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Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 03/2015, Volume 283, Issue 3, pp. 168 - 177
Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition between humans and rodents is... 
Biomarkers | Inflammation | Bile acids | HMGB1 | Primary human hepatocytes | Obstructive cholestasis | RAT HEPATOCYTES | ACETAMINOPHEN HEPATOTOXICITY | INDUCED LIVER-INJURY | CELL-DEATH | DUCT-LIGATED MICE | RECEPTOR TGR5 | URSODEOXYCHOLIC ACID | ONCOTIC NECROSIS | PRIMARY BILIARY-CIRRHOSIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PRIMARY SCLEROSING CHOLANGITIS | Bile Acids and Salts - blood | Species Specificity | Bile Acids and Salts - toxicity | Humans | Mice, Inbred C57BL | Cells, Cultured | Hepatocytes - pathology | Biomarkers - blood | Hepatocytes - metabolism | Jaundice, Obstructive - pathology | Necrosis | Dose-Response Relationship, Drug | Animals | Cholestasis, Extrahepatic - blood | Jaundice, Obstructive - blood | Glycochenodeoxycholic Acid - toxicity | Acetylation | Primary Cell Culture | Keratin-18 - blood | Cholestasis, Extrahepatic - pathology | HMGB1 Protein - blood | Hepatocytes - drug effects | Keratin | Care and treatment | Jaundice, Obstructive | Analysis | Cholestasis | Deoxycholic acid | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | GLYCINE | PATIENTS | INJURIES | RODENTS | BILIARY TRACT | TOXICITY | LEVELS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | POLYPEPTIDES | NECROSIS | CHOLIC ACID | INFLAMMATION | LIVER | LIVER CELLS | AMINOTRANSFERASES | BILE | bile acids | primary human hepatocytes | inflammation | biomarkers | obstructive cholestasis | apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 2016, Volume 11, Issue 3, pp. e0149782 - e0149782
Cholestasis is characterized by accumulation of bile acids and inflammation, causing hepatocellular damage. Still, liver damage markers are highest in acute... 
OBSTRUCTIVE CHOLESTASIS | FXR | OXIDATIVE STRESS | ACTIVATION | INDUCED APOPTOSIS | SALT EXPORT PUMP | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | FARNESOID-X-RECEPTOR | ISOLATED RAT HEPATOCYTES | MOLECULAR-MECHANISMS | Bile Acids and Salts - pharmacology | Reactive Oxygen Species - metabolism | Cholestasis - complications | Apoptosis - drug effects | Bile Acids and Salts - toxicity | Humans | Transcriptional Activation - drug effects | Hepatocytes - pathology | Hepatocytes - metabolism | ATP-Binding Cassette Transporters - genetics | Time Factors | Cytoprotection - drug effects | Liver Diseases - complications | Hormesis | Hepatocytes - drug effects | Cytokines - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Cholestasis - chemically induced | Hep G2 Cells | Isoxazoles - pharmacology | Vitamin K 3 - pharmacology | Cholestasis - pathology | Tumor Necrosis Factor-alpha - pharmacology | Cholestasis - prevention & control | ATP Binding Cassette Transporter, Subfamily B, Member 11 | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Development and progression | Liver diseases | Prognosis | Bile acids | Research | Oxidative stress | Salts | Laboratories | Toxicity | Liver | Gallbladder diseases | Cytotoxicity | Cholic acid | Caspase-3 | Ursodeoxycholic acid | Ischemia | Rodents | Hepatology | Gastroenterology | Damage accumulation | Taurocholic acid | Cytokines | Menadione | Intracellular levels | Mortality | Caspase | Superoxide | Tumor necrosis factor-α | Gene expression | Medicine | Acids | Hepatocytes | Cell death | Intracellular | Preconditioning | Cholestasis | Metabolic disorders | Apoptosis | Bile | Index Medicus
Journal Article