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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2011, Volume 79, Issue 3, pp. 884 - 891
Purpose The vitamin E analog γ-tocotrienol (GT3) is a powerful radioprotector. GT3 reduces postradiation vascular peroxynitrite production, an effect dependent... 
Radiology | Hematology, Oncology and Palliative Medicine | Oxidative stress | Nitric oxide synthase | Tetrahydrobiopterin | Vitamin E | Endothelial cells | Radiation | TOTAL-BODY IRRADIATION | CELLS | ENDOTHELIAL DYSFUNCTION | NITRIC-OXIDE SYNTHASE | ADHESION MOLECULES | ONCOLOGY | GTP-CYCLOHYDROLASE-I | REGULATORY PROTEIN | HYDROGEN-PEROXIDE | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Endothelium, Vascular - cytology | Transcription, Genetic - drug effects | Whole-Body Irradiation | Biopterin - pharmacology | Apoptosis - drug effects | Vitamin E - analogs & derivatives | Biological Availability | Endothelium, Vascular - drug effects | Male | Intracellular Signaling Peptides and Proteins - metabolism | Biopterin - analogs & derivatives | Biopterin - metabolism | Chromans - pharmacology | Colony-Forming Units Assay | Lung - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Radiation Dosage | Random Allocation | GTP Cyclohydrolase - metabolism | Peroxynitrous Acid - biosynthesis | Animals | Bone Marrow Cells | Endothelium, Vascular - metabolism | Protein Binding | Mice | Nitric Oxide Synthase - metabolism | Biopterin - analysis | Oxidative Stress - drug effects | Endothelial Cells - drug effects | Vitamin E - pharmacology | Peroxynitrite | tetrahydrobiopterin | Free radicals | Transcription | Guanosine | Lung | regulatory proteins | Cofactors | Nitric-oxide synthase | reductase | GTP cyclohydrolase | Feedback | Bone marrow | Supplementation | Apoptosis | endothelial cells | nitric oxide synthase | radiation | oxidative stress | vitamin E
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2002, Volume 22, Issue 10, pp. 1655 - 1661
Objective-Tetrahydrobiopterin (BH4) is Of fundamental importance for the normal function of endothelial NO synthase. The purpose of this study was to... 
Hypercholesterolemia | Sepiapterin | Tetrahydrobiopterin | Nitric oxide | Endothelium | N-acetylcysteine | VITAMIN-C | endothelium | CELLS | nitric oxide | tetrahydrobiopterin | sepiapterin | NITRIC-OXIDE SYNTHASE | INTRACELLULAR TETRAHYDROBIOPTERIN | DEFICIENT MICE | hypercholesterolemia | ENDOTHELIUM-DEPENDENT VASODILATION | ARTERIES | GTP CYCLOHYDROLASE-I | SUPEROXIDE GENERATION | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | HEMATOLOGY | Free Radical Scavengers - pharmacology | Antioxidants - metabolism | Cholesterol - blood | Nitric Oxide Synthase - physiology | Endothelium, Vascular - drug effects | Male | Aorta, Thoracic - chemistry | Endothelium, Vascular - enzymology | Hyperlipidemias - enzymology | Biopterin - analogs & derivatives | Oxygen - metabolism | Biopterin - metabolism | Sulfhydryl Compounds - metabolism | Pterins | Aorta, Thoracic - drug effects | Aorta, Thoracic - pathology | Ionophores - pharmacology | Muscle, Smooth, Vascular - drug effects | Rabbits | Pteridines - pharmacology | Vasodilator Agents - pharmacology | Hyperlipidemias - metabolism | Oxidation-Reduction | Acetylcholine - pharmacology | Nitric Oxide Synthase Type III | Calcimycin - pharmacology | Arteriosclerosis - enzymology | Aorta, Thoracic - enzymology | Animals | Diet | Acetylcysteine - pharmacology | Hyperlipidemias - pathology | Arteriosclerosis - metabolism | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism | Arteriosclerosis - pathology | Muscle, Smooth, Vascular - enzymology
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 650, Issue 1, pp. 371 - 377
Journal Article
Hypertension, ISSN 0194-911X, 09/2008, Volume 52, Issue 3, pp. 563 - 572
We investigated whether aliskiren, a direct renin inhibitor, improves NO bioavailability and protects against spontaneous atherosclerotic changes. We also... 
Oxidative stress | Renin inhibitor | Endothelial function | endothelial function | SYSTEM | ACTIVATION | EFFICACY | CARDIOVASCULAR EVENTS | ANGIOTENSIN-II | BLOOD-PRESSURE | RECEPTOR ANTAGONIST | SYNTHASE | PERIPHERAL VASCULAR DISEASE | renin inhibitor | HYPERTENSION | oxidative stress | VALSARTAN | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Valsartan | Endothelium, Vascular - drug effects | Male | Biopterin - analogs & derivatives | Tyrosine - analogs & derivatives | Biopterin - metabolism | Heart Rate - drug effects | Lipids - blood | Inflammation Mediators - metabolism | Blood Pressure - drug effects | Nitric Oxide Synthase Type III - metabolism | Drug Therapy, Combination | Proto-Oncogene Proteins c-akt - metabolism | Endothelium, Vascular - immunology | Hyperlipidemias - immunology | Amides - pharmacology | Rabbits | Atherosclerosis - immunology | Vasodilator Agents - pharmacology | Hyperlipidemias - metabolism | Acetylcholine - pharmacology | Hyperlipidemias - drug therapy | Valine - analogs & derivatives | Renin - blood | Atherosclerosis - metabolism | Tyrosine - metabolism | Animals | Renin - antagonists & inhibitors | Endothelium, Vascular - metabolism | Fumarates - pharmacology | HSP90 Heat-Shock Proteins - metabolism | Oxidative Stress - drug effects | Valine - pharmacology | Vasodilation - drug effects | Nitric Oxide - metabolism | Atherosclerosis - prevention & control
Journal Article
Pflugers Archiv European Journal of Physiology, ISSN 0031-6768, 05/2010, Volume 459, Issue 6, pp. 923 - 939
Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone, inhibits platelet function, prevents adhesion of leukocytes, and... 
Reactive oxygen species | AT1 receptor antagonists | Vitamin E | Vitamin C | Polyphenols | Endothelial NO synthase | ACE inhibitors | Statins | AT receptor antagonists | PHYSIOLOGY | COA REDUCTASE INHIBITORS | SPONTANEOUSLY HYPERTENSIVE-RATS | MESSENGER-RNA EXPRESSION | LOW-DENSITY-LIPOPROTEIN | HUMAN ENDOTHELIAL-CELLS | ANGIOTENSIN-CONVERTING-ENZYME | II-INDUCED HYPERTENSION | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-SUPEROXIDE DISMUTASE | CORONARY-ARTERY-DISEASE | Receptor, Angiotensin, Type 1 | Phosphorylation | Reactive Oxygen Species - metabolism | Vascular Diseases - etiology | Antioxidants - metabolism | Humans | Protein Multimerization | NADPH Oxidases - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Biopterin - analogs & derivatives | Arginine - analogs & derivatives | Biopterin - metabolism | Calcium - physiology | Superoxides - metabolism | Thioredoxins - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Electron Transport - physiology | Nitric Oxide Synthase Type III - metabolism | Heme Oxygenase (Decyclizing) - metabolism | Superoxide Dismutase - metabolism | Cardiovascular Diseases - etiology | Glutathione Peroxidase - metabolism | Xanthine Oxidase - metabolism | Risk Factors | Nitric Oxide - physiology | Renin-Angiotensin System - physiology | Mitochondria - metabolism | Vascular Diseases - physiopathology | Aryldialkylphosphatase - metabolism | Catalase - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Oxidative Stress - drug effects | Arginine - metabolism | Oxidases | Oxidative stress | Superoxide | Thioredoxin | Endothelium | Antioxidants | Purines | Blood circulation disorders | Molybdenum compounds | Nitric oxide | Heme | Peroxidase | Molecular weight | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 11/2009, Volume 297, Issue 5, pp. 1829 - 1836
Endothelial nitric oxide synthase (eNOS) uncoupling is a mechanism that leads to endothelial dysfunction. Previously, we reported that shear stress-induced... 
Tetrahydrobiopterin | Nitrotyrosine | Superoxide | CELLS | tetrahydrobiopterin | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PEROXYNITRITE | NITRIC-OXIDE SYNTHASE | IMPAIRMENT | BIOPTERIN | SHEAR-STRESS | PERIPHERAL VASCULAR DISEASE | nitrotyrosine | GENERATION | superoxide | EXPRESSION | Mesenteric Arteries - physiopathology | Pterins - metabolism | Age Factors | Biopterin - pharmacology | Protein Multimerization | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - enzymology | Biopterin - analogs & derivatives | Tyrosine - analogs & derivatives | Biopterin - metabolism | Dose-Response Relationship, Drug | Time Factors | Superoxides - metabolism | Nitric Oxide Synthase Type III - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Vasodilator Agents - pharmacology | Oxidation-Reduction | Acetylcholine - pharmacology | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Enzyme Stability | Alcohol Oxidoreductases - metabolism | GTP Cyclohydrolase - metabolism | Nitric Oxide Synthase Type III - genetics | Nitric Oxide Synthase Type III - antagonists & inhibitors | Tyrosine - metabolism | Animals | Pterins - pharmacology | Mice | Vasodilation - drug effects | Mesenteric Arteries - enzymology | Aging - metabolism | Cardiovascular system | Coenzymes | Vascular endothelium | Amino acids | Research | Properties
Journal Article
Journal Article
The Journal of Physical Chemistry B, ISSN 1520-6106, 08/2007, Volume 111, Issue 32, pp. 9651 - 9654
Journal Article
Journal of Pediatrics, The, ISSN 0022-3476, 2012, Volume 160, Issue 4, pp. 544 - 552.e4
Journal Article