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PloS one, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0159998 - e0159998
...) scavenger or alleviate the acute toxic metal overload in vivo. In this study, we investigated the inhibitory effect of Tiron on matrix metalloproteinase (MMP... 
IRRADIATION | OXIDATIVE STRESS | HUMAN SKIN | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MECHANISMS | SODIUM 4,5-DIHYDROXYBENZENE-1,3-DISULFONATE | INDUCTION | C-JUN | NF-KAPPA-B | PROTEIN-KINASES | Promoter Regions, Genetic - radiation effects | Binding Sites - radiation effects | Humans | Transcriptional Activation - drug effects | Skin Aging - radiation effects | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology | Promoter Regions, Genetic - drug effects | Transcription Factor AP-1 - metabolism | Dermis - drug effects | Cytoprotection - drug effects | Signal Transduction - radiation effects | Dermis - cytology | Matrix Metalloproteinase 1 - genetics | Fibroblasts - metabolism | MAP Kinase Signaling System - radiation effects | Dermis - metabolism | Skin Aging - drug effects | Transcriptional Activation - radiation effects | Cells, Cultured | Dermis - radiation effects | Matrix Metalloproteinase 3 - metabolism | Antioxidants - pharmacology | Ultraviolet Rays - adverse effects | MAP Kinase Signaling System - drug effects | Fibroblasts - radiation effects | Signal Transduction - drug effects | Fibroblasts - drug effects | Transcription Factor AP-1 - radiation effects | Cytoprotection - genetics | Matrix Metalloproteinase 1 - metabolism | Cytoprotection - radiation effects | Matrix Metalloproteinase 3 - genetics | Genetic aspects | Skin | Genetic transcription | RNA | Analysis | Enzyme-linked immunosorbent assay | Oxidative stress | Reactive oxygen species | Transcription factors | Senescence | Oncology | Activation | Matrix metalloproteinase | Kinases | Proteins | Antioxidants | Signal transduction | Consent | Transcription activation | Fibroblasts | Aging | Biocompatibility | Metalloproteinase | Interstitial collagenase | Stromelysin 1 | Oxygen | Wound healing | U.V. radiation | Activator protein 1 | MAP kinase | Gene expression | Medicine | Signaling | Collagen | In vivo methods and tests | Mutation | Binding sites | Apoptosis | Index Medicus
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2017, Volume 94, Issue 3, pp. 431 - 446
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 529, Issue 7584, pp. 110 - 114
...)-binding sites, compromising binding of this methylation-sensitive insulator protein. Reduced CTCF binding is associated with loss of insulation between topological domains and aberrant gene activation... 
MAINTENANCE | METHYLATION | LANDSCAPE | DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | ARCHITECTURE | PHENOTYPE | EXPRESSION | 2-HYDROXYGLUTARATE | PRINCIPLES | Chromatin - metabolism | Up-Regulation | Humans | Glioma - genetics | Base Sequence | Glioma - pathology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Chromatin - drug effects | Repressor Proteins - metabolism | Oncogenes - genetics | Insulator Elements - genetics | Glioma - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Isocitrate Dehydrogenase - genetics | DNA Methylation - genetics | Down-Regulation - drug effects | Mutation - genetics | CRISPR-Cas Systems - genetics | Insulator Elements - drug effects | Phenotype | Isocitrate Dehydrogenase - chemistry | Receptor, Platelet-Derived Growth Factor alpha - genetics | CCCTC-Binding Factor | CpG Islands - genetics | Protein Binding | Isocitrate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Enhancer Elements, Genetic - genetics | Glutarates - metabolism | Cell Transformation, Neoplastic - drug effects | Chromatin - genetics | DNA Methylation - drug effects | Glioma - drug therapy | Complications and side effects | Care and treatment | Platelet-derived growth factor | Gliomas | Analysis | Influence | Genetic aspects | Research | Methylation | Oncogenes | DNA methylation | Epigenetics | Genomes | Mutation | Gene expression | Binding sites | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 50, pp. E8051 - E8058
.... The generally large, flat, and relatively featureless binding sites of protein complexes pose many challenges for drug design... 
Druggable surface | Direct coupling analysis | Drug design | Protein-protein interface | Hot spots | drug design | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | DIMERIZATION | protein-protein interface | INHIBITION | CONSERVATION | hot spots | CDK1 | HOT-SPOTS | direct coupling analysis | HIV-1 PROTEASE | BINDING-SITES | WEB SERVER | druggable surface | COMPUTATIONAL PREDICTION | Histone Deacetylase 1 - chemistry | Molecular Probes | HIV Protease - drug effects | Humans | Proto-Oncogene Proteins c-mdm2 - chemistry | CDC2-CDC28 Kinases - antagonists & inhibitors | Repressor Proteins - antagonists & inhibitors | HIV Protease Inhibitors - pharmacology | Proto-Oncogene Proteins c-mdm2 - drug effects | CDC2 Protein Kinase - drug effects | Drug Design | Histone Deacetylase 1 - drug effects | CDC2 Protein Kinase - chemistry | Histone Deacetylase 1 - antagonists & inhibitors | Binding Sites | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Molecular Docking Simulation - methods | Repressor Proteins - chemistry | Protein Interaction Domains and Motifs - drug effects | CDC2 Protein Kinase - antagonists & inhibitors | HIV-1 - drug effects | CDC2-CDC28 Kinases - chemistry | CDC2-CDC28 Kinases - drug effects | Histone Deacetylases - chemistry | HIV Protease Inhibitors - chemistry | Tumor Necrosis Factor-alpha - chemistry | Tumor Necrosis Factor-alpha - drug effects | HIV-1 - enzymology | Histone Deacetylases - drug effects | Repressor Proteins - drug effects | HIV Protease - chemistry | Protein Multimerization - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Evolution, Molecular | Observations | Protein-protein interactions | Biological Sciences | PNAS Plus | protein−protein interface
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 05/2008, Volume 28, Issue 20, pp. 5149 - 5158
Journal Article
Nature (London), ISSN 0028-0836, 2014, Volume 509, Issue 7502, pp. 641 - 644
Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States(1... 
APOPTOSIS | CELLS | MECHANISMS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | DISEASE | Iliac Artery - pathology | Protein-Serine-Threonine Kinases - deficiency | Constriction, Pathologic - pathology | Mitochondria, Heart - metabolism | Iliac Artery - drug effects | Apoptosis - drug effects | Humans | Myocytes, Smooth Muscle - pathology | Iliac Artery - injuries | Arteries - injuries | Secondary Prevention | Mitochondria, Heart - drug effects | Angioplasty, Balloon - adverse effects | Membrane Potential, Mitochondrial - drug effects | Dichloroacetic Acid - therapeutic use | Gene Knockdown Techniques | Swine | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Hyperplasia - drug therapy | Mammary Arteries - drug effects | Myocytes, Smooth Muscle - drug effects | Coronary Vessels - injuries | Disease Models, Animal | Constriction, Pathologic - prevention & control | Rabbits | Coronary Vessels - drug effects | Coronary Vessels - pathology | Aorta - drug effects | Protein-Serine-Threonine Kinases - genetics | Rats | Mammary Arteries - injuries | Arteries - drug effects | Aorta - injuries | Arteries - pathology | Enzyme Activation - drug effects | Tunica Intima - injuries | Aorta - pathology | Hyperplasia - pathology | Tunica Intima - drug effects | Animals | Tunica Intima - pathology | Mammary Arteries - pathology | Dichloroacetic Acid - pharmacology | Cell Proliferation - drug effects | Stents - adverse effects | Complications and side effects | Patient outcomes | Genetic aspects | Research | Coronary heart disease | Health aspects | Risk factors | Stent (Surgery) | Apoptosis | Permeability | Angioplasty | Rodents | Binding sites | Veins & arteries | Index Medicus
Journal Article
Journal Article