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Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 728 - 732
The gateway to morphine biosynthesis in opium poppy (Papaver somniferum) is the stereochemical inversion of (S)-reticuline since the enzyme yielding the first... 
SYNTHASE | (S)-TETRAHYDROPROTOBERBERINE OXIDASE | 1,2-DEHYDRORETICULINE | COPTIS-JAPONICA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BENZYLISOQUINOLINE ALKALOID METABOLISM | REDUCTASE | MOLECULAR-CLONING | NOSCAPINE BIOSYNTHESIS | CULTURED-CELLS | MORPHINE ALKALOIDS | Aldehyde Reductase - genetics | Exons | Saccharomyces cerevisiae - genetics | Stereoisomerism | Ligases - genetics | Open Reading Frames | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Morphine - biosynthesis | Carbohydrate Epimerases - antagonists & inhibitors | Papaver - genetics | Opium - chemistry | Benzylisoquinolines - chemistry | Saccharomyces cerevisiae - metabolism | Morphinans - metabolism | Bromoviridae - genetics | Base Sequence | Escherichia coli - metabolism | Gene Expression Regulation, Plant | Aldehyde Reductase - metabolism | Opium - metabolism | Plant Proteins - metabolism | Alkaloids - biosynthesis | Recombinant Proteins - metabolism | Morphinans - chemistry | Oxidation-Reduction | Introns | Morphine - chemistry | Ligases - metabolism | Gene Fusion | Recombinant Proteins - genetics | Aldo-Keto Reductases | Plant Proteins - genetics | Benzylisoquinolines - metabolism | Bromoviridae - metabolism | Escherichia coli - genetics | Cytochrome P-450 Enzyme System - genetics | Papaver - metabolism | Carbohydrate Epimerases - genetics | Alkaloids - chemistry | Carbohydrate Epimerases - metabolism | Plant biology | Enzymes | Biosynthesis | Flowers & plants | Narcotics
Journal Article
Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7322, pp. 461 - 467
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2016, Volume 101, pp. 87 - 99
Tetrandrine is an alkaloid constituent of the root of S. Moore. The long-term clinical uses of tetrandrine for treatments of rheumatalgia and arthralgia as... 
Aryl hydrocarbon receptor | Treg cells | Tetrandrine | Collagen-induced arthritis | Th17 cells | RHEUMATOID-ARTHRITIS | ACTIVATION | DENDRITIC CELLS | TOLERANCE | PATHOGENESIS | AUTOIMMUNE ARTHRITIS | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | LIGAND ACTS | DIFFERENTIATION | EXPRESSION | Arthritis, Experimental - drug therapy | Spleen - immunology | Male | Spleen - drug effects | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Arthritis, Rheumatoid - metabolism | Th17 Cells - drug effects | Basic Helix-Loop-Helix Transcription Factors - metabolism | Th17 Cells - metabolism | Arthritis, Rheumatoid - drug therapy | Lymph Nodes - drug effects | Benzylisoquinolines - pharmacology | Basic Helix-Loop-Helix Transcription Factors - agonists | Basic Helix-Loop-Helix Transcription Factors - genetics | Specific Pathogen-Free Organisms | Joints - drug effects | Receptors, Aryl Hydrocarbon - genetics | Lymph Nodes - metabolism | Joints - pathology | Lymph Nodes - immunology | Receptors, Aryl Hydrocarbon - agonists | T-Lymphocytes, Regulatory - drug effects | Signal Transduction - drug effects | Th17 Cells - immunology | Benzylisoquinolines - therapeutic use | Cytochrome P-450 CYP1A1 - genetics | T-Lymphocytes, Regulatory - metabolism | Lymph Nodes - pathology | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Inflammation Mediators - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Mice, Inbred DBA | Inflammation Mediators - antagonists & inhibitors | Antirheumatic Agents - pharmacology | Spleen - pathology | Joints - metabolism | Antirheumatic Agents - therapeutic use | Th17 Cells - pathology | Cell Line | Lymphopoiesis - drug effects | Inflammation Mediators - blood | Arthritis, Experimental - immunology | Mesentery | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A1 - chemistry | Arthritis, Rheumatoid - pathology | Up-Regulation - drug effects | Animals | Spleen - metabolism | Joints - immunology | Lower Extremity | Arthritis, Rheumatoid - immunology | Collagen | Arthritis
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2011, Volume 164, Issue 2b, pp. 731 - 742
Journal Article
The Plant Journal, ISSN 0960-7412, 03/2012, Volume 69, Issue 6, pp. 1052 - 1063
Opium poppy ( Papaver somniferum ) remains the sole commercial source for several pharmaceutical alkaloids including the narcotic analgesics codeine and... 
specialized metabolism | benzylisoquinoline alkaloids | functional genomics | metabolic engineering | opium poppy | virus‐induced gene silencing | virus-induced gene silencing | PAPAVER-SOMNIFERUM | SALUTARIDINOL 7-O-ACETYLTRANSFERASE | CALIFORNIA POPPY | RNAI SUPPRESSION | CODEINONE REDUCTASE | SOMATIC EMBRYOGENESIS | CELL-CULTURES | PLANT SCIENCES | ALKALOID BIOSYNTHESIS | MOLECULAR-CLONING | NORCOCLAURINE SYNTHASE | Genes, Plant | Plant Viruses - genetics | Agrobacterium tumefaciens - genetics | Morphine - biosynthesis | Substrate Specificity | Immunoblotting | Papaver - genetics | Chromatography, High Pressure Liquid | Gene Knockdown Techniques - methods | Alcohol Oxidoreductases - genetics | Morphinans - metabolism | Gene Expression Regulation, Plant | Papaver - enzymology | Plant Viruses - metabolism | Plant Proteins - metabolism | NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases | Metabolic Engineering - methods | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Silencing | Morphine - metabolism | Genetic Vectors - metabolism | Alcohol Oxidoreductases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Genetic Vectors - genetics | Gene Expression Regulation, Enzymologic | Plant Proteins - genetics | Agrobacterium tumefaciens - metabolism | Benzylisoquinolines - metabolism | Papaver - metabolism | Plant biology | Enzymes | Biosynthesis | Flowers & plants | Narcotics | Gene expression | Drugs | Post-transcription | Transcription | Antibodies | Morphine | Naltrexone | Codeine | Polymerase chain reaction | Alkaloids | Gene silencing | reductase | Analgesics | Buprenorphine | oxycodone | genomics | Pharmaceuticals
Journal Article