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2013, ISBN 1439891672, xxii, 562
"Natural products play crucial roles in modern drug development and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug... 
chemistry | Bioorganic chemistry | Bioactive compounds | Natural products | Biological Agents | pharmacology | Drug Discovery
Book
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
The Plant Cell, ISSN 1040-4651, 8/2013, Volume 25, Issue 8, pp. 3117 - 3132
Arabidopsis thaliana plants fend off insect attack by constitutive and inducible production of toxic metabolites, such as glucosinolates (GSs). A triple mutant... 
Transcriptional regulatory elements | Insect larvae | RESEARCH ARTICLES | Genes | Glucosinolates | Biosynthesis | Gene expression regulation | Herbivores | Phytophagous insects | Genotypes | Plant cells | HERBIVORES | PLUTELLA-XYLOSTELLA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT SCIENCES | CELL BIOLOGY | INDUCED RESISTANCE | THALIANA | DEFENSE SIGNALING PATHWAYS | MYB | GENE-EXPRESSION | ACCUMULATION | PROTEINS | JASMONATE RESPONSES | Herbivory - physiology | Trans-Activators - chemistry | Promoter Regions, Genetic - genetics | Arabidopsis Proteins - metabolism | Biosynthetic Pathways - genetics | Gene Expression Regulation, Plant | Trans-Activators - genetics | Insecta - physiology | Protein Structure, Tertiary | Arabidopsis Proteins - genetics | Plant Leaves - parasitology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry | Mutation - genetics | Feeding Behavior - physiology | Arabidopsis - metabolism | Arabidopsis - genetics | Glucosinolates - biosynthesis | Animals | Arabidopsis Proteins - chemistry | Plant Leaves - metabolism | Models, Biological | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Protein Binding | Arabidopsis - parasitology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Trans-Activators - metabolism | Arabidopsis thaliana | Glucose metabolism | Transcription factors | Physiological aspects | Genetic aspects | Research
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