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Journal of Neuroscience, ISSN 0270-6474, 10/2011, Volume 31, Issue 41, pp. 14600 - 14610
Orexin A and B are hypothalamic peptides known to modulate arousal, feeding, and reward via OX1 and OX2 receptors. Orexins are also antinociceptive in the... 
ENERGY HOMEOSTASIS | SYNAPTIC-TRANSMISSION | FEEDING-BEHAVIOR | PHOSPHOLIPASE-C | NEURONS | SPINAL-CORD | DIACYLGLYCEROL LIPASE | STRESS-INDUCED ANALGESIA | NEUROSCIENCES | HIPPOCAMPAL SYNAPSES | HYPOCRETIN OREXIN | Cannabinoid Receptor Modulators - pharmacology | Benzoxazoles - pharmacology | Electric Stimulation | Neural Pathways - drug effects | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | gamma-Aminobutyric Acid - metabolism | Periaqueductal Gray - drug effects | Male | Receptors, Neuropeptide - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Pain - metabolism | Neural Pathways - physiology | Lactones - pharmacology | Neural Inhibition - physiology | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Pain - drug therapy | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Urea - analogs & derivatives | Endocannabinoids | Disease Models, Animal | Pyrazoles - pharmacology | Animals, Newborn | Orexins | Enzyme Inhibitors - pharmacology | Receptors, Neuropeptide - antagonists & inhibitors | Morpholines - pharmacology | Rats | Neuropeptides - metabolism | Pain Measurement - drug effects | Orexin Receptors | Pain - pathology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Calcium Channel Blockers | Glycerides - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Benzoxazines - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Periaqueductal Gray - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Urea - pharmacology | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 49, Issue 4, pp. 589 - 601
Dopamine neurons in the ventral tegmental area (VTA) represent a critical site of synaptic plasticity induced by addictive drugs. Orexin/hypocretin-containing... 
SYSNEURO | HUMDISEASE | MOLNEURO | PROTEIN-KINASE-C | AMPA RECEPTORS | NMDA RECEPTORS | HYPOTHALAMIC NEUROPEPTIDES | LONG-TERM POTENTIATION | RAT-BRAIN | NEUROSCIENCES | MIDBRAIN DOPAMINERGIC-NEURONS | VENTRAL TEGMENTAL AREA | METHYL-D-ASPARTATE | NUCLEUS-ACCUMBENS | Benzoxazoles - pharmacology | Neuronal Plasticity - drug effects | Male | N-Methylaspartate - pharmacology | Drug Interactions | Neuronal Plasticity - physiology | Cyclic AMP - analogs & derivatives | Time Factors | Neuropeptides - pharmacology | Behavior, Animal - drug effects | Lysine - metabolism | Anesthetics, Local - administration & dosage | Dopamine - metabolism | Animals, Newborn | Lysine - analogs & derivatives | Synapses - drug effects | Neuronal Plasticity - radiation effects | Enzyme Inhibitors - pharmacology | Rats | Behavior, Animal - physiology | Excitatory Amino Acid Agonists - pharmacology | Thionucleotides - pharmacology | Rats, Sprague-Dawley | Immunohistochemistry - methods | Cocaine - administration & dosage | Analysis of Variance | Urea - pharmacology | Intracellular Signaling Peptides and Proteins - pharmacology | Motor Activity - physiology | Tyrosine 3-Monooxygenase - metabolism | Excitatory Postsynaptic Potentials - radiation effects | Motor Activity - drug effects | Ventral Tegmental Area - cytology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Quinoxalines - pharmacology | Urea - analogs & derivatives | Neurons - physiology | Neurons - drug effects | Electric Stimulation - methods | Orexins | Synapses - physiology | Calcium Channel Blockers - pharmacology | Cyclic AMP - pharmacology | Animals | In Vitro Techniques | Protein Kinase C - pharmacology | Methyl aspartate | Dopamine | Universities and colleges | Neurons | Brain | Neurosciences | Rodents | Addictive behaviors | Cocaine | Behavior | Kinases | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 06/2016, Volume 105, pp. 577 - 586
The orexin system consists of orexin A/hypocretin 1 and orexin B/hypocretin 2, and OX1 and OX2 receptors. Our previous electrophysiological study showed that... 
Periaqueductal gray | Pain | OX1 and OX2 receptors | Cannabinoid | Orexin | Stress-induced analgesia | PROTEIN | RAT | INVOLVEMENT | LATERAL HYPOTHALAMUS STIMULATION | ANTINOCICEPTION | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | HYPOCRETIN OREXIN | NUCLEUS-ACCUMBENS | NEURONS | PHARMACOLOGY & PHARMACY | EXPRESSION | Benzoxazoles - pharmacology | Neurons - pathology | Pain Perception - physiology | Periaqueductal Gray - drug effects | Analgesics, Opioid - pharmacology | Male | Nociceptive Pain - drug therapy | Nociceptive Pain - metabolism | Isoquinolines - pharmacology | Pain Perception - drug effects | Receptor, Cannabinoid, CB1 - agonists | Stress, Psychological - metabolism | Urea - analogs & derivatives | Neurons - metabolism | Corticosterone - blood | Hypothalamus - drug effects | Neurons - drug effects | Orexin Receptors - metabolism | Stress, Psychological - drug therapy | Mice, Inbred C57BL | Nociceptive Pain - pathology | Proto-Oncogene Proteins c-fos - metabolism | Morpholines - pharmacology | Hypothalamus - pathology | Periaqueductal Gray - metabolism | Naphthalenes - pharmacology | Stress, Psychological - pathology | Receptor, Cannabinoid, CB1 - metabolism | Animals | Hypothalamus - metabolism | Signal Transduction - drug effects | Naloxone - pharmacology | Benzoxazines - pharmacology | Orexin Receptors - agonists | Pyridines - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Periaqueductal Gray - pathology | Urea - pharmacology | Physiological aspects | Medical colleges | Analgesia | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 535, Issue 1, pp. 135 - 144
Dopamine D2 receptor antagonists induce hyperprolactinemia depending on the extent of D2 receptor blockade. We compared the effects of the new antipsychotic... 
Partial agonist | Antipsychotics | Dopamine D2 receptor | Rat | Prolactin | Sf9 cell | CLOZAPINE | prolactin | CORTICOSTERONE | ANTAGONIST | rat | NEUROENDOCRINE | HIGH-AFFINITY | MECHANISMS | partial agonist | PITUITARY-GLAND | HORMONE | PROFILE | dopamine D2 receptor | antipsychotics | PHARMACOLOGY & PHARMACY | SECRETION | Serotonin 5-HT1 Receptor Agonists | Benzoxazoles - pharmacology | Humans | Male | Quinolones - pharmacology | Aripiprazole | Receptors, Dopamine D2 - metabolism | Serotonin Receptor Agonists - pharmacology | Spodoptera | Dose-Response Relationship, Drug | Clozapine - pharmacology | Dioxanes - pharmacology | Radioligand Assay | Haloperidol - pharmacology | Cell Line | Dopamine Agonists - pharmacology | Receptors, Dopamine D2 - agonists | Tropanes - pharmacology | Rats | Sulfur Radioisotopes | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Binding, Competitive - drug effects | Prolactin - blood | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Analysis of Variance | Dopamine Antagonists - pharmacology | Antipsychotic Agents - pharmacology | Dopamine D2 Receptor Antagonists | GTP-Binding Proteins - metabolism | Dopamine | Analysis | Dioxin | Guanosine | Phenols | Clozapine | Haloperidol | G proteins | Peptide hormones | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 04/2018, Volume 43, Issue 5, pp. 1001 - 1009
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1486 - 1490
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2013, Volume 73, pp. 122 - 137
Neurogenesis requires the balance between the proliferation of newly formed progenitor cells and subsequent death of surplus cells. RT-PCR and... 
Brain subventricular zone | P2X7 receptors | Adult neural progenitor cells | Extracellular ATP | NEURONAL PROGENITORS | NERVOUS-SYSTEM | STEM-CELLS | MURINE HIPPOCAMPUS | PURINERGIC P2X7 | NEUROSCIENCES | FUNCTIONAL P2X RECEPTORS | NUCLEOTIDE RECEPTORS | PHARMACOLOGY & PHARMACY | ECTO-ATPASE NTPDASE2 | PRECURSOR CELLS | Receptors, Purinergic P2X7 - drug effects | Tetrazoles - pharmacology | Calcium - metabolism | Benzoxazoles - metabolism | Caspase 3 - metabolism | Lateral Ventricles - metabolism | Purinergic P2X Receptor Antagonists - pharmacology | Lateral Ventricles - cytology | Stem Cells - metabolism | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Adenosine Triphosphate - antagonists & inhibitors | Pyridoxal Phosphate - analogs & derivatives | Lateral Ventricles - physiology | Membrane Potentials - drug effects | Cell Survival - drug effects | Quinolinium Compounds - metabolism | Calcium - pharmacology | Pyridoxal Phosphate - pharmacology | Rosaniline Dyes - pharmacology | Lateral Ventricles - drug effects | Membrane Potentials - physiology | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | Receptors, Purinergic P2X7 - physiology | Mice, Knockout | Animals | Stem Cells - drug effects | Stem Cells - physiology | Mice | Pyridines - pharmacology | Primary Cell Culture | Neurosciences | Genetic engineering | RNA | Cells | Index Medicus | ATP
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2011, Volume 31, Issue 44, pp. 15944 - 15955
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1724 - 1736
Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin... 
hypocretin | PKC | cue | nicotine | reinstatement | glutamate | PROTEIN-KINASE-C | NMDA RECEPTORS | PSYCHIATRY | COCAINE-SEEKING | SYNAPTIC PLASTICITY | REWARD | NEUROSCIENCES | ADDICTION | GLUTAMATE RECEPTORS | OREXIN/HYPOCRETIN | AMPA RECEPTORS | ALCOHOL-SEEKING | PHARMACOLOGY & PHARMACY | Benzoxazoles - pharmacology | Nicotine - administration & dosage | Phosphorylation | Nucleus Accumbens - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Conditioning, Operant - physiology | Extinction, Psychological - drug effects | Male | Nicotine - pharmacology | Self Administration | Isoquinolines - pharmacology | Conditioning, Operant - drug effects | Orexin Receptors - physiology | Piperidines - pharmacology | Urea - analogs & derivatives | Neurons - physiology | p38 Mitogen-Activated Protein Kinases - metabolism | Hypothalamus - drug effects | Neurons - drug effects | Extinction, Psychological - physiology | Nicotinic Agonists - pharmacology | Receptors, AMPA - metabolism | Cues | Orexin Receptor Antagonists | Piperidines - administration & dosage | Microinjections | Hypothalamus - physiology | Drug-Seeking Behavior - physiology | Drug-Seeking Behavior - drug effects | Nerve Tissue Proteins - metabolism | Nicotinic Agonists - administration & dosage | Animals | Signal Transduction - drug effects | Prefrontal Cortex - metabolism | Signal Transduction - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Urea - pharmacology | Index Medicus | Cortex (prefrontal) | Addicció | Farmacologia | Nicotina | Behavioral Science | Addiction & Substance Abuse | Animal models | Neuropeptides | Original | Hypocretin | Nicotine
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 592, Issue 1, pp. 160 - 166
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e39131 - e39131
Journal Article