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Journal Article
Circulation, ISSN 0009-7322, 07/2017, Volume 136, Issue 3, pp. 249 - 259
Journal Article
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, p. 1377
Journal Article
Journal Article
Circulation (New York, N.Y.), ISSN 0009-7322, 09/2016, Volume 134, Issue 10, pp. 752 - 772
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e30555
Background: Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM). Methods... 
SELECTIVE SGLT2 INHIBITOR | SODIUM | HOMEOSTASIS | HYPERGLYCEMIA | DAPAGLIFLOZIN | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | COTRANSPORTER | PROXIMAL TUBULAR CELLS | T-1095 | Thiophenes - therapeutic use | Diabetes Mellitus, Experimental - drug therapy | Humans | Body Weight - drug effects | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | Hyperglycemia - drug therapy | Sodium-Glucose Transporter 1 - genetics | Muscle, Skeletal - drug effects | Hyperglycemia - pathology | Sodium-Glucose Transport Proteins - metabolism | Glucosides - therapeutic use | Weight Gain - drug effects | Sodium-Glucose Transporter 1 - metabolism | Diabetes Mellitus, Experimental - metabolism | Kidney - physiopathology | Sodium-Glucose Transport Proteins - genetics | CHO Cells | Sodium-Glucose Transporter 2 - genetics | Cricetinae | Glucose Tolerance Test | Kidney - drug effects | Sodium-Glucose Transporter 2 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Rats | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hyperglycemia - metabolism | Rats, Zucker | Animals | Canagliflozin | Diabetes Mellitus, Experimental - pathology | Mice, Obese | Mice | Blood Glucose - metabolism | Type 2 diabetes | Glucose metabolism | Obesity | Blood sugar | Analysis | Body weight | Glycosylated hemoglobin | Diabetes therapy | Cell culture | Animal models | Renal function | Laboratories | Liver | Homeostasis | Fuel consumption | Diabetic neuropathy | Glucose | Oocytes | Hyperglycemia | Rodents | Hemoglobin | Glucose transporter | Excretion | Kidneys | Secretion | Research & development--R&D | Diabetes mellitus | Pharmacology | Insulin | Body weight gain | Myoblasts | Beta cells | Sodium | Weight reduction | Insulin resistance | Diabetes | Mutation | Transporter | Kidney transplantation | Pharmaceuticals | Research & development | R&D
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2016, Volume 65, Issue 5, pp. 1190 - 1195
Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release... 
INSULIN | KETOACIDOSIS | SGLT2 | ENDOCRINOLOGY & METABOLISM | Glucose Intolerance - metabolism | Glycosuria - chemically induced | Carbohydrate Metabolism - drug effects | Lipolysis - drug effects | Benzhydryl Compounds - administration & dosage | Humans | Glucagon-Like Peptide 1 - blood | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Glucagon - blood | Glucose Intolerance - blood | Glucose Intolerance - drug therapy | Benzhydryl Compounds - adverse effects | Hypoglycemic Agents - administration & dosage | Time Factors | Glucosides - therapeutic use | C-Reactive Protein - analysis | Benzhydryl Compounds - therapeutic use | Insulin Secretion | Glucosides - adverse effects | Hypoglycemic Agents - therapeutic use | 3-Hydroxybutyric Acid - blood | Sodium-Glucose Transporter 2 - metabolism | Glucose Intolerance - urine | 3-Hydroxybutyric Acid - agonists | Renal Elimination - drug effects | Sodium-Glucose Transporter 2 Inhibitors | Membrane Transport Modulators - administration & dosage | Diabetes Mellitus, Type 2 - urine | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Algorithms | Glucosides - administration & dosage | 3-Hydroxybutyric Acid - metabolism | Lipid Metabolism - drug effects | Membrane Transport Modulators - therapeutic use | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Membrane Transport Modulators - adverse effects | Hypoglycemic Agents - adverse effects | Energy Metabolism - drug effects | Type 2 diabetes | Care and treatment | Glucagon | Dosage and administration | Triglycerides | Research | Insulin
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 11/2009, Volume 297, Issue 5, pp. 1105 - 1114
Journal Article
Circulation, ISSN 0009-7322, 10/2017, Volume 136, Issue 17, pp. 1643 - 1658
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2012, Volume 165, Issue 5, pp. 1361 - 1374
.... Metabolic and hepatic effects of pentoxifylline were assessed in a murine model of obesity and type 2 diabetes... 
glucose | ChREBP | pentoxifylline | methylxanthine | fatty liver | drug‐induced liver injury | obesity | drug-induced liver injury | TRIGLYCERIDE TRANSFER PROTEIN | ELEMENT-BINDING PROTEIN | FACTOR-KAPPA-B | NONALCOHOLIC STEATOHEPATITIS | DIET-INDUCED OBESITY | PARTIAL LEPTIN DEFICIENCY | CYCLIC-AMP | IN-VIVO | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | METABOLIC-DISORDERS | Glucose Transporter Type 2 - genetics | Humans | Intestinal Absorption - drug effects | Male | Adipocytes - drug effects | Glycolysis - drug effects | Jejunum - metabolism | Glycolysis - genetics | Jejunum - drug effects | Inflammation - metabolism | Lipogenesis - genetics | Liver - drug effects | Pentoxifylline - pharmacology | Biomarkers - metabolism | Fatty Liver - metabolism | Liver - metabolism | Biomarkers - blood | Blood Glucose - drug effects | Cell Line, Tumor | Glucose - metabolism | Blood Glucose - genetics | Mice, Obese | Transaminases - blood | Mice | Oxidative Stress - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - genetics | Glucose Tolerance Test - methods | Diabetes Mellitus, Type 2 - metabolism | Obesity - genetics | Glucose Transporter Type 2 - metabolism | Sodium-Glucose Transporter 1 - genetics | Glycolysis - physiology | Lipids - blood | Sodium-Glucose Transporter 1 - metabolism | Nuclear Proteins - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | Fatty Liver - genetics | Mice, Inbred C57BL | Oxidative Stress - genetics | Glucose - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | Obesity - metabolism | Transcription Factors - metabolism | Animals | Intestinal Absorption - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adipocytes - metabolism | Lipogenesis - drug effects | Triglycerides - blood | Inflammation - genetics | Oxidative Stress | Biological Markers | Liver | Lipids | Adipocytes | Glucose | Intestinal Absorption | Life Sciences | Jejunum | Diabetes Mellitus, Type 2 | Lipogenesis | Pharmaceutical sciences | Obesity | Glucose Tolerance Test | Glucose Transporter Type 2 | Sodium-Glucose Transporter 1 | Blood Glucose | Inflammation | Triglycerides | Pharmacology | Nuclear Proteins | Pentoxifylline | Fatty Liver | Transaminases | Glycolysis | Transcription Factors | Sterol Regulatory Element Binding Protein 1 | Research Papers
Journal Article
Journal Article