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Angewandte Chemie International Edition, ISSN 1433-7851, 04/2017, Volume 56, Issue 18, pp. 5125 - 5129
Meta‐C−H functionalization of benzylamines has been developed using a PdII/transient mediator strategy. Using 2‐pyridone ligands and 2‐carbomethoxynorbornene... 
amination | meta-C−H arylation | pyridone ligand | chlorination | benzylamines | AROMATIC FUNCTIONALIZATION | PALLADIUM | CATALYSIS | ACTIVATION | ARENES | CHEMISTRY, MULTIDISCIPLINARY | NORBORNENE | BOND ARYLATION | PHENOLS | ANILINES | meta-C-H arylation | BORYLATION | Ligands | Amination | Chlorination | meta-C–H arylation
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2012, Volume 134, Issue 44, pp. 18237 - 18240
An auxiliary-assisted, copper catalyzed or promoted sulfenylation of benzoic acid derivative β-C–H bonds and benzylamine derivative γ-C–H bonds has been... 
Benzoic Acid - chemistry | Benzylamines - chemistry | Copper - chemistry | Catalysis | Disulfides - chemistry | Halogenation
Journal Article
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 01/2018, Volume 319, Issue 2, pp. 130 - 142
IMPORTANCE New therapeutic approaches for Alzheimer disease (AD) are needed. OBJECTIVE To assess whether idalopirdine, a selective 5-hydroxytryptamine-6... 
DONEPEZIL | 5-HT6 RECEPTOR ANTAGONIST | MODERATE | MEDICINE, GENERAL & INTERNAL | DOUBLE-BLIND | SEROTONIN | SB-742457 | RATING-SCALE | VALIDITY | Serotonin Antagonists - administration & dosage | Benzylamines - adverse effects | Humans | Middle Aged | Male | Indans - therapeutic use | Benzylamines - administration & dosage | Indoles - administration & dosage | Dose-Response Relationship, Drug | Serotonin Antagonists - adverse effects | Treatment Failure | Aged, 80 and over | Female | Drug Therapy, Combination | Accidental Falls | Alzheimer Disease - psychology | Double-Blind Method | Alzheimer Disease - drug therapy | Serotonin Antagonists - therapeutic use | Cognition - drug effects | Indoles - adverse effects | Galantamine - therapeutic use | Piperidines - therapeutic use | Cholinesterase Inhibitors - adverse effects | Indoles - therapeutic use | Aged | Rivastigmine - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Benzylamines - therapeutic use | Treatment outcome | Care and treatment | Safety and security measures | Analysis | Clinical trials | Dosage and administration | Cholinesterase inhibitors | Alzheimer's disease | Drugs | Medical research | Activities of daily living | Galantamine | Neurodegenerative diseases | Serotonin | Medical treatment | Cognitive ability | Medical services | Cognition | Patients | Cholinesterase | Randomization | Safety engineering | Donepezil | Alzheimers disease | Original Investigation | Research
Journal Article
European Journal of Neurology, ISSN 1351-5101, 02/2013, Volume 20, Issue 2, pp. 271 - 280
Background and purpose Safinamide is an α‐aminoamide with both dopaminergic and non‐dopaminergic mechanisms of action in Phase III clinical development as a... 
safinamide | add‐on | Parkinson's disease | dopamine agonist | α‐aminoamide | Add-on | Safinamide | α-aminoamide | Dopamine agonist | alpha-aminoamide | DRUG | MANAGEMENT | MOVEMENT-DISORDER SOCIETY | RANDOMIZED CONTROLLED-TRIAL | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROLOGICAL SOCIETIES | MAO-B INHIBITION | ANTICONVULSANT ACTIVITY | DOUBLE-BLIND | JOINT TASK-FORCE | add-on | EUROPEAN FEDERATION | Early Medical Intervention - methods | Alanine - therapeutic use | Benzylamines - adverse effects | Alanine - adverse effects | Humans | Middle Aged | Dopamine Agonists - therapeutic use | Male | Parkinson Disease - drug therapy | Benzylamines - administration & dosage | Antiparkinson Agents - therapeutic use | Alanine - analogs & derivatives | Alanine - administration & dosage | Aged, 80 and over | Adult | Female | Drug Therapy, Combination | Severity of Illness Index | Alanine - pharmacokinetics | Double-Blind Method | Dopamine Agonists - pharmacokinetics | Antiparkinson Agents - pharmacokinetics | Dopamine Agonists - administration & dosage | Aged | Antiparkinson Agents - administration & dosage | Benzylamines - pharmacokinetics | Benzylamines - therapeutic use | Dopa | Analysis | Drugs | Dopamine | Neurodegenerative diseases | Clinical trials | Data processing | Levodopa | Statistics | Movement disorders | Baseline studies
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1408 - 1415
Journal Article
Neuropharmacology, ISSN 0028-3908, 12/2018, Volume 143, pp. 186 - 204
Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and... 
Giant depolarizing potentials | GABA | Neonatal seizures | Anti-seizure drugs | Epilepsy | GABA ACTIONS | CATION-CHLORIDE COTRANSPORTERS | DRUG DISCOVERY | AQUAPORIN 4 | WATER PERMEABILITY | NEUROSCIENCES | PYRAMIDAL NEURONS | PILOCARPINE MODEL | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | KINDLED RATS | Phenobarbital - pharmacology | Bumetanide - analogs & derivatives | Benzylamines - chemical synthesis | Rats, Wistar | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Seizures - drug therapy | Sodium Potassium Chloride Symporter Inhibitors - pharmacokinetics | Epilepsy - metabolism | Seizures - metabolism | Anticonvulsants - pharmacology | Oocytes | Brain - metabolism | Bumetanide - chemistry | Female | Drug Evaluation, Preclinical | Solute Carrier Family 12, Member 2 - metabolism | Anticonvulsants - pharmacokinetics | Anticonvulsants - chemical synthesis | Tissue Culture Techniques | Xenopus laevis | Phenobarbital - pharmacokinetics | Bumetanide - pharmacokinetics | Bumetanide - pharmacology | Brain - drug effects | Drug Synergism | Benzylamines - chemistry | Animals | Anticonvulsants - chemistry | Sodium Potassium Chloride Symporter Inhibitors - chemistry | Epilepsy - drug therapy | Mice | Benzylamines - pharmacokinetics | Benzylamines - pharmacology | Phenobarbital | Neurons | Analysis | Diuretics | Seizures (Medicine) | Permeability
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2010, Volume 50, Issue 12, pp. 1450 - 1460
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 6, pp. 1022 - 1033
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 01/2011, Volume 57, Issue 2, pp. 173 - 180
Journal Article