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Journal of hepatology, ISSN 0168-8278, 06/2015, Volume 62, Issue 6, pp. 1398 - 1404
[Display omitted] Bile acids (BAs) are major regulators of hepatic BA and lipid metabolism but their mechanisms of action in non-alcoholic fatty liver disease (NAFLD... 
Gastroenterology and Hepatology | 3-hydroxy-3-methylglutaryl-CoA reductase | Stearoyl-CoA desaturase | Non-alcoholic fatty liver disease | Lipogenesis | FGF19 | 3-hydroxy-3-methylglutaryl- CoA reductase | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Ursodeoxycholic Acid - administration & dosage | Oleic Acid - metabolism | Bile Acids and Salts - biosynthesis | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Intra-Abdominal Fat - metabolism | Obesity, Morbid - drug therapy | Non-alcoholic Fatty Liver Disease - drug therapy | Ursodeoxycholic Acid - pharmacology | Stearoyl-CoA Desaturase - biosynthesis | Liver - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Lipid Metabolism - drug effects | Intra-Abdominal Fat - drug effects | Obesity, Morbid - metabolism | Physiological aspects | Obesity | Ursodiol | Deoxycholic acid | Index Medicus | BAs, bile acids | nCEH, neutral cholesterol ester hydrolase | ApoB, apolipoprotein B | LDLR, low density lipoprotein receptor | FGF19, fibroblast growth factor 19 | VLDL, very low density lipoproteins | ABC, ATP-binding cassette | TGs, triglycerides | NAFLD, non-alcoholic fatty liver disease | OA, oleic acid | C4, 7α-hydroxy-4-cholesten-3-one | SHP, small heterodimer partner | SREBP1c, sterol regulatory element-binding protein-1c | CA, cholic acid | PA, palmitic acid | FATP1, fatty acid transport protein 1 | UDCA, ursodeoxycholic acid | FAs, fatty acides | HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase | vWAT, visceral white adipose tissue | SCD, stearoyl-Coa desaturase | CYP7A1, cholesterol 7α-hydroxylase | NASH, non-alcoholic steatohepatitis | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | MA, myristic acid | FASN, fatty acid synthase | MTTP, microsomal triglyceride transfer protein | SA, stearic acid | NONALCOHOLIC | FATTY LIVER-DISEASE | NUCLEAR RECEPTOR | CHOLESTEROL-METABOLISM | TRANSPORT | Endokrinologi och diabetes | FEEDBACK-REGULATION | STEATOHEPATITIS | PLACEBO-CONTROLLED TRIAL | COA DESATURASE | EXPRESSION | Endocrinology and Diabetes | ADIPOSE-TISSUE
Journal Article
Journal of hepatology, ISSN 0168-8278, 01/2013, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions including stimulation of bile flow, intestinal absorption... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 04/2015, Volume 148, Issue 4, pp. 751 - 761.e8
Journal Article