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Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2014, Volume 74, Issue 1, pp. 95 - 115
This study evaluated the preclinical pharmacokinetics (PK) and disposition of Fruquintinib (HMPL-013), a small molecule vascular endothelial growth factor... 
Fruquintinib | Medicine & Public Health | Disposition | Oncology | Cancer Research | HMPL-013 | Pharmacology/Toxicology | Pharmacokinetics | Allometric scaling | Modeling | HALF-LIFE | NONSPECIFIC-BINDING | CLEARANCE | FACTOR RECEPTORS | PROTEIN-BINDING | IN-VITRO | POTENT | ONCOLOGY | DRUGS | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | ENDOTHELIAL GROWTH-FACTOR | Inactivation, Metabolic | Drugs, Investigational - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Bile - chemistry | Humans | Microsomes, Liver - metabolism | Drugs, Investigational - pharmacokinetics | Cytochrome P-450 Enzyme System - metabolism | Quinazolines - pharmacokinetics | Benzofurans - administration & dosage | Benzofurans - pharmacology | Biological Availability | Male | Drugs, Investigational - metabolism | Intestinal Absorption | Benzofurans - pharmacokinetics | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Drug Interactions | Quinazolines - metabolism | Microsomes, Liver - drug effects | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | Quinazolines - administration & dosage | Microsomes, Liver - enzymology | Drug Evaluation, Preclinical | Caco-2 Cells | Protein Kinase Inhibitors - pharmacokinetics | Food-Drug Interactions | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacokinetics | Random Allocation | Protein Kinase Inhibitors - administration & dosage | Angiogenesis Inhibitors - metabolism | Animals | Models, Biological | Drugs, Investigational - administration & dosage | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Benzofurans - metabolism | Protein Kinase Inhibitors - metabolism | Physiological aspects | Permeability | Metabolites | Vascular endothelial growth factor | Gastrointestinal system | Protein binding
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2005, Volume 45, Issue 12, pp. 1345 - 1359
Journal Article
Journal Article
British journal of clinical pharmacology, ISSN 0306-5251, 2011, Volume 72, Issue 2, pp. 235 - 246
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: This study provides antimuscarinic agents for overactive bladder (OAB) display variable association with side effects... 
blood−brain barrier | fesoterodine | pharmacokinetics | CNS | overactive bladder | antimuscarinic | Antimuscarinic | Overactive bladder | Blood-brain barrier | Fesoterodine | Pharmacokinetics | blood-brain barrier | OXYBUTYNIN | TOLTERODINE | OLDER | COGNITIVE IMPAIRMENT | TROSPIUM CHLORIDE | BLOOD-BRAIN-BARRIER | RECEPTOR ANTAGONIST | P-GLYCOPROTEIN | ANTICHOLINERGIC DRUGS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | Mandelic Acids - pharmacokinetics | Humans | Solifenacin Succinate | Male | Receptors, Muscarinic - metabolism | Chromatography, High Pressure Liquid | Benzofurans - pharmacokinetics | Brain - metabolism | Tandem Mass Spectrometry | Urinary Bladder, Overactive - drug therapy | Tolterodine Tartrate | Muscarinic Antagonists - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Cell Line | Pyrrolidines - pharmacokinetics | Rats | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Randomized Controlled Trials as Topic | Animals | Tetrahydroisoquinolines - pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cresols - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Quinuclidines - pharmacokinetics | Urinary incontinence | Analysis | Oxybutynin | Permeability | Drug therapy | Blood proteins | Protein binding | Brain | Acetylcholine receptors (muscarinic) | Central nervous system | Membrane permeability | Clinical trials | Data processing | Cerebrospinal fluid | Plasma proteins | Side effects | Urinary bladder | P-Glycoprotein | Geriatrics | Uropharmacology Themed Section
Journal Article
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 06/2016, Volume 1022, pp. 6 - 12
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 04/2012, Volume 19, Issue 12, pp. 1846 - 1863
New-generation antidepressants are a heterogeneous class of drugs used in the treatment of depression and related disorders. This review deals with the first... 
Paroxetine | Antidepressants | Fluoxetine | Pharmacological properties | Selective serotonin reuptake inhibitors (SSRIs) | Therapeutic drug monitoring (TDM) | Vilazodone | Fluvoxamine | Sertraline | Chemical-clinical correlations | Citalopram | ELECTRON-CAPTURE DETECTION | POSTTRAUMATIC-STRESS-DISORDER | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | fluvoxamine | TANDEM MASS-SPECTROMETRY | pharmacological properties | OBSESSIVE-COMPULSIVE DISORDER | PERFORMANCE LIQUID-CHROMATOGRAPHY | chemical-clinical correlations | therapeutic drug monitoring (TDM) | fluoxetine | paroxetine | selective serotonin reuptake inhibitors (SSRIs) | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSIVE DISORDER | PLACEBO-CONTROLLED TRIAL | NEW-GENERATION ANTIDEPRESSANTS | citalopram | TRANSPORTER BINDING PROFILE | vilazodone | sertraline | SOLID-PHASE EXTRACTION | Paroxetine - pharmacokinetics | Serotonin Uptake Inhibitors - pharmacokinetics | Fluoxetine - pharmacokinetics | Humans | Citalopram - adverse effects | Depressive Disorder - drug therapy | Paroxetine - therapeutic use | Sertraline - adverse effects | Paroxetine - adverse effects | Benzofurans - pharmacokinetics | Sertraline - pharmacokinetics | Vilazodone Hydrochloride | Sertraline - therapeutic use | Fluoxetine - therapeutic use | Piperazines - pharmacokinetics | Fluoxetine - adverse effects | Fluvoxamine - therapeutic use | Benzofurans - therapeutic use | Serotonin Uptake Inhibitors - therapeutic use | Fluvoxamine - pharmacokinetics | Serotonin Uptake Inhibitors - adverse effects | Piperazines - therapeutic use | Benzofurans - adverse effects | Depressive Disorder - metabolism | Fluvoxamine - adverse effects | Piperazines - adverse effects | Indoles - adverse effects | Citalopram - pharmacokinetics | Citalopram - therapeutic use | Indoles - pharmacokinetics | Indoles - therapeutic use | Drug Monitoring
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7241 - 7257
In order to explore novel tau-imaging agents that can selectively detect neurofibrillary tangles in Alzheimer's disease (AD) brains, we designed and... 
LANSOPRAZOLE | CHEMISTRY, MEDICINAL | BENZIMIDAZOLE DERIVATIVES | RADIOLIGAND | PHOTOISOMERIZATION | BIOLOGICAL EVALUATION | HYPOTHETICAL MODEL | PATHOLOGY | MILD COGNITIVE IMPAIRMENT | DYNAMIC BIOMARKERS | PET | Styrenes - chemical synthesis | Brain - diagnostic imaging | Iodine Radioisotopes | Pyridines - chemistry | Stereoisomerism | Humans | Styrenes - pharmacokinetics | Pyridines - pharmacokinetics | tau Proteins - metabolism | Male | Structure-Activity Relationship | Benzimidazoles - chemistry | Temporal Lobe - diagnostic imaging | Benzothiazoles - pharmacokinetics | Radiopharmaceuticals - chemical synthesis | Alzheimer Disease - pathology | Benzofurans - chemistry | Benzofurans - pharmacokinetics | Brain - metabolism | Styrenes - chemistry | Benzothiazoles - chemical synthesis | Neurofibrillary Tangles - metabolism | Amyloid beta-Peptides - metabolism | Temporal Lobe - pathology | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Benzimidazoles - chemical synthesis | Pyridines - chemical synthesis | Benzimidazoles - pharmacokinetics | Benzofurans - chemical synthesis | Temporal Lobe - metabolism | Benzoxazoles - chemical synthesis | Autoradiography | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Animals | Benzoxazoles - chemistry | Alzheimer Disease - metabolism | Radionuclide Imaging | Benzothiazoles - chemistry | Brain - pathology | Neurofibrillary Tangles - diagnostic imaging | Aged | Mice | Alzheimer Disease - diagnostic imaging | Thiophenes - chemistry | Benzoxazoles - pharmacokinetics
Journal Article