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Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2009, Volume 34, Issue 3, pp. 681 - 697
Psychopharmacological studies have implicated the mesolimbic dopamine (DA) system in the mediation of cost/benefit evaluations about delay or effort-related... 
Discounting | Gambling | Amphetamine | Parkinson's disease | D | receptors | D-1 RECEPTOR | PSYCHIATRY | discounting | amphetamine | gambling | NEUROCHEMICAL PROFILE | NORMAL VOLUNTEERS | NEUROSCIENCES | VENTROMEDIAL PREFRONTAL CORTEX | D-2 receptors | IMPULSIVE BEHAVIOR | D-3 receptors | PHARMACOLOGY & PHARMACY | RECEPTOR GENE | D-AMPHETAMINE | PROBABILISTIC REINFORCEMENT | WORKING-MEMORY | PARKINSONS-DISEASE | Receptors, Dopamine D4 - agonists | Rats, Long-Evans | Decision Making - drug effects | Risk | Receptors, Dopamine D4 - antagonists & inhibitors | Pyrrolidines - pharmacology | Conditioning, Operant - drug effects | Receptors, Dopamine D1 - agonists | Behavior, Animal - drug effects | Benzamides - pharmacology | Benzopyrans - pharmacology | Receptors, Dopamine D3 - antagonists & inhibitors | Oxazines - pharmacology | Receptors, Dopamine D1 - antagonists & inhibitors | Dopamine Agonists - pharmacology | Dextroamphetamine - pharmacology | Receptors, Dopamine D2 - agonists | Rats | Behavior, Animal - physiology | Bromocriptine - pharmacology | Benzazepines - pharmacology | Piperazines - pharmacology | Naphthalenes - pharmacology | Receptors, Dopamine D3 - agonists | Reinforcement Schedule | Pyrroles - pharmacology | Animals | Dopamine Antagonists - pharmacology | Decision Making - physiology | Pyridines - pharmacology | Dopamine D2 Receptor Antagonists | Salicylamides - pharmacology | Index Medicus
Journal Article
Life Sciences, ISSN 0024-3205, 2003, Volume 73, Issue 4, pp. 471 - 485
Antinociceptive profiles of decursinol were examined in ICR mice. Decursinol administered orally (from 5 to 200 mg/kg) showed an antinociceptive effect in a... 
Serotonin receptor | α 2 adrenoceptor | Antinociception | Decursinol | Histamine receptor | Adenosine receptor | Inflammatory pain | adrenoceptor | MEDICINE, RESEARCH & EXPERIMENTAL | antinociception | histamine receptor | MORPHINE | ADENOSINE | STIMULI | SPINAL-CORD | RECEPTOR | serotonin receptor | RESPONSES | alpha adrenoceptor | PAIN | adenosine receptor | inflammatory pain | PHARMACOLOGY & PHARMACY | MICE | FORMALIN TEST | SUBSTANCE-P | decursinol | Analgesics - pharmacology | Models, Chemical | Histamine H2 Antagonists - pharmacology | Butyrates - pharmacology | Male | Substance P - pharmacology | Adrenergic alpha-Antagonists - pharmacology | Methysergide - pharmacology | Xanthines - pharmacology | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Theobromine - analogs & derivatives | Cyproheptadine - pharmacology | Piperidines - pharmacology | Pain - drug therapy | Butyrates - administration & dosage | Theobromine - pharmacology | Benzopyrans - pharmacology | Ranitidine - pharmacology | Glutamic Acid - pharmacology | Administration, Oral | Receptors, Adrenergic - metabolism | Protein Kinase C - antagonists & inhibitors | Serotonin Antagonists - pharmacology | Mice, Inbred ICR | Receptors, Serotonin - metabolism | Interleukin-1 - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Benzopyrans - administration & dosage | Receptors, Histamine - metabolism | Animals | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | Receptors, Purinergic P1 - metabolism | Interferon-gamma - pharmacology | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2005, Volume 315, Issue 3, pp. 1346 - 1353
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2009, Volume 4, Issue 9, pp. e7124 - e7124
Background: Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular... 
MULTIDISCIPLINARY SCIENCES | Drug Evaluation, Preclinical - methods | Automation | Models, Chemical | Humans | Multiprotein Complexes | Enzyme Inhibitors - pharmacology | Perhexiline - pharmacology | Transcription Factors - antagonists & inhibitors | Autophagy - physiology | Autophagy - drug effects | Cardiovascular Agents - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Proteins | Transcription Factors - metabolism | Signal Transduction - drug effects | Niclosamide - pharmacology | Acetophenones - pharmacology | Nutritional Sciences | TOR Serine-Threonine Kinases | Antinematodal Agents - pharmacology | Benzopyrans - pharmacology | Amiodarone - pharmacology | Tuberous sclerosis | Starvation | Cell death | Drug approval | Health aspects | Protein kinases | Cell culture | Cardiovascular disease | Biochemistry | Amiodarone | Cancer therapies | Sclerosis | Fibroblasts | Physiology | Inhibition | Catalysis | Heart failure | Rapamycin | Exposure | Metabolism | Chemicals | TSC2 protein | Insects | Protein synthesis | Cardiovascular diseases | Phagocytosis | TOR protein | Drugs | Tuberous sclerosis 2 protein | Phosphorylation | Parkinsons disease | Niclosamide | Biosynthesis | Catalytic activity | Kinases | Autophagy | Modulators | Cell cycle | Nutrients | Electromyography | Killing | Diabetes mellitus | Pharmacology | Embryo fibroblasts | Angina pectoris | Signaling | Protein kinase | Nutrient availability | Molecular biology | Apoptosis | Cancer | Index Medicus
Journal Article
Blood Cells, Molecules and Diseases, ISSN 1079-9796, 03/2016, Volume 57, pp. 85 - 90
Granulocyte-macrophage colony stimulating factor (GM-CSF) induces procoagulant activity of macrophages. Tissue factor (TF) is a membrane-bound glycoprotein and... 
Neurokinin 1 receptor | Granulocyte-macrophage colony-stimulating factor | Substance P | Tissue factor | ACTIVATION | ADIPOCYTES | MECHANISM | MONOCYTES | NEUROKININ-1 RECEPTOR | INDUCTION | MICROPARTICLES | ENDOTHELIAL-CELLS | INHIBITOR | HEMATOLOGY | PROCOAGULANT ACTIVITY | Free Radical Scavengers - pharmacology | RNA, Small Interfering - genetics | Adipocytes - secretion | Dynamins - metabolism | Humans | NADPH Oxidases - metabolism | Adipocytes - cytology | Arrestins - genetics | Substance P - pharmacology | Phosphorylcholine - analogs & derivatives | Arrestins - metabolism | rho-Associated Kinases - antagonists & inhibitors | Pyrrolidines - pharmacology | Macrophages - secretion | Neurokinin-1 Receptor Antagonists - pharmacology | Thiocarbamates - pharmacology | rho-Associated Kinases - metabolism | Substance P - biosynthesis | Phosphorylcholine - pharmacology | Acetophenones - pharmacology | NADPH Oxidases - genetics | Benzopyrans - pharmacology | Thromboplastin - biosynthesis | Amides - pharmacology | Dynamins - antagonists & inhibitors | Signal Transduction | NADPH Oxidases - antagonists & inhibitors | Gene Expression Regulation | Dynamins - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Morpholines - pharmacology | rho-Associated Kinases - genetics | Macrophages - cytology | Arrestins - antagonists & inhibitors | beta-Arrestin 2 | beta-Arrestins | Macrophages - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Primary Cell Culture | Macrophage Activation - drug effects | RNA, Small Interfering - metabolism | Thromboplastin - secretion | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 9, pp. 2513 - 2521
The dopamine D3 receptor, which is highly enriched in nucleus accumbens (NAc), has been suggested to play an important role in reinforcement and reward. To... 
Nucleus accumbens | Protein kinase A | receptor | Trafficking | Dynamin | GABA | Dopamine D | Intracellular Signaling Peptides and Proteins - pharmacology | Phosphorylation | Sulpiride - pharmacology | Synaptic Transmission - physiology | Peptide Fragments - pharmacology | Membrane Potentials - radiation effects | Patch-Clamp Techniques - methods | Dynamins - pharmacology | Neural Inhibition - physiology | Neural Inhibition - radiation effects | Drug Interactions | Biphenyl Compounds - pharmacology | Nucleus Accumbens - cytology | Neurons - physiology | Synaptic Transmission - drug effects | Benzopyrans - pharmacology | Neurons - drug effects | Dopamine Antagonists | Electric Stimulation - methods | Oxazines - pharmacology | Membrane Potentials - drug effects | Dopamine Agonists - pharmacology | Insulin - pharmacology | Blotting, Western - methods | Dopamine - pharmacology | Enzyme Inhibitors - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Nucleus Accumbens - radiation effects | Membrane Potentials - physiology | Piperazines - pharmacology | Rats, Sprague-Dawley | Endocytosis - physiology | Cyclic AMP - pharmacology | Immunohistochemistry - methods | Animals | Synaptic Transmission - radiation effects | Analysis of Variance | Receptors, Dopamine D3 - physiology | Receptors, GABA-A - physiology | In Vitro Techniques | Neurons - radiation effects | Nucleus Accumbens - drug effects | Neural Inhibition - drug effects | Index Medicus
Journal Article
Molecules, ISSN 1420-3049, 01/2013, Volume 18, Issue 1, pp. 1325 - 1336
The current study targets the chemical constituents of Caesalpinia decapetala (Roth) Alston and investigates the bioactivities of the isolated compounds.... 
Caesalpinia decapetala (Roth) Alston | Chemical constituents | DPPH | MTT | Structure elucidation | CHEMISTRY, ORGANIC | chemical constituents | structure elucidation | Free Radical Scavengers - pharmacology | Plant Extracts - chemistry | Triterpenes - pharmacology | Free Radical Scavengers - chemistry | Plant Extracts - pharmacology | Humans | Stilbenes - chemistry | Stilbenes - pharmacology | Benzopyrans - chemistry | Triterpenes - chemistry | Picrates - chemistry | Benzyl Alcohols - pharmacology | Ascorbic Acid - chemistry | Glucosides - chemistry | Inhibitory Concentration 50 | Flavonoids - pharmacology | Molecular Structure | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzyl Alcohols - chemistry | Cell Survival - drug effects | Benzyl Alcohols - isolation & purification | Glucosides - pharmacology | Emodin - pharmacology | Free Radicals - chemistry | Emodin - isolation & purification | Antineoplastic Agents | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Emodin - chemistry | Benzopyrans - isolation & purification | Free Radical Scavengers - isolation & purification | Glucosides - isolation & purification | Caesalpinia - chemistry | Stilbenes - isolation & purification | Cell Line, Tumor | Triterpenes - isolation & purification | Flavonoids - isolation & purification | Antineoplastic Agents, Phytogenic - pharmacology | Flavonoids - chemistry | Antineoplastic Agents, Phytogenic - isolation & purification | Index Medicus
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 530, Issue 1, pp. 144 - 151
The mechanisms underlying transient receptor potential vanilloid receptor type 1 (TRPV1)-independent relaxation elicited by capsaicin were studied by measuring... 
Capsaicin | Intestine | Capsazepine | K + channel | Myosin light chain | channel | CELLS | intestine | GENE-RELATED PEPTIDE | MECHANISM | KINASE | VANILLOID RECEPTOR | TETRAETHYLAMMONIUM | RELEASE | K+ channel | SIGNAL-TRANSDUCTION | SMOOTH-MUSCLE | myosin light chain | INHIBITION | capsaicin | capsazepine | PHARMACOLOGY & PHARMACY | Diclofenac - pharmacology | Tetraethylammonium - pharmacology | Calcium - metabolism | Capsaicin - pharmacology | Potassium Channels - physiology | Dimethyl Sulfoxide - pharmacology | Male | Peptide Fragments - pharmacology | Apamin - pharmacology | Dose-Response Relationship, Drug | Muscle, Smooth - drug effects | Ileum - drug effects | Glyburide - pharmacology | Piperidines - pharmacology | Charybdotoxin - pharmacology | Potassium Chloride - pharmacology | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Caffeine - pharmacology | Muscle, Smooth - physiology | Phosphorylation - drug effects | Benzopyrans - pharmacology | 4-Aminopyridine - pharmacology | Potassium Channel Blockers - pharmacology | Pyrazoles - pharmacology | Diterpenes - pharmacology | Guinea Pigs | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Phosphodiesterase Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Papaverine - pharmacology | Barium - pharmacology | Nitroarginine - pharmacology | Animals | Ileum - physiology | Myosin Light Chains - metabolism | Capsaicin - antagonists & inhibitors | Muscle Relaxation - drug effects | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Guanethidine - pharmacology | Acetylcholine | Peptides | Glibenclamide | Muscle proteins | Myosin | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2013, Volume 33, Issue 11, pp. 4875 - 4885
The GABAergic projection neurons in the substantia nigra pars reticulata (SNr) are key basal ganglia output neurons. The activity of these neurons is... 
EFFERENT PROJECTIONS | NEURONAL-ACTIVITY | NIGRA PARS-RETICULATA | NUCLEUS TEGMENTI PEDUNCULOPONTINUS | BASAL GANGLIA | SYNAPTIC-TRANSMISSION | GLOBUS-PALLIDUS | DEEP-BRAIN-STIMULATION | CENTRAL-NERVOUS-SYSTEM | SUBSTANTIA-NIGRA | NEUROSCIENCES | Electric Stimulation | Neural Pathways - drug effects | GABAergic Neurons - physiology | Glutamates - metabolism | Male | Serotonin - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Neural Pathways - physiology | Substantia Nigra - cytology | Serotonin Receptor Agonists - pharmacology | Ion Channel Gating - physiology | GABAergic Neurons - cytology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Female | Tetrodotoxin - pharmacology | Benzopyrans - pharmacology | Action Potentials - drug effects | Presynaptic Terminals - drug effects | Valine - analogs & derivatives | GABAergic Neurons - drug effects | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Presynaptic Terminals - physiology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Serotonin Antagonists - pharmacology | Serotonin Plasma Membrane Transport Proteins - metabolism | Subthalamic Nucleus - physiology | Patch-Clamp Techniques | Pyrroles - pharmacology | Animals | Analysis of Variance | Serotonin - metabolism | Mice | Pyridines - pharmacology | Valine - pharmacology | In Vitro Techniques | Ion Channel Gating - drug effects | Index Medicus | serotonin | substantia nigra pars reticulata | subthalamic nucleus | burst firing | 5-HT1B receptor | complex EPSCs | Parkinson’s disease
Journal Article
Circulation Research, ISSN 0009-7330, 11/2004, Volume 95, Issue 10, pp. 989 - 997
Stimulation of α1-adrenoceptors induces proliferation of vascular smooth muscle cells (SMCs) and contributes to arterial remodeling. Although activation of... 
Vascular smooth muscle cell proliferation | Signal transduction | α-adrenergic receptor | Reactive oxygen species | Metalloproteinase | ADVENTITIAL FIBROBLASTS | CARDIAC & CARDIOVASCULAR SYSTEMS | signal transduction | HB-EGF | metalloproteinase | PROTEIN-COUPLED RECEPTORS | ANGIOTENSIN-II | CELL REPLICATION | vascular smooth muscle cell proliferation | MATRIX METALLOPROTEINASES | IN-VITRO | SIGNALING PATHWAY | RAT CAROTID-ARTERY | reactive oxygen species | BALLOON INJURY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | alpha-adrenergic receptor | Glycine - analogs & derivatives | MAP Kinase Signaling System - physiology | MAP Kinase Kinase 2 - physiology | Nitriles - pharmacology | Adrenergic alpha-1 Receptor Agonists | Receptor, Epidermal Growth Factor - drug effects | MAP Kinase Kinase 1 - physiology | Quinazolines | Phenylephrine - pharmacology | Thrombin - pharmacology | Protein Processing, Post-Translational - drug effects | Cell Division | Flavonoids - pharmacology | Phosphorylation - drug effects | Benzopyrans - pharmacology | Myocytes, Smooth Muscle - drug effects | Receptor, Epidermal Growth Factor - physiology | Hydroxamic Acids - pharmacology | Myocytes, Smooth Muscle - cytology | Aorta, Thoracic - pathology | Organ Culture Techniques | Receptors, Adrenergic, alpha-1 - physiology | Butadienes - pharmacology | Mitogen-Activated Protein Kinase 1 - physiology | Myocytes, Smooth Muscle - enzymology | Dipeptides - pharmacology | Rats | Aorta, Thoracic - injuries | Imidazoles - pharmacology | Tyrphostins - pharmacology | Muscle, Smooth, Vascular - cytology | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - physiology | Bacterial Proteins - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Glycine - pharmacology | Catheterization - adverse effects | Pyridines - pharmacology | Index Medicus
Journal Article