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Bioconjugate Chemistry, ISSN 1043-1802, 04/2015, Volume 26, Issue 4, pp. 746 - 754
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2018, Volume 28, Issue 8, pp. 1417 - 1422
Rhomboids are intramembrane serine proteases with diverse physiological functions in organisms ranging from archaea to humans. Crystal structure analysis has... 
Intramembrane proteases | Rhomboid proteases | Inhibition | Benzoxazinones | Molecular docking | DESIGN | CHEMISTRY, MEDICINAL | INTRAMEMBRANE PROTEOLYSIS | SERINE PROTEASES | MECHANISM | SPECIFICITY | ALTERNATE SUBSTRATE-INHIBITORS | CRYSTAL-STRUCTURE | HUMAN-LEUKOCYTE ELASTASE | CHEMISTRY, ORGANIC | CATHEPSIN-G | GLPG | Styrenes - chemical synthesis | Benzoxazines - chemical synthesis | Drosophila - chemistry | Humans | Drosophila Proteins - metabolism | Endopeptidases - chemistry | Styrenes - chemistry | Serine Proteinase Inhibitors - chemistry | Cattle | Escherichia coli Proteins - antagonists & inhibitors | Transforming Growth Factor alpha - metabolism | Benzoxazines - chemistry | Catalytic Domain | Serine Proteinase Inhibitors - chemical synthesis | DNA-Binding Proteins - antagonists & inhibitors | Escherichia coli - enzymology | Membrane Proteins - genetics | Enzyme Assays | DNA-Binding Proteins - genetics | Serine - chemistry | DNA-Binding Proteins - chemistry | Drug Discovery | Animals | Endopeptidases - genetics | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Chymotrypsin - chemistry | Escherichia coli Proteins - genetics | Molecular Docking Simulation | Mutation | Escherichia coli Proteins - chemistry | Chymotrypsin | Protease inhibitors | Liability (Law) | Analysis | Escherichia coli | Crystals | Physiological aspects | Thrombin | Structure | Mass spectrometry
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12934 - 12946
Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we... 
BRAIN CHOLESTEROL | TURNOVER | cholesterol metabolism | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | D-ASPARTATE RECEPTORS | enzyme catalysis | cytochrome P450 | central nervous system (CNS) | MASS-SPECTROMETRY | HEPATIC-MICROSOMAL CYTOCHROME | cholesterol | 24-HYDROXYLASE | TRANSCRIPTIONAL REGULATION | EXPRESSION | glutamate | DRUG-INTERACTION | Anti-HIV Agents - pharmacology | gamma-Aminobutyric Acid - metabolism | Benzoxazines - metabolism | Acetylcholine - metabolism | Cholesterol 24-Hydroxylase - genetics | Recombinant Fusion Proteins - metabolism | Deuterium Exchange Measurement | Nerve Tissue Proteins - chemistry | Biocatalysis - drug effects | Anti-HIV Agents - metabolism | Cholesterol 24-Hydroxylase - metabolism | Binding Sites | Peptide Fragments - genetics | Benzoxazines - chemistry | Cholesterol 24-Hydroxylase - chemistry | Allosteric Regulation - drug effects | Acetylcholine - chemistry | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Nerve Tissue Proteins - agonists | gamma-Aminobutyric Acid - chemistry | Models, Molecular | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Anti-HIV Agents - chemistry | Peptide Fragments - chemistry | Benzoxazines - pharmacology | Aspartic Acid - metabolism | Ligands | Protein Conformation | Glutamic Acid - metabolism | Molecular Docking Simulation | Aspartic Acid - chemistry | Mutation | Amino Acid Substitution | Glutamic Acid - chemistry | Enzymology
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2015, Volume 54, Issue 16, pp. 4945 - 4948
Journal Article
Organic Letters, ISSN 1523-7060, 02/2013, Volume 15, Issue 4, pp. 848 - 851
Journal Article
International Journal of Biological Sciences, ISSN 1449-2288, 09/2014, Volume 10, Issue 10, pp. 1084 - 1096
Journal Article
Chemical Communications, ISSN 1359-7345, 01/2013, Volume 49, Issue 5, pp. 502 - 504
A new cresyl violet-based ratiometric fluorescence probe is developed and applied to fluorescence imaging of H2S in living cells and zebrafish in vivo. 
H2S | CHEMISTRY, MULTIDISCIPLINARY | Fluorescent Dyes - chemistry | Animals | MCF-7 Cells | Benzoxazines - chemical synthesis | Humans | Hydrogen Sulfide - chemistry | Zebrafish | Azides - chemical synthesis | Azides - chemistry | Microscopy, Fluorescence | Benzoxazines - chemistry
Journal Article
Reactive and Functional Polymers, ISSN 1381-5148, 08/2018, Volume 129, pp. 76 - 88
Journal Article
Life Sciences, ISSN 0024-3205, 02/2014, Volume 97, Issue 1, pp. 55 - 63
Journal Article