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Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2007, Volume 321, Issue 3, pp. 930 - 937
We have previously shown that the endocannabinoid anandamide and its metabolically stable analog ( R )-methanandamide produce vasorelaxation in rabbit aortic... 
SYNTHASE | 4,5-DIAMINOFLUORESCEIN DIACETATE | VASORELAXATION | CB1 | PHOSPHORYLATION | PROTEIN-KINASE | PHARMACOLOGY | ENDOCANNABINOIDS | PHARMACOLOGY & PHARMACY | MESENTERIC-ARTERY | COMBINATION | Cannabinoid Receptor Modulators - pharmacology | Receptor, Cannabinoid, CB2 - physiology | Receptor, Cannabinoid, CB2 - agonists | Bornanes - pharmacology | Benzofurans - pharmacology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - physiology | Dose-Response Relationship, Drug | Resorcinols - pharmacology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Cyclohexanols - pharmacology | Phosphorylation - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Endocannabinoids | Pertussis Toxin - pharmacology | Pyrazoles - pharmacology | Rabbits | Endothelial Cells - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Animals | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Signal Transduction - drug effects | Endothelial Cells - cytology | Benzoxazines - pharmacology | Polyunsaturated Alkamides - pharmacology | Signal Transduction - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Nitric Oxide - metabolism | Endothelial Cells - drug effects | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2001, Volume 423, Issue 1, pp. 71 - 83
Prucalopride is a novel enterokinetic compound and is the first representative of the benzofuran class. We set out to establish its pharmacological profile in... 
Enterokinetic | Prucalopride | 5-HT 4 receptor | receptor | 5-HT | prucalopride | enterokinetic | LONGITUDINAL MUSCLE | R093877 | CHRONIC CONSTIPATION | STIMULATION | 5-HYDROXYTRYPTAMINE | GASTROINTESTINAL TRANSIT | 5-HT4 receptor | PIG PROXIMAL COLON | CIRCULAR SMOOTH-MUSCLE | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | 5-HT4 RECEPTORS | Esophagus - drug effects | Electric Stimulation | Receptors, Cholecystokinin - antagonists & inhibitors | Gallbladder - drug effects | Humans | Colon - drug effects | Male | Esophagus - physiology | Serotonin Receptor Agonists - pharmacology | Ileum - drug effects | Piperidines - pharmacology | Dioxanes - pharmacology | Granisetron - pharmacology | Rabbits | Guinea Pigs | Rats | Sulfonamides - pharmacology | Indomethacin - pharmacology | Receptors, Gastrointestinal Hormone - antagonists & inhibitors | Muscle Contraction - drug effects | Receptors, Dopamine D4 | Serotonin Receptor Agonists - metabolism | Gallbladder - physiology | Benzofurans - metabolism | Colon - physiology | Rats, Wistar | Sincalide - pharmacology | Benzofurans - pharmacology | Stomach - physiology | Receptors, Dopamine D2 - metabolism | Serotonin - pharmacology | Dose-Response Relationship, Drug | Motilin - analogs & derivatives | Female | Indoles - pharmacology | Stomach - drug effects | CHO Cells | Binding, Competitive | Cell Line | Cricetinae | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Receptors, Neuropeptide - antagonists & inhibitors | Motilin - pharmacology | Serotonin Antagonists - pharmacology | Receptors, Serotonin - metabolism | Carbachol - pharmacology | Gastrointestinal Agents - pharmacology | Animals | Dogs | Ileum - physiology | In Vitro Techniques | Gastrointestinal Agents - metabolism | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2014, Volume 58, Issue 12, pp. 7215 - 7224
Direct-acting antivirals (DAAs) targeting proteins encoded by the hepatitis C virus (HCV) genome have great potential for the treatment of HCV infections.... 
PROTEIN 5B POLYMERASE | NS5B POLYMERASE | NONNUCLEOSIDE INHIBITORS | PRECLINICAL CHARACTERIZATION | IN-VITRO | DEPENDENT RNA-POLYMERASE | CRYSTAL-STRUCTURE | DE-NOVO INITIATION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CHIMERIC REPLICONS | TREATMENT-NAIVE PATIENTS | Replicon - drug effects | Triazoles - chemistry | Humans | Hepacivirus - genetics | Benzofurans - pharmacology | RNA Replicase - antagonists & inhibitors | Structure-Activity Relationship | Pyridazines - pharmacology | Benzimidazoles - chemistry | Pyrones - pharmacology | Benzofurans - chemistry | Pyrones - chemistry | Antiviral Agents - chemistry | Cyclohexanols - chemistry | Enzyme Inhibitors - chemistry | Cyclohexanols - pharmacology | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Sulfonamides - chemistry | Purines - pharmacology | RNA Replicase - genetics | Viral Proteins - chemistry | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Thiophenes - pharmacology | Viral Proteins - genetics | Genotype | Viral Proteins - antagonists & inhibitors | Recombinant Proteins - genetics | Sulfonamides - pharmacology | Pyridazines - chemistry | Triazoles - pharmacology | Drug Resistance, Viral - genetics | Hepacivirus - enzymology | Purines - chemistry | RNA Replicase - chemistry | Benzimidazoles - pharmacology | Thiophenes - chemistry | Index Medicus | Antiviral Agents
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2007, Volume 30, Issue 1, pp. 54 - 58
Solifenacin succinate [YM905; (3R)-1-azabicyclo[2.2.2]oct-3-yl(1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate monosuccinate] is a new muscarinic... 
bladder capacity | solifenacin | urinary bladder | muscarinic receptor | Muscarinic receptor | Solifenacin | Urinary bladder | Bladder capacity | OVERACTIVE BLADDER SYNDROME | M-3 MUSCARINIC RECEPTORS | RAT | URINARY-BLADDER | DETRUSOR OVERACTIVITY | TOLTERODINE | SALIVARY-GLAND | IN-VITRO | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | MICE | Cricetulus | Rats, Wistar | Solifenacin Succinate | Benzofurans - pharmacology | Male | Phenylpropanolamine - pharmacology | Receptors, Muscarinic - metabolism | Muscarinic Antagonists - therapeutic use | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Mandelic Acids - pharmacology | Muscle, Smooth - drug effects | Urinary Bladder, Overactive - drug therapy | Quinuclidines - therapeutic use | Receptors, Muscarinic - drug effects | Transfection | Muscarinic Antagonists - pharmacology | Tolterodine Tartrate | Urination - drug effects | Benzilates - pharmacology | Cholinergic Agonists - pharmacology | Cresols - pharmacology | CHO Cells | Muscarinic Antagonists - metabolism | Binding, Competitive | Tetrahydroisoquinolines - pharmacology | Cricetinae | Quinuclidines - pharmacology | Rats | Atropine - pharmacology | Tetrahydroisoquinolines - therapeutic use | Rats, Sprague-Dawley | Carbachol - pharmacology | Animals | Muscle Contraction - drug effects | Tetrahydroisoquinolines - metabolism | N-Methylscopolamine - metabolism | Urinary Bladder - drug effects | Benzhydryl Compounds - pharmacology | In Vitro Techniques | Quinuclidines - metabolism | Index Medicus
Journal Article
The AAPS Journal, ISSN 1550-7416, 4/2013, Volume 15, Issue 2, pp. 395 - 406
Journal Article
Neuropharmacology, ISSN 0028-3908, 2009, Volume 57, Issue 4, pp. 356 - 368
To date, it has been thought that cannabinoid receptors in CNS are primarily of the CB1R subtype, with CB2R expressed only in glia and peripheral tissues.... 
Entorhinal | GABA | Inhibition | Cannabinoid | IPSC | MOUSE-BRAIN | ENDOGENOUS CANNABINOIDS | CEREBELLAR PURKINJE-CELLS | PHARMACOLOGICAL CHARACTERIZATION | NEUROSCIENCES | SELECTIVE LIGANDS | IN-VITRO | NETWORK OSCILLATIONS | DEPOLARIZATION-INDUCED SUPPRESSION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | RAT ENTORHINAL CORTEX | Cannabinoid Receptor Modulators - pharmacology | Rats, Wistar | Receptor, Cannabinoid, CB2 - agonists | gamma-Aminobutyric Acid - metabolism | Benzofurans - administration & dosage | Benzofurans - pharmacology | Male | Quinolones - pharmacology | Hippocampus - drug effects | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Indoles - administration & dosage | Receptor, Cannabinoid, CB1 - agonists | Dioxoles - administration & dosage | Neurons - physiology | Dioxoles - pharmacology | Indoles - pharmacology | Synaptic Transmission - drug effects | Neurons - drug effects | Endocannabinoids | Synapses - drug effects | Cannabinoids - administration & dosage | Synapses - physiology | Rats | Entorhinal Cortex - drug effects | Arachidonic Acids - pharmacology | Cannabinoids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Glycerides - pharmacology | Quinolones - administration & dosage | Animals | Central Nervous System Agents - administration & dosage | Central Nervous System Agents - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Hippocampus - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Entorhinal Cortex - physiology | RNA | Analysis | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2014, Volume 79, pp. 467 - 475
Endocannabinoids (eCBs) modulate synaptic transmission in the brain, but little is known of their regulatory role in nigral dopaminergic neurons, and whether... 
Electrophysiology | Cannabinoids | Parkinson's disease | Synaptic transmission | Dopaminergic | ENDOGENOUS CANNABINOIDS | RAT | SYNAPTIC-TRANSMISSION | ANANDAMIDE | METABOTROPIC GLUTAMATE | DOPAMINERGIC-NEURONS | SELF-INHIBITION | RELEASE | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | DIACYLGLYCEROL LIPASE | RECEPTORS | Endocannabinoids - metabolism | Synaptic Transmission - physiology | Rats, Wistar | Calcium - metabolism | Benzofurans - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Piperidines - pharmacology | Dopamine Agents - pharmacology | Neurons - physiology | Cannabinoid Receptor Antagonists - pharmacology | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Synaptic Transmission - drug effects | Neurons - drug effects | Dopamine - metabolism | Guanosine Diphosphate - pharmacology | Pyrazoles - pharmacology | Levodopa - pharmacology | Dopamine - pharmacology | Inhibitory Postsynaptic Potentials - physiology | Rats | Thionucleotides - pharmacology | Arachidonic Acids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Substantia Nigra - drug effects | Animals | Dopamine - analogs & derivatives | Guanosine Diphosphate - analogs & derivatives | Central Nervous System Agents - pharmacology | Glutamic Acid - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Substantia Nigra - physiology | Inhibitory Postsynaptic Potentials - drug effects | Receptors, Metabotropic Glutamate - antagonists & inhibitors | GABA | Glutamate | Gross domestic product | Dopamine receptors | Index Medicus
Journal Article
JOURNAL OF NATURAL PRODUCTS, ISSN 0163-3864, 01/2011, Volume 74, Issue 1, pp. 79 - 81
Journal Article
Glia, ISSN 0894-1491, 04/2012, Volume 60, Issue 4, pp. 605 - 614
Journal Article