeutic use | Female | Benzodioxoles - therapeutic use | RANK Ligand - therapeutic use | Anabolic Agents - therapeutic use | Osteoporosis - prevention & control | Risk Assessment | Osteoporotic Fractures - prevention & control | Risk Factors | Bone Resorption - drug therapy | Bone Density Conservation Agents - therapeutic use | Denosumab | Absorptiometry, Photon | Genetic Markers - immunology | Osteoclasts - metabolism | Osteoporosis, Postmenopausal - drug therapy | Randomized Controlled Trials as Topic | Bone Density - drug effects | Quinazolines - therapeutic use | Aged | Osteoblasts - metabolism | Intercellular Signaling Peptides and Proteins - immunology | Osteoporosis | Complications and side effects | Care and treatment | Diagnosis | Bones | Vitamin D | Womens health | Metabolic disorders | Index Medicus | Abridged Index Medicus | Cathepsin K | Cytokines | Proteinase | Socio-economic aspects | SOST protein | Osteoblasts | Post-menopause | Bone resorption | NF- Kappa B protein | Bone mass | Fractures | Reviews | Aging | Monoclonal antibodies | Osteoclasts | Dkk1 protein | Osteogenesis | Communication
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 2018, Volume 25, Issue 37, pp. 4918 - 4928
Recently many studies showed anticancer activities of piperine, a pungent alkaloid found in black pepper and some other Piper species. We attempted to... 
Alkaloid | Piperine | Antimutagen | P. nigrum | Antineoplast | Chemoprevention | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Drug Resistance, Multiple - drug effects | Humans | Neoplasm Invasiveness - prevention & control | Polyunsaturated Alkamides - therapeutic use | Benzodioxoles - metabolism | Biological Availability | Neoplasms - prevention & control | Stem Cells - cytology | Antimutagenic Agents - pharmacology | Anticarcinogenic Agents - pharmacokinetics | Inactivation, Metabolic - drug effects | Piperidines - pharmacology | Neoplasm Metastasis - prevention & control | Piper - metabolism | Neovascularization, Pathologic - prevention & control | Alkaloids - metabolism | Alkaloids - biosynthesis | Benzodioxoles - therapeutic use | Antineoplastic Agents, Phytogenic - therapeutic use | Drug Evaluation, Preclinical | Antineoplastic Agents, Phytogenic - pharmacokinetics | Anticarcinogenic Agents - therapeutic use | Cell Survival - drug effects | Alkaloids - pharmacology | Piperidines - metabolism | Neoplasms - blood supply | Antioxidants - pharmacology | Polyunsaturated Alkamides - metabolism | Neoplasms - drug therapy | Animals | Piperidines - therapeutic use | Polyunsaturated Alkamides - pharmacology | Stem Cells - drug effects | Alkaloids - therapeutic use | Cell Proliferation - drug effects | Neoplasms - pathology | Benzodioxoles - pharmacology | Drug Resistance, Neoplasm - drug effects | Medical research | Enzymes | Transcription factors | Cell survival | Data acquisition | Multidrug resistance | Material requirements planning | Clinical trials | Cytotoxicity | Metastases | Anticancer properties | Antioxidants | Angiogenesis | Stem cells | Cell cycle | MRP1 protein | Cancer | Apoptosis
Journal Article
The New England journal of medicine, ISSN 1533-4406, 10/2018, Volume 379, Issue 17, pp. 1599 - 1611
... Phe508del alleles or a gating or residual-function CFTR mutation), small-molecule CFTR modulators provide therapeutic benefit by restoring CFTR activity. 5 However... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Pyrazoles - therapeutic use | Forced Expiratory Volume - drug effects | Humans | Pyrrolidines - adverse effects | Chloride Channel Agonists - therapeutic use | Male | Aminophenols - therapeutic use | Chloride Channel Agonists - adverse effects | Aminophenols - adverse effects | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Sweat - chemistry | Young Adult | Quinolones - adverse effects | Quinolones - therapeutic use | Adult | Benzodioxoles - adverse effects | Female | Benzodioxoles - therapeutic use | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Double-Blind Method | Cells, Cultured | Genotype | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Chlorides - analysis | Indoles - adverse effects | Cystic Fibrosis - genetics | Adolescent | Alleles | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Indoles - therapeutic use | Mutation | Cystic Fibrosis - drug therapy | Drug Combinations | Cystic fibrosis | Ivacaftor | Genetic aspects | Dosage and administration | Drug therapy | Epithelial cells | Chloride transport | Clinical trials | Recovery of function | Patients | Proteins | Genotype & phenotype | Conductance | Cystic fibrosis transmembrane conductance regulator | Protein transport | Sweat | Binding sites | Genotypes | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 11/2017, Volume 377, Issue 21, pp. 2013 - 2023
Journal Article
Fitoterapia, ISSN 0367-326X, 09/2014, Volume 97, pp. 1 - 14
Journal Article