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Cell Stem Cell, ISSN 1934-5909, 06/2016, Volume 18, Issue 6, pp. 769 - 781
Leber congenital amaurosis (LCA) is an inherited retinal dystrophy that causes childhood blindness. Photoreceptors are especially sensitive to an intronic... 
RETINAL DEGENERATION | JOUBERT-SYNDROME | CELLS | LEBER CONGENITAL AMAUROSIS | TRANSITION ZONE | MUTATION | GENES | LINKED RETINITIS-PIGMENTOSA | CEP290 | CENTROSOMAL PROTEIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Leber Congenital Amaurosis - pathology | Optic Disk - cytology | Retinal Pigment Epithelium - metabolism | Humans | Blindness - pathology | Male | Organogenesis - drug effects | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Retinal Pigment Epithelium - pathology | Retinal Pigment Epithelium - ultrastructure | RNA Splicing - genetics | Antigens, Neoplasm - metabolism | Cilia - drug effects | Inheritance Patterns - genetics | Blindness - therapy | Induced Pluripotent Stem Cells - cytology | Neoplasm Proteins - genetics | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Retinal Pigment Epithelium - drug effects | rab GTP-Binding Proteins - metabolism | Antigens, Neoplasm - genetics | RNA Splicing - drug effects | Photoreceptor Cells, Vertebrate - ultrastructure | Induced Pluripotent Stem Cells - drug effects | RNA, Messenger - genetics | Exons - genetics | Fibroblasts - pathology | Cilia - metabolism | Eye Proteins - metabolism | Cell Differentiation - drug effects | Fibroblasts - drug effects | Morpholinos - pharmacology | Opsins - metabolism | Photoreceptor Cells, Vertebrate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173301 - e0173301
We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-17A, IL-6 and IL-23, in protein and mRNA levels and their... 
TEARS | INTERLEUKIN-17 | SIGNS | MULTIDISCIPLINARY SCIENCES | PATHOGENIC T(H)17 CELLS | SYMPTOMS | DIAGNOSTIC-TESTS | DIFFERENTIATION | SJOGREN-SYNDROME | Biomarkers - metabolism | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Sjogren's Syndrome - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Conjunctiva - metabolism | Cornea - metabolism | Interleukin-17 - metabolism | Interleukin-23 - metabolism | Th17 Cells - metabolism | Dry Eye Syndromes - metabolism | Female | Aged | Interleukin-6 - metabolism | Fluorescein - metabolism | Eye diseases | Care and treatment | Genetic aspects | Research | Interleukins | Gene expression | Pathogenesis | Chains (polymeric) | Assaying | Metastases | Eye | Proteins | Signal transduction | Histopathology | Surgery | Classification | Tubes | Eye (anatomy) | Breakup | Bioindicators | Diagnosis | Public health | Antigens | Bovine serum albumin | Evaluation | Cytokines | Interleukin 12 | Time measurement | Epithelium | Patients | Interleukin 17 | Studies | Hospitals | Biomarkers | Collection | Infiltration | Colitis | Cornea | Sjogren's syndrome | Conferences | Transforming growth factor-b | Glands | Antibodies | Staining | Clinical trials | Scoring | mRNA | Infections | Tissues | Inflammatory diseases | Interleukin 6 | Biomedical materials | Lymphocytes | Rodents | Quality | Interleukin 1 | Tumor necrosis factor-TNF | Children | Rubber | Interleukin 8 | Hypertension | Desiccants | Diabetes mellitus | Inflammation | Evaporation | Chronic fatigue syndrome | CD4 antigen | Blindness | In vivo methods and tests | Differentiation | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e58000 - e58000
Corneal endothelial dysfunctions occurring in patients with Fuchs' endothelial corneal dystrophy, pseudoexfoliation syndrome, corneal endotheliitis, and... 
ALLOGRAFT-REJECTION | KERATOPLASTY | TO-MESENCHYMAL TRANSITION | ROCK INHIBITOR | PRIMATE | VIVO | MULTIDISCIPLINARY SCIENCES | AQUEOUS-HUMOR | RABBIT MODEL | AMNIOTIC MEMBRANE | TRANSPLANTATION | Collagen Type I - metabolism | Signal Transduction | Endothelial Cells - metabolism | Fibroblasts - physiology | Humans | Cells, Cultured | Cornea - physiology | Regenerative Medicine - methods | Cornea - metabolism | Endothelium, Corneal - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Phenotype | Animals | Receptors, Transforming Growth Factor beta - metabolism | Bone Morphogenetic Protein 7 - metabolism | Primates | Transforming Growth Factor beta - antagonists & inhibitors | Cell Membrane - metabolism | Wound Healing - physiology | Zonula Occludens-1 Protein - metabolism | Transforming Growth Factor beta - metabolism | Fibroblasts - metabolism | Cell culture | Cornea | Animal models | Transparency | Collagen (type I) | Transforming growth factor-b | Grain cultivation | Transplantation | Fibronectin | Regeneration (physiology) | Proteins | Engineering | Rodents | Cell cycle | Inhibition | Localization | Growth factors | Expansion | Biomedical engineering | Cultivation | Na+/K+-exchanging ATPase | Monkeys & apes | Zonula occludens-1 protein | Endothelial cells | Endothelium | Medicine | Regeneration | Signaling | Inhibitors | Corneal dystrophy | Blindness | Monolayers | Dystrophy | Prostate | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e94313 - e94313
Age-related macular degeneration (AMD) is the most prevalent cause of blindness in the elderly, and its exsudative subtype critically depends on local... 
DENDRITIC CELLS | MICROGLIA | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | BLOOD-VESSELS | MONOCYTES | MACULAR DEGENERATION | RECEPTOR | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | AGE | Microglia - metabolism | Vascular Endothelial Growth Factor A - biosynthesis | Retina - metabolism | Macular Degeneration - immunology | Dendritic Cells - immunology | Choroidal Neovascularization - etiology | CD11c Antigen - metabolism | Choroidal Neovascularization - pathology | Choroid - pathology | Dendritic Cells - metabolism | Macrophages - immunology | Disease Models, Animal | Lasers - adverse effects | Choroid - metabolism | Endothelial Cells - metabolism | Immunophenotyping | Phagocytes - metabolism | Phagocytes - immunology | Endothelial Cells - immunology | Macular Degeneration - metabolism | Macrophages - metabolism | Phenotype | Receptors, CCR2 - metabolism | Animals | Intracellular Space - metabolism | Mice | CD11b Antigen - metabolism | Macular Degeneration - pathology | Elderly people | CC chemokine receptors | Flow cytometry | Animal models | Retina | Leukocytes (mononuclear) | Kinases | Macrophages | Vascularization | Recruitment | Macular degeneration | Phagocytes | Immunology | CCR2 protein | Lasers | Eye (anatomy) | Degeneration | Vascular endothelial growth factor | Age | Dendritic cells | Astrocytes | Gene expression | Endothelial cells | Microglia | Cytometry | Monocytes | Blindness | Photoreceptors | Elderly | Chemokines | Monocyte chemoattractant protein 1 | Geriatrics | Index Medicus
Journal Article
Acta Histochemica, ISSN 0065-1281, 01/2017, Volume 119, Issue 1, pp. 1 - 9
Diabetic retinopathy is a common complication of type 2 diabetes and the leading cause of blindness in adults of working age. The aim of this work was to study... 
Immunohistochemistry | Diabetic retinopathy | Meriones shawi | Cone photoreceptors loss | High fat diet | CALCIUM-BINDING PROTEINS | IMMUNOREACTIVITY | RAT RETINA | GLIAL REACTIVITY | CALRETININ | CELL BIOLOGY | SAND RAT | DISEASE | ANIMAL-MODELS | RETINOPATHY | EXPRESSION | Glial Fibrillary Acidic Protein - genetics | Microglia - metabolism | Calcium - metabolism | Amacrine Cells - pathology | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Experimental - genetics | Amacrine Cells - metabolism | Diet, High-Fat - adverse effects | Parvalbumins - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | Diabetic Retinopathy - pathology | Retinal Rod Photoreceptor Cells - metabolism | Glial Fibrillary Acidic Protein - metabolism | Rhodopsin - metabolism | Obesity - genetics | Gliosis - pathology | Retinal Cone Photoreceptor Cells - pathology | Microglia - pathology | Parvalbumins - genetics | Obesity - etiology | Microfilament Proteins - metabolism | Diabetic Retinopathy - etiology | Calbindin 2 - genetics | Diabetes Mellitus, Experimental - metabolism | Microfilament Proteins - genetics | Gliosis - etiology | Gene Expression | Gliosis - genetics | Calbindin 2 - metabolism | Gliosis - metabolism | Diabetic Retinopathy - metabolism | Diabetic Retinopathy - genetics | Obesity - metabolism | Obesity - pathology | Animals | Diabetes Mellitus, Experimental - etiology | Rhodopsin - genetics | Gerbillinae | Retinal Rod Photoreceptor Cells - cytology | Diabetes Mellitus, Experimental - pathology | Diabetes Mellitus, Type 2 - pathology | Blood Glucose - metabolism | Retinal Cone Photoreceptor Cells - metabolism | Type 2 diabetes | Enzymes | Rhodopsin | Diet therapy | Analysis | Body weight | Blindness | Glucose | Dextrose | Target marketing | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 12/2017, Volume 552, Issue 7684, pp. 248 - 252
Diabetic retinopathy is an important cause of blindness in adults(1,2), and is characterized by progressive loss of vascular cells and slow dissolution of... 
BLOOD-RETINAL BARRIER | ACID | ANGIOGENESIS | CHOLESTEROL | STABILITY | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | DEPENDENT ENDOCYTOSIS | MEMBRANES | VE-CADHERIN | ASSOCIATION | Retina - drug effects | Retina - metabolism | Cadherins - metabolism | Pericytes - drug effects | Humans | Capillary Permeability - drug effects | Male | Diabetic Retinopathy - pathology | Antigens, CD - metabolism | Vitreous Body - metabolism | Pericytes - pathology | Retina - enzymology | Intercellular Junctions - pathology | Female | Cell Membrane - drug effects | Disease Models, Animal | Ependymoglial Cells | Cell Survival - drug effects | Endothelial Cells - metabolism | Mice, Inbred C57BL | Solubility | Pancreatic Elastase - metabolism | Fatty Acids, Unsaturated - metabolism | Diabetic Retinopathy - metabolism | Disease Progression | Cell Movement - drug effects | Diabetic Retinopathy - prevention & control | Animals | Carrier Proteins - metabolism | Diabetic Retinopathy - enzymology | Intercellular Junctions - drug effects | Presenilin-1 - metabolism | Mice | Endothelial Cells - pathology | Epoxide Hydrolases - antagonists & inhibitors | Retina - pathology | Docosahexaenoic Acids - metabolism | Endothelial Cells - drug effects | Prevention | Physiological aspects | Enzymes | Diabetic retinopathy | Hydrolases | Epoxy compounds | Retinopathy | Pathogenesis | Cell junctions | Retina | Glial cells | Cell interactions | Kinases | Docosahexaenoic acid | Epoxide hydrolase | Vascularization | Proteins | Signal transduction | Hyperglycemia | N-Cadherin | Rodents | Inhibition | Growth factors | Edema | Abnormalities | Diabetes mellitus | Permeability | Cadherin | Cholesterol | Endothelial cells | Acids | Presenilin 1 | Nitric oxide | Blindness | Vitreous humour | Adults | Infiltration | Diabetes | Staphylococcal enterotoxin H | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2958 - 16
Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional... 
SKELETAL-MUSCLE | NADPH OXIDASE | DOMINANT OPTIC ATROPHY | BACTERIAL CLEARANCE | FUSION | METABOLISM | MULTIDISCIPLINARY SCIENCES | DEGRANULATION | RELEASE | MITOCHONDRIAL-DNA | OPA1 MUTATIONS | Lung - microbiology | Neutrophils - cytology | Reactive Oxygen Species - metabolism | Extracellular Traps - metabolism | Humans | Actins - metabolism | Gene Expression Profiling | Electron Transport Complex I - metabolism | Glycolysis - physiology | Microtubules - metabolism | Mitochondria - genetics | Pseudomonas aeruginosa - pathogenicity | Adenosine Triphosphate - metabolism | Bone Marrow | Neutrophils - metabolism | GTP Phosphohydrolases - immunology | Mitochondria - metabolism | Immunity, Innate | Electron Transport Complex I - drug effects | Mice, Knockout | Mitochondrial Membranes - metabolism | Pseudomonas Infections - immunology | Animals | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Mice | Lung - immunology | Structural integrity | NADH-ubiquinone oxidoreductase | Optic nerve | Neutrophils | Leukocytes (neutrophilic) | Membrane proteins | Atrophy | Proteins | NAD | Electron transport chain | Mitochondria | Optic atrophy | Blindness | Glycolysis | Pseudomonas aeruginosa | Mutation | Electron transport | ATP | Immune system | Index Medicus
Journal Article
Aging Cell, ISSN 1474-9718, 04/2017, Volume 16, Issue 2, pp. 349 - 359
The dry (nonneovascular) form of age‐related macular degeneration ( AMD ), a leading cause of blindness in the elderly, has few, if any, treatment options at... 
lysosomes; mechanistic target of rapamycin | visual cycle proteins | transcription factors EB (TFEB) and E3 (TFE3) | amino acid transporter (PAT4/SLC36A4) | age‐related macular degeneration | coordinated lysosomal expression and regulation (CLEAR) network | mouse model | signal transduction | retinal pigmented epithelium (RPE) | complex 1 (mTORC1) | photoreceptor degeneration | age-related macular degeneration | CLEARANCE | RAG GTPASES | ATPASE | TFEB | mechanistic target of rapamycin | AUTOPHAGY | RPE65 | LYSOSOMAL BIOGENESIS | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | MTORC1 ACTIVATION | SENSES | DEGRADATION | lysosomes | Crystallins - metabolism | Retinal Pigment Epithelium - metabolism | Phosphorylation | Epithelial Cells - metabolism | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Retinal Photoreceptor Cell Outer Segment - metabolism | Visual Pathways - metabolism | Epithelial Cells - ultrastructure | Gene Regulatory Networks | Amino Acid Transport Systems - metabolism | Mechanistic Target of Rapamycin Complex 1 | Mice, Knockout | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Animals | Lysosomes - metabolism | Retinal Pigment Epithelium - ultrastructure | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cytosol - metabolism | Retinal Pigment Epithelium - cytology | Aging - metabolism | Macular degeneration | Analysis | Blindness | Development and progression | Amino acids | Cellular signal transduction | DNA binding proteins | Adenosine triphosphatase | TOR protein | H+-transporting ATPase | Transcription factors | Lecithin | Epithelial cells | Lysosomes | Retina | Rapamycin | Electron microscopy | Acyltransferase | Epithelium | Retinal pigment epithelium | Vitamin A | Crystallin | Retinal degeneration | Photoreceptors | Cytoplasm | Geriatrics | Index Medicus | amino acid transporter (PAT4 | Original | SLC36A4
Journal Article
Cellular Signalling, ISSN 0898-6568, 04/2013, Volume 25, Issue 4, pp. 829 - 838
Epithelial–mesenchymal transition (EMT), proliferation and migration of RPE cells characterize the development of proliferative vitreoretinopathy (PVR) and... 
mTOR | Thrombin | ERK1/2 | p70S6K | Akt | RPE cells | MTOR | P70S6K | MAMMALIAN TARGET | RISK-FACTORS | AKT/PKB | PHOSPHORYLATION | PROTEIN-KINASE | CANCER | CELL BIOLOGY | RICTOR-MTOR COMPLEX | DISEASE | MOLECULAR-MECHANISMS | Cyclin D1 - metabolism | Retinal Pigment Epithelium - metabolism | TOR Serine-Threonine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphoproteins - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 2 | Phosphoproteins - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Cyclin D1 - antagonists & inhibitors | Thrombin - pharmacology | RNA Interference | Regulatory-Associated Protein of mTOR | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Retinal Pigment Epithelium - drug effects | Cell Line | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Rats | Phosphoproteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cyclin D1 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Cell Proliferation - drug effects | RNA, Small Interfering | Retinal Pigment Epithelium - cytology | Mitogen-Activated Protein Kinase 1 - metabolism | Membrane lipids | Inositol | Synthesis | Epidermal growth factor | Platelet-derived growth factor | Glycogen | Stem cells | Blindness | Plant lipids | Personal video recorders | Index Medicus | Cellular | Phosphorylation | Migration | Activation | Gene expression | Signalling
Journal Article