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Journal of Biological Chemistry, ISSN 0021-9258, 03/2009, Volume 284, Issue 12, pp. 8023 - 8032
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 4, pp. 1645 - 1661
.... GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders... 
IN-VITRO | CHEMISTRY, MEDICINAL | GSK-3 INHIBITORS | ASSAY | MECHANISM | MODELS | STRUCTURAL REQUIREMENTS | ANALOGS | DERIVATIVES | Microglia - metabolism | Humans | Cell Membrane Permeability | Nitrites - metabolism | Substrate Specificity | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Neurons - cytology | Structure-Activity Relationship | Neural Stem Cells - cytology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuroprotective Agents - pharmacology | Swine | Thiadiazoles - chemistry | Imines - chemistry | Neurogenesis - drug effects | Neurons - metabolism | Cell Death - drug effects | Imines - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Neurons - drug effects | Thiadiazoles - pharmacology | Astrocytes - cytology | Microglia - cytology | Astrocytes - drug effects | Neuroprotective Agents - chemistry | Microglia - drug effects | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Membranes, Artificial | Models, Molecular | Rats | Hippocampus - cytology | Imines - pharmacology | Blood-Brain Barrier - metabolism | Neuroprotective Agents - chemical synthesis | Animals | Thiadiazoles - chemical synthesis | Cell Differentiation - drug effects | Lipopolysaccharides - pharmacology | Protein Binding | In Vitro Techniques | Astrocytes - metabolism
Journal Article
Journal Article
Neoplasia, ISSN 1476-5586, 2013, Volume 15, Issue 8, pp. 975 - IN30
Journal Article
Journal Article
Neuropsychopharmacology (New York, N.Y.), ISSN 1740-634X, 2006, Volume 31, Issue 12, pp. 2716 - 2727
In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving... 
Cocaine | Dopamine release | Receptor occupancy | Cue-elicited craving | Dopamine receptors | PET neuroimaging | LINEAR-REGRESSION | ACTIVATION | HUMAN BRAIN | cocaine | PSYCHIATRY | dopamine release | VISUAL SEXUAL STIMULI | NEUROSCIENCES | GRAPHICAL ANALYSIS | dopamine receptors | POSITRON-EMISSION-TOMOGRAPHY | MEMORY-SYSTEMS | cue-elicited craving | REFERENCE TISSUE MODEL | receptor occupancy | DORSAL STRIATUM | PHARMACOLOGY & PHARMACY | IMAGE REGISTRATION | Predictive Value of Tests | Dopamine Uptake Inhibitors - adverse effects | Synaptic Transmission - physiology | Humans | Raclopride - metabolism | Male | Positron-Emission Tomography | Cocaine-Related Disorders - physiopathology | Corpus Striatum - metabolism | Receptors, Dopamine - drug effects | Cocaine-Related Disorders - metabolism | Cocaine-Related Disorders - diagnostic imaging | Up-Regulation - physiology | Functional Laterality - drug effects | Adult | Female | Synaptic Transmission - drug effects | Functional Laterality - physiology | Neurons - metabolism | Cocaine - adverse effects | Neurons - drug effects | Dopamine Antagonists | Dopamine - metabolism | Cues | Binding, Competitive - physiology | Corpus Striatum - physiopathology | Presynaptic Terminals - drug effects | Receptors, Dopamine - metabolism | Binding, Competitive - drug effects | Up-Regulation - drug effects | Magnetic Resonance Imaging | Brain Mapping | Corpus Striatum - drug effects | Presynaptic Terminals - metabolism | Carbon Radioisotopes
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 550, Issue 7674, pp. 128 - 132
...(1) and is associated with multiple diseases. Histone deacetylase inhibitors are currently approved to treat certain cancers, but progress on the development of drug-like histone actyltransferase inhibitors has lagged behind(2... 
ANDROGEN RECEPTOR | ACETYLTRANSFERASES P300 | MULTIDISCIPLINARY SCIENCES | SMALL-MOLECULE INHIBITOR | HISTONE | Catalytic Domain - drug effects | p300-CBP Transcription Factors - antagonists & inhibitors | Prostatic Neoplasms, Castration-Resistant - enzymology | Histone Acetyltransferases - chemistry | Humans | Receptors, Androgen - metabolism | Crystallography, X-Ray | Male | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - enzymology | Hematologic Neoplasms - pathology | Cell Lineage - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | Prostatic Neoplasms, Castration-Resistant - pathology | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Biocatalysis - drug effects | Histone Acetyltransferases - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | p300-CBP Transcription Factors - chemistry | Binding, Competitive | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Models, Molecular | Neoplasms - enzymology | Prostatic Neoplasms, Castration-Resistant - drug therapy | Antineoplastic Agents - chemistry | Mice, SCID | Enzyme Inhibitors - therapeutic use | Acetyl Coenzyme A - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Animals | Histone Acetyltransferases - antagonists & inhibitors | Cell Line, Tumor | Hematologic Neoplasms - drug therapy | Protein Conformation | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Care and treatment | Chemical inhibitors | Usage | Transferases | Binding proteins | Health aspects | Tumors | Histone deacetylase | Transcription factors | Molecular structure | Transcription | Peptides | Androgen receptors | Amino acids | Event-related potentials | Selectivity | Catalytic activity | Kinases | Experiments | Crystallography | Proteins | CREB-binding protein | Castration | Xenografts | Coenzyme A | Acetylation | Catalysis | Inhibition | Crystal structure | Hematology | Feasibility studies | Cyclic AMP response element-binding protein | Histone acetyltransferase | Inhibitors | Microscopy | Natural products | Regulatory mechanisms (biology) | Epigenetics | Ligands | Prostate cancer | Prostate | Cancer | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2013, Volume 272, Issue 1, pp. 127 - 136
Journal Article
Journal Article
Journal Article
Nature (London), ISSN 0028-0836, 11/2009, Volume 462, Issue 7270, pp. 182 - 188
Direct inhibition of transcription factor complexes remains a central challenge in the discipline of ligand discovery. In general, these proteins lack surface... 
PROGENITOR CELLS | ACTIVATION | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | T-CELL LEUKEMIA | C-MYC | GAMMA-SECRETASE INHIBITORS | MUTATIONS | HUMAN HOMOLOG | MASTERMIND | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Transcription Factors - chemistry | Humans | Transcriptional Activation - drug effects | Genome - genetics | Receptor, Notch1 - chemistry | Cell Membrane Permeability | Substrate Specificity | DNA-Binding Proteins - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Protein Binding - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Binding, Competitive | Protein Structure, Tertiary | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Drosophila Proteins - chemistry | Receptor, Notch1 - metabolism | Genome - drug effects | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Peptides - pharmacology | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Receptor, Notch1 - antagonists & inhibitors | Transcription factors | Research | Ligands (Biochemistry) | Peptide bonds
Journal Article