Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (843) 843
Publication (59) 59
Book Review (18) 18
Book Chapter (5) 5
Book / eBook (3) 3
Conference Proceeding (2) 2
Government Document (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (550) 550
chemistry, organic (270) 270
benzylidene compounds - chemistry (268) 268
benzylidene compounds - pharmacology (239) 239
benzylidene compounds - chemical synthesis (210) 210
animals (205) 205
humans (181) 181
chemistry, medicinal (174) 174
derivatives (153) 153
biochemistry & molecular biology (137) 137
molecular structure (134) 134
structure-activity relationship (131) 131
chemistry, multidisciplinary (126) 126
mice (107) 107
analysis (88) 88
chemistry (85) 85
cell line, tumor (82) 82
stereoisomerism (80) 80
male (76) 76
antineoplastic agents - pharmacology (75) 75
rats (75) 75
chemistry, applied (62) 62
antineoplastic agents - chemical synthesis (61) 61
antineoplastic agents - chemistry (57) 57
benzylidene acetals (57) 57
catalysis (57) 57
synthesis (57) 57
models, molecular (56) 56
cancer (55) 55
dose-response relationship, drug (55) 55
pharmacology & pharmacy (55) 55
glycosylation (54) 54
analogs (53) 53
chemistry, physical (53) 53
magnetic resonance spectroscopy (51) 51
apoptosis (49) 49
aldehydes (47) 47
female (46) 46
article (44) 44
molecular conformation (44) 44
organic chemistry (43) 43
cell proliferation - drug effects (40) 40
chemical properties (39) 39
drug design (39) 39
inhibitors (38) 38
cell survival - drug effects (36) 36
microbial sensitivity tests (36) 36
apoptosis - drug effects (35) 35
ketones (35) 35
benzylidene (34) 34
drug screening assays, antitumor (34) 34
enzyme inhibitors - pharmacology (33) 33
acid (32) 32
cells (32) 32
cytotoxicity (32) 32
research (32) 32
activation (31) 31
crystallography, x-ray (31) 31
agents (29) 29
cell biology (29) 29
molecular docking simulation (29) 29
benzylidene compounds - therapeutic use (28) 28
biological evaluation (28) 28
chemical synthesis (28) 28
kinetics (28) 28
ligands (28) 28
piperidones - pharmacology (28) 28
chemistry, inorganic & nuclear (27) 27
efficient (26) 26
enzyme inhibitors - chemical synthesis (26) 26
inhibitory concentration 50 (26) 26
carbohydrate benzylidene acetals (25) 25
design (25) 25
inhibition (25) 25
oligosaccharide synthesis (25) 25
organic-synthesis (25) 25
aromatic-aldehydes (24) 24
carbohydrate conformation (24) 24
carbohydrate sequence (24) 24
fluorescence (24) 24
physical chemistry (24) 24
chemical phenomena (23) 23
oxidation-reduction (23) 23
proteins (23) 23
acetals - chemistry (22) 22
cell line (22) 22
chemical sciences (22) 22
drug discovery (22) 22
expression (22) 22
facile synthesis (22) 22
molecular sequence data (22) 22
biochemistry, general (21) 21
complexes (21) 21
cyclization (21) 21
enzyme inhibitors - chemistry (21) 21
mechanism (21) 21
models, chemical (21) 21
4,6-o-benzylidene acetals (20) 20
benzylidene compounds (20) 20
inorganic chemistry (20) 20
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (825) 825
French (7) 7
German (7) 7
Polish (6) 6
Chinese (3) 3
Japanese (2) 2
Italian (1) 1
Russian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Fluorescent Metallacage-Core Supramolecular Polymer Gel Formed by Orthogonal Metal Coordination and Host-Guest Interactions
by Lu, Chenjie and Zhang, Mingming and Tang, Danting and Yan, Xuzhou and Zhang, Zeyuan and Zhou, Zhixuan and Song, Bo and Wang, Heng and Li, Xiaopeng and Yin, Shouchun and Sepehrpour, Hajar and Stang, Peter J
Journal of the American Chemical Society, ISSN 0002-7863, 06/2018, Volume 140, Issue 24, pp. 7674 - 7680
Herein, we report the preparation of a multifunctional metallacage-core supramolecular gel by orthogonal metal coordination and host-guest interactions. A... 
TETRAPHENYLETHENE | CATALYSIS | HYDROGELS | NETWORK | REMOVAL | CONSTRUCTION | COMPLEXES | POST-ASSEMBLY POLYMERIZATION | EMISSION | DISCRETE ORGANOPLATINUM(II) METALLACYCLES | CHEMISTRY, MULTIDISCIPLINARY | Gels - chemical synthesis | Crown Ethers - chemical synthesis | Polymers - chemical synthesis | Crown Ethers - chemistry | Rheology | Fluorescence | Benzylidene Compounds - chemical synthesis | Benzylidene Compounds - chemistry | Coordination Complexes - chemistry | Organoplatinum Compounds - chemical synthesis | Macromolecular Substances - chemistry | Coordination Complexes - chemical synthesis | Polymers - chemistry | Gels - chemistry | Macromolecular Substances - chemical synthesis | Organoplatinum Compounds - chemistry | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text The discovery of oxazolones-grafted spirooxindoles via three-component diversity oriented synthesis and their preliminary biological evaluation
by Dong, Hui and Song, Sicheng and Li, Jingjing and Xu, Chunyun and Zhang, Haowei and Ouyang, Liang
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2015, Volume 25, Issue 17, pp. 3585 - 3591
A facile method via 1,3-dipolar cycloaddition of substituted benzylidene-2-phenyloxazolone under mild conditions with azomethine ylides, which were generated... 
1,3-Dipolar cycloaddition | Spirooxindole derivatives | Multi-component reactions | Azomethine ylides | ISATIN | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | 1,3-DIPOLAR | CHEMISTRY, ORGANIC | MULTICOMPONENT REACTIONS | HETEROCYCLES | CYCLOADDITIONS | STEREOCENTERS | CHEMISTRY | PYRROLIZIDINES | DERIVATIVES | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Benzylidene Compounds - chemistry | Pyrrolidines - pharmacology | Azo Compounds - chemistry | Thiosemicarbazones - chemistry | Spiro Compounds - chemical synthesis | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Azo Compounds - pharmacology | Spiro Compounds - chemistry | Models, Molecular | Thiosemicarbazones - chemical synthesis | Azo Compounds - chemical synthesis | Oxazolone - chemistry | Benzylidene Compounds - chemical synthesis | Antineoplastic Agents - chemistry | Cycloaddition Reaction | Drug Discovery | Pyrrolidines - chemistry | Neoplasms - drug therapy | Oxazolone - analogs & derivatives | Benzylidene Compounds - pharmacology | Oxazolone - chemical synthesis | Pyrrolidines - chemical synthesis | Cell Line, Tumor | Indoles - chemistry | Oxazolone - pharmacology | Spiro Compounds - pharmacology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes
by Nandi, Debkumar and Ghosh, Debalina and Chen, Shih-Ji and Kuo, Bing-Chiuan and Wang, Nancy M and Lee, Hon Man
Journal of Organic Chemistry, ISSN 0022-3263, 04/2013, Volume 78, Issue 7, pp. 3445 - 3451
A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily... 
PHTHALIDES | O-IODOBENZOIC ACID | 3-SUBSTITUTED ISOCOUMARINS | C-H OLEFINATION | CHEMISTRY, ORGANIC | HYDRANGEAE DULCIS-FOLIUM | VAR. THUNBERGII | ALKYNES | DERIVATIVES | CYCLIZATION | CARBOXYLIC-ACIDS | Vinyl Compounds - chemistry | Oxidation-Reduction | Benzoates - chemistry | Isocoumarins - chemical synthesis | Ligands | Organometallic Compounds - chemistry | Benzylidene Compounds - chemical synthesis | Molecular Structure | Catalysis | Benzylidene Compounds - chemistry | Isocoumarins - chemistry | Palladium - chemistry | Thermal properties | Analysis | Oxidation-reduction reaction | Palladium | Chemical properties | Hydrogen bonding | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Synthesis, crystal structures, and urease inhibition of an acetohydroxamate-coordinated oxovanadium(V) complex derived from N′-(3-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide
by Qu, Dan and Niu, Fang and Zhao, Xinlu and Yan, Ke-Xiang and Ye, Yu-Ting and Wang, Jia and Zhang, Mei and You, Zhonglu
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2015, Volume 23, Issue 9, pp. 1944 - 1949
A new benzohydrazone compound ′-(3-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide (H L) was prepared. Reaction of H L and acetohydroxamic acid (HAHA) with... 
Urease inhibition | Oxovanadium(V) complex | Benzohydrazone | Crystal structure | STATES | CHEMISTRY, MEDICINAL | ASSAY | VANADIUM HALOPEROXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | MODEL | BASE | HYDRAZONE LIGAND | DERIVATIVES | METAL-COMPLEXES | Enzyme Inhibitors - pharmacology | Hydroxamic Acids - chemistry | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Urease - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Vanadates - chemistry | Benzylidene Compounds - chemistry | Hydrazones - chemistry | Dose-Response Relationship, Drug | Helicobacter pylori - enzymology | Organometallic Compounds - chemical synthesis | Enzyme Inhibitors - chemistry | Vanadates - pharmacology | Organometallic Compounds - chemistry | Urease - metabolism | Molecular Structure | Hydroxamic Acids - pharmacology | Organometallic Compounds - pharmacology | Enzymes | Hydrolases | Structure | Crystals | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text 2-Heteroarylimino-5-benzylidene-4-thiazolidinones analogues of 2-thiazolylimino-5-benzylidene-4-thiazolidinones with antimicrobial activity: Synthesis and structure–activity relationship
by Vicini, Paola and Geronikaki, Athina and Incerti, Matteo and Zani, Franca and Dearden, John and Hewitt, Mark
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 7, pp. 3714 - 3724
2-Heteroarylimino-5-benzylidene-4-thiazolidinones, unsubstituted or carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesised... 
DEREK | 4-Thiazolidinone derivatives | QSAR | Antibacterial activity/antifungal activity | 4-THIAZOLIDINONES | DESIGN | CHEMISTRY, MEDICINAL | LOCAL-ANESTHETIC ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | 4-thiazolidinone derivatives | antibacterial activity/antifungal activity | DERIVATIVES | Thiazolidines - chemical synthesis | Microbial Viability - drug effects | Benzylidene Compounds - chemical synthesis | Structure-Activity Relationship | Benzylidene Compounds - chemistry | Anti-Bacterial Agents - chemical synthesis | Benzylidene Compounds - pharmacology | Anti-Bacterial Agents - chemistry | Drug Design | Anti-Bacterial Agents - pharmacology | Molecular Structure | Thiazolidines - pharmacology | Thiazolidines - chemistry | Heterocyclic compounds | Pharmacy | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Synthesis of indenyl ethers by gold(I)-catalyzed intramolecular carboalkoxylation of alkynes
by Dubé, Pascal and Toste, F. Dean
Journal of the American Chemical Society, ISSN 0002-7863, 09/2006, Volume 128, Issue 37, pp. 12062 - 12063
The gold(I)-catalyzed carboalkoxylation of alkynes to form indanone derivatives from readily available ortho-acetylenic benzylic ethers is described.... 
REARRANGEMENT | GOLD | ASYMMETRIC-SYNTHESIS | TERMINAL ALKYNES | ACETALS | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | PLATINUM CATALYST | CYCLIZATION | CATALYZED CYCLOISOMERIZATION REACTIONS | ENYNES | Gold - chemistry | Ethers - chemical synthesis | Indenes - chemical synthesis | Oxidation-Reduction | Ethers - chemistry | Alkynes - chemistry | Benzylidene Compounds - chemical synthesis | Catalysis | Benzylidene Compounds - chemistry | Gold | Enols | Chemical properties | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Multitarget-directed benzylideneindanone derivatives: Anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease
by Huang, Ling and Lu, Chuanjun and Sun, Yang and Mao, Fei and Luo, Zonghua and Su, Tao and Jiang, Huailei and Shan, Wenjun and Li, Xingshu
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2012, Volume 55, Issue 19, pp. 8483 - 8492
A novel series of benzylideneindanone derivatives were designed, synthesized, and evaluated as multitarget-directed ligands against Alzheimer's disease. The in... 
OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | MULTIFUNCTIONAL AGENTS | ANALOGS | BERBERINE DERIVATIVES | HYPOTHESIS | BIOLOGICAL EVALUATION | ACETYLCHOLINESTERASE INHIBITORS | BINDING | MOLECULES | Antioxidants - chemistry | Humans | Isoenzymes - chemistry | Structure-Activity Relationship | Amyloid - chemistry | Monoamine Oxidase Inhibitors - chemical synthesis | Zinc - chemistry | Benzylidene Compounds - chemistry | Monoamine Oxidase - chemistry | Copper - chemistry | Indans - chemistry | Iron - chemistry | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Recombinant Proteins - chemistry | Benzylidene Compounds - chemical synthesis | Antioxidants - chemical synthesis | Peptide Fragments - chemistry | Cations, Divalent | Indans - chemical synthesis | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Amyloid beta-Peptides - chemistry | Chelating Agents - chemical synthesis | Isoenzymes - antagonists & inhibitors | Monoamine Oxidase - metabolism | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Synthesis of the Marine Myxobacterial Antibiotic Enhygrolide A
by Muddala, Ramesh and Acosta, Jaime A. M and Barbosa, Luiz C. A and Boukouvalas, John
Journal of Natural Products, ISSN 0163-3864, 07/2017, Volume 80, Issue 7, pp. 2166 - 2169
The first synthesis of enhygrolide A, a scarce gamma-alkylidenebutenolide antibiotic of the obligate marine myxobacterium Enhygromyxa salina, was achieved in... 
RARE ACTINOMYCETE | METABOLITES | CHEMISTRY, MEDICINAL | ACID | ANALOGS | NATURAL-PRODUCTS | PHARMACOLOGY & PHARMACY | NOSTOCLIDE-I | BUTENOLIDE | STRUCTURE ELUCIDATION | DISCOVERY | PLANT SCIENCES | Stereoisomerism | 4-Butyrolactone - pharmacology | 4-Butyrolactone - chemical synthesis | Benzylidene Compounds - chemical synthesis | Benzylidene Compounds - chemistry | Alkylation | Anti-Bacterial Agents - chemical synthesis | Marine Biology | Myxococcales - chemistry | Benzylidene Compounds - pharmacology | Anti-Bacterial Agents - chemistry | 4-Butyrolactone - chemistry | Anti-Bacterial Agents - pharmacology | Molecular Structure | 4-Butyrolactone - analogs & derivatives | Catalysis | Aldehydes - chemistry | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Synthesis, structure, and bioactivity of N′-substituted benzylidene-3,4,5-trimethoxybenzohydrazide and 3-acetyl-2-substituted phenyl-5-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1,3,4-oxadiazole derivatives
by Jin, Linhong and Chen, Zhuo and Chen, Jiang and Song, Baoan and Yang, Song and Li, Qianzhu and Hu, Deyu and Xu, Ruiqing
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 19, pp. 5036 - 5040
A series of 3-acetyl-2-substituted phenyl-5-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1,3,4-oxadiazole were synthesized through cyclization of N′-substituted... 
Antitumor activity | 1,3,4-Oxadiazole derivatives | Synthesis | 3,4,5-Trimethoxybenzohydrazide | synthesis | INSECTICIDAL ACTIVITY | CHEMISTRY, MEDICINAL | antitumor activity | CHEMISTRY, ORGANIC | 1,3,4-oxadiazole derivatives | 3,4,5-trimethoxybenzohydrazide | Cell Survival - drug effects | Oxadiazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Crystallography, X-Ray | Benzylidene Compounds - chemical synthesis | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Benzylidene Compounds - chemistry | Neoplasms - drug therapy | Benzylidene Compounds - pharmacology | Oxadiazoles - pharmacology | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Neoplasms - pathology | Oxadiazoles - chemistry | Spectrum Analysis | Drug Screening Assays, Antitumor | Prevention | Cell research | Acetic anhydride | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2,4-thiazolidinedione derivatives
by Patil, Vijay and Tilekar, Kalpana and Mehendale-Munj, Sonali and Mohan, Rhea and Ramaa, C.S
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 10, pp. 4539 - 4544
In the present work, ten novel derivatives ( ) of 5-benzylidene-2,4-thiazolidinediones were synthesized and their structures were determined by analytical and... 
Cytotoxicity | Sulforhodamine B assay | 5-benzylidene-2,4-thiazolidinediones | Knoevenagel condensation | APOPTOSIS | CHEMISTRY, MEDICINAL | ACTIVATED RECEPTOR-GAMMA | MECHANISMS | ARREST | REDUCTION | PROSTATE-CANCER CELLS | GROWTH | PPAR-GAMMA | DIFFERENTIATION | THIAZOLIDINEDIONES | Antineoplastic Agents - chemical synthesis | Humans | Leukemia - drug therapy | Benzylidene Compounds - chemical synthesis | Thiazolidinediones - chemistry | Antineoplastic Agents - chemistry | Benzylidene Compounds - chemistry | Breast Neoplasms - drug therapy | Benzylidene Compounds - pharmacology | Thiazolidinediones - chemical synthesis | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Thiazolidinediones - pharmacology | Drug Screening Assays, Antitumor | Cell research | Analysis | Leukemia | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Near-infrared fluorescence amplified organic nanoparticles with aggregation-induced emission characteristics for in vivo imaging
by Geng, Junlong and Zhu, Zhenshu and Qin, Wei and Ma, Lin and Hu, Yong and Gurzadyan, Gagik G and Tang, Ben Zhong and Liu, Bin
Nanoscale, ISSN 2040-3364, 01/2014, Volume 6, Issue 2, pp. 939 - 945
Near-infrared (NIR) fluorescence signals are highly desirable to achieve high resolution in biological imaging. To obtain NIR emission with high brightness,... 
PHYSICS, APPLIED | YIELD | MATERIALS SCIENCE, MULTIDISCIPLINARY | RESONANCE ENERGY-TRANSFER | CONVENIENT | NANOSCIENCE & NANOTECHNOLOGY | CONJUGATED POLYMER | CANCER | CHEMISTRY, MULTIDISCIPLINARY | QUANTUM DOTS | RED | NIR | SILICA NANOPARTICLES | BIOPROBES | Cell Survival - drug effects | Fluorescent Dyes - chemistry | NIH 3T3 Cells | Organosilicon Compounds - chemical synthesis | Nanoparticles - chemistry | Male | Nitriles - chemical synthesis | Benzylidene Compounds - chemical synthesis | Benzylidene Compounds - chemistry | Nanoparticles - toxicity | Mice, Inbred ICR | Animals | Organosilicon Compounds - chemistry | Spectroscopy, Near-Infrared | Nitriles - chemistry | Fluorescence Resonance Energy Transfer | Mice | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain
by Pourshojaei, Yaghoub and Gouranourimi, Ali and Hekmat, Shohre and Asadipour, Ali and Rahmani-Nezhad, Samira and Moradi, Alireza and Nadri, Hamid and Moghadam, Farshad Homayouni and Emami, Saeed and Foroumadi, Alireza and Shafiee, Abbas
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, pp. 181 - 189
A series of 3-(4-(aminoalkoxy)benzylidene)-chroman-4-ones - were designed and synthesized as analogs of homoisoflavonoids which are well known natural products... 
Docking study | Acetylcholinesterase | Alzheimer's disease | Chroman-4-one | Homoisoflavonoids | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | DOCKING | SITE ACETYLCHOLINESTERASE INHIBITORS | POTENT | BIOLOGICAL EVALUATION | COUMARIN DERIVATIVES | Amines - chemistry | Catalytic Domain | Cholinesterase Inhibitors - chemistry | Models, Molecular | Benzylidene Compounds - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Amines - chemical synthesis | Benzylidene Compounds - chemistry | Chromones - chemistry | Benzylidene Compounds - pharmacology | Cholinesterase Inhibitors - pharmacology | Cyclization | Drug Design | Inhibitory Concentration 50 | Chromones - pharmacology | Amines - pharmacology | Chromones - chemical synthesis | Drugstores | Amines | Pharmacy | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Synthesis and screening of ursolic acid-benzylidine derivatives as potential anti-cancer agents
by Dar, Bilal Ahmad and Lone, Ali Mohd and Shah, Wajaht Amin and Qurishi, Mushtaq Ahmad
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2016, Volume 111, pp. 26 - 32
Ursolic acid present abundantly in plant kingdom is a well-known compound with various promising biological activities including, anti-cancer,... 
Benzylidine | Claisen Schmidt condensation | Ursolic acid | Aromatic aldehydes | Cytotoxic activity | ANTI-AIDS AGENTS | APOPTOSIS | CHEMISTRY, MEDICINAL | MECHANISM | ANTIFUNGAL ACTIVITY | DOWN-REGULATION | OLEANOLIC ACID | IN-VITRO | HIV AGENTS | CHALCONES | Cell Line | Triterpenes - pharmacology | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Benzylidene Compounds - chemical synthesis | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Benzylidene Compounds - chemistry | Dose-Response Relationship, Drug | Triterpenes - chemistry | Benzylidene Compounds - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Cycle - drug effects | Drug Evaluation, Preclinical | Drug Screening Assays, Antitumor | Cytochrome c | Proteins | Antimitotic agents | Care and treatment | Leukemia | Antineoplastic agents | Aldehydes | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: Design, synthesis, crystal structures, and biological evaluation
by Zidar, Nace and Tomašić, Tihomir and Šink, Roman and Kovač, Andreja and Patin, Delphine and Blanot, Didier and Contreras-Martel, Carlos and Dessen, Andréa and Premru, Manica Müller and Zega, Anamarija and Gobec, Stanislav and Mašič, Lucija Peterlin and Kikelj, Danijel
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2011, Volume 46, Issue 11, pp. 5512 - 5523
Mur ligases (MurC–MurF), a group of bacterial enzymes that catalyze four consecutive steps in the formation of cytoplasmic peptidoglycan precursor, are... 
5-Benzylidenethiazolidine-2,4-dione | Peptidoglycan biosynthesis | MurD ligase | 5-Benzylidenerhodanine | Inhibitor | CHEMISTRY, MEDICINAL | L-ALANINE | RHODANINE | ESCHERICHIA-COLI | POTENTIAL INHIBITORS | DISCOVERY | ADDING ENZYME | BIOSYNTHESIS ENZYMES MURD | GLUTAMIC-ACID-DERIVATIVES | STEPS | Chemistry Techniques, Synthetic | Thiazolidines - chemical synthesis | Molecular Conformation | Bacteria - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | Crystallography, X-Ray | Benzylidene Compounds - chemical synthesis | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Benzylidene Compounds - chemistry | Benzylidene Compounds - pharmacology | Peptide Synthases - chemistry | Enzyme Inhibitors - chemistry | Drug Design | Amides - chemistry | Inhibitory Concentration 50 | Bacteria - enzymology | Thiazolidines - pharmacology | Peptide Synthases - antagonists & inhibitors | Thiazolidines - chemistry | Uracil - chemistry | Universities and colleges | Structure | Glutamate | Ligases | Antibacterial agents | Crystals | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text Synthesis of novel benzylidene analogues of betulinic acid as potent cytotoxic agents
by Gupta, Nidhi and Rath, Santosh K and Singh, Jasvinder and Singh, Shashank and Qayum, Arem and Sangwan, Payare L
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2017, Volume 135, pp. 517 - 530
Different benzylidene derivatives ( and ) of betulinic acid were designed and synthesized in an effort to develop potent anticancer agents. All the synthesized... 
Cytotoxicity | Benzylidene derivatives | Colony formation | Betulinic acid | CANCER-CELLS | CHEMISTRY, MEDICINAL | ASSAY | TRITERPENOIDS | NVX-207 | BIOLOGICAL-ACTIVITIES | APOPTOTIC AGENTS | IN-VITRO | DERIVATIVES | Cytotoxins - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Benzylidene Compounds - chemical synthesis | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Benzylidene Compounds - chemistry | Dose-Response Relationship, Drug | Benzylidene Compounds - pharmacology | Cytotoxins - pharmacology | Cytotoxins - chemistry | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
16. Full Text Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists
by Huang, Huang and Yu, Ying and Gao, Zhenting and Zhang, Yong and Li, Chenjing and Xu, Xing and Jin, Hui and Yan, Wenzhong and Ma, Ruoqun and Zhu, Jin and Shen, Xu and Jiang, Hualiang and Chen, Lili and Li, Jian
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 16, pp. 7037 - 7053
LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 +/- 11.75 mu... 
CHEMISTRY, MEDICINAL | CHOLESTEROL | SALT EXPORT PUMP | LIVER | DISEASE | BILE-ACID RECEPTOR | METABOLIC-DISORDERS | IDENTIFICATION | EXPRESSION | AGONISTS | ORPHAN NUCLEAR RECEPTOR | Pyrazoles - chemical synthesis | Stereoisomerism | Humans | Transcriptional Activation | Anticholesteremic Agents - chemistry | Biological Availability | Male | Structure-Activity Relationship | Benzylidene Compounds - chemistry | Pyrazoles - chemistry | HEK293 Cells | Chenodeoxycholic Acid - pharmacology | Transcription, Genetic | Pyrazoles - pharmacology | Anticholesteremic Agents - chemical synthesis | Pyrazolones - chemical synthesis | Pyrazolones - chemistry | Liver - metabolism | Mice, Inbred C57BL | Solubility | Models, Molecular | Rats | Benzylidene Compounds - chemical synthesis | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | Hep G2 Cells | Triglycerides - metabolism | Animals | Benzylidene Compounds - pharmacology | Databases, Chemical | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Pyrazolones - pharmacology | Mice | Anticholesteremic Agents - pharmacology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
17. Full Text Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors
by Bae, Yun Soo and Choi, Sun and Park, Jung Jae and Joo, Jung Hee and Cui, Minghua and Cho, Hyunsung and Lee, Sang Hyup and Lee, Won Jae
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2016, Volume 24, Issue 18, pp. 4144 - 4151
We report the synthesis of novel 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins , and their biological evaluation using NADPH oxidase (NOX) 1 and 4.... 
NADPH oxidase (NOX) | Thiohydantoin | Benzylidene | Aluminum chloride | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | CHEMISTRY, ORGANIC | DERIVATIVES | EXPRESSION | HUMAN ENDOTHELIAL-CELLS | Cell Line | Thiohydantoins - pharmacology | Humans | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | NADPH Oxidases - metabolism | Benzylidene Compounds - chemical synthesis | NADPH Oxidase 4 | Enzyme Inhibitors - chemical synthesis | Thiohydantoins - chemical synthesis | Benzylidene Compounds - chemistry | NADPH Oxidase 1 | Animals | Benzylidene Compounds - pharmacology | Enzyme Inhibitors - chemistry | Methylation | Thiohydantoins - chemistry | Oxidases | Analysis | Drugstores | Pharmacy | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
18. Full Text Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors
by Jin, Rong and Chen, Qiuxiang and Yao, Song and Bai, Encheng and Fu, Weitao and Wang, Jiabing and Wang, Ledan and Du, Xiaojing and Wei, Tao and Xu, Haineng and Jiang, Chengxi and Qiu, Peihong and Wu, Jianzhang and Li, Wulan and Liang, Guang
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 218 - 228
EF24 is an IKKβ inhibitor (IC : 72 μM) containing various anti-tumor activities. In this study, a series of EF24 analogs targeting IKKβ were designed and... 
Synthesis | IKKβ inhibitor | Molecular docking | Anti-tumor activity | APOPTOSIS | MOLECULAR-DYNAMICS | CHEMISTRY, MEDICINAL | IKK beta inhibitor | PERFORMANCE | CANCER | MONO-CARBONYL ANALOGS | ANTICANCER | PATHWAY | CURCUMIN ANALOGS | LEUKEMIA INVOLVEMENT | NF-KAPPA-B | Neoplasms - metabolism | Piperidones - chemical synthesis | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | NF-kappa B - metabolism | Antineoplastic Agents - therapeutic use | Piperidones - therapeutic use | Benzylidene Compounds - chemistry | G2 Phase Cell Cycle Checkpoints - drug effects | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Benzylidene Compounds - chemical synthesis | Antineoplastic Agents - chemistry | Piperidones - pharmacology | Neoplasms - drug therapy | Piperidones - chemistry | Animals | Benzylidene Compounds - pharmacology | Signal Transduction - drug effects | Benzylidene Compounds - therapeutic use | Mice, Nude | Cell Line, Tumor | Molecular Docking Simulation | Neoplasms - pathology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights