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Brain, ISSN 0006-8950, 05/2016, Volume 139, Issue 5, pp. 1551 - 1567
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2018, Volume 37, Issue 7, p. n/a
The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we... 
tau | aggregation | liquid–liquid phase separation | Alzheimer's disease | phosphorylation | MICROTUBULE-BINDING | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POSTTRANSLATIONAL MODIFICATIONS | GRANULES | DROPLETS | CELL BIOLOGY | TRANSITION | liquid-liquid phase separation | PAIRED HELICAL FILAMENTS | MUTATIONS | DOMAINS | Phosphorylation | Molecular Weight | Humans | tau Proteins - metabolism | tau Proteins - chemistry | Brain - metabolism | DNA-Binding Proteins - metabolism | Sequence Analysis, Protein | Sf9 Cells | Neurofibrillary Tangles - metabolism | Cloning, Molecular | HEK293 Cells | Aged, 80 and over | Female | Neurons - metabolism | Benzothiazoles - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Biophysical Phenomena | Mice, Transgenic | Recombinant Proteins - genetics | Neurodegenerative Diseases - metabolism | tau Proteins - isolation & purification | Animals | Escherichia coli - genetics | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Heterogeneous Nuclear Ribonucleoprotein A1 - metabolism | Mice | Neuroblastoma - metabolism | Liquid-Liquid Extraction | Protein Aggregation, Pathological - metabolism | Brain | Seeds | Neurodegenerative diseases | Neurons | Amyotrophic lateral sclerosis | Forming | Agglomeration | Seeding | Molecular weight | Neurological diseases | Proteins | FUS protein | Neurofibrillary tangles | Aggregates | Tau protein | Phase separation | Dementia disorders | Droplets | Mutation | Frontotemporal dementia | Alzheimers disease | Recombinant | Physiology | Protein Biosynthesis & Quality Control
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0146296
Naringenin (NGN) exhibits anti-inflammatory and antioxidant activities, but it remains undetermined its topical actions against ultraviolet B (UVB)-induced... 
ANTIOXIDANT ACTIVITY | HAIRLESS MICE | NADPH OXIDASE | IN-VITRO | LEUKOCYTE RECRUITMENT | INDUCED GENERATION | MULTIDISCIPLINARY SCIENCES | ANION-INDUCED PAIN | FACTOR-KAPPA-B | PIMENTA-PSEUDOCARYOPHYLLUS EXTRACT | HACAT HUMAN KERATINOCYTES | Tumor Necrosis Factor-alpha - metabolism | Heme Oxygenase-1 - metabolism | Gene Expression - drug effects | Edema - genetics | Glutathione - metabolism | Glutathione Reductase - metabolism | Skin - metabolism | Tumor Necrosis Factor-alpha - genetics | Administration, Cutaneous | Interleukin-1beta - genetics | Glutathione Reductase - genetics | Heme Oxygenase-1 - genetics | Interleukin-1beta - metabolism | Lipid Peroxidation - drug effects | Superoxides - metabolism | Interleukin-10 - metabolism | NF-E2-Related Factor 2 - genetics | Benzothiazoles - antagonists & inhibitors | Superoxides - antagonists & inhibitors | Hydroxyl Radical - antagonists & inhibitors | Benzothiazoles - metabolism | Interleukin-6 - metabolism | Skin - pathology | Edema - prevention & control | Glutathione Peroxidase - metabolism | Interleukin-6 - genetics | Catalase - genetics | Flavanones - pharmacology | Mice, Hairless | Hydroxyl Radical - metabolism | Inflammation | Antioxidants - pharmacology | Sulfonic Acids - metabolism | Glutathione Peroxidase - genetics | Sulfonic Acids - antagonists & inhibitors | Ultraviolet Rays - adverse effects | Catalase - metabolism | Edema - etiology | Animals | Skin - radiation effects | Interleukin-10 - genetics | NF-E2-Related Factor 2 - metabolism | Mice | Oxidative Stress - drug effects | Edema - pathology | Skin - drug effects | Antioxidants | Oxidative stress | Care and treatment | Ultraviolet radiation | Analysis | Lipid peroxidation | Dosage and administration | Skin | Research | Dermatitis | Risk factors | Naringenin | Life assessment | Iron | Interleukin 6 | Signal transduction | Mitochondria | Catalase | Glutathione reductase | Rodents | Heme | Hydroxyl radicals | Tumor necrosis factor-TNF | Peroxidase | Inhibition | Glutathione | Peroxidation | Citrus fruits | Formulations | Glutathione peroxidase | Edema | Cytokines | U.V. radiation | Heme oxygenase (decyclizing) | Superoxide | Stability analysis | Hairless | Gene expression | Sulfonic acid | Oxygenase | Flavonoids | Interleukin 10 | Irradiation | In vivo methods and tests | Topical application | Radiation damage | Reductase
Journal Article
International immunology, ISSN 0953-8178, 12/2014, Volume 26, Issue 12, pp. 673 - 684
Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53... 
GCN2 kinase | indoleamine 2 | proliferation | T cells | aerobic glycolysis | 3-dioxygenase | glutaminolysis | p53 | CANCER-CELLS | ACTIVATION | P53-INDUCIBLE REGULATOR | TOLERANCE | IMMUNOLOGY | TRYPTOPHAN CATABOLISM | GLUTAMINE-METABOLISM | INHIBITION | ARYL-HYDROCARBON RECEPTOR | indoleamine 2,3-dioxygenase | EXPRESSION | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | L-Lactate Dehydrogenase - metabolism | Leukocytes, Mononuclear - metabolism | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Middle Aged | Glucose Transporter Type 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Healthy Volunteers | Lymphocyte Culture Test, Mixed | Mechanistic Target of Rapamycin Complex 1 | Toluene - analogs & derivatives | Multiprotein Complexes - metabolism | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Isoenzymes - metabolism | Mitochondrial Proteins - metabolism | T-Lymphocytes - drug effects | Tryptophan - analogs & derivatives | Leukocytes, Mononuclear - immunology | Lactic Acid - biosynthesis | Adult | Female | Toluene - pharmacology | Leukocytes, Mononuclear - drug effects | Benzothiazoles - pharmacology | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Carrier Proteins - metabolism | Glucose - metabolism | Glucosephosphate Dehydrogenase - metabolism | Glycolysis | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Tryptophan - pharmacology | Enzyme Activation | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23367
Background: Recent studies have demonstrated that activation of autophagy increases the lifespan of organisms from yeast to flies. In contrast to the lifespan... 
LIFE-SPAN EXTENSION | PATHOGENESIS | OXIDATIVE STRESS | INHIBITION | DISRUPTION | MULTIDISCIPLINARY SCIENCES | GENES | RESISTANCE | MITOCHONDRIAL DYSFUNCTION | SUPPRESSION | CELL BIOLOGY | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Sequestosome-1 Protein | Humans | Cellular Senescence - drug effects | Male | Autophagy - physiology | Phosphoproteins - metabolism | Fibroblasts - ultrastructure | Tumor Suppressor Protein p53 - genetics | Small Ubiquitin-Related Modifier Proteins - genetics | Toluene - analogs & derivatives | RNA Interference | Time Factors | beta-Galactosidase - metabolism | Autophagy - genetics | Toluene - pharmacology | Child | Fibroblasts - metabolism | Autophagy-Related Protein 12 | Cellular Senescence - genetics | Ubiquitin-Activating Enzymes - genetics | Lysosome-Associated Membrane Glycoproteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Benzothiazoles - pharmacology | Small Ubiquitin-Related Modifier Proteins - metabolism | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - physiology | Signal Transduction - genetics | Microscopy, Electron | Ubiquitin-Activating Enzymes - metabolism | Blotting, Western | Autophagy-Related Protein 7 | Acetylcysteine - pharmacology | Lysosome-Associated Membrane Glycoproteins - genetics | Signal Transduction - physiology | Fibroblasts - cytology | Primary Cell Culture | Adaptor Proteins, Signal Transducing - metabolism | Lysosomal-Associated Membrane Protein 2 | Acetylcysteine | Tumor proteins | Genetic translation | Cells | Protein binding | TOR protein | Huntingtons disease | Senescence | Phosphorylation | Yeast | p53 Protein | Impairment | Galactosidase | Viruses | Homology | Activation | Biochemistry | Autophagy | Fibroblasts | Aging | Cytokines | LAMP-2 protein | Translation initiation | Rapamycin | Ribosomal protein S6 | siRNA | Mammals | Membrane proteins | Medicine | Life span | Morphology | Initiation factor eIF-4E | Molecular biology | Alzheimers disease | Phagocytosis | Apoptosis
Journal Article
STEM CELLS, ISSN 1066-5099, 08/2011, Volume 29, Issue 8, pp. 1186 - 1195
Gamete failure‐derived infertility affects millions of people worldwide; for many patients, gamete donation by unrelated donors is the only available... 
Human induced pluripotent stem cells | Haploid cells | Meiosis | Germ cells | In vitro differentiation | DERIVATION | HUMAN TESTIS | MOUSE | PRIMORDIAL GERM-CELLS | CULTURE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SEMINIFEROUS EPITHELIUM | IN-VITRO | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENERATION | DIFFERENTIATION | FETAL | HEMATOLOGY | Nestin | Vimentin - metabolism | Humans | Fibroblast Growth Factor 2 - pharmacology | Male | Spermatogonia - metabolism | Antigens, CD - metabolism | DNA Methylation | Stage-Specific Embryonic Antigens - metabolism | Karyotyping | 3-Hydroxysteroid Dehydrogenases - metabolism | Cell Culture Techniques | Spermatogonia - cytology | DEAD-box RNA Helicases - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Promoter Regions, Genetic | Gene Expression | Induced Pluripotent Stem Cells - physiology | Benzothiazoles - pharmacology | Colforsin - pharmacology | Gene Expression Regulation | Nuclear Proteins - metabolism | Leukemia Inhibitory Factor - pharmacology | Nerve Tissue Proteins - metabolism | Proteins - genetics | Triazoles - pharmacology | DEAD-box RNA Helicases - genetics | Adaptor Proteins, Signal Transducing | Proteins - metabolism | Cell Differentiation - drug effects | Ploidies | Histones - metabolism | Intermediate Filament Proteins - metabolism
Journal Article
Toxicology, ISSN 0300-483X, 2007, Volume 232, Issue 3, pp. 216 - 225
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2013, Volume 25, Issue 11, pp. 2198 - 2209
While transforming growth factor-β (TGF-β1)-induced SMAD2/3 signaling is a critical event in the progression of chronic kidney disease, the role of non-SMAD... 
PAI-1 | TGF-β1 | Obstructive nephropathy | SMAD signaling | Renal fibrosis | p53 | P53 | Endothelium, Vascular - cytology | Receptor, Epidermal Growth Factor - agonists | Receptor, Epidermal Growth Factor - genetics | Reactive Oxygen Species - metabolism | Endothelium, Vascular - drug effects | Smad3 Protein - metabolism | Tumor Suppressor Protein p53 - genetics | Renal Insufficiency, Chronic - metabolism | Toluene - analogs & derivatives | Smad3 Protein - genetics | Receptor, Epidermal Growth Factor - metabolism | Isoquinolines - pharmacology | Smad2 Protein - genetics | Renal Insufficiency, Chronic - genetics | Myocytes, Smooth Muscle - drug effects | Toluene - pharmacology | Mink | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Signal Transduction | Benzothiazoles - pharmacology | Gene Expression Regulation | Smad2 Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Tyrphostins - pharmacology | Renal Insufficiency, Chronic - pathology | Pyrroles - pharmacology | Serpin E2 - genetics | Animals | Endothelium, Vascular - metabolism | Fibroblasts - drug effects | Fibrosis | Connective Tissue Growth Factor - genetics | Fibroblasts - cytology | Mice | Pyridines - pharmacology | Quinazolines - pharmacology | Serpin E2 - metabolism | Connective Tissue Growth Factor - metabolism
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2007, Volume 321, Issue 3, pp. 1154 - 1160
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 112 - 117
Many craniofacial disorders are caused by heterozygous mutations in general regulators of housekeeping cellular functions such as transcription or ribosome... 
PATHOGENESIS | CELLS | PROTEIN | ENDONUCLEASE | RNA HELICASE DDX21 | DNA | MULTIDISCIPLINARY SCIENCES | PREVENTION | TREACHER-COLLINS-SYNDROME | NEURAL CREST | P53 | Xenopus | Chromatin - metabolism | Cell Nucleolus - pathology | Embryonic Stem Cells - cytology | Mandibulofacial Dysostosis - embryology | Humans | Protein Transport - drug effects | DNA-Directed RNA Polymerases - deficiency | RNA, Ribosomal - genetics | RNA Polymerase I - antagonists & inhibitors | Mandibulofacial Dysostosis - genetics | Cell Nucleus - metabolism | Skull - pathology | Nuclear Proteins - deficiency | Cell Nucleolus - drug effects | Stress, Physiological - drug effects | Neural Crest - enzymology | Benzothiazoles - pharmacology | Phenotype | Zebrafish Proteins - deficiency | Ribosomes - genetics | Mice | DNA Damage | HeLa Cells | Embryonic Stem Cells - metabolism | RNA Helicases - metabolism | Mandibulofacial Dysostosis - pathology | Neural Crest - pathology | Ribosomal Proteins - biosynthesis | Ribosomes - metabolism | DNA, Ribosomal - metabolism | Phosphoproteins - metabolism | Zebrafish - embryology | Cell Nucleus - pathology | Cell Nucleolus - metabolism | DEAD-box RNA Helicases - deficiency | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | DNA, Ribosomal - genetics | Cell Nucleolus - genetics | Ribosomal Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Organ Specificity | DEAD-box RNA Helicases - genetics | Animals | Phosphoproteins - deficiency | RNA, Ribosomal - biosynthesis | Cell Nucleus - drug effects | Naphthyridines - pharmacology | Apoptosis | Nucleolus organizer region | Genetic aspects | Gene mutations | Observations | Neural crest | Craniofacial dysostosis | Chromatin | Transcription | Genomics | p53 Protein | Genes | DNA damage | Ribosomal DNA | Disorders | Homeostasis | Biosynthesis | Genomes | DNA-directed RNA polymerase | Proteins | DNA helicase | Nucleoli | Embryogenesis | Cell activation | RNA processing | Chemical synthesis | Deoxyribonucleic acid--DNA | Anemia | rRNA | RNA polymerase | Embryonic growth stage | Polymerase | DNA biosynthesis | Craniofacial growth | Ribonucleic acids | Stem cells | Mutation | Developmental disabilities | Tumors | RNA helicase
Journal Article
Journal Article