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Clinical Cancer Research, ISSN 1078-0432, 08/2015, Volume 21, Issue 16, pp. 3705 - 3715
Purpose: Bruton's tyrosine kinase (BTK) is a critical enzyme in the B-cell receptor pathway and is inhibited by ibrutinib due to covalent binding to the kinase... 
B-CELL RECEPTOR | TUMOR PROLIFERATION | BRUTONS TYROSINE KINASE | CLL | ONCOLOGY | BCL-2 INHIBITOR | INITIAL THERAPY | IN-VIVO | PCI-32765 | KINASE INHIBITOR IBRUTINIB | SINGLE-ARM | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Apoptosis - drug effects | Humans | Neoplastic Cells, Circulating - metabolism | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Purines - administration & dosage | Bendamustine Hydrochloride - administration & dosage | Protein-Tyrosine Kinases - genetics | Female | bcl-X Protein - biosynthesis | Protein-Tyrosine Kinases - biosynthesis | B-Cell Activating Factor - biosynthesis | Neoplastic Cells, Circulating - drug effects | Pyrimidines - administration & dosage | Gene Expression Regulation, Leukemic - drug effects | Nitrophenols - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Pyrazoles - administration & dosage | B-Cell Activating Factor - genetics | Biphenyl Compounds - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Isoquinolines - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - genetics | Sulfonamides - administration & dosage
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2014, Volume 20, Issue 7, pp. 1900 - 1909
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 04/2015, Volume 17, Issue 4, pp. 414 - 422
Aim: To describe the clinical effects of single and multiple doses of a potent, selective, orally administered, small-molecule antagonist of the human glucagon... 
pharmacokinetics | diabetes care | glucagon antagonist | pharmacology | Pharmacology | Glucagon antagonist | Pharmacokinetics | Diabetes care | HYPERGLUCAGONEMIA | MELLITUS | KNOCKOUT MICE | INSULIN | OBESITY | GLUCONEOGENESIS | ALPHA CELL HYPERPLASIA | ENDOCRINOLOGY & METABOLISM | POSTPRANDIAL HYPERGLYCEMIA | PLASMA-GLUCOSE | Glycated Hemoglobin A - analysis | Single-Blind Method | Hypoglycemia - epidemiology | Receptors, Glucagon - antagonists & inhibitors | Humans | Middle Aged | Half-Life | Male | Risk | Diabetes Mellitus, Type 2 - metabolism | Biphenyl Compounds - therapeutic use | Glucagon - blood | Glucagon - agonists | Dose-Response Relationship, Drug | Hypoglycemia - prevention & control | Hypoglycemic Agents - blood | Hypoglycemic Agents - administration & dosage | Adult | Female | Biphenyl Compounds - blood | Hypoglycemia - chemically induced | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Biphenyl Compounds - pharmacokinetics | Hypoglycemic Agents - pharmacokinetics | Molecular Targeted Therapy - adverse effects | Double-Blind Method | Cross-Over Studies | Diabetes Mellitus, Type 2 - blood | Biphenyl Compounds - administration & dosage | Aged | Glucagon - secretion | Diabetes Mellitus, Type 2 - drug therapy | Cohort Studies | Type 2 diabetes | Glucagon | Blood sugar | Low density lipoproteins | Fasting | Diabetes | Glucose
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2012, Volume 27, Issue 11, pp. 2251 - 2258
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2016, Volume 75, Issue 1, pp. 113 - 125.e5
Background The hedgehog pathway inhibitor sonidegib demonstrated meaningful tumor shrinkage in more than 90% of patients with locally advanced basal cell... 
Dermatology | Basal Cell Carcinoma Outcomes with LDE225 Treatment study | hedgehog pathway inhibitor | sonidegib | locally advanced basal cell carcinoma | metastatic basal cell carcinoma | advanced basal cell carcinoma | Locally advanced basal cell carcinoma | Advanced basal cell carcinoma | Metastatic basal cell carcinoma | Sonidegib | Hedgehog pathway inhibitor | HEDGEHOG PATHWAY | MULTICENTER | VISMODEGIB | MANAGEMENT | EFFICACY | GUIDELINES | OPEN-LABEL | DERMATOLOGY | DOSE-ESCALATION | UPDATE | INHIBITOR | Skin Neoplasms - drug therapy | Humans | Middle Aged | Carcinoma, Basal Cell - secondary | Biphenyl Compounds - adverse effects | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Biphenyl Compounds - therapeutic use | Young Adult | Pyridines - adverse effects | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Smoothened Receptor - antagonists & inhibitors | Pyridines - therapeutic use | Skin Neoplasms - pathology | Pyridines - administration & dosage | Double-Blind Method | Survival Rate | Disease Progression | Biphenyl Compounds - administration & dosage | Carcinoma, Basal Cell - drug therapy | Aged | Medical research | Care and treatment | Basal cell carcinoma | Analysis | Patient outcomes | Corn | Medicine, Experimental | Skin | Metastasis | Drug therapy | Cancer
Journal Article
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 22, pp. 11399 - 11412
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2011, Volume 149, Issue 2, pp. 168 - 174
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 6, pp. 716 - 728
Journal Article
Lancet, The, ISSN 0140-6736, 2017, Volume 389, Issue 10073, pp. 1035 - 1042
Journal Article
Journal Article
Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 2012, Volume 8, Issue 5, pp. 740 - 747
Journal Article