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1. Full Text Biopharmaceutical challenges associated with drugs with low aqueous solubility—The potential impact of lipid-based formulations
by O'Driscoll, C.M and Griffin, B.T
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2008, Volume 60, Issue 6, pp. 617 - 624
The percentage of new chemical entities synthesised with low aqueous solubility and high therapeutic efficacy is growing, this presents major challenges for... 
Bioactive excipients | Lipid-based formulations | In vitro–in vivo correlations | Solubility | In vitro-in vivo correlations | lipid-based formulations | DELIVERY SYSTEMS | LIPOPHILIC DRUGS | DOSAGE FORMS | RAT MODEL | in vitro-in vivo correlations | P-GLYCOPROTEIN | INTESTINAL LYMPHATIC TRANSPORT | IN-VITRO | bioactive excipients | solubility | CLASSIFICATION-SYSTEM | PHARMACOLOGY & PHARMACY | ORAL DELIVERY | CACO-2 CELLS | Lipids - chemistry | Animals | Chemistry, Pharmaceutical - methods | Administration, Oral | Humans | Drug Design | Pharmaceutical Preparations - chemistry | Water - chemistry | Pharmaceutical Preparations - administration & dosage | Drug Carriers - chemistry | Gastrointestinal Tract - metabolism
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2. Full Text Food Protein‐Derived Bioactive Peptides: Production, Processing, and Potential Health Benefits
by Udenigwe, Chibuike C and Aluko, Rotimi E
Journal of Food Science, ISSN 0022-1147, 01/2012, Volume 77, Issue 1, pp. R11 - R24
:  Bioactive peptides (BAPs), derived through enzymatic hydrolysis of food proteins, have demonstrated potential for application as health‐promoting agents... 
bioactive peptides | multifunctional | functional food | hypertension | human health | Hypertension | Human health | Bioactive peptides | Multifunctional | Functional food | LONG-TERM INTAKE | INHIBITORY PEPTIDES | I-CONVERTING-ENZYME | FOOD SCIENCE & TECHNOLOGY | SALMON ONCORHYNCHUS-KETA | BLOOD-PRESSURE | ANTIOXIDANT PROPERTIES | MARINE OLIGOPEPTIDE PREPARATION | NITRIC-OXIDE PRODUCTION | STRUCTURAL REQUIREMENTS | MULTIFUNCTIONAL PEPTIDES | Peptide Fragments - metabolism | Humans | Functional Food - analysis | Dietary Supplements - analysis | Chronic Disease - prevention & control | Dietary Proteins - metabolism | Animals | Peptide Fragments - adverse effects | Peptide Fragments - therapeutic use | Dietary Proteins - adverse effects | Dietary Supplements - adverse effects | Dietary Proteins - therapeutic use | Peptide Hydrolases - metabolism | Antioxidants | Hydrolysis | Composition | Functional foods | Analysis | Chemical properties | Health aspects | Peptide bonds | Human | Peptides | Health | Production methods | Homeostasis | Feasibility | Foods
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3. Full Text 5′‐Adenosine monophosphate‐activated protein kinase: A potential target for disease prevention by curcumin
by Soltani, Arash and Salmaninejad, Arash and Jalili‐Nik, Mohammad and Soleimani, Anvar and Javid, Hossein and Hashemy, Seyed Isaac and Sahebkar, Amirhossein
Journal of Cellular Physiology, ISSN 0021-9541, 03/2019, Volume 234, Issue 3, pp. 2241 - 2251
Curcumin (diferuloylmethane), a yellowish agent extracted from turmeric, is a bioactive compound known for its anti‐inflammatory, antiproliferative,... 
AMP‐activated protein kinase | inflammation | curcumin | AMP-activated protein kinase | METABOLIC SYNDROME | PHYSIOLOGY | PIPERINE COMBINATION | SULFUR MUSTARD | FATTY LIVER-DISEASE | AMPK SIGNALING PATHWAY | RANDOMIZED CONTROLLED-TRIAL | CELL BIOLOGY | HEPATIC STELLATE CELLS | THERAPEUTIC TARGET | QUALITY-OF-LIFE | TYPE-2 DIABETES-MELLITUS | Proteins | Physiological aspects | Adenosine | Cellular signal transduction | Adenylic acid | Protein kinases | Energy metabolism | Regulators | Pathogenesis | Homeostasis | Kinases | Anticancer properties | Prevention | Signal transduction | Bioactive compounds | Atherosclerosis | Curcumin | Adenosine triphosphate | Adenosine monophosphate | AMP | Medical treatment | Diabetes mellitus | Inflammation | Metabolism | Energy balance | Protein kinase | Adenosine kinase | Arteriosclerosis | Transduction | ATP | Regulatory proteins | Apoptosis
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4. Full Text The pharmacological potential of mushrooms
by Lindequist, Ulrike and Niedermeyer, Timo H. J and Jülich, Wolf-Dieter
Evidence-based Complementary and Alternative Medicine, ISSN 1741-427X, 09/2005, Volume 2, Issue 3, pp. 285 - 299
This review describes pharmacologically active compounds from mushrooms. Compounds and complex substances with antimicrobial, antiviral, antitumor,... 
Antimicrobial | Basidiomycetes | Bioactive compounds | Antiatherogenic | Antitumor | RIBOSOME-INACTIVATING PROTEIN | antimicrobial | AGARICUS-BLAZEI MURILL | BIOLOGICALLY-ACTIVE SUBSTANCES | antitumor | EDIBLE MUSHROOM | GANODERMA-LUCIDUM | WATER-SOLUBLE LIGNIN | RADICAL SCAVENGING ACTIVITY | basidiomycetes | HUMAN IMMUNODEFICIENCY VIRUS | antiatherogenic | INTEGRATIVE & COMPLEMENTARY MEDICINE | bioactive compounds | PLEUROTUS-OSTREATUS | LENTINUS-EDODES MYCELIA | Reviews
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5. Full Text Bioactive Natural Constituents from Food Sources-Potential Use in Hypertension Prevention and Treatment
by Huang, Wu-Yang and Davidge, Sandra T and Wu, Jianping
Critical Reviews in Food Science and Nutrition, ISSN 1040-8398, 01/2013, Volume 53, Issue 6, pp. 615 - 630
Prevention and management of hypertension are the major public health challenges worldwide. Uncontrolled high blood pressure may lead to a shortened life... 
antihypertensive effect | Hypertension prevention | food sources | ACE inhibitor | bioactive constituents | WAKAME UNDARIA-PINNATIFIDA | I-CONVERTING-ENZYME | FOOD SCIENCE & TECHNOLOGY | EGG-WHITE PROTEINS | NUTRITION & DIETETICS | HIGH-BLOOD-PRESSURE | LEG BONE PROTEIN | TUBER STORAGE PROTEIN | TAINONG NO. 1 | ACE-INHIBITORY PEPTIDES | CHICKEN BREAST MUSCLE | MUNG-BEAN PROTEIN | Eggs - analysis | Antihypertensive Agents - pharmacology | Fabaceae - chemistry | Fruit - chemistry | Meat - analysis | Humans | Hypertension - drug therapy | Antioxidants - pharmacology | Vegetables - chemistry | Animals | Hypertension - prevention & control | Nuts - chemistry | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Dairy Products - analysis | Edible Grain - chemistry | Tea - chemistry
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6. Full Text Soy glycinin as food-grade Pickering stabilizers: Part. III. Fabrication of gel-like emulsions and their potential as sustained-release delivery systems for β-carotene
by Liu, Fu and Tang, Chuan-He
Food Hydrocolloids, ISSN 0268-005X, 05/2016, Volume 56, pp. 434 - 444
Formulation of food-grade Pickering emulsions has attracted growing attention in the food and drug fields, due to their promising potential as novel delivery... 
Sustained release | Soy glycinin | Pickering emulsion | Emulsion gel | β-Carotene | beta-Carotene | BIOACCESSIBILITY | DESIGN | PROTEIN | PH 3.0 | PARTICLES | FOOD SCIENCE & TECHNOLOGY | LIPID DIGESTION | EMULSIFIERS | BIOACTIVE COMPONENTS | VITRO DIGESTION METHOD | CHEMISTRY, APPLIED | IN-WATER EMULSIONS | Proteins | Networks | Emulsions | Delivery systems | Droplets | Formations | Digestion | Foods
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7. Full Text High-Resolution Screening Combined with HPLC-HRMS-SPE-NMR for Identification of Potential Health-Promoting Constituents in Sea Aster and SearocketNew Nordic Food Ingredients
by Wubshet, Sileshi G and Schmidt, Jeppe S and Wiese, Stefanie and Staerk, Dan
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 09/2013, Volume 61, Issue 36, pp. 8616 - 8623
Sea aster (Aster tripolium L.) and searocket (Cakile maritima Scop.), potential ingredients in the New Nordic Diet, were analyzed by high-resolution radical... 
high-resolution screening | HPLC-SPE-tube transfer NMR | New Nordic Diet | α-glucosidase | radical scavenging | BIOACTIVE COMPOUNDS | ASSAY | ANTIOXIDANTS | FOOD SCIENCE & TECHNOLOGY | NUCLEAR-MAGNETIC-RESONANCE | CHROMATOGRAPHY | alpha-glucosidase | INHIBITORY-ACTIVITIES | AGRICULTURE, MULTIDISCIPLINARY | PLANT-EXTRACTS | COUPLING HPLC | CHEMISTRY, APPLIED | NUTRACEUTICALS | Chromatography, High Pressure Liquid - methods | Flavonoids - analysis | Magnetic Resonance Spectroscopy - methods | Brassicaceae - chemistry | Humans | Health Promotion | Diet | Norway | Mass Spectrometry | Solid Phase Extraction - methods | Free Radical Scavengers - analysis | Aster Plant - chemistry | Antioxidants - analysis
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8. Full Text Synephrine – A potential biomarker for orange honey authenticity
by Tette, Patrícia A.S and Guidi, Letícia R and Bastos, Esther M.A.F and Fernandes, Christian and Gloria, Maria Beatriz A
Food Chemistry, ISSN 0308-8146, 08/2017, Volume 229, pp. 527 - 533
A LC-MS/MS method for synephrine as a biomarker for orange honey authenticity was developed and validated. The sample was extracted with 5% TCA and cleaned up... 
Honey | Biomarker | Amines | Orange honey | Citrus honey | Synephrine | Botanical origin | FOOD SCIENCE & TECHNOLOGY | COMPONENTS | CLASSIFICATION | BIOACTIVE AMINES | PESTICIDES | PERFORMANCE LIQUID-CHROMATOGRAPHY | EXTRACTION | NUTRITION & DIETETICS | MASS SPECTROMETRY | OPTIMIZATION | CHEMISTRY, APPLIED | Tandem Mass Spectrometry | Honey - classification | Limit of Detection | Food Contamination - analysis | Synephrine - analysis | Chromatography, Liquid | Honey - analysis | Pollen - chemistry | Citrus sinensis - chemistry | Citrus | Citrus fruits | Analysis | Index Medicus
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9. Full Text Phenolic compounds, antioxidant potential and antiproliferative potential of 10 common edible flowers from China assessed using a simulated in vitro digestion–dialysis process combined with cellular assays
by Huang, Weisu and Mao, Shuqin and Zhang, Liuquan and Lu, Baiyi and Zheng, Lufei and Zhou, Fei and Zhao, Yajing and Li, Maiquan
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 11/2017, Volume 97, Issue 14, pp. 4760 - 4769
BACKGROUND Phenolic compounds could be sensitive to digestive conditions, thus a simulated in vitro digestion–dialysis process and cellular assays was used to... 
in vitro digestion–dialysis | antioxidant | antiproliferative | bioaccessibility | phenolics | CAPACITY | BIOACTIVE COMPOUNDS | DIETARY-SUPPLEMENTS | STABILITY | FOOD SCIENCE & TECHNOLOGY | MODEL | POLYPHENOLS | SEED | AGRICULTURE, MULTIDISCIPLINARY | VEGETABLES | CHEMISTRY, APPLIED | in vitro digestion-dialysis | FOOD | A549 Cells | Plants, Edible - chemistry | Antineoplastic Agents, Phytogenic - analysis | Coumaric Acids - analysis | Gastric Juice - metabolism | Humans | Dialysis - methods | Rutin - analysis | Digestion | Flowers - chemistry | Hep G2 Cells | Phenols - analysis | China | Gallic Acid - analysis | Cell Line, Tumor | Antioxidants - analysis | Antioxidants | Chemical industry | Herbicides | Pesticides industry | Flowers | Gallic acid | Hemodialysis | Rutin | Phenolic compounds | Ferulic acid | Acids | Fluorescence recovery after photobleaching | Cell lines | Phenols | In vivo methods and tests | Dialysis
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10. Full Text Nanostructured lipid carriers (NLC): A potential delivery system for bioactive food molecules
by Tamjidi, Fardin and Shahedi, Mohammad and Varshosaz, Jaleh and Nasirpour, Ali
Innovative Food Science and Emerging Technologies, ISSN 1466-8564, 07/2013, Volume 19, pp. 29 - 43
Particle size and physical state of the lipid phase are major factors influencing the permanence of lipid dispersions. Nanostructured lipid carriers (NLC) are... 
Lipid crystallization | Bioactive compounds | Functional foods | Lipid nanoparticles | Lipid nanocarriers | Nutraceuticals | WATER-SOLUBLE DRUG | FOOD SCIENCE & TECHNOLOGY | NUCLEAR-MAGNETIC-RESONANCE | NANOPARTICLES SLN | CHEMICAL-STABILITY | SOLVENT DIFFUSION METHOD | ELECTRON-MICROSCOPY | STRUCTURAL INVESTIGATIONS | PARENTERAL DELIVERY | IN-VITRO | PHYSICOCHEMICAL CHARACTERIZATION | Carriers | Encapsulation | Stability | Delivery systems | Lipids | Nanostructure | Dispersions | Foods
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11. Full Text Investigation into the potential of commercially available lesser mealworm (A. diaperinus) protein to serve as sources of peptides with DPP-IV inhibitory activity
by Lacroix, Isabelle M.E and Dávalos Terán, Irene and Fogliano, Vincenzo and Wichers, Harry J
International Journal of Food Science and Technology, ISSN 0950-5423, 2019, Volume 54, Issue 3, pp. 696 - 704
Food-derived peptides are known to possess inhibitory activity against the dipeptidyl-peptidase IV (DPP-IV) enzyme, a target in the management of type 2... 
hydrolysates | type 2 diabetes | lesser mealworm (A. diaperinus) protein | Dipeptidyl-peptidase IV inhibitors | in vitro digestion | in vitro digestion | Dipeptidyl‐peptidase IV inhibitors | BIOACTIVE PEPTIDES | diaperinus) protein | SAFETY | FOOD SCIENCE & TECHNOLOGY | ENZYMATIC-HYDROLYSIS | lesser mealworm (A | FRACTIONS | EDIBLE INSECTS | GENERATION | DIPEPTIDYL | Type 2 diabetes | Proteins | Proteases | Functional foods | Investigations | Peptidase | Peptides | Diabetes mellitus | Commodities | Thermolysin | Hydrolysates | Ultrafiltration | Inhibitors | Insects | Digestive enzymes | Protein sources | Diabetes mellitus (non-insulin dependent) | Food
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