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Cell Stem Cell, ISSN 1934-5909, 07/2016, Volume 19, Issue 1, pp. 23 - 37
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2013, Volume 110, Issue 25, pp. E2298 - E2307
Chronic myeloid leukemia responds well to therapy targeting the oncogenic fusion protein BCR-ABL1 in chronic phase, but is resistant to treatment after it... 
Cancer stem cell | Biomarker | Xenograft | Wnt pathway | CHRONIC MYELOGENOUS LEUKEMIA | MOLECULAR-BIOLOGY | MULTIDISCIPLINARY SCIENCES | BCR-ABL | KINASE 1 | TRANSLATION INITIATION | biomarker | BETA-CATENIN | PROTEIN-SYNTHESIS | cancer stem cell | xenograft | MESSENGER-RNA | EIF4E PHOSPHORYLATION | SIGNALING PATHWAY | Phosphorylation - physiology | RNA, Small Interfering - genetics | Blast Crisis - drug therapy | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Eukaryotic Initiation Factor-4E - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Neoplastic Stem Cells - pathology | Female | Protein-Serine-Threonine Kinases - metabolism | Aniline Compounds - pharmacology | Blast Crisis - pathology | Purines - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Bone Marrow Cells - pathology | beta Catenin - metabolism | Xenograft Model Antitumor Assays | Animals | K562 Cells | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Blast Crisis - metabolism | Bone Marrow Cells - metabolism | Signal transduction | Phosphorylation | Leukemia | Stem cells | Pharmacology | Kinases | Gene expression | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Leukemia, ISSN 0887-6924, 08/2015, Volume 29, Issue 8, pp. 1637 - 1647
Journal Article
Blood, ISSN 0006-4971, 07/2015, Volume 126, Issue 3, pp. 291 - 299
Journal Article
Blood, ISSN 0006-4971, 06/2013, Volume 121, Issue 24, pp. 4821 - 4831
Malignant cells may evade death from cytotoxic agents if they are in a dormant state. The hostmicroenvironment plays important roles in cancer progression, but... 
CANCER-CELLS | MULTIPLE-MYELOMA | PROGENITOR CELLS | PROGNOSTIC-FACTORS | ALPHABETA | INTEGRIN | HEMATOPOIETIC STEM-CELLS | MICE | HEMATOLOGY | MINIMAL RESIDUAL DISEASE | OSTEOBLASTIC NICHE | Neoplasm, Residual - pathology | Osteopontin - genetics | Neoplasm Transplantation | Blast Crisis - drug therapy | Cytarabine - pharmacology | Neoplasm, Residual - metabolism | Osteopontin - antagonists & inhibitors | Humans | Child, Preschool | Tumor Microenvironment | Ki-67 Antigen - metabolism | Male | Transplantation, Heterologous | Osteopontin - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Bone Marrow - metabolism | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child | Cell Adhesion - genetics | Blast Crisis - pathology | Signal Transduction | Antibodies, Neutralizing - pharmacology | Cell Adhesion - drug effects | Mice, SCID | Neoplasm, Residual - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Osteoblasts - pathology | Drug Resistance, Neoplasm - genetics | Animals | Ki-67 Antigen - genetics | Bone Marrow - pathology | Blast Crisis - genetics | Mice | Blast Crisis - metabolism | Osteoblasts - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus | Abridged Index Medicus | Plenary Paper
Journal Article
Leukemia, ISSN 0887-6924, 04/2017, Volume 31, Issue 10, pp. 2065 - 2074
Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent beta-catenin activation, remain formidable... 
CHRONIC MYELOGENOUS LEUKEMIA | LONG-TERM | AML | ONCOLOGY | WNT/BETA-CATENIN | MASS CYTOMETRY | HEMATOPOIETIC STEM-CELLS | IMATINIB | SELF-RENEWAL | DIFFERENTIATION | HEMATOLOGY | CML STEM | RNA, Small Interfering - genetics | Blast Crisis - drug therapy | Coculture Techniques | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Mesenchymal Stromal Cells - cytology | Leukemia, Myeloid, Accelerated Phase - pathology | RNA Interference | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Female | Pyrimidinones - pharmacology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Leukemia, Myeloid, Accelerated Phase - drug therapy | Blast Crisis - pathology | Neoplasm Proteins - biosynthesis | Pyrimidinones - therapeutic use | Pyrimidines - pharmacology | Random Allocation | Mice, SCID | beta Catenin - genetics | Mice, Knockout | Drug Synergism | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrimidines - therapeutic use | beta Catenin - antagonists & inhibitors | Fusion Proteins, bcr-abl - antagonists & inhibitors | Mice, Inbred NOD | Drug Resistance, Neoplasm - drug effects | Index Medicus | Original
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2007, Volume 117, Issue 9, pp. 2408 - 2421
Blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph1-positive) acute lymphocytic leukemia (ALL) are 2 fatal... 
MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | POLYMERASE-CHAIN-REACTION | ABL TYROSINE KINASE | ACUTE LYMPHOBLASTIC-LEUKEMIA | BCR-ABL | IMMUNOSUPPRESSIVE AGENT | FUSION GENE | PROTEIN PHOSPHATASE 2A | TUMOR-GROWTH | CHRONIC MYELOID-LEUKEMIA | Phosphorylation | Blast Crisis - drug therapy | Humans | Phosphoprotein Phosphatases - metabolism | Gene Expression Regulation, Neoplastic | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Time Factors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Propylene Glycols - therapeutic use | Molecular Structure | Tumor Cells, Cultured | Protein Phosphatase 2 | Cell Survival - drug effects | Dasatinib | Blast Crisis - pathology | Fingolimod Hydrochloride | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - genetics | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Propylene Glycols - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Sphingosine - therapeutic use | Blast Crisis - genetics | Mice | Thiazoles - pharmacology | Benzamides | Blast Crisis - metabolism | Fusion Proteins, bcr-abl - metabolism | Sphingosine - chemistry | Drug Resistance, Neoplasm - drug effects | Enzyme inhibitors | Analysis | Leukemia | Philadelphia chromosome | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2007, Volume 109, Issue 8, pp. 3207 - 3213
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 10/2009, Volume 114, Issue 18, pp. 3909 - 3916
Understanding how the immune system in patients with cancer interacts with malignant cells is critical for the development of successful immunotherapeutic...