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risk factors (30) 30
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1. Full Text KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas
by Hsu, Maylee and Sasaki, Motoko and Igarashi, Saya and Sato, Yasunori and Nakanuma, Yasuni
Cancer, ISSN 0008-543X, 05/2013, Volume 119, Issue 9, pp. 1669 - 1674
BACKGROUND: Similar to the pancreatic intraepithelial neoplasia (PanIN)‐pancreatic carcinoma sequence model, intrahepatic cholangiocarcinoma (ICC) also... 
GNAS | mutation | biliary intraepithelial neoplasia | KRAS | intrahepatic cholangiocarcinoma | p53 | PATHOLOGY | TRENDS | BILE-DUCTS | LESIONS | HEDGEHOG | GLANDS | ONCOLOGY | LIVER | INTRADUCTAL PAPILLARY NEOPLASM | EXPRESSION | Immunohistochemistry | Liver Neoplasms - genetics | Humans | DNA Primers | GTP-Binding Protein alpha Subunits, Gs - genetics | Chromogranins | Genes, p53 | Base Sequence | Polymerase Chain Reaction | Bile Duct Neoplasms | Cholangiocarcinoma - genetics | Bile Ducts, Intrahepatic | Mutation | Biliary Tract Neoplasms - genetics | Genes, ras | Tumor proteins | Mutation (Biology) | Research | Index Medicus | Abridged Index Medicus
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2. Full Text Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma
by Kim, Hyo Jung and Kim, Jae Seon and Kim, Baek Hee and Bak, Young-Tae
Digestive Surgery, ISSN 0253-4886, 02/2018, Volume 35, Issue 2, pp. 116 - 120
Backgrounds and Aims: Biliary intraepithelial neoplasia (BilIN) is a precursor of cholangiocarcinoma (CC) and it has been associated with several chronic... 
Original Paper | Biliary intraepithelial neoplasia | Ki-67 | Cholangiocarcinoma | CRITERIA | SURGERY | INTRAHEPATIC CHOLANGIOCARCINOMA | BILE-DUCT | PROPOSAL | EPITHELIAL LESIONS | TRACT | INTEROBSERVER AGREEMENT | HEPATOLITHIASIS | GASTROENTEROLOGY & HEPATOLOGY
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3. Full Text Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis
by Rougemont, Laura Rubbia-Brandt and Genevay, Muriel and McKee, Thomas A and Gremaud, Magali and Mentha, Gilles and Rubbia-Brandt, Laura
Virchows Archiv, ISSN 0945-6317, 06/2010, Volume 456, Issue 6, pp. 711 - 717
Biliary intraepithelial neoplasia (BilIN), a preneoplastic condition that may precede invasive intrahepatic cholangiocarcinoma (ICC), has been compared to... 
FISH | Biliary dysplasia | Multifocal intrahepatic cholangiocarcinoma | DUCT DYSPLASIA | HYBRIDIZATION | PATHOLOGY | LESIONS | INACTIVATION | HEPATITIS-C VIRUS | LIVER | TUMOR-SUPPRESSOR | EXPRESSION | PROGRESSION MODEL | PRIMARY SCLEROSING CHOLANGITIS | Humans | In Situ Hybridization, Fluorescence | Male | Genes, p16 | Precancerous Conditions - genetics | Cholangiocarcinoma - pathology | Cholangiocarcinoma - genetics | Liver Cirrhosis - pathology | Adult | Bile Ducts, Intrahepatic | Precancerous Conditions - pathology | Bile Duct Neoplasms - genetics | Bile Duct Neoplasms - pathology | Dysplasia | Analysis | Alcoholism | Fluorescence | Development and progression | Tumor proteins | Hepatitis C | Health aspects | Liver cirrhosis | Index Medicus
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4. Full Text Biliary intraepithelial neoplasia: An international interobserver agreement study and proposal for diagnostic criteria
by Zen, Yoh and Adsay, N Volkan and Bardadin, Krystof and Colombari, Romano and Ferrell, Linda and Haga, Hironori and Hong, Seung-Mo and Hytiroglou, Prodromos and Klöppel, Günter and Lauwers, Gregory Y and Van Leeuwen, Dirk J and Notohara, Kenji and Oshima, Kiyoko and Quaglia, Alberto and Sasaki, Motoko and Sessa, Fausto and Suriawinata, Arief and Tsui, Wilson and Atomi, Yutaka and Nakanuma, Yasuni
Modern Pathology, ISSN 0893-3952, 06/2007, Volume 20, Issue 6, pp. 701 - 709
Cholangiocarcinoma of the intrahepatic and extrahepatic bile ducts develops through a multistep histopathologic sequence. Premalignant or non-invasive... 
BilIN | Biliary dysplasia | Bile duct | Cholangiocarcinoma | Intrahepatic cholangiocarcinoma | BILE-DUCT | DYSPLASIA | CLASSIFICATION | PATHOLOGY | intrahepatic cholangiocarcinoma | BillN | biliary dysplasia | bile duct | INTRADUCTAL PAPILLARY NEOPLASM | MUCINOUS NEOPLASMS | cholangiocarcinoma | EXPRESSION | CARCINOMA | PATHOLOGICAL FEATURES | PRIMARY SCLEROSING CHOLANGITIS | Bile Ducts, Intrahepatic - pathology | Carcinoma in Situ - classification | Biliary Tract Neoplasms - classification | Carcinoma in Situ - pathology | Humans | Liver Diseases - pathology | Terminology as Topic | International Cooperation | Lithiasis - pathology | Biliary Tract Neoplasms - diagnosis | Choledochal Cyst - pathology | Cholangitis, Sclerosing - pathology | Bile Ducts, Extrahepatic - pathology | Carcinoma in Situ - diagnosis | Biliary Tract Neoplasms - pathology
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5. Full Text Intra-ampullary papillary-tubular neoplasm (IAPN): Characterization of tumoral intraepithelial neoplasia occurring within the ampulla: A clinicopathologic analysis of 82 cases
by Ohike, Nobuyuki and Kim, Grace E and Tajiri, Takuma and Krasinskas, Alyssa and Basturk, Olca and Coban, Ipek and Bandyopadhyay, Sudeshna and Morohoshi, Toshio and Goodman, Michael and Kooby, David A and Sarmiento, Juan M and Adsay, N. Volkan
American Journal of Surgical Pathology, ISSN 0147-5185, 12/2010, Volume 34, Issue 12, pp. 1731 - 1748
Background: There has been no uniform terminology for systematic analysis of mass-forming preinvasive neoplasms (which we term tumoral intraepithelial... 
intra-ampullary | tumoral intraepithelial neoplasia | papillary | ampullary | tubular | ampulla | SURGERY | BILE-DUCT | INTESTINAL PATHWAY | BILIARY-TRACT | PATHOLOGY | IMMUNOHISTOCHEMICAL ANALYSIS | MUCINOUS NEOPLASMS | 20 EXPRESSION | FAMILIAL ADENOMATOUS POLYPOSIS | CELL-DIFFERENTIATION | CLINICOPATHOLOGICAL ANALYSIS | PATHOLOGICAL FEATURES | Immunohistochemistry | United States - epidemiology | Adenocarcinoma - pathology | Carcinoma in Situ - pathology | Humans | Middle Aged | Male | Survival Rate | Pancreaticoduodenectomy | Adenocarcinoma - metabolism | Ampulla of Vater - metabolism | Common Bile Duct Neoplasms - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Ampulla of Vater - surgery | Female | Aged | Common Bile Duct Neoplasms - surgery | Carcinoma in Situ - metabolism | Adenocarcinoma - mortality | Ampulla of Vater - pathology | Common Bile Duct Neoplasms - pathology
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6. Full Text Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia
by Sato, Yasunori and Sato, Yasunori and Sasaki, Motoko and Sasaki, Motoko and Harada, Kenichi and Harada, Kenichi and Aishima, Shinichi and Aishima, Shinichi and Fukusato, Toshio and Fukusato, Toshio and Ojima, Hidenori and Ojima, Hidenori and Kanai, Yae and Kanai, Yae and Kage, Masayoshi and Kage, Masayoshi and Nakanuma, Yasuni and Nakanuma, Yasuni and Tsubouchi, Hirohito and Tsubouchi, Hirohito and Hepatolithiasis Subdiv and Hepatolithiasis Subdivision of Intractable Hepatobiliary Diseases Study Group of Japan (Chairman, Hirohito Tsubouchi)
Journal of Gastroenterology, ISSN 0944-1174, 1/2014, Volume 49, Issue 1, pp. 64 - 72
Flat epithelial lesions of the biliary tract cannot be detected by the image analysis, and the diagnosis entirely depends on pathological examination. The... 
Biliary intraepithelial neoplasia | Flat epithelial lesion | Medicine & Public Health | Colorectal Surgery | Reactive atypia | Hepatology | Gastroenterology | Abdominal Surgery | Intraepithelial spreading | Surgical Oncology | Cholangiocarcinoma | INTRAHEPATIC CHOLANGIOCARCINOMA | BILE-DUCT | LIVER-CIRRHOSIS | INTRADUCTAL PAPILLARY NEOPLASM | INTEROBSERVER AGREEMENT | PERIPHERAL-TYPE | HEPATOLITHIASIS | SPREAD | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | PRIMARY SCLEROSING CHOLANGITIS | Cholangiocarcinoma - pathology | Diagnosis, Differential | Algorithms | Carcinoma in Situ - genetics | Carcinoma in Situ - pathology | Neoplasm Invasiveness | Humans | Bile Ducts, Intrahepatic | Bile Duct Neoplasms - genetics | Bile Duct Neoplasms - pathology | Medical colleges | Analysis
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7. Full Text A rare case of symptomatic grossly-visible biliary intraepithelial neoplasia mimicking cholangiocarcinoma
by Yoshida, N and Aoyagi, T and Kimura, Y and Naito, Y and Izuwa, A and Mizoguchi, K and Ishii, K and Tanaka, Y and Ohnishi, E and Miura, S and Shimamura, S and Shirahama, N and Kaneshiro, K and Saruwatari, A and Iwanaga, A and Sadakari, Y and Hirokata, G and Ogata, T and Taniguchi, M
WORLD JOURNAL OF SURGICAL ONCOLOGY, ISSN 1477-7819, 11/2019, Volume 17, Issue 1, pp. 1 - 6
BackgroundBiliary intraepithelial neoplasia (BilIN) is often distinguished by what it is not: the precancerous lesions are not mass-forming, are not the cause... 
SURGERY | TRACT | Biliary intraepithelial neoplasia (BilIN) | BILE-DUCT | ONCOLOGY | RESECTION | PROPOSAL | EPITHELIAL LESIONS | EXPRESSION | Cholangiocarcinoma | Bile duct | MARGIN STATUS
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8. Full Text Biliary intraepithelial neoplasia in patients without chronic biliary disease: Analysis of liver explants with alcoholic cirrhosis, hepatitis C infection, and noncirrhotic liver diseases
by Wu, Tsung-Teh and Levy, Michael and Correa, Arlene M and Rosen, Charles B and Abraham, Susan C
Cancer, ISSN 0008-543X, 10/2009, Volume 115, Issue 19, pp. 4564 - 4575
Biliary intraepithelial neoplasia (BilIN) represents a spectrum of proliferative and/or cytologically atypical lesions of the large intrahepatic bile ducts.... 
Biliary intraepithelial neoplasia | Cirrhosis | Dysplasia | Bile ducts | Liver | Alcohol | Hepatitis C | Cholangiocarcinoma | Transplant | Prevalence | Cholangiocarcinoma - complications | Liver Cirrhosis - complications | Liver Cirrhosis, Alcoholic - pathology | Humans | Middle Aged | Liver Diseases - pathology | Biliary Tract Neoplasms - etiology | Child, Preschool | Infant | Male | Hepatectomy | Cholangiocarcinoma - pathology | Adolescent | Liver Cirrhosis - pathology | Liver Diseases - complications | Adult | Female | Hepatitis C - complications | Aged | Liver Cirrhosis, Alcoholic - complications | Biliary Tract Neoplasms - pathology | Biliary tract diseases | Care and treatment | Research | Patient outcomes | Index Medicus | Abridged Index Medicus
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9. Full Text Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct—an immunohistochemical study of 110 cases of hepatolithiasis
by Zen, Yoh and Sasaki, Motoko and Fujii, Takahiko and Chen, Tse-Ching and Chen, Miin-Fu and Yeh, Ta-Sen and Jan, Yi-Yin and Huang, Shiu-Feng and Nimura, Yuji and Nakanuma, Yasuni
Journal of Hepatology, ISSN 0168-8278, 02/2006, Volume 44, Issue 2, pp. 350 - 358
Two types of neoplastic lesions preceding invasive intrahepatic cholangiocarcinoma (ICC) are identified: a flat-type neoplastic lesion called ‘biliary... 
Dysplasia | Biliary papillomatosis | Colloid carcinoma | Intrahepatic cholangiocarcinoma | PanIN | PANCREAS | TUMORS | intrahepatic cholangiocarcinoma | MUC5AC | dysplasia | biliary papillomatosis | colloid carcinoma | TRACT | LIVER | GASTROENTEROLOGY & HEPATOLOGY | CARCINOMA | PROGRESSION | Immunohistochemistry | Bile Ducts, Intrahepatic - pathology | Diagnosis, Differential | Bile Duct Neoplasms - metabolism | Humans | Cholangiocarcinoma - metabolism | Disease Progression | Mucins - biosynthesis | Cholangiocarcinoma - pathology | Keratins - biosynthesis | Cholelithiasis - metabolism | Adenocarcinoma, Papillary - metabolism | Cholelithiasis - pathology | Bile Duct Neoplasms - pathology | Neoplasm Staging | Precancerous Conditions | Biomarkers, Tumor - biosynthesis | Adenocarcinoma, Papillary - pathology | Medical colleges | Tumors
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10. Full Text Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia
by Sasaki, Motoko, MD, PhD and Nitta, Takeo, MD, PhD and Sato, Yasunori, MD, PhD and Nakanuma, Yasuni, MD, PhD
Human Pathology, ISSN 0046-8177, 2015, Volume 46, Issue 2, pp. 202 - 209
Summary Similar to the pancreatic carcinoma sequence model, cholangiocarcinoma reportedly follows a stepwise carcinogenesis process via the precursor lesion... 
Pathology | Beclin-1 | Biliary intraepithelial neoplasia (BilIN) | Intrahepatic cholangiocarcinoma | KRAS | p62/sequestosome-1 | Autophagy | Microtubule-associated proteins light chain 3 beta (LC3) | UNITED-STATES | Intrahepatic cholangtocarcinoma | BILE-DUCT | PATHOLOGY | CELLULAR SENESCENCE | CANCER | P62 | PATHOGENESIS | DISEASE | EXPRESSION | INTRAHEPATIC CHOLANGIOCARCINOMAS | Proto-Oncogene Proteins - metabolism | Bile Ducts, Intrahepatic - pathology | Proto-Oncogene Proteins p21(ras) | Bile Duct Neoplasms - metabolism | Cholangiocarcinoma - diagnosis | Microtubule-Associated Proteins - metabolism | Humans | Liver - metabolism | ras Proteins - metabolism | Autophagy - physiology | Cholangiocarcinoma - metabolism | Apoptosis Regulatory Proteins - metabolism | Immunohistochemistry - methods | Bile Duct Neoplasms - diagnosis | Cholangiocarcinoma - pathology | Bile Ducts, Intrahepatic - metabolism | Membrane Proteins - metabolism | Autophagy - genetics | Bile Duct Neoplasms - pathology | Neoplasm Staging | RNA-Binding Proteins - metabolism | Development and progression | Deregulation | Tumor proteins | Analysis | Mutation | Mortality | Liver | Rodents | Bile | Index Medicus
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11. Full Text Tumoral versus flat intraepithelial neoplasia of pancreatobiliary tract, gallbladder, and ampulla of vater
by Jang, Kee-Taek and Ahn, Sangjeong
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 05/2016, Volume 140, Issue 5, pp. 429 - 436
Context.-The identification of a precursor lesion is important to understanding the histopathologic and genetic alterations in carcinogenesis. There are a... 
MEDICINE, RESEARCH & EXPERIMENTAL | BILE-DUCT | OVARIAN-TYPE STROMA | ADENOMA-CARCINOMA SEQUENCE | PATHOLOGY | TUBULAR ADENOMA | SQUAMOUS-CELL CARCINOMA | CYSTIC NEOPLASM | PAPILLARY-MUCINOUS NEOPLASMS | LATERALLY SPREADING TUMORS | MEDICAL LABORATORY TECHNOLOGY | INTRADUCTAL TUBULOPAPILLARY NEOPLASMS | CLINICOPATHOLOGICAL FEATURES | Education, Medical, Continuing | Adenocarcinoma, Mucinous - pathology | Pancreatic Neoplasms - diagnosis | Carcinoma, Squamous Cell - pathology | Humans | Carcinogenesis | Carcinoma, Squamous Cell - diagnosis | Precancerous Conditions - diagnosis | Pathology, Clinical - manpower | Precancerous Conditions - pathology | Ampulla of Vater - diagnostic imaging | Ampulla of Vater - pathology | Biliary Tract Neoplasms - pathology | Gallbladder Neoplasms - diagnosis | Common Bile Duct Neoplasms - diagnosis | Adenocarcinoma in Situ - pathology | Diagnosis, Differential | Carcinoma in Situ - pathology | Pancreatic Neoplasms - pathology | Papilloma, Intraductal - pathology | Carcinoma, Papillary - pathology | Biliary Tract Neoplasms - diagnosis | Pathology, Clinical - methods | Adenocarcinoma, Mucinous - diagnosis | Papilloma, Intraductal - diagnosis | Pathology, Clinical - trends | Pathology, Clinical - education | Adenocarcinoma in Situ - diagnosis | Gallbladder Neoplasms - pathology | Carcinoma in Situ - diagnosis | Carcinoma, Papillary - diagnosis | Common Bile Duct Neoplasms - pathology | Dysplasia | Index Medicus | Abridged Index Medicus
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12. Full Text Biliary intraepithelial neoplasia in liver parenchyma of the caudate lobe: honeycomb appearance
by Higaki, Tokio and Higaki, Tokio and Yamazaki, Shintaro and Yamazaki, Shintaro and Sugitani, Masahiko and Sugitani, Masahiko and Takayama, Tadatoshi and Takayama, Tadatoshi
European Surgery, ISSN 1682-8631, 4/2019, Volume 51, Issue 2, pp. 66 - 70
Biliary intraepithelial neoplasia (BilIN) was newly defined by the WHO in 2010 and is characterized by biliary cell atypia with an intraductal papillary... 
Biliary intraepithelial neoplasia | Medicine & Public Health | Cardiac Surgery | Caudate lobe tumor | Surgery | Concomitant IVC resection | Abdominal Surgery | Vascular Surgery | General Surgery | Honeycomb appearance | SURGERY | Honey-comb appearance | TRACT | EXTRAHEPATIC BILE-DUCT | ADENOMA | Medical colleges | Liver cancer | Liver | Tumors
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13. Full Text Detection of High-Grade Pancreatic Intraepithelial Neoplasia without Morphological Changes of the Main Pancreatic Duct over a Long Period: Importance for Close Follow-Up for Confirmation
by Yamao, Kentaro and Takenaka, Mamoru and Nakai, Atsushi and Omoto, Shunske and Kamata, Ken and Minaga, Kosuke and Miyata, Takeshi and Imai, Hajime and Sakurai, Toshiharu and Watanabe, Tomohiro and Nishida, Naoshi and Matsumoto, Ippei and Takeyama, Yosihumi and Chikugo, Takaaki and Kudo, Masatoshi
Oncology, ISSN 0030-2414, 12/2017, Volume 93, Issue 1, pp. 81 - 86
Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural... 
Pancreato-Biliary Cancer - Clinical Study | High-grade pancreatic intraepithelial neoplasia | Carcinoma in situ | Distal main pancreatic duct dilation | Pancreatic cancer | Localized main pancreatic duct stenosis | Neoplasm Grading | Carcinoma in Situ - pathology | Pancreatic Neoplasms - diagnosis | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - diagnosis | Male | Aged | Carcinoma in Situ - diagnosis | Carcinoma, Pancreatic Ductal - pathology
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14. Full Text Expression of cell cycle–related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm
by Nakanishi, Yoshitsugu, MD and Zen, Yoh, MD and Kondo, Satoshi, MD and Itoh, Tomoo, MD and Itatsu, Keita, MD and Nakanuma, Yasuni, MD
Human Pathology, ISSN 0046-8177, 2008, Volume 39, Issue 8, pp. 1153 - 1161
Summary Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for... 
Pathology | BilIN | Intraductal papillary neoplasm | Biliary dysplasia | DPC4 | Cell cycle | BILE-DUCT | cell cycle | DUCTAL ADENOCARCINOMA | DPC4 INACTIVATION | PANCREAS | PATHOLOGY | intraductal papillary neoplasm | TUMORS | biliary dysplasia | LIVER | MUCINOUS NEOPLASMS | Bi1IN | CARCINOMA | PATHOLOGICAL FEATURES | PROGRESSION | Immunohistochemistry | Cell Cycle Proteins - analysis | Humans | Middle Aged | Male | Cholangiocarcinoma - metabolism | Cyclin D1 - analysis | Tumor Suppressor Protein p53 - analysis | Bile Duct Neoplasms - chemistry | Mucin-1 - analysis | Precancerous Conditions - classification | Mucins - analysis | Mucins - metabolism | Aged, 80 and over | Adult | Female | Precancerous Conditions - pathology | Mucin-1 - metabolism | Bile Duct Neoplasms - classification | Mucin-2 | Cyclin-Dependent Kinase Inhibitor p21 - analysis | Precancerous Conditions - chemistry | Cholangiocarcinoma - chemistry | Aged | Bile Duct Neoplasms - pathology | Smad4 Protein - analysis | Medical colleges | Dysplasia | Zen Buddhism | Tumor proteins | Tumors | Proteins | Pancreas | Bile | Index Medicus
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15. Full Text Pancreatic intraepithelial neoplasia in heterotopic pancreas: Incidentally diagnosed on endoscopic mucosal resection of a duodenal polyp
by Safadi, Sarah and Martin, David R and Rustagi, Tarun
BMJ Case Reports, ISSN 1757-790X, 2018, Volume 2018, p. bcr-2018-224414
Heterotopic pancreas is the presence of pancreatic tissue outside its normal location. It can develop similar pathological conditions that develop in the... 
endoscopic mucosal resection | pancreas and biliary tract | endoscopy | small intestine | duodenal adenoma | EMR | Pathology | Stomach | Ultrasonic imaging | Cellular biology | Cysts | Biopsy | Pancreatitis | Cardiovascular disease | Endoscopy | Pancreas | Tumors
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16. Full Text Biliary intraepithelial neoplasia (BilIN) is frequently found in surgical margins of biliary tract cancer resection specimens but has no clinical implications
by Matthaei, Hanno and Matthaei, Hanno and Lingohr, Philipp and Lingohr, Philipp and Strässer, Anke and Strässer, Anke and Dietrich, Dimo and Dietrich, Dimo and Rostamzadeh, Babak and Rostamzadeh, Babak and Glees, Simone and Glees, Simone and Roering, Martin and Roering, Martin and Möhring, Pauline and Möhring, Pauline and Scheerbaum, Martin and Scheerbaum, Martin and Stoffels, Burkhard and Stoffels, Burkhard and Kalff, Jörg C and Kalff, Jörg C and Schäfer, Nico and Schäfer, Nico and Kristiansen, Glen and Kristiansen, Glen
Virchows Archiv, ISSN 0945-6317, 2/2015, Volume 466, Issue 2, pp. 133 - 141
Biliary tract cancers are aggressive tumors of which the incidence seems to increase. Resection with cancer-free margins is crucial for curative therapy.... 
Pathology | Biliary intraepithelial neoplasia (BilIN) | Medicine & Public Health | Precursor lesions | Margin | SURVIVAL | ADDITIONAL RESECTION | HILAR CHOLANGIOCARCINOMA | EXTRAHEPATIC CHOLANGIOCARCINOMA | MORTALITY-RATES | PATHOLOGY | TRENDS | LIVER | TREE | DUCT CANCER | EPIDEMIOLOGY | Neoplasm, Residual - pathology | Adenocarcinoma - pathology | Carcinoma in Situ - pathology | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Biliary Tract Neoplasms - mortality | Adult | Female | Aged | Neoplasm, Residual - mortality | Carcinoma in Situ - mortality | Infant, Newborn | Adenocarcinoma - mortality | Biliary Tract Neoplasms - pathology | Health aspects | Surgery
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