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1. Serum vaccine antibody concentrations in children exposed to perfluorinated compounds
by Grandjean, Philippe and Andersen, Elisabeth Wreford and Budtz-Jørgensen, Esben and Nielsen, Flemming and Mølbak, Ka Re and Weihe, Pal and Heilmann, Carsten
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 01/2012, Volume 307, Issue 4, pp. 391 - 397
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Fluorocarbons - toxicity | Prenatal Exposure Delayed Effects | Prospective Studies | Food Contamination | Humans | Child, Preschool | Polychlorinated Biphenyls - blood | Seafood | Male | Diphtheria Toxoid - immunology | Milk, Human - chemistry | Maternal Exposure | Fluorocarbons - blood | Immunity, Humoral | Female | Odds Ratio | Child | Immunization | Immune Tolerance | Tetanus Toxoid - administration & dosage | Environmental Exposure - adverse effects | Pregnancy | Diphtheria Toxoid - administration & dosage | Antibody Formation - drug effects | Denmark | Tetanus Toxoid - immunology | Proteins | Medical research | Chemical compounds | Children & youth
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2. Full Text The role of glucagon in the acute therapeutic effects of SGLT2 inhibition
by Hædersdal, Sofie and Lund, Asger and Nielsen-Hannerup, Elisabeth and Maagensen, Henrik and van Hall, Gerrit and Holst, Jens J and Knop, Filip K and Vilsbøll, Tina
Diabetes (New York, N.Y.), ISSN 0012-1797, 12/2020, Volume 69, Issue 12, pp. 2619 - 2629
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Glucosides - blood | Benzhydryl Compounds - administration & dosage | Humans | Half-Life | Glucosides - pharmacokinetics | Benzhydryl Compounds - blood | Biphenyl Compounds - therapeutic use | Sodium-Glucose Transporter 2 Inhibitors - pharmacokinetics | Sodium-Glucose Transporter 2 Inhibitors - blood | Sodium-Glucose Transporter 2 Inhibitors - administration & dosage | Diabetes Mellitus, Type 2 - therapy | Glucosides - therapeutic use | Biphenyl Compounds - blood | Drug Therapy, Combination | Benzhydryl Compounds - therapeutic use | C-Peptide - metabolism | Benzhydryl Compounds - pharmacokinetics | Sodium-Glucose Transporter 2 Inhibitors - therapeutic use | Biphenyl Compounds - pharmacokinetics | Blood Glucose - drug effects | Glucosides - administration & dosage | Glycerol - metabolism | Gastric Emptying - drug effects | Biphenyl Compounds - administration & dosage | Glucagon - metabolism | Glycerol - blood | Energy Metabolism - drug effects | Type 2 diabetes | Physiological aspects | Research | Glucagon | Fasting | Glucose | Diabetes | Diabetes mellitus (non-insulin dependent) | Index Medicus | Abridged Index Medicus | Metabolism
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3. Full Text Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition
by Tamaki, Hiroki and Harashima, Nanae and Hiraki, Miho and Arichi, Naoko and Nishimura, Nobuhiro and Shiina, Hiroaki and Naora, Kohji and Harada, Mamoru
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 22, pp. 11399 - 11412
Bcl-2 | Bcl-xL | Prostate cancer | Docetaxel | Apoptosis | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Piperazines - administration & dosage | Prostatic Neoplasms - metabolism | Caspase Inhibitors - pharmacology | Caspase 9 - metabolism | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Male | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Prostatic Neoplasms - genetics | Transfection | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Aniline Compounds - administration & dosage | Prostatic Neoplasms - drug therapy | Caspase Inhibitors - administration & dosage | Prostatic Neoplasms - pathology | Aniline Compounds - pharmacology | Nitrophenols - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Sulfonamides - pharmacology | Piperazines - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Mice, Nude | Biphenyl Compounds - administration & dosage | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Sulfonamides - administration & dosage | Index Medicus
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4. Full Text Pharmacological and protein profiling suggests venetoclax (ABT-199) as optimal partner with ibrutinib in chronic lymphocytic leukemia
by Cervantes-Gomez, Fabiola and Lamothe, Betty and Woyach, Jennifer A and Wierda, William G and Keating, Michael J and Balakrishnan, Kumudha and Gandhi, Varsha
Clinical cancer research, ISSN 1078-0432, 08/2015, Volume 21, Issue 16, pp. 3705 - 3715
Life Sciences & Biomedicine | Oncology | Science & Technology | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Apoptosis - drug effects | Humans | Neoplastic Cells, Circulating - metabolism | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Purines - administration & dosage | Bendamustine Hydrochloride - administration & dosage | Protein-Tyrosine Kinases - genetics | Female | bcl-X Protein - biosynthesis | Protein-Tyrosine Kinases - biosynthesis | B-Cell Activating Factor - biosynthesis | Neoplastic Cells, Circulating - drug effects | Pyrimidines - administration & dosage | Gene Expression Regulation, Leukemic - drug effects | Nitrophenols - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Pyrazoles - administration & dosage | B-Cell Activating Factor - genetics | Agammaglobulinaemia Tyrosine Kinase | Biphenyl Compounds - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Isoquinolines - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - genetics | Sulfonamides - administration & dosage | Index Medicus
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5. Full Text Antioxidant activity and mechanisms of action of natural compounds isolated from lichens: A systematic review
by White, Pollyanna A. S and Oliveira, Rita C. M and Oliveira, Aldeidia P and Serafini, Mairim R and Araújo, Adriano A. S and Gelain, Daniel P and Moreira, Jose C. F and Almeida, Jackson R. G. S and Quintans, Jullyana S. S and Quintans-Junior, Lucindo J and Santos, Marcio R. V
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2014, Volume 19, Issue 9, pp. 14496 - 14527
Antioxidants | Lichens | Antioxidant response elements | DPPH | Chronic disease | Cancer | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Antioxidants - chemistry | Free Radical Scavengers - metabolism | Oxidation-Reduction | Oxidative Stress | Humans | Lichens - chemistry | Antioxidant Response Elements | Antioxidants - pharmacology | Neoplasms - drug therapy | Picrates - administration & dosage | Picrates - chemistry | Biphenyl Compounds - administration & dosage | Biphenyl Compounds - chemistry | Benzofurans - metabolism | Index Medicus | lichens | cancer | antioxidants | antioxidant response elements | chronic disease
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6. Full Text A Multicenter, Double-blind, Randomized, Placebo-controlled Trial of the β3-Adrenoceptor Agonist Solabegron for Overactive Bladder
by Ohlstein, Eliot H and von Keitz, Alexander and Michel, Martin C
European urology, ISSN 0302-2838, 2012, Volume 62, Issue 5, pp. 834 - 840
Urology | Urinary incontinence | Overactive bladder | β3-adrenoceptor | Solabegron | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Urinary system involvement in other diseases. Miscellaneous | Benzoates - adverse effects | Benzoates - therapeutic use | Humans | Middle Aged | Biphenyl Compounds - adverse effects | Urodynamics - drug effects | Adrenergic beta-3 Receptor Agonists - adverse effects | Biphenyl Compounds - therapeutic use | Young Adult | Urinary Bladder, Overactive - drug therapy | Time Factors | Urinary Bladder, Overactive - physiopathology | Urination - drug effects | Adult | Female | Aniline Compounds - administration & dosage | Republic of Korea | Adrenergic beta-3 Receptor Agonists - administration & dosage | Argentina | Urinary Incontinence - physiopathology | Double-Blind Method | Drug Administration Schedule | Europe | Linear Models | Treatment Outcome | Benzoates - administration & dosage | Urinary Incontinence - drug therapy | New Zealand | Adrenergic beta-3 Receptor Agonists - therapeutic use | Biphenyl Compounds - administration & dosage | Taiwan | Urinary Bladder - physiopathology | South Africa | Urinary Bladder - drug effects | Aged | Aniline Compounds - therapeutic use | Aniline Compounds - adverse effects | Australia | Index Medicus
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7. Full Text Dose-Additive Carcinogenicity of a Defined Mixture of "Dioxin-Like Compounds"
by Nigel J. Walker and Patrick W. Crockett and Abraham Nyska and Amy E. Brix and Michael P. Jokinen and Donald M. Sells and James R. Hailey and Micheal Easterling and Joseph K. Haseman and Ming Yin and Michael E. Wyde and John R. Bucher and Christopher J. Portier
Environmental health perspectives, ISSN 0091-6765, 1/2005, Volume 113, Issue 1, pp. 43 - 48
Pathology | Dose response relationship | Liver | Chemical mixtures | Environmental health | Dioxins | Research | Dosage | Neoplasia | Carcinogenicity | Modeling | PCBs | Persistent organochlorine pollutants | Mixtures | TEF | Dioxin | Risk assessment | POPs | Polychlorinated biphenyls | Toxic equivalency factor | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Environmental Pollutants - poisoning | Lung Neoplasms - chemically induced | Risk Assessment | Carcinogens - adverse effects | Humans | Lung Neoplasms - veterinary | Liver Neoplasms - chemically induced | Polychlorinated Dibenzodioxins - poisoning | Rats | Reference Values | Dioxins - poisoning | Rats, Sprague-Dawley | Carcinogens - administration & dosage | Polychlorinated Dibenzodioxins - administration & dosage | Dose-Response Relationship, Drug | Mouth Neoplasms - chemically induced | Animals | Liver Neoplasms - veterinary | Environmental Pollutants - administration & dosage | Biological Assay | Dioxins - administration & dosage | Female | Mouth Neoplasms - veterinary | Index Medicus | risk assessment | dioxin | polychlorinated biphenyls | toxic equivalency factor | persistent organochlorine pollutants | carcinogenicity | mixtures
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8. Full Text Nanoincorporation of bioactive compounds from red grape pomaces: In vitro and ex vivo evaluation of antioxidant activity
by Manconi, Maria and Marongiu, Francesca and Manca, Maria Letizia and Caddeo, Carla and Sarais, Giorgia and Cencetti, Claudia and Pucci, Laura and Longo, Vincenzo and Bacchetta, Gianluigi and Fadda, Anna Maria
International journal of pharmaceutics, ISSN 0378-5173, 05/2017, Volume 523, Issue 1, pp. 159 - 166
Phospholipid vesicles | Human erythrocytes | Antioxidant | Rheology | Grape pomace extract | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Green Chemistry Technology | Phenols - isolation & purification | Fatty Acids - chemistry | Antioxidants - chemistry | Fatty Acids - isolation & purification | Fruit - chemistry | Humans | Vitis | Drug Carriers - administration & dosage | Phospholipids - chemistry | Drug Carriers - chemistry | Erythrocytes - drug effects | Antioxidants - isolation & purification | Ethanol - chemistry | Picrates - chemistry | Antioxidants - administration & dosage | Olive Oil - chemistry | Fatty Acids - administration & dosage | Phenols - administration & dosage | Phenols - chemistry | Biphenyl Compounds - chemistry | Propylene Glycol - chemistry | Nanotechnology | Antioxidants | Agricultural biotechnology | Analysis | Monounsaturated fatty acids | Phospholipids | Isoflavones | Index Medicus
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9. Full Text Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance
by Montoya, G.A and Strauss, V and Fabian, E and Kamp, H and Mellert, W and Walk, T and Looser, R and Herold, M and Krennrich, G and Peter, E and van Ravenzwaay, B
Toxicology letters, ISSN 0378-4274, 03/2014, Volume 225, Issue 2, pp. 240 - 251
Metabolomics | Pattern | Biomarker | Toxicity | Thyroid | Mode of action | Life Sciences & Biomedicine | Toxicology | Science & Technology | Methimazole - administration & dosage | Niacinamide - analogs & derivatives | Liver - enzymology | Rats, Wistar | Rats | Chlorodiphenyl (54% Chlorine) - administration & dosage | Male | Ethylenethiourea - administration & dosage | Antithyroid Agents - administration & dosage | Metabolomics - methods | Niacinamide - administration & dosage | Animals | Liver - drug effects | Metabolome - drug effects | Thyroid Hormones - blood | Biphenyl Compounds - administration & dosage | Female | Thyroid Gland - metabolism | Thyroid Gland - drug effects | Metabolites | Hormones | Index Medicus
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10. Full Text Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies
by Stoch, SA and Zajic, S and Stone, J and Miller, DL and Van Dyck, K and Gutierrez, MJ and De Decker, M and Liu, L and Liu, Q and Scott, BB and Panebianco, D and Jin, B and Duong, LT and Gottesdiener, K and Wagner, JA
Clinical pharmacology and therapeutics, ISSN 0009-9236, 08/2009, Volume 86, Issue 2, pp. 175 - 182
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Biphenyl Compounds - pharmacokinetics | Cathepsin K | Bone Resorption - blood | Double-Blind Method | Drug Administration Schedule | Peptides | Administration, Oral | Humans | Middle Aged | Bone Resorption - drug therapy | Biphenyl Compounds - adverse effects | Collagen Type I | Treatment Outcome | Procollagen - blood | Biomarkers - blood | Biphenyl Compounds - therapeutic use | Osteoporosis, Postmenopausal - drug therapy | Biphenyl Compounds - pharmacology | Biphenyl Compounds - administration & dosage | Peptide Fragments - blood | Female | Aged | Cathepsins - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
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11. Full Text A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor sonidegib (LDE225) in patients with advanced solid tumors
by Rodon, Jordi and Tawbi, Hussein A and Thomas, Anne L and Stoller, Ronald G and Turtschi, Christian P and Baselga, Jose and Sarantopoulos, John and Mahalingam, Devalingam and Shou, Yaping and Moles, Melissa A and Yang, Lin and Granvil, Camille and Hurh, Eunju and Rose, Kristine L and Amakye, Dereck D and Dummer, Reinhard and Mita, Alain C
Clinical cancer research, ISSN 1078-0432, 04/2014, Volume 20, Issue 7, pp. 1900 - 1909
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Carcinoma, Basal Cell - genetics | Humans | Middle Aged | Biphenyl Compounds - adverse effects | Pyridines - pharmacokinetics | Male | Pyridines - adverse effects | Medulloblastoma - pathology | Smoothened Receptor | Aged, 80 and over | Adult | Female | Gene Expression Regulation, Neoplastic - drug effects | Medulloblastoma - genetics | Biphenyl Compounds - pharmacokinetics | Pyridines - administration & dosage | Signal Transduction | Administration, Oral | Transcription Factors - biosynthesis | Carcinoma, Basal Cell - pathology | Maximum Tolerated Dose | Biphenyl Compounds - administration & dosage | Receptors, G-Protein-Coupled - antagonists & inhibitors | Carcinoma, Basal Cell - drug therapy | Aged | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Medulloblastoma - drug therapy | Neoplasm Staging | Index Medicus
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