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index medicus (103) 103
apoptosis (94) 94
bim (79) 79
humans (73) 73
bcl-2-like protein 11 (66) 66
animals (50) 50
proto-oncogene proteins - metabolism (44) 44
membrane proteins - metabolism (43) 43
apoptosis regulatory proteins - metabolism (40) 40
cell biology (35) 35
apoptosis - drug effects (33) 33
apoptosis regulatory proteins - genetics (33) 33
membrane proteins - genetics (33) 33
proto-oncogene proteins - genetics (33) 33
cell line, tumor (31) 31
oncology (29) 29
biochemistry & molecular biology (27) 27
mice (26) 26
bcl-2 family (24) 24
expression (24) 24
phosphorylation (24) 24
proteins (24) 24
cell death (23) 23
apoptosis - physiology (21) 21
bim protein (20) 20
proto-oncogene proteins c-bcl-2 - metabolism (20) 20
gene expression (19) 19
immunology (19) 19
biological phenomena, cell phenomena, and immunity (17) 17
signal transduction (17) 17
activation (16) 16
cancer (16) 16
female (16) 16
hemic and lymphatic diseases (16) 16
bcl-2 (15) 15
bh3-only proteins (15) 15
cell-death (15) 15
research (15) 15
family-member bim (14) 14
male (13) 13
mutation (13) 13
chemotherapy (12) 12
down-regulation (12) 12
in-vivo (12) 12
kinases (12) 12
research article (12) 12
tumors (12) 12
antineoplastic agents - pharmacology (11) 11
death (11) 11
induced apoptosis (11) 11
lymphocytes (11) 11
original (11) 11
proto-oncogene proteins - physiology (11) 11
analysis (10) 10
apoptosis - genetics (10) 10
apoptosis regulatory proteins - physiology (10) 10
article (10) 10
biology (10) 10
cell survival (10) 10
medicine (10) 10
mice, knockout (10) 10
original article (10) 10
protein (10) 10
proto-oncogene proteins c-bcl-2 - genetics (10) 10
apoptosis regulatory proteins (9) 9
bax (9) 9
bcl-2 protein (9) 9
extracellular signal-regulated map kinases - metabolism (9) 9
genetic aspects (9) 9
health aspects (9) 9
leukemia (9) 9
membrane proteins - physiology (9) 9
mice, inbred c57bl (9) 9
middle aged (9) 9
mitochondria (9) 9
neoplasms (9) 9
pathway (9) 9
protein binding (9) 9
rats (9) 9
rna (9) 9
rna interference (9) 9
survival (9) 9
t cells (9) 9
up-regulation (9) 9
autophagy (8) 8
bh3-only protein (8) 8
cells (8) 8
cells, cultured (8) 8
family (8) 8
forkhead transcription factors - metabolism (8) 8
homeostasis (8) 8
mcl-1 (8) 8
multidisciplinary sciences (8) 8
neurosciences (8) 8
science (8) 8
signal transduction - drug effects (8) 8
t-lymphocytes - cytology (8) 8
transcription (8) 8
adult (7) 7
apoptosis regulatory proteins - biosynthesis (7) 7
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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 13, pp. 10166 - 10177
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19331 - 19339
We have previously shown that the cell death-promoting protein Bcl-2-interacting mediator of cell death (Bim) is ubiquitinated and degraded following a... 
CHAIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BH3-ONLY PROTEIN | ADENOSINE | DEGRADATION | DEPENDENT APOPTOSIS | REGULATED KINASES 1/2 | UBIQUITIN LIGASES | BIM(EL) | FAMILY | Tetradecanoylphorbol Acetate - pharmacology | Brain Ischemia - genetics | Brain Ischemia - metabolism | Embryo, Mammalian - metabolism | Ubiquitination | Carcinogens - pharmacology | Bcl-2-Like Protein 11 | Mitogen-Activated Protein Kinase 1 - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Phosphorylation - drug effects | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation - genetics | Membrane Proteins - genetics | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Ischemic Preconditioning | Rats | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Proteins - genetics | Animals | Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Protein Binding | Mice | Mutation | Ubiquitin-Protein Ligases - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Ubiquitin | Molecular Bases of Disease | E3 Ubiquitin Ligase | Neuron | Ischemia | Cell Death | Neurobiology | MAP kinases (MAPKs) | ERK
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2013, Volume 89, Issue 3
ABSTRACT Oocyte-secreted factors (OSFs) maintain the low incidence of cumulus cell apoptosis. In this report, we described that the presence of oocytes... 
atresia | GDF9 | porcine/pig | BIM | apoptosis | cumulus cell | cumulus cells | oocyte-follicle interactions
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2011, Volume 186, Issue 2, pp. 799 - 806
Peripheral CD4(+)V beta 5(+) T cells are tolerized to an endogenous mouse mammary tumor virus superantigen either by deletion or TCR revision. Through TCR... 
BCL-2 TRANSGENE | IMMUNE-SYSTEM | RECEPTOR-ALPHA CHAINS | NEGATIVE SELECTION | AUTOREACTIVE THYMOCYTES | IMMUNOLOGY | PERIPHERAL T-CELLS | EXPRESSION | CUTTING EDGE | THYMIC EMIGRANTS | TRANSGENIC MICE | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Cell Death - immunology | Cell Survival - genetics | Lymphocyte Depletion | Proto-Oncogene Proteins - biosynthesis | Receptors, Antigen, T-Cell - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Membrane Proteins - deficiency | Signal Transduction - immunology | Bcl-2-Like Protein 11 | Cell Death - genetics | Apoptosis Regulatory Proteins - deficiency | Membrane Proteins - physiology | CD4-Positive T-Lymphocytes - virology | Apoptosis Regulatory Proteins - biosynthesis | Genes, RAG-1 - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Mammary Tumor Virus, Mouse - immunology | Signal Transduction - genetics | Proto-Oncogene Proteins - deficiency | Cell Survival - immunology | Mice, Knockout | Autoantigens - physiology | Cell Differentiation - immunology | Membrane Proteins - biosynthesis | Animals | Gene Rearrangement, T-Lymphocyte - immunology | Proto-Oncogene Proteins - physiology | Apoptosis Regulatory Proteins - physiology | Mice | Receptors, Antigen, T-Cell - genetics | Index Medicus | Abridged Index Medicus | Bcl-2 | apoptosis | TCR revision | tolerance | T cell selection | Bim
Journal Article
Journal Article
Chinese Journal of Lung Cancer, ISSN 1009-3419, 2016, Volume 19, Issue 11, pp. 789 - 792
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2013, Volume 455, Issue 1, pp. 15 - 25
Neuronal apoptotic death generally requires de novo transcription, and activation of the transcription factor c-Jun has been shown to be necessary in multiple... 
Nerve growth factor (NGF) | Neurons | RIP (receptor-interacting protein)-associated ICH-1 [ICE (interleukin-1β-converting enzyme)/CED-3 (cell-death determining 3) homologue 1] protein with a death domain (RAIDD) | Bcl-2-interacting mediator of cell death (Bim) | Caspase-2 | β-amyloid | BCL-2 FAMILY-MEMBER | ALZHEIMERS-DISEASE | INDUCED TOXICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYMPATHETIC NEURONS | determining 3) homologue 1] protein with a death domain (RAIDD | neurons | RIP (receptor-interacting protein)-associated ICH-1 [ICE (interleuldn-1 beta-converting enzyme)/CED-3 (cell-death | ADAPTER MOLECULE | CELL-DEATH | beta-amyloid | nerve growth factor (NGF) | caspase-2 | PC12 CELLS | TERMINAL KINASE ACTIVATION | TROPHIC FACTOR WITHDRAWAL | BH3-ONLY PROTEINS | Caspase 2 - genetics | Transcription, Genetic - drug effects | Apoptosis - drug effects | Amyloid beta-Peptides - pharmacology | Transcriptional Activation - drug effects | Neurons - cytology | Caspase 2 - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | CRADD Signaling Adaptor Protein - genetics | Fetus | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins - metabolism | CRADD Signaling Adaptor Protein - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins c-jun - genetics | Rats | Proto-Oncogene Proteins - genetics | Rats, Sprague-Dawley | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Proto-Oncogene Proteins c-jun - metabolism | Nerve Growth Factor - deficiency | Primary Cell Culture | Index Medicus | RAIDD | NGF | Bim
Journal Article
FEBS Letters, ISSN 0014-5793, 2009, Volume 583, Issue 12, pp. 1873 - 1879
Bcl-2-interacting mediator of cell death (Bim) has been considered to initiate intrinsic apoptotic pathway through Bax activation. Previous studies indicated... 
Bax | BimL | Bcl-xL | Ultraviolet irradiation | c-Jun N-terminal kinase | RNAi | laser confocal scanning microscopy | RNA interference | JNK | Bim | fluorescence resonance energy transfer | Ultraviolet | LCSM | Co-immunoprecipitation | Bcl-2-interacting mediator of cell death | shRNA | short hairpin RNA | FRET | CO-IP | SURVIVAL | TRANSLOCATION | PROAPOPTOTIC ACTIVITY | ISOFORMS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | FAMILY | MEMBER | CELL BIOLOGY | PROTEIN BIM | BIOPHYSICS | ASSOCIATION | Immunoprecipitation | Apoptosis - radiation effects | bcl-X Protein - genetics | Cercopithecus aethiops | DNA Primers - genetics | Transfection | Ultraviolet Rays | Bcl-2-Like Protein 11 | RNA Interference | Base Sequence | Apoptosis Regulatory Proteins - genetics | Fluorescence Resonance Energy Transfer | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Microscopy, Confocal | Animals | Membrane Proteins - antagonists & inhibitors | Models, Biological | Apoptosis Regulatory Proteins - antagonists & inhibitors | Protein Binding | Apoptosis - physiology | bcl-X Protein - metabolism | COS Cells | RNA | Fluorescence | Apoptosis | Index Medicus
Journal Article
Acta pharmaceutica Sinica. B, ISSN 2211-3835, 01/2017, Volume 7, Issue 1, p. 18
Apoptosis, especially the intrinsic mitochondrial cell death pathway, is regulated by the BCL-2 family of proteins. Defects in apoptotic machinery are one of... 
Journal Article
Chinese Journal of Lung Cancer, ISSN 1009-3419, 11/2016, Volume 19, Issue 11, pp. 789 - 792
B细胞淋巴瘤-2促细胞凋亡(B-cell lymphoma 2 interacting mediator of cell death, BIM )基因作为抑癌基因,在调控细胞凋亡中起重要作用。在非小细胞肺癌(non-small cell lung cancer,... 
Chemotherapy | Mini-Review | BIM | 酪氨酸激酶抑制剂 | 综述 | 化疗 | 肺肿瘤 | BCL-2-interacting mediator of cell death (BIM) | Tyrosine kinase inhibitors | Lung neoplasms
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2005, Volume 388, Issue 1, pp. 185 - 194
The regulation of survival and cell death is a key determinant of cell fate. Recent evidence shows that survival and death machineries are regulated along the... 
Signal transduction | Bim (Bcl-2-interacting mediator of cell death) | Fibroblast growth factor (FGF) | Mitosis | Cell cycle | Apoptosis | BCL-2 RELATIVE BIM | SURVIVAL | PROAPOPTOTIC ACTIVITY | cell cycle | signal transduction | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | DEATH | mitosis | FAMILY-MEMBER BIM | MICROTUBULE DYNAMICS | PATHWAY | fibroblast growth factor (FGF) | CELL-CYCLE | BH3-ONLY PROTEINS | Proto-Oncogene Proteins - metabolism | NIH 3T3 Cells | Phosphorylation | Signal Transduction | MAP Kinase Kinase Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | CDC2 Protein Kinase - metabolism | Animals | Bcl-2-Like Protein 11 | Mitosis - physiology | Membrane Proteins - metabolism | Mice | Protein Processing, Post-Translational | Apoptosis - physiology | Fibroblast Growth Factors - physiology | Index Medicus | TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling | PI3K, phosphoinositide 3-kinase | CIP, calf intestine phosphatase | HEK, human embryonic kidney | TBST, Tris-buffered saline with Tween 20 | BH, Bcl-2 homology | ERK kinase | DTT, dithiothreitol | ERK, extracellular-signal-regulated kinase | DMEM, Dulbecco's modified Eagle's medium | P-Bim, phosphorylated Bim | Bim, Bcl-2-interacting mediator of cell death | BimEL, extra-long Bim | Cdk, cyclin-dependent kinase | FGF, fibroblast growth factor | MEK, mitogen-activated protein kinase | HA, haemagglutinin | IP, immunoprecipitation | BimS, short Bim | MT, microtubule | bFGF, basic fibroblast growth factor | BimL, long BIM | FBS, foetal bovine serum
Journal Article
FEBS Journal, ISSN 1742-464X, 11/2009, Volume 276, Issue 21, pp. 6050 - 6062
The BCL‐2 homology domain 3 (BH3)‐only protein, B‐cell lymphoma 2 interacting mediator of cell death (BIM) is a potent pro‐apoptotic protein belonging to the... 
ribosomal protein S6 kinase (RSK) | extracellular signal‐regulated kinase 1/2 (ERK1/2) | epidermal growth factor receptor (EGFR) | v‐raf murine sarcoma viral oncogene homologue B1 (BRAF) | breakpoint cluster region/Abelson murine leukaemia viral oncogene (BCR/ABL) | BCL‐2‐interacting mediator of cell death (BIM) | protein kinase B (PKB) | mitogen‐MAPK or ERK Kinase 1/2 (MEK1/2) | B‐cell lymphoma 2 (BCL‐2) | V-raf murine sarcoma viral oncogene homologue B1 (BRAF) | BCL-2-interacting mediator of cell death (BIM) | B-cell lymphoma 2 (BCL-2) | Epidermal growth factor receptor (EGFR) | Breakpoint cluster region/Abelson murine leukaemia viral oncogene (BCR/ABL) | CHRONIC MYELOGENOUS LEUKEMIA | v-raf murine sarcoma viral oncogene homologue B1 (BRAF) | ABL TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORAL MEK INHIBITOR | DEPENDENT APOPTOSIS | ABL | 2 (ERK1 | REGULATED KINASES 1/2 | INDUCE APOPTOSIS | HEMATOPOIETIC PROGENITORS | extracellular signal-regulated kinase 1 | CHRONIC MYELOID-LEUKEMIA | 2 (MEK1 | BH3-ONLY PROTEIN BIM(EL) | mitogen-MAPK or ERK Kinase 1 | Abelson murine leukaemia viral oncogene (BCR | BCL-2 FAMILY | breakpoint cluster region | Receptor, Epidermal Growth Factor - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Cell Survival | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Autophagy | Neoplasms - drug therapy | Animals | Bcl-2-Like Protein 11 | Membrane Proteins - physiology | Proto-Oncogene Proteins B-raf - genetics | Fusion Proteins, bcr-abl - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Apoptosis Regulatory Proteins - physiology | Protein Processing, Post-Translational | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Neoplasms - pathology | Oncogenes | Apoptosis | Epidermal growth factor | Sarcoma | Ribosomal proteins | Leukemia | Biochemistry | Lymphomas | Protein kinases | Signal transduction | Oncology | Chemotherapy | Kinases | Index Medicus
Journal Article
Brain Research, ISSN 0006-8993, 2016, Volume 1648, Issue Pt B, pp. 603 - 616
Abstract In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological... 
Neurology | Wolfram syndrome | Ischemia | Glioblastoma | ER stress | Hormesis | Parkinson׳s disease | Autophagy | Proteasome | Parkinson's disease | UBIQUITIN-PROTEASOME SYSTEM | TISSUE-PLASMINOGEN ACTIVATOR | ER-STRESS | TRANSCRIPTION FACTOR XBP1 | ENDOPLASMIC-RETICULUM STRESS | NEUROSCIENCES | BETA-CELL FUNCTION | UNFOLDED PROTEIN RESPONSE | CENTRAL-NERVOUS-SYSTEM | TRANSIENT CEREBRAL-ISCHEMIA | PARKINSONS-DISEASE | Animals | Signal Transduction | Humans | Ubiquitin - metabolism | Nervous System Diseases - metabolism | Proteasome Endopeptidase Complex - metabolism | Nervous System Diseases - complications | Unfolded Protein Response - physiology | Proteostasis Deficiencies - complications | Endoplasmic Reticulum Stress - physiology | Nervous System Diseases - therapy | Health aspects | Nervous system diseases | Analysis | Index Medicus | Life Sciences | ATF4, activating transcription factor 4 | CDNF, cerebral dopamine neurotrophic factor | glutamate antiporter | ATF6α, activating transcription factor 6α | S1P, site 1 protease | CIRBP, cold-inducible RNA binding protein | Ca2+ ATPase | tPA, tissue plasminogen activator | Wfs1, wolframin | PERK, protein kinase RNA-like ER kinase | OGD, oxygen and glucose deprivation | UPR, unfolded protein response | CHOP, C | DA, dopaminergic | BI-1, Bax-inhibitor-1 | LRRK2, leucine-rich repeat kinase 2 | GRP78, binding immunoglobulin protein | IRE1, inositol-requiring enzyme 1 | JNK, Jun amino terminal kinase | ASK1, apoptosis signal regulating kinase 1 | EGFR, epidermal growth factor receptor | HIF-1, hypoxia-inducible transcription factor-1 | 3-MA, 3-methyladenine | SNpc, substantia nigra pars compacta | Ub, ubiquitin | 6-OHDA, 6-hydroxydopamine | BDNF, brain-derived neurotrophic factor | SERCA, sarcoplasmic-ER Mg2 | eIF2α, eukaryotic translation initiation factor 2α | ARE, anti-oxidant response element | PD, Parkinson’s disease | PUMA, p53 upregulated modulator of apoptosis | BiP | PMD, protein misfolding disorder | nAChRs, nicotinic acetylcholine receptors | XBP1, x-box binding protein 1 | ERAD, ER-associated protein degradation | Bim, Bcl-2-interacting mediator of cell death | MCAO, middle cerebral artery occlusion | ROS, reactive oxygen species | Hsp70, heat shock protein 70 | xCT, cystine | GADD34, growth arrest and DNA damage–inducible 34 | iPSC, induced pluripotent stem cell | UPS, ubiquitin proteasome system | PHD, prolyl-hydroxylases | MPTP, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | RIDD, regulated IRE1-dependent decay | MANF, mesencephalic astrocyte-derived neurotrophic factor | RBM3, RNA binding motif 3 | SOD, superoxide dismutase | S2P, site 2 protease | GEF, guanine nucleotide exchange factor | EBP-homologous protein | IRI, ischemia reperfusion injury | ER, endoplasmic reticulum | HD, Huntington’s disease | HO-1, heme oxygenase-1 | NF-KB, nuclear factor-kappa B
Journal Article