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1. Rivaroxaban - Metabolism, Pharmacologic Properties and Drug Interactions
by Kvasnicka, Tomas and Malikova, Ivana and Zenahlikova, Zuzana and Kettnerova, Karolína and Brzezkova, Radka and Zima, Tomas and Ulrych, Jan and Briza, Jan and Netuka, Ivan and Kvasnicka, Jan
Current drug metabolism, ISSN 1389-2002, 2017, Volume 18, Issue 7, pp. 636 - 642
Background: Rivaroxaban represents a selective direct inhibitor of activated coagulation factor X (FXa) having peroral bioavailability and prompt onset of... 
Anticoagulants | atrial fibrillation | pharmacodynamics | venous thromboembolism | direct factor Xa inhibitor | rivaroxaban | stroke | BAY-59-7939 | BAY 59-7939 | SAFETY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREVENTION | IN-VITRO | FACTOR-XA INHIBITOR | WARFARIN | POPULATION PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | NONVALVULAR ATRIAL-FIBRILLATION | Coagulation factor X | Knee | Prophylaxis | Clinical trials | Antagonists | Coefficient of variation | Bleeding | Molecular weight | Fibrillation | Ischemia | Low molecular weights | Surgery | Drug metabolism | Thromboembolism | Heart diseases | Vitamin K | Hip joint | Stroke | Knee (anatomy) | Pharmacology | Bioavailability | Metabolism | Hip | Embolism | Coagulation factors | Biomarkers | Adults | Heparin | Pharmacokinetics
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2. Full Text Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: Pharmacological and metabolism-based investigation
by Poudyal, Hemant and Lemonakis, Nikolaos and Efentakis, Panagiotis and Gikas, Evangelos and Halabalaki, Maria and Andreadou, Ioanna and Skaltsounis, Leandros and Brown, Lindsay
Pharmacological Research, ISSN 1043-6618, 03/2017, Volume 117, pp. 32 - 45
Metabolic syndrome is a clustering of interrelated risk factors for cardiovascular disease and diabetes. The Mediterranean diet has been proposed as an... 
Hydroxytyrosol | Obesity | Olives | Olive oil | Metabolic syndrome | Cardiovascular | HIGH-CARBOHYDRATE | OXIDATIVE STRESS | MEDITERRANEAN DIET | HUMAN HEALTH | DOWN-REGULATION | BIOLOGICAL-ACTIVITIES | OLIVE OIL POLYPHENOLS | ANESTHETIZED RABBITS | PHARMACOLOGY & PHARMACY | VASCULAR ENDOTHELIAL-CELLS | CORONARY-HEART-DISEASE | Biomarkers - metabolism | Dietary Fats - adverse effects | Obesity - drug therapy | Rats, Wistar | Phenylethyl Alcohol - analogs & derivatives | Liver - metabolism | Diet, High-Fat - adverse effects | Rats | Male | Metabolic Syndrome - metabolism | Cardiovascular System - drug effects | Metabolic Syndrome - drug therapy | Obesity - metabolism | Phenylethyl Alcohol - pharmacology | Animals | Cardiovascular System - metabolism | Liver - drug effects | Dietary Carbohydrates - adverse effects | Oxidative Stress - drug effects | Disease Models, Animal | Physiological aspects | Drugstores | Pharmacy | Liver | Investigations | Liver diseases | Phosphatases | Low density lipoproteins | Glucose | Fatty acids | Risk factors | Dextrose | Metabolites | Blood lipids | Mass spectrometry | High performance liquid chromatography
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3. Full Text Target identification and mechanism of action in chemical biology and drug discovery
by Schenone, Monica and Dančík, Vlado and Wagner, Bridget K and Clemons, Paul A
Nature Chemical Biology, ISSN 1552-4450, 04/2013, Volume 9, Issue 4, pp. 232 - 240
Target-identification and mechanism-of-action studies have important roles in small-molecule probe and drug discovery. Biological and technological advances... 
IN-VITRO | SMALL-MOLECULE PROBES | HIGH-THROUGHPUT | GENETICS | MAMMALIAN HISTONE DEACETYLASE | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELECTIVE ENRICHMENT | PROTEIN QUANTITATION | EXPRESSION | PROTEOMICS | Reverse Genetics | Small Molecule Libraries - pharmacology | Saccharomyces cerevisiae - genetics | Humans | Saccharomyces cerevisiae - drug effects | Small Molecule Libraries - metabolism | Molecular Targeted Therapy | Drug Discovery | Saccharomyces cerevisiae - metabolism | Small Molecule Libraries - chemistry | Phenotype | Animals | High-Throughput Screening Assays | Validation Studies as Topic | RNA Interference | Mass Spectrometry | Isotope Labeling | Drug Evaluation, Preclinical | Biomarkers, Pharmacological - chemistry | Biomarkers, Pharmacological - metabolism | Proteins | Molecules | Biology | Drug therapy | Chemicals
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4. Full Text Target validation using chemical probes
by Bunnage, Mark E and Chekler, Eugene L. Piatnitski and Jones, Lyn H
Nature Chemical Biology, ISSN 1552-4450, 04/2013, Volume 9, Issue 4, pp. 195 - 199
  Fully proled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for rigorous preclinical target... 
ZEBRAFISH EMBRYOS | BROMODOMAINS | POTENT | SMALL-MOLECULE INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE INHIBITORS | IDENTIFICATION | DISCOVERY | PROTEOMICS | Molecular Probes - chemistry | Molecular Probes - metabolism | Validation Studies as Topic | Humans | Cell Membrane Permeability | Structure-Activity Relationship | Drug Evaluation, Preclinical | Molecular Targeted Therapy | Biomarkers, Pharmacological - chemistry | Biomarkers, Pharmacological - metabolism | Drug Discovery | Biology | Chemicals
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5. Full Text Response prediction in chronic hepatitis c by assessment of IP-10 and IL28B-related single nucleotide polymorphisms
by Lagging, Martin and Askarieh, Galia and Negro, F and Bibert, S and Söderholm, Jonas and Westin, Johan and Lindh, Magnus and Romero, Ana and Missale, Gabriele and Ferrari, Carlo and Neumann, Avidan and Pawlotsky, Jean-Michel and Haagmans, Bart and Zeuzem, Stefan and Bochud, Pierre-Yves and Hellstrand, Kristoffer and DITTO-HCV Study Grp and DITTO-HCV Study Group and for the DITTO-HCV Study Group and Institutionen för biomedicin, avdelningen för infektionssjukdomar and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi and Institute of Biomedicine, Department of Infectious Medicine and Sahlgrenska akademin and Institute of Biomedicine, Department of Microbiology and Immunology
PLoS ONE, ISSN 1932-6203, 03/2011, Volume 6, Issue 2, p. e17232
textabstractBackground: High baseline levels of IP-10 predict a slower first phase decline in HCV RNA and a poor outcome following interferon/ribavirin therapy... 
GENETIC-VARIATION | IL28B | CLEARANCE | PLUS RIBAVIRIN | VIRUS-INFECTION | THERAPY | PEGINTERFERON ALPHA-2A | PROTEIN-10 | BIOLOGY | VIRAL RESPONSE | ASSOCIATION | Prognosis | Humans | Middle Aged | Polymorphism, Single Nucleotide - physiology | Male | Recombinant Proteins | Interleukins - analysis | Interleukins - metabolism | Interleukins - genetics | Chemokine CXCL10 - analysis | RNA, Viral - genetics | Adult | Female | Biomarkers, Pharmacological - analysis | Pharmacogenetics | Drug Administration Schedule | Antiviral Agents - therapeutic use | Interferon-alpha - therapeutic use | RNA, Viral - analysis | Hepatitis C, Chronic - diagnosis | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Interferon-alpha - administration & dosage | Chemokine CXCL10 - genetics | Interferon alpha-2 | Hepatitis C, Chronic - genetics | Biomarkers, Pharmacological - metabolism | Chemokine CXCL10 - metabolism | Medical research | Care and treatment | RNA | Infection | Analysis | Medicine, Experimental | Genetic aspects | Interferon | Single nucleotide polymorphisms | Hepatitis C virus | Hepatitis C | Chromosomes | Health aspects | Therapy | Liver | Infections | Genomes | Single-nucleotide polymorphism | Ribonucleic acid--RNA | Patients | Ribavirin | Virology | Carriers | Hepatitis | Ethics | Infectious diseases | Hospitals | Correlation analysis | Gastroenterology | Predictions | IP-10 protein | Pretreatment | Genotypes | Pharmacological | Viral | Mikrobiologi inom det medicinska området | Single Nucleotide | genetics | administration & dosage | Interleukins | drug therapy | Interferon-alpha | physiology | diagnosis | Antiviral Agents | analysis | Chemokine CXCL10 | Chronic | Microbiology in the medical area | Biomarkers | metabolism | therapeutic use | Polymorphism | Ribonucleic acid
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6. Full Text Clinical and Biochemical Consequences of CYP17A1 Inhibition with Abiraterone Given with and without Exogenous Glucocorticoids in Castrate Men with Advanced Prostate Cancer
by Attard, Gerhardt and Reid, Alison H. M and Auchus, Richard J and Hughes, Beverly A and Cassidy, Amy Mulick and Thompson, Emilda and Oommen, Nikhil Babu and Folkerd, Elizabeth and Dowsett, Mitch and Arlt, Wiebke and de Bono, Johann S
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 02/2012, Volume 97, Issue 2, pp. 507 - 516
Context: Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that is active in castration-resistant prostate cancer. Objective:... 
Androstenols - adverse effects | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Glucocorticoids - administration & dosage | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Enzyme Inhibitors - administration & dosage | Antineoplastic Agents, Hormonal - adverse effects | Chemotherapy, Adjuvant | Glucocorticoids - adverse effects | Prostatic Neoplasms - drug therapy | Biomarkers - metabolism | Carcinoma - drug therapy | Enzyme Inhibitors - adverse effects | Biomarkers, Pharmacological - analysis | Antineoplastic Agents, Hormonal - pharmacology | Prostatic Neoplasms - surgery | Androstenols - pharmacology | Antineoplastic Agents, Hormonal - administration & dosage | Carcinoma - surgery | Biomarkers - analysis | Enzyme Inhibitors - pharmacology | Androstenes | Treatment Outcome | Disease Progression | Orchiectomy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Androstenols - administration & dosage | Steroid 17-alpha-Hydroxylase - metabolism | Carcinoma - metabolism | Biomarkers, Pharmacological - metabolism | TRIAL | HUMAN CYTOCHROME P450(17-ALPHA) | CELLS | PATHWAY | STEROIDAL INHIBITORS | GUIDELINES | ENDOCRINOLOGY & METABOLISM | KETOCONAZOLE | ACETATE | DIHYDROTESTOSTERONE | REMAINS
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7. Full Text High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new‐onset rheumatoid arthritis
by Wang, J and Shan, Y and Jiang, Z and Feng, J and Li, C and Ma, L and Jiang, Y
Clinical & Experimental Immunology, ISSN 0009-9104, 11/2013, Volume 174, Issue 2, pp. 212 - 220
Summary This study aimed to examine the frequency of different subsets of circulating B and T follicular helper (Tfh) cells in patients with new‐onset... 
CD86 | B cells | Tfh cells | therapy | Therapy | RA | TRIPTERYGIUM-WILFORDII | SUBPOPULATIONS | IMMUNOLOGY | SUBSET | IL-21 | NECROSIS-FACTOR | IMMUNE-RESPONSES | EXPANSION | GERMINAL-CENTERS | DIFFERENTIATION | EXPRESSION | Immunoglobulin D - metabolism | Lymphocyte Activation | Humans | Middle Aged | Programmed Cell Death 1 Receptor - metabolism | Immunophenotyping | Male | Disease Progression | Lymphocyte Subsets - immunology | Antigens, CD - metabolism | B-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - immunology | Adult | Female | Immunologic Memory | Aged | Inducible T-Cell Co-Stimulator Protein - metabolism | Arthritis, Rheumatoid - immunology | Toll-Like Receptor 9 - metabolism | Biomarkers, Pharmacological - metabolism | Rheumatoid factor | Care and treatment | Arthritis | Analysis | Drug therapy | Rheumatoid arthritis | Immune system | Apoptosis | Original
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8. Full Text Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
by Ramirez, Victoria and Troth, Sean and Perentes, Elias and Vaidya, Vishal S and Holder, Daniel J and Bobadilla, Norma A and Goering, Peter L and Collings, Fitz B and Gerhold, David and Maurer, Gérard and Muniappa, Nagaraja and Vonderscher, Jacky and Thudium, Douglas and Marrer, Estelle and Ozer, Josef S and Cordier, André and Bonventre, Joseph V and Sistare, Frank D and Dieterle, Frank
Nature Biotechnology, ISSN 1087-0156, 05/2010, Volume 28, Issue 5, pp. 478 - 485
Kidney toxicity accounts both for the failure of many drug candidates as well as considerable patient morbidity. Whereas histopathology remains the gold... 
KIM-1 | CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | URINE | RECEPTOR | CONFERS | NEPHROTOXICITY | Cell Adhesion Molecules - genetics | Oligonucleotide Array Sequence Analysis | Rats, Wistar | Cell Adhesion Molecules - urine | Blood Urea Nitrogen | Kidney Function Tests - methods | Male | Gentamicins - toxicity | Biomarkers, Pharmacological - urine | Kidney Function Tests - standards | Cisplatin - toxicity | Drug-Related Side Effects and Adverse Reactions | Drug Evaluation, Preclinical | Acetylglucosaminidase - urine | Kidney - drug effects | Reperfusion Injury | Rats | Kidney - injuries | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Cyclosporine - toxicity | Animals | Thioacetamide - toxicity | Histocytochemistry | Creatinine - blood | ROC Curve | Biomarkers, Pharmacological - metabolism | Immunoglobulins | Patient outcomes | Physiological aspects | Research | Kidney diseases | Diagnosis | Biological markers | T cells | Drug therapy | Biotechnology | Pharmacology | Molecular biology | Toxicity | Index Medicus
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9. Full Text A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function
by Roth, Daniel R and Sina, Joseph F and Troth, Sean and Holder, Daniel and Forest, Tom and Clouse, Holly K and Chibout, Salah-Dine and Maurer, Gérard and Wahl, Daniel and Topper, Michael J and Grenet, Olivier and Legay, François and Staedtler, Frank and Erdos, Zoltan and Jin, Hong and Sistare, Frank D and Gerhold, David L and Dieterle, Frank and Verdes, Pablo and Perentes, Elias and Vlasakova, Katerina and Ozer, Josef S and Glaab, Warren E and Thudium, Douglas T and Vonderscher, Jacky and Muniappa, Nagaraja and Mahl, Andreas and Bailey, Wendy J and Yu, Yan and Cordier, André and Skopek, Thomas R and Reynolds, Spencer
Nature Biotechnology, ISSN 1087-0156, 05/2010, Volume 28, Issue 5, pp. 486 - 494
The Predictive Safety Testing Consortium's first regulatory submission to qualify kidney safety biomarkers revealed two deficiencies. To address the need for... 
CYSTATIN-C | MOLECULE-1 | ACUTE KIDNEY INJURY | CLUSTERIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Kidney - drug effects | Rats, Wistar | Cystatin C - blood | Blood Urea Nitrogen | Kidney Diseases - diagnosis | Rats | Kidney Function Tests - methods | Male | Gentamicins - toxicity | Carbapenems - toxicity | Rats, Sprague-Dawley | Biomarkers, Pharmacological - blood | Biomarkers, Pharmacological - urine | Kidney - metabolism | Animals | Drug-Related Side Effects and Adverse Reactions | Creatinine - blood | Female | ROC Curve | Biomarkers, Pharmacological - metabolism | Aminoglycosides | Kidney failure | Diagnosis | Biological markers | Analysis | Biomarkers | Patient safety | Biotechnology | Pharmacology | Kidney diseases | Index Medicus
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10. Full Text Long-Term Outcome and MGMT as a Predictive Marker in 24 Patients With Atypical Pituitary Adenomas and Pituitary Carcinomas Given Treatment With Temozolomide
by Bengtsson, Daniel and Schrøder, Henrik Daa and Andersen, Marianne and Maiter, Dominique and Berinder, Katarina and Feldt Rasmussen, Ulla and Rasmussen, Åse Krogh and Johannsson, Gudmundur and Hoybye, Charlotte and van der Lely, Aart Jan and Petersson, Maria and Ragnarsson, Oskar and Burman, Pia and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 04/2015, Volume 100, Issue 4, pp. 1689 - 1698
Context/Objective: Locally aggressive pituitary tumors (LAPT) and pituitary carcinomas respond poorly to conventional therapy and cytotoxic drugs. Temozolomide... 
MALIGNANT GLIOMA | RESISTANT | GLIOBLASTOMA | THERAPY | PROMOTER METHYLATION | ENDOCRINOLOGY & METABOLISM | REPAIR PROTEIN MSH6 | EXPERIENCE | OF-THE-LITERATURE | TUMORS | O-6-METHYLGUANINE DNA METHYLTRANSFERASE | Pituitary Neoplasms - diagnosis | Prognosis | Follow-Up Studies | Dacarbazine - therapeutic use | Humans | Middle Aged | Male | Adenoma - metabolism | Young Adult | Adenoma - drug therapy | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Biomarkers, Tumor - metabolism | Adult | Female | Carcinoma - pathology | Carcinoma - drug therapy | Adenoma - diagnosis | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Carcinoma - diagnosis | Pituitary Neoplasms - pathology | Treatment Outcome | Pituitary Neoplasms - metabolism | Antineoplastic Agents, Alkylating - therapeutic use | Pituitary Neoplasms - drug therapy | Adolescent | Adenoma - pathology | Aged | Carcinoma - metabolism | Biomarkers, Pharmacological - metabolism | Klinisk medicin | Clinical Medicine | Endocrinology & Metabolism
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11. Full Text Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
by Pizzagalli, Diego A
Neuropsychopharmacology, ISSN 0893-133X, 01/2011, Volume 36, Issue 1, pp. 183 - 206
Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising predictor of treatment response in depression, but neither the... 
emotion regulation | rostral anterior cingulate cortex | emotional biases | depression | rumination | biomarkers | DORSOLATERAL PREFRONTAL CORTEX | GLUCOSE METABOLIC-RESPONSE | ANTERIOR CINGULATE CORTEX | PSYCHIATRY | DEFAULT-MODE NETWORK | LATE-LIFE DEPRESSION | NEUROSCIENCES | TRANSCRANIAL MAGNETIC STIMULATION | RAPID ANTIDEPRESSANT RESPONSE | PHARMACOLOGY & PHARMACY | CEREBRAL-BLOOD-FLOW | WHITE-MATTER ABNORMALITIES | TOTAL SLEEP-DEPRIVATION | Outcome Assessment (Health Care) - methods | Depressive Disorder, Major - physiopathology | Depressive Disorder, Major - metabolism | Humans | Nerve Net - drug effects | Cognition - drug effects | Nerve Net - physiology | Antidepressive Agents - therapeutic use | Gyrus Cinguli - chemistry | Prefrontal Cortex - drug effects | Cognition - physiology | Gyrus Cinguli - physiology | Antidepressive Agents - pharmacology | Gyrus Cinguli - drug effects | Prefrontal Cortex - chemistry | Biomarkers, Pharmacological - chemistry | Biomarkers, Pharmacological - metabolism | Prefrontal Cortex - physiology | Nerve Net - chemistry | Depressive Disorder, Major - drug therapy | biological psychiatry | frontocingulate | cognition | psychiatry & behavioral sciences | depression, unipolar | bipolar | Neuropsychopharmacology Reviews
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