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Journal Article
Expert Opinion on Drug Metabolism & Toxicology, ISSN 1742-5255, 10/2012, Volume 8, Issue 10, pp. 1247 - 1261
Introduction: Restless legs syndrome (RLS) is a common neurological disorder that might impair nocturnal rest causing decreased alertness, depressed mood,... 
toxicology | periodic leg movements | ropinirole | absorption | pramipexole | restless legs syndrome | rotigotine | augmentation | distribution | levodopa | iron | pregabalin | gabapentin enacarbil | metabolism | pharmacokinetic | dopamine | elimination | tolerance | Dopamine | Elimination | Tolerance | Iron | Pregabalin | Metabolism | Pharmacokinetic | Pramipexole | Augmentation | Restless legs syndrome | Ropinirole | Toxicology | Absorption | Distribution | Rotigotine | Levodopa | Periodic leg movements | Gabapentin enacarbil | CLINICAL PHARMACOKINETICS | ROTIGOTINE TRANSDERMAL PATCH | DOPAMINE-RECEPTOR AGONISTS | PHARMACOLOGY & PHARMACY | PARKINSONS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OPEN-LABEL | STATE PHARMACOKINETIC PROPERTIES | DOUBLE-BLIND | SYNDROME RLS | LONG-TERM TREATMENT | Thiophenes - therapeutic use | Thiophenes - adverse effects | Humans | Dopamine Agonists - therapeutic use | Levodopa - pharmacokinetics | Tetrahydronaphthalenes - therapeutic use | Dopamine Agonists - adverse effects | Ergolines - adverse effects | Dopamine Agents - therapeutic use | Tetrahydronaphthalenes - adverse effects | Benzothiazoles - pharmacokinetics | Carbamates - pharmacokinetics | Dopamine Agents - adverse effects | Ergolines - pharmacokinetics | Restless Legs Syndrome - drug therapy | Anticonvulsants - adverse effects | Dopamine Agents - pharmacokinetics | Amines - therapeutic use | Amines - adverse effects | gamma-Aminobutyric Acid - therapeutic use | Neuralgia - physiopathology | gamma-Aminobutyric Acid - adverse effects | gamma-Aminobutyric Acid - pharmacokinetics | Anticonvulsants - pharmacokinetics | Cyclohexanecarboxylic Acids - therapeutic use | Levodopa - therapeutic use | Cyclohexanecarboxylic Acids - adverse effects | Anticonvulsants - therapeutic use | Dopamine Agonists - pharmacokinetics | Tetrahydronaphthalenes - pharmacokinetics | Treatment Outcome | Neuralgia - drug therapy | Randomized Controlled Trials as Topic | Ergolines - therapeutic use | Thiophenes - pharmacokinetics | Indoles - adverse effects | Levodopa - adverse effects | Amines - pharmacokinetics | Carbamates - adverse effects | Indoles - pharmacokinetics | Indoles - therapeutic use | Benzothiazoles - therapeutic use | Cyclohexanecarboxylic Acids - pharmacokinetics | Carbamates - therapeutic use | gamma-Aminobutyric Acid - analogs & derivatives | Benzothiazoles - adverse effects | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7241 - 7257
In order to explore novel tau-imaging agents that can selectively detect neurofibrillary tangles in Alzheimer's disease (AD) brains, we designed and... 
LANSOPRAZOLE | CHEMISTRY, MEDICINAL | BENZIMIDAZOLE DERIVATIVES | RADIOLIGAND | PHOTOISOMERIZATION | BIOLOGICAL EVALUATION | HYPOTHETICAL MODEL | PATHOLOGY | MILD COGNITIVE IMPAIRMENT | DYNAMIC BIOMARKERS | PET | Styrenes - chemical synthesis | Brain - diagnostic imaging | Iodine Radioisotopes | Pyridines - chemistry | Stereoisomerism | Humans | Styrenes - pharmacokinetics | Pyridines - pharmacokinetics | tau Proteins - metabolism | Male | Structure-Activity Relationship | Benzimidazoles - chemistry | Temporal Lobe - diagnostic imaging | Benzothiazoles - pharmacokinetics | Radiopharmaceuticals - chemical synthesis | Alzheimer Disease - pathology | Benzofurans - chemistry | Benzofurans - pharmacokinetics | Brain - metabolism | Styrenes - chemistry | Benzothiazoles - chemical synthesis | Neurofibrillary Tangles - metabolism | Amyloid beta-Peptides - metabolism | Temporal Lobe - pathology | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Benzimidazoles - chemical synthesis | Pyridines - chemical synthesis | Benzimidazoles - pharmacokinetics | Benzofurans - chemical synthesis | Temporal Lobe - metabolism | Benzoxazoles - chemical synthesis | Autoradiography | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Animals | Benzoxazoles - chemistry | Alzheimer Disease - metabolism | Radionuclide Imaging | Benzothiazoles - chemistry | Brain - pathology | Neurofibrillary Tangles - diagnostic imaging | Aged | Mice | Alzheimer Disease - diagnostic imaging | Thiophenes - chemistry | Benzoxazoles - pharmacokinetics
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 08/2011, Volume 51, Issue 8, pp. 1177 - 1185
Dexpramipexole (KNS‐760704; [6R]‐4,5,6,7‐tetrahydro‐N6‐propyl‐2,6‐benzothiazole‐diamine) is a novel synthetic amino‐benzothiazole in development for the... 
pharmacokinetics and drug metabolism | motor neuron disease | dexpramipexole | safety | amyotrophic lateral sclerosis | (R)‐(+)‐pramipexole,(6R)‐4,5,6,7‐tetrahydro‐N6‐propyl‐2,6‐benzothiazole‐diamine | neurology | KNS‐760704 | pharmaceutical research and development | KNS-760704 | (R)-(+)-pramipexole, (6R)-4,5,6,7-tetrahydro-N6- propyl-2,6-benzothiazole-diamine | ACTIVATION | (R)-(+)-pramipexole, (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine | ALS | MECHANISMS | AMYOTROPHIC-LATERAL-SCLEROSIS | METHYLPYRIDINIUM ION | DIHYDROCHLORIDE | CELL-DEATH | DOPAMINE AGONIST | PHARMACOLOGY & PHARMACY | AGONIST PRAMIPEXOLE | EPIDEMIOLOGY | Drugs, Investigational - adverse effects | Humans | Middle Aged | Drugs, Investigational - pharmacokinetics | Half-Life | Male | Metabolic Clearance Rate | Dopamine Agonists - adverse effects | Benzothiazoles - pharmacokinetics | Drugs, Investigational - analysis | Intestinal Absorption | Dose-Response Relationship, Drug | Adult | Female | Double-Blind Method | Food-Drug Interactions | Urine - chemistry | Dopamine Agonists - pharmacokinetics | Benzothiazoles - analysis | Plasma - chemistry | Dopamine Agonists - administration & dosage | Drugs, Investigational - administration & dosage | Dopamine Agonists - analysis | Benzothiazoles - adverse effects | Benzothiazoles - administration & dosage | Pharmacokinetics | Amyotrophic lateral sclerosis
Journal Article
Brain, ISSN 0006-8950, 03/2017, Volume 140, Issue 3, pp. 764 - 780
Journal Article
Journal Article
Journal Article
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