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British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 734 - 743
Background and purpose: Although CB1 receptor activation evokes neuroprotection in response to cannabinoids, some cannabinoids have been reported to be... 
Neuroprotection | Peroxisome proliferator-activated receptors (PPARs) | Cannabinoids | N-oleoylethanolamine | GAMMA | CELLS | FOCAL CEREBRAL-ISCHEMIA | ANANDAMIDE | ENDOCANNABINOID SYSTEM | NUCLEAR RECEPTOR | peroxisome proliferator-activated receptors (PPARs) | neuroprotection | cannabinoids | THERAPEUTIC TARGETS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | TRANSCRIPTION FACTOR | BRAIN | Luciferases - metabolism | Humans | Benzoxazines - metabolism | Male | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | Neuroprotective Agents - metabolism | Luciferases - genetics | Oleic Acids - metabolism | Arachidonic Acids - metabolism | Fenofibrate - pharmacology | Neuroprotective Agents - pharmacology | Transfection | I-kappa B Kinase - metabolism | Cerebral Cortex - drug effects | Oleic Acids - pharmacology | Dronabinol - pharmacology | Naphthalenes - metabolism | Cannabinoids - metabolism | Endocannabinoids | Fenofibrate - metabolism | Mice, Inbred C57BL | Morpholines - pharmacology | Fatty Acids, Unsaturated - pharmacology | Morpholines - metabolism | PPAR alpha - genetics | Polyunsaturated Alkamides - metabolism | Arachidonic Acids - pharmacology | Cannabinoids - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Animals | Benzoxazines - pharmacology | Cyclooxygenase 2 - metabolism | Polyunsaturated Alkamides - pharmacology | Protein Binding | Recombinant Fusion Proteins - genetics | Ligands | PPAR alpha - agonists | Mice | HeLa Cells | PPAR alpha - metabolism | Dronabinol - metabolism | Research Papers
Journal Article
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 08/2007, Volume 82, Issue 2, pp. 197 - 203
Journal Article
Neuron, ISSN 0896-6273, 10/2016, Volume 92, Issue 2, pp. 479 - 492
Long-term changes of neurotransmitter release are critical for proper brain function. However, the molecular mechanisms underlying these changes are poorly... 
endocannabinoid | protein translation | CB1 receptor | presynaptic | GABA | interneuron | inhibition | superresolution microscopy | synaptic plasticity | LTD | CANNABINOID RECEPTORS | RAT HIPPOCAMPAL-NEURONS | DEPRESSION | POTENTIATION | INHIBITORY SYNAPSES | GABAERGIC SYNAPSES | AXONAL MESSENGER-RNA | TRANSLATION INITIATION | LOCAL TRANSLATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | Optical Imaging | Pyramidal Cells - metabolism | Protein Biosynthesis | Neural Inhibition | TOR Serine-Threonine Kinases - metabolism | gamma-Aminobutyric Acid - metabolism | Ribosomes - metabolism | Neuronal Plasticity - physiology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Neurons - metabolism | Imaging, Three-Dimensional | Pyrazoles - pharmacology | Signal Transduction | Mice, Inbred C57BL | Axons - metabolism | Morpholines - pharmacology | Rats | Cell Body - metabolism | Hippocampus - cytology | Rats, Sprague-Dawley | Long-Term Synaptic Depression | Molecular Dynamics Simulation | Naphthalenes - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Patch-Clamp Techniques | Animals | Interneurons - metabolism | Image Processing, Computer-Assisted | Microscopy | Benzoxazines - pharmacology | Presynaptic Terminals - metabolism | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Medical colleges | Protein biosynthesis | Neurophysiology | Genetic translation | Resveratrol | Proteins | Short term | Scholarships & fellowships | Localization | Protein synthesis
Journal Article
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 01/2010, Volume 31, Issue 2, pp. 286 - 301
Both the endocannabinoid and noradrenergic systems have been implicated in neuropsychiatric disorders. Importantly, low levels of norepinephrine are seen in... 
adrenergic receptor | cannabinoid receptor type 1 | Sprague–Dawley | nucleus accumbens | nucleus of the solitary tract | Nucleus accumbens | Nucleus of the solitary tract | Sprague-Dawley | Adrenergic receptor | Cannabinoid receptor type 1 | BETA-ADRENERGIC-RECEPTOR | MEDIATED DOWN-REGULATION | ENDOCANNABINOID SYSTEM | NEUROSCIENCES | PREFRONTAL CORTEX | ADRENOCEPTOR BINDING-SITES | MESSENGER-RNA | RAT FRONTAL-CORTEX | NUCLEUS-ACCUMBENS SHELL | DEPRESSED SUICIDE VICTIMS | BETA-ADRENERGIC RECEPTOR | Cannabinoid Receptor Modulators - metabolism | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Benzoxazines - metabolism | Limbic System - anatomy & histology | Male | Limbic System - metabolism | Neurons - ultrastructure | Receptor, Cannabinoid, CB1 - agonists | Synapses - metabolism | Neurons - metabolism | Prosencephalon - metabolism | Calcium Channel Blockers - metabolism | Naphthalenes - metabolism | Cannabinoids - metabolism | Rats | Morpholines - metabolism | Receptors, Adrenergic, beta-1 - metabolism | Rats, Sprague-Dawley | Receptor, Cannabinoid, CB1 - metabolism | Neural Pathways - anatomy & histology | Animals | Norepinephrine - metabolism | Neural Pathways - metabolism | Prosencephalon - anatomy & histology | Brain | Nervous system diseases | Neurosciences | Antidepressants | Depression, Mental | Cannabinoid receptor type1
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12934 - 12946
Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we... 
BRAIN CHOLESTEROL | TURNOVER | cholesterol metabolism | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | D-ASPARTATE RECEPTORS | enzyme catalysis | cytochrome P450 | central nervous system (CNS) | MASS-SPECTROMETRY | HEPATIC-MICROSOMAL CYTOCHROME | cholesterol | 24-HYDROXYLASE | TRANSCRIPTIONAL REGULATION | EXPRESSION | glutamate | DRUG-INTERACTION | Anti-HIV Agents - pharmacology | gamma-Aminobutyric Acid - metabolism | Benzoxazines - metabolism | Acetylcholine - metabolism | Cholesterol 24-Hydroxylase - genetics | Recombinant Fusion Proteins - metabolism | Deuterium Exchange Measurement | Nerve Tissue Proteins - chemistry | Biocatalysis - drug effects | Anti-HIV Agents - metabolism | Cholesterol 24-Hydroxylase - metabolism | Binding Sites | Peptide Fragments - genetics | Benzoxazines - chemistry | Cholesterol 24-Hydroxylase - chemistry | Allosteric Regulation - drug effects | Acetylcholine - chemistry | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Nerve Tissue Proteins - agonists | gamma-Aminobutyric Acid - chemistry | Models, Molecular | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Anti-HIV Agents - chemistry | Peptide Fragments - chemistry | Benzoxazines - pharmacology | Aspartic Acid - metabolism | Ligands | Protein Conformation | Glutamic Acid - metabolism | Molecular Docking Simulation | Aspartic Acid - chemistry | Mutation | Amino Acid Substitution | Glutamic Acid - chemistry | Enzymology
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 03/2016, Volume 310, Issue 5, pp. F372 - F384
Renovascular hypertension (RVH) is a common cause of both cardiovascular and renal morbidity and mortality. In renal artery stenosis (RAS), atrophy in the... 
Hypertension | CCL2 | Macrophages | Parenchymal cells | Renal artery stenosis | CCR2 | parenchymal cells | GENETIC DEFICIENCY | PHYSIOLOGY | DB/DB MICE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INJURY | SMAD3 PROTECTS | DIABETIC-NEPHROPATHY | CHEMOKINE RECEPTORS CCR2 | macrophages | renal artery stenosis | DISEASE | UROLOGY & NEPHROLOGY | ARTERY STENOSIS | KIDNEY | hypertension | Mannose-Binding Lectins - metabolism | Kidney - pathology | Arginase - metabolism | Male | Molecular Targeted Therapy | Hypertension, Renovascular - genetics | Hypertension, Renovascular - metabolism | Receptors, CCR2 - antagonists & inhibitors | Atrophy | Hypertension, Renovascular - drug therapy | Lectins, C-Type - metabolism | Kidney - metabolism | Nephritis, Interstitial - metabolism | Nephritis, Interstitial - pathology | Piperidines - pharmacology | Time Factors | Nephritis, Interstitial - prevention & control | Protective Agents - pharmacology | Renal Artery Obstruction - genetics | Antigens, Differentiation - metabolism | Chemokine CCL2 - metabolism | Cytoprotection | Disease Models, Animal | Renal Artery Obstruction - drug therapy | Kidney - drug effects | Macrophages - pathology | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Chemokine CCL2 - genetics | Mice, Transgenic | Hypertension, Renovascular - pathology | Macrophages - metabolism | Receptors, CCR2 - metabolism | Animals | Signal Transduction - drug effects | Benzoxazines - pharmacology | Macrophages - drug effects | Renal Artery Obstruction - metabolism | Nitric Oxide Synthase Type II - metabolism | Renal Artery Obstruction - pathology | Complications and side effects | Chronic kidney failure | Renovascular hypertension | Development and progression | Health aspects | Chemokine receptors
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0171506
The first step of the benzoxazinoid (BX) synthesis pathway is catalyzed by an enzyme with indole-3-glycerol phosphate lyase activity encoded by 3 genes, Bx1,... 
MOLECULAR CHARACTERIZATION | HYDROXAMIC ACIDS | CHROMOSOMAL LOCALIZATION | GENE | STRIPE-MOSAIC-VIRUS | MULTIDISCIPLINARY SCIENCES | PLANT RESISTANCE | BENZOXAZINOID BIOSYNTHESIS | MAIZE | WHEAT | INNATE IMMUNITY | Glycerophosphates - metabolism | Benzoxazines - metabolism | Triticum - growth & development | Lyases - metabolism | Mosaic Viruses - metabolism | Triticum - metabolism | Secale - genetics | Seeds - growth & development | Gene Expression Regulation, Developmental | Germination - genetics | Plants, Genetically Modified | Gene Expression Regulation, Plant | Lyases - genetics | Plant Proteins - metabolism | Zea mays - metabolism | Recombinant Proteins - metabolism | Zea mays - genetics | Seeds - metabolism | Genetic Vectors - chemistry | Secale - metabolism | Hordeum - metabolism | Seeds - genetics | Gene Silencing | Genetic Vectors - metabolism | Recombinant Proteins - genetics | Triticum - genetics | Plant Proteins - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Plant Leaves - growth & development | Hordeum - growth & development | Hordeum - genetics | Zea mays - growth & development | Secale - growth & development | Mosaic Viruses - genetics | Viruses | Genetic transcription | Gene expression | Analysis | Post-transcription | Plant resistance | Genes | Indole | Imbibition | Soil sciences | Homology | Biosynthesis | Biochemistry | Maize | Kinases | Accumulation | Bx1 gene | Leaves | Inoculation | DNA methylation | Physiology | Chemical synthesis | Chromosomes | Deoxyribonucleic acid--DNA | Expression vectors | Rye | Barley | Plants (botany) | Glycerol | Corn | Rye gene | Functional analysis | Vectors (Biology) | Epigenetics | Genetic engineering | Wheat | Deoxyribonucleic acid | DNA
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2005, Volume 25, Issue 11, pp. 2874 - 2884
Despite the profound effect of cannabinoids on motor function, and their therapeutic potential in Parkinson's and Huntington's diseases, the cellular and... 
Striatum | receptor | Dopamine | GABA | Cannabinoid | Glutamate | Knock-out | Release | CB | ENDOGENOUS CANNABINOIDS | cannabinoid | release | SYNAPTIC-TRANSMISSION | ENDOCANNABINOID SYSTEM | knock-out | NEUROSCIENCES | NUCLEUS-ACCUMBENS | striatum | RAT BASAL GANGLIA | MESSENGER-RNA | CB1 receptor | SENSITIVE RECEPTORS | LONG-TERM DEPRESSION | dopamine | glutamate | PARKINSONS-DISEASE | Synaptosomes - drug effects | Tyrosine 3-Monooxygenase - metabolism | Rats, Wistar | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Male | Benzoxazines | Synaptosomes - metabolism | Corpus Striatum - cytology | Corpus Striatum - metabolism | Corpus Striatum - ultrastructure | Receptor, Cannabinoid, CB1 - physiology | Dose-Response Relationship, Drug | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Synapses - metabolism | Tritium - metabolism | Piperidines - pharmacology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Tetrodotoxin - pharmacology | Dopamine - metabolism | Pyrazoles - pharmacology | Synapses - drug effects | Blotting, Western - methods | Vesicular Glutamate Transport Protein 1 - metabolism | Vesicular Glutamate Transport Protein 2 - metabolism | Neurotransmitter Agents - metabolism | Morpholines - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Potassium - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Immunohistochemistry - methods | Animals | Rimonabant | Corpus Striatum - drug effects | Glutamic Acid - metabolism | Mice | Receptor, Cannabinoid, CB1 - deficiency | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Cellular | Molecular
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2006, Volume 46, Issue 12, pp. 1426 - 1438
Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of drugs such as bupropion, efavirenz, propofol, and selegiline, among others. More than 200... 
HPLC/MS/MS | P450 2B6 | rhCYP2B6 | Drug‐drug interactions | in vitro | Drug-drug interactions | In vitro | Raloxifene Hydrochloride - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Sertraline - chemistry | Bupropion - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Antifungal Agents - chemistry | Xenobiotics - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Xenobiotics - classification | Clotrimazole - metabolism | Platelet Aggregation Inhibitors - pharmacology | Oxazines - pharmacology | Antifungal Agents - pharmacology | Itraconazole - metabolism | Serotonin Uptake Inhibitors - metabolism | Clotrimazole - pharmacology | Serotonin Uptake Inhibitors - chemistry | Antidepressive Agents, Second-Generation - pharmacology | Clotrimazole - chemistry | Itraconazole - chemistry | Selective Estrogen Receptor Modulators - metabolism | Ticlopidine - analogs & derivatives | Raloxifene Hydrochloride - metabolism | Platelet Aggregation Inhibitors - chemistry | Oxazines - chemistry | Kinetics | Serotonin Uptake Inhibitors - pharmacology | Selective Estrogen Receptor Modulators - pharmacology | Bupropion - metabolism | Ticlopidine - pharmacology | Area Under Curve | Reverse Transcriptase Inhibitors - pharmacology | Ticlopidine - chemistry | Benzoxazines | Xenobiotics - pharmacokinetics | Itraconazole - pharmacology | Oxazines - metabolism | Microsomes, Liver - drug effects | Antifungal Agents - metabolism | Ticlopidine - metabolism | Molecular Structure | Platelet Aggregation Inhibitors - metabolism | Sertraline - metabolism | Sertraline - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Algorithms | Bupropion - pharmacology | Reverse Transcriptase Inhibitors - metabolism | Antidepressive Agents, Second-Generation - metabolism | Raloxifene Hydrochloride - chemistry | Cytochrome P-450 CYP2B6 | Cytochromes | Research | Health aspects | Drug interactions
Journal Article