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Circulation, ISSN 0009-7322, 08/2007, Volume 116, Issue 8, pp. 944 - 953
Background - Tetrahydrobiopterin (BH4) deficiency is reported to uncouple the enzymatic activity of endothelial nitric oxide synthase in diabetes mellitus. The... 
Nitric oxide synthase | Hyperglycemia | Nitric oxide | Atherosclerosis | Endothelium | atherosclerosis | endothelium | nitric oxide | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROTIC PLAQUES | ENDOTHELIAL DYSFUNCTION | NITRIC-OXIDE SYNTHASE | PROSTACYCLIN SYNTHASE | VASCULAR-DISEASE | hyperglycemia | PROTEIN-DEGRADATION | REGULATORY PROTEIN | PERIPHERAL VASCULAR DISEASE | nitric oxide synthase | GENE-TRANSFER | HEMATOLOGY | TYROSINE NITRATION | Diabetes Mellitus, Experimental - drug therapy | Reactive Oxygen Species - metabolism | Biopterin - deficiency | Ubiquitin - metabolism | Guanosine Triphosphate - metabolism | Spin Labels | Biopterin - analogs & derivatives | Biopterin - metabolism | Diabetes Mellitus, Experimental - prevention & control | Cyclic N-Oxides - pharmacology | Diabetes Mellitus, Experimental - metabolism | Umbilical Veins - cytology | Aorta - enzymology | Organ Culture Techniques | Nitrogen - metabolism | Mice, Inbred C57BL | Cells, Cultured | Glucose - pharmacology | Antioxidants - pharmacology | GTP Cyclohydrolase - metabolism | Leupeptins - pharmacology | Tyrosine - metabolism | Animals | Endothelial Cells - cytology | Cysteine Proteinase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Control | Physiological aspects | Development and progression | Diabetes | Research | Ubiquitin-proteasome system | Guanosine triphosphatase
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 11/2011, Volume 7, Issue 11, pp. 1323 - 1334
Tetrahydrobiopterin (BH 4 ) deficiency is a genetic disorder associated with a variety of metabolic syndromes such as phenylketonuria (PKU). In this article,... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Tyrosine | Phenylketonuria | Phenylalanine | Tetrahydrobiopterin | AMPK | Akt | Autophagy | mTORC1 | tetrahydrobiopterin | autophagy | phenylalanine | MENTAL-RETARDATION | RAG GTPASES | CELL-PROLIFERATION | CELL BIOLOGY | AMINO-ACID | TYROSINE SUPPLEMENTATION | DIHYDROPTERIDINE REDUCTASE DEFICIENCY | tyrosine | MATERNAL PHENYLKETONURIA | phenylketonuria | GENETIC MOUSE MODEL | PHENYLALANINE-HYDROXYLASE DEFICIENCY | PARKINSONS-DISEASE | NIH 3T3 Cells | Liver - pathology | Biopterin - deficiency | Biopterin - pharmacology | Tyrosine - deficiency | Humans | Multiprotein Complexes | Infant | Male | Ras Homolog Enriched in Brain Protein | Biopterin - analogs & derivatives | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Liver - drug effects | Biopterin - therapeutic use | Female | Phenylketonurias - pathology | Child | Phenylalanine Hydroxylase - metabolism | Phenylalanine - metabolism | Liver - ultrastructure | Alcohol Oxidoreductases - metabolism | Neuropeptides - metabolism | Down-Regulation - drug effects | Tyrosine - metabolism | Animals | Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Mice | TOR Serine-Threonine Kinases | Alcohol Oxidoreductases - deficiency | Phenylketonurias - drug therapy | Basic Research Paper
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 1/2013, Volume 36, Issue 1, pp. 7 - 13
Journal Article