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Nature Neuroscience, ISSN 1097-6256, 08/2013, Volume 16, Issue 8, pp. 1154 - 1161
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7579, pp. 477 - 483
At least 120 non-olfactory G-protein-coupled receptors in the human genome are 'orphans' for which endogenous ligands are unknown, and many have no selective... 
EXTRACELLULAR ACIDIFICATION | ACTIVATION | COMPLEX | OGR1 | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | CAMP ACCUMULATION | SMOOTH-MUSCLE-CELLS | EXPRESSION | CANCER | Anti-Anxiety Agents - metabolism | Lorazepam - pharmacology | Memory - drug effects | Receptors, G-Protein-Coupled - metabolism | Humans | Anti-Anxiety Agents - analysis | Male | Receptors, G-Protein-Coupled - agonists | Lorazepam - analysis | Benzyl Alcohols - pharmacology | HEK293 Cells | Anti-Anxiety Agents - chemistry | Female | Triazines - chemistry | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Triazines - metabolism | Triazines - pharmacology | Lorazepam - metabolism | Anti-Anxiety Agents - pharmacology | Models, Molecular | Drug Discovery | Mice, Knockout | Triazines - analysis | Fear | Animals | Receptors, G-Protein-Coupled - deficiency | Signal Transduction - drug effects | Benzyl Alcohols - analysis | Allosteric Site | Lorazepam - chemistry | Receptors, G-Protein-Coupled - antagonists & inhibitors | Conditioning, Classical | Benzyl Alcohols - metabolism | Ligands | Mice | Receptors, G-Protein-Coupled - chemistry | Physiological aspects | Cell receptors | Identification and classification | Ligands (Biochemistry) | Proteins | Yeast | Rodents | Physiology | Genomes | Kinases | proton-sensing | virtual screening | GPR68 | GPR65 | positive allosteric modulator (PAM) | functional selectivity | allosteric modulator
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 112 - 115
Protease-activated receptors ( PARs) are a family of G-proteincoupled receptors ( GPCRs) that are irreversibly activated by proteolytic cleavage of the N... 
PHENIX | THROMBIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Allosteric Site - drug effects | Humans | Receptor, PAR-2 - metabolism | Imidazoles - chemistry | Models, Molecular | Crystallography, X-Ray | Antibodies, Blocking - pharmacology | Imidazoles - pharmacology | Benzimidazoles - chemistry | Receptor, PAR-2 - chemistry | Immunoglobulin Fab Fragments - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Signal Transduction - drug effects | Antibodies, Blocking - chemistry | Immunoglobulin Fab Fragments - chemistry | Benzyl Alcohols - pharmacology | Benzimidazoles - pharmacology | Ligands | Benzodioxoles - chemistry | Kinetics | Benzodioxoles - pharmacology | Physiological aspects | Cell receptors | Allosteric proteins | Cytochrome | Residues | G protein-coupled receptors | Peptides | Molecular structure | Hydrogen | Homology | Antagonists | Hydrophobicity | Hydrogen bonding | Optimization | Proteins | Lipophilic | Allosteric properties | Imidazole | Cleavage | Inhibition | Thromboembolism | Lysozyme | Hydrogen ion concentration | Deoxyribonucleic acid--DNA | Cultivation | Architecture | Fab | Crystals | Crystallization | Pharmacology | Inflammation | Glycosylation | Computer programs | Chemistry | Diffraction | Antagonist drugs | Lysine | Isoforms | Computer applications | Mutation | Internet | Receptor mechanisms | Binding sites | Glutamine | Cancer
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 04/2016, Volume 182, pp. 190 - 199
Journal Article
Molecules, ISSN 1420-3049, 01/2013, Volume 18, Issue 1, pp. 1325 - 1336
The current study targets the chemical constituents of Caesalpinia decapetala (Roth) Alston and investigates the bioactivities of the isolated compounds.... 
Caesalpinia decapetala (Roth) Alston | Chemical constituents | DPPH | MTT | Structure elucidation | CHEMISTRY, ORGANIC | chemical constituents | structure elucidation | Free Radical Scavengers - pharmacology | Plant Extracts - chemistry | Triterpenes - pharmacology | Free Radical Scavengers - chemistry | Plant Extracts - pharmacology | Humans | Stilbenes - chemistry | Stilbenes - pharmacology | Benzopyrans - chemistry | Triterpenes - chemistry | Picrates - chemistry | Benzyl Alcohols - pharmacology | Ascorbic Acid - chemistry | Glucosides - chemistry | Inhibitory Concentration 50 | Flavonoids - pharmacology | Molecular Structure | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzyl Alcohols - chemistry | Cell Survival - drug effects | Benzyl Alcohols - isolation & purification | Glucosides - pharmacology | Emodin - pharmacology | Free Radicals - chemistry | Emodin - isolation & purification | Antineoplastic Agents | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Emodin - chemistry | Benzopyrans - isolation & purification | Free Radical Scavengers - isolation & purification | Glucosides - isolation & purification | Caesalpinia - chemistry | Stilbenes - isolation & purification | Cell Line, Tumor | Triterpenes - isolation & purification | Flavonoids - isolation & purification | Antineoplastic Agents, Phytogenic - pharmacology | Flavonoids - chemistry | Antineoplastic Agents, Phytogenic - isolation & purification
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e50716
Umeclidinium bromide (GSK573719; UMEC), a new long-acting muscarinic receptor antagonist (LAMA), is in development with vilanterol (GW642444; VI), a selective... 
Adrenergic beta-2 Receptor Agonists - pharmacokinetics | Humans | Middle Aged | Muscarinic Antagonists - adverse effects | Benzyl Alcohols - administration & dosage | Benzyl Alcohols - adverse effects | Male | Quinuclidines - administration & dosage | Adrenergic beta-2 Receptor Agonists - pharmacology | Chlorobenzenes - administration & dosage | Young Adult | Chlorobenzenes - pharmacokinetics | Drug Interactions | Adrenergic beta-2 Receptor Agonists - adverse effects | Dry Powder Inhalers - instrumentation | Muscarinic Antagonists - pharmacology | Benzyl Alcohols - pharmacology | Chlorobenzenes - pharmacology | Patient Safety | Adult | Muscarinic Antagonists - pharmacokinetics | Benzyl Alcohols - pharmacokinetics | Drug Therapy, Combination | Quinuclidines - adverse effects | Double-Blind Method | Quinuclidines - pharmacology | Cross-Over Studies | Muscarinic Antagonists - administration & dosage | Chlorobenzenes - adverse effects | Adrenergic beta-2 Receptor Agonists - administration & dosage | Aged | Quinuclidines - pharmacokinetics | Medicine, Experimental | Medical research | Respiratory agents | Lung diseases, Obstructive | Care and treatment | Heart beat | Health care | Drugs | Pharmacodynamics | Acetylcholine receptors (muscarinic) | Laboratories | Medical treatment | Lung diseases | Systematic review | Pharmacology | Vital signs | Assessments | Powder | Heart rate | Human subjects | Studies | Obstructive lung disease | Chronic obstructive pulmonary disease | Blood pressure | Safety | Pharmacokinetics | Potassium | Drug dosages
Journal Article