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Journal of clinical immunology, ISSN 1573-2592, 2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis
Journal Article
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 523, Issue 7562, pp. 555 - 560
Journal Article
Gynecologic oncology, ISSN 0090-8258, 2005, Volume 99, Issue 2, pp. 267 - 277
When ovarian carcinoma is diagnosed in stage I, up to 90% of patients can be cured with surgery and currently available chemotherapy. At present, less than 25%... 
HK6 | Claudin 3 | Tumor markers | HK10 | Ovarian carcinoma | CA125 | Osteopontin | FACTOR VEGF | DIAGNOSIS | tumor markers | osteopontin | ovarian carcinoma | SERUM | HUMAN TISSUE KALLIKREINS | OBSTETRICS & GYNECOLOGY | BREAST-CANCER | claudin 3 | ONCOLOGY | GENE-EXPRESSION | PATIENT SURVIVAL | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Epididymal Secretory Proteins - biosynthesis | Immunohistochemistry | Vascular Endothelial Growth Factor A - biosynthesis | Epithelial Cells - metabolism | Kallikreins - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | Middle Aged | Antigens, Neoplasm - biosynthesis | GPI-Linked Proteins | Ovarian Neoplasms - pathology | beta-Defensins | Sialoglycoproteins - biosynthesis | Antigens - blood | CA-125 Antigen - biosynthesis | CA-19-9 Antigen - biosynthesis | Antigens, Neoplasm - blood | Female | Kallikreins - blood | Ovarian Neoplasms - metabolism | CA-19-9 Antigen - blood | Membrane Proteins - blood | Cystadenoma - metabolism | CA-125 Antigen - blood | Vascular Endothelial Growth Factor A - blood | Membrane Glycoproteins - blood | Ovarian Neoplasms - blood | Sialoglycoproteins - blood | Epithelial Cells - pathology | Glycoproteins - blood | Cystadenoma - blood | Claudin-3 | Mucin-1 | Mucins - blood | Biomarkers, Tumor - blood | Glycoproteins - biosynthesis | Mucins - biosynthesis | Membrane Proteins - biosynthesis | Epididymal Secretory Proteins - metabolism | Antigens - biosynthesis | Neoplasm Staging | Biomarkers, Tumor - biosynthesis | Antigens | Chemotherapy | Oncology, Experimental | Flexible response (Strategy) | Research | Universities and colleges | Deterrence (Strategy) | Cancer | Ovarian cancer
Journal Article
Inflammation, ISSN 0360-3997, 8/2013, Volume 36, Issue 4, pp. 921 - 931
Murine macrophages are activated by interferon-γ (IFN-γ) and/or Toll-like receptor (TLR) agonists such as bacterial endotoxin (lipopolysaccharide [LPS]) to... 
Pathology | alternative activation | Medicine & Public Health | Rheumatology | adenosine receptor | Internal Medicine | macrophage | TLR | Pharmacology/Toxicology | IL-4Rα | ACTIVATION | A(2A) RECEPTORS | C/EBP-BETA | IL-10 PRODUCTION | INJURY | IL-4R alpha | IMMUNOLOGY | MURINE | CELL BIOLOGY | REPAIR | LIPOPOLYSACCHARIDE | TRANSCRIPTIONAL REGULATION | EXPRESSION | Vascular Endothelial Growth Factor A - biosynthesis | Nitric Oxide Synthase Type II - biosynthesis | Mannose-Binding Lectins - biosynthesis | Arginase - biosynthesis | Intercellular Signaling Peptides and Proteins - biosynthesis | Male | Lectins, C-Type - biosynthesis | Lectins - biosynthesis | Interleukin-4 Receptor alpha Subunit - genetics | Cell Differentiation | Receptors, Cell Surface - biosynthesis | Macrophages - immunology | Interleukin-12 - biosynthesis | Interleukin-4 Receptor alpha Subunit - metabolism | Signal Transduction | Purinergic P1 Receptor Agonists - pharmacology | Cells, Cultured | Mice, Transgenic | Adenosine - pharmacology | Receptor, Adenosine A2A - metabolism | beta-N-Acetylhexosaminidases - biosynthesis | Neovascularization, Physiologic - immunology | Macrophage Activation | Animals | Adenosine - metabolism | Interleukin-10 - biosynthesis | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Tumor Necrosis Factor-alpha - biosynthesis | Physiological aspects | Cell receptors | Genetic aspects | Cellular signal transduction | Research | Macrophages | IL4Rα | Alternative Activation | Adenosine Receptor | Macrophage
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 3, pp. 315 - 327
Inactivation of the TCA cycle enzyme, fumarate hydratase ( FH), drives a metabolic shift to aerobic glycolysis in FH-deficient kidney tumors and cell lines... 
CELLS | SUCCINATE-DEHYDROGENASE | COMPLEX-II | ONCOLOGY | GLUCOSE-METABOLISM | GROWTH | HEREDITARY LEIOMYOMATOSIS | RENAL-CANCER | CARCINOMA | HYPOXIA-INDUCIBLE FACTOR-1 | REGULATORY PROTEINS | CELL BIOLOGY | AMP-Activated Protein Kinases - metabolism | Tumor Suppressor Protein p53 - biosynthesis | Cation Transport Proteins - biosynthesis | Humans | Leiomyomatosis - metabolism | Fumarate Hydratase - deficiency | Kidney Neoplasms - metabolism | Glycolysis - drug effects | Iron Regulatory Protein 2 - biosynthesis | Neoplastic Syndromes, Hereditary | Fumarate Hydratase - metabolism | Ribose - biosynthesis | Acetyl Coenzyme A - biosynthesis | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Iron - deficiency | Leiomyomatosis - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Leiomyomatosis - congenital | Ribosomal Protein S6 - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | NADP - biosynthesis | Uterine Neoplasms | Animals | Iron Regulatory Protein 1 - metabolism | Thenoyltrifluoroacetone - pharmacology | Ribosomal Protein S6 - metabolism | Kidney Neoplasms - enzymology | Skin Neoplasms | Acetyl-CoA Carboxylase - biosynthesis | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Iron Regulatory Protein 1 - biosynthesis | Acetyl-CoA Carboxylase - metabolism | Iron Regulatory Protein 2 - metabolism | Enzymes | Glucose metabolism | Research | Tumor proteins | Oncology, Experimental | Cancer
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 2006, Volume 341, Issue 4, pp. 1135 - 1140
Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a pancreatic endocrine phenotype in vitro and to reverse diabetes in an animal model.... 
Human | Nestin | Adipose tissue | Glucagon | Isl-1 | Differentiation | Insulin | Mesenchymal stem cells | ABCG2 | PROGENITOR CELLS | VITRO | differentiation | TRANSPORTER | insulin | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | nestin | ENDOCRINE | adipose tissue | BIOPHYSICS | HUMAN BONE-MARROW | mesenchymal stem cells | IN-VIVO | glucagon | PANCREATIC BETA-CELLS | STROMAL CELLS | human | BRAIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Glucagon - biosynthesis | Homeodomain Proteins - biosynthesis | Neoplasm Proteins - biosynthesis | Humans | Cells, Cultured | Adipose Tissue - cytology | Intermediate Filament Proteins - biosynthesis | Mesenchymal Stromal Cells - metabolism | Proto-Oncogene Proteins c-kit - biosynthesis | Insulin - biosynthesis | Somatostatin - biosynthesis | ATP-Binding Cassette Transporters - biosynthesis | Mesenchymal Stromal Cells - cytology | Stem Cell Factor - biosynthesis | Nerve Tissue Proteins - biosynthesis | Thy-1 Antigens - biosynthesis | LIM-Homeodomain Proteins | Cell Differentiation | Transcription Factors | Stem cell research | Analysis | Stem cells | Somatostatin | Diabetes | Hormones | Intermediate filament proteins | TRANSCRIPTION FACTORS | PANCREAS | PHENOTYPE | BONE MARROW | CELL PROLIFERATION | 60 APPLIED LIFE SCIENCES | INSULIN | POLYMERASE CHAIN REACTION | IN VITRO | SOMATOSTATIN | MICE | STEM CELLS | ADIPOSE TISSUE | GLUCAGON
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2012, Volume 287, Issue 34, pp. 29003 - 29020
The processes by which cells sense and respond to ambient oxygen concentration are fundamental to cell survival and function, and they commonly target gene... 
CELLS | REGULATORY ELEMENT DATABASE | INDUCIBLE FACTOR-I | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | RECEPTOR | MESSENGER-RNA STABILITY | TUMOR ANGIOGENESIS | MICRORNAS | ENDOTHELIAL GROWTH-FACTOR | PROMOTES ANGIOGENESIS | Endothelium, Vascular - cytology | Human Umbilical Vein Endothelial Cells | Vascular Endothelial Growth Factor A - biosynthesis | Humans | Gene Expression Regulation, Enzymologic - physiology | Endothelium, Vascular - enzymology | Proto-Oncogene Proteins - biosynthesis | Vascular Endothelial Growth Factor A - genetics | Oxygen - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Cell Hypoxia | DEAD-box RNA Helicases - biosynthesis | Glucose Transporter Type 1 - biosynthesis | Tumor Suppressor Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Vascular Endothelial Growth Factor Receptor-2 - biosynthesis | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Vascular Endothelial Growth Factor Receptor-1 - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Ribonuclease III - genetics | Membrane Proteins - genetics | Adaptation, Physiological - physiology | MicroRNAs - biosynthesis | Proto-Oncogene Proteins - genetics | Vascular Endothelial Growth Factor Receptor-1 - biosynthesis | Ribonuclease III - biosynthesis | Hep G2 Cells | DEAD-box RNA Helicases - genetics | Membrane Proteins - biosynthesis | Glucose Transporter Type 1 - genetics | MicroRNAs - genetics | Tumor Suppressor Proteins - biosynthesis | Gene Regulation | MicroRNA | Molecular Biology | Dicer | Molecular Cell Biology | Hypoxia | Hypoxia-inducible Factor (HIF) | Endothelial Cell | Endothelium
Journal Article