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1989, ISBN 8716148347, Volume no. 49., 28
Book
Biophysical Journal, ISSN 0006-3495, 01/2015, Volume 108, Issue 2, pp. 39a - 39a
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1674, pp. 275 - 282
Coagulation factor VIII (FVIII) is an important glycoprotein involved in the extrinsic coagulation cascade. Mutations in FVIII gene results in hemophilia A, a... 
Selective reaction monitoring (SRM) | Coagulation factor VIII | Mass spectrometry | Hemophilia A | Glycoproteins - chemistry | Mass Spectrometry - methods | Factor VIII - chemistry | Quality Control | Index Medicus
Journal Article
Haemophilia, ISSN 1351-8216, 03/2019, Volume 25, Issue 2, pp. e86 - e93
Background In a previous smaller study, we found evidence of a diminished global coagulation capacity after maximal exercise in patients with severe... 
MODERATE | FIBRINOLYSIS | THROMBIN GENERATION | BLOOD-COAGULATION | PHARMACOKINETICS | STRENUOUS EXERCISE | HEMOPHILIA-A | PARAMETERS | HEMATOLOGY | VON-WILLEBRAND-FACTOR | HEMOSTASIS | Exercise | Hemophilia | Blood coagulation factors | Coagulation factors | Statistical analysis | Von Willebrand factor | Coagulation | Thrombin | Coagulation factor VIII | Index Medicus
Journal Article
by Sabater-Lleal, Maria and Huffman, Jennifer E and de Vries, Paul S and Marten, Jonathan and Mastrangelo, Michael A and Song, Ci and Pankratz, Nathan and Ward-Caviness, Cavin K and Yanek, Lisa R and Trompet, Stella and Delgado, Graciela E and Guo, Xiuqing and Bartz, Traci M and Martinez-Perez, Angel and Germain, Marine and de Haan, Hugoline G and Ozel, Ayse B and Polasek, Ozren and Smith, Albert V and Eicher, John D and Reiner, Alex P and Tang, Weihong and Davies, Neil M and Stott, David J and Rotter, Jerome I and Tofler, Geoffrey H and Boerwinkle, Eric and de Maat, Moniek P.M and Kleber, Marcus E and Welsh, Paul and Brody, Jennifer A and Chen, Ming-Huei and Vaidya, Dhananjay and Soria, José Manuel and Suchon, Pierre and van Hylckama Vlieg, Astrid and Desch, Karl C and Kolcic, Ivana and Joshi, Peter K and Launer, Lenore J and Harris, Tamara B and Campbell, Harry and Rudan, Igor and Becker, Diane M and Li, Jun Z and Rivadeneira, Fernando and Uitterlinden, André G and Hofman, Albert and Franco, Oscar H and Cushman, Mary and Psaty, Bruce M and Morange, Pierre-Emmanuel and McKnight, Barbara and Chong, Michael R and Fernandez-Cadenas, Israel and Rosand, Jonathan and Lindgren, Arne and Gudnason, Vilmundur and Wilson, James F and Hayward, Caroline and Ginsburg, David and Fornage, Myriam and Rosendaal, Frits R and Souto, Juan Carlos and Becker, Lewis C and Jenny, Nancy S and März, Winfried and Jukema, J Wouter and Dehghan, Abbas and Trégouët, David-Alexandre and Morrison, Alanna C and Johnson, Andrew D and O’Donnell, Christopher J and Strachan, David P and Lowenstein, Charles J and Smith, Nicholas L and INVENT Consortium MEGASTROKE Cons and INVENT Consortium; MEGASTROKE Consortium of the International Stroke Genetics Consortium (ISGC)
Circulation, ISSN 0009-7322, 01/2019, Volume 139, Issue 5, pp. 620 - 635
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 129, Issue 2, pp. 501 - 509.e5
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0183590 - e0183590
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 02/2017, Volume 15, Issue 2, pp. 329 - 340
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49481 - e49481
Animal models of the bleeding disorder, hemophilia A, have been an integral component of the biopharmaceutical development process and have facilitated the... 
HIGH-LEVEL EXPRESSION | PROTEIN | MULTIDISCIPLINARY SCIENCES | HEMOPHILIA-A MICE | ENDOTHELIAL-CELLS | SUBUNIT DISSOCIATION | GENE-THERAPY | PORCINE FACTOR-VIII | SECRETION | TRANSPLANTATION | MOLECULES | Protein Structure, Tertiary | Recombinant Proteins - therapeutic use | Cell Line | Sequence Deletion | Cricetinae | Humans | Mice, Inbred C57BL | Protein Multimerization | Factor VIII - chemistry | Factor VIII - isolation & purification | Recombinant Proteins - chemistry | Recombinant Proteins - biosynthesis | Sheep, Domestic - metabolism | Polysaccharides - metabolism | Recombinant Proteins - isolation & purification | Animals | Proteolysis | Protein Binding | Mice | Thrombin - metabolism | Hemophilia A - drug therapy | Factor VIII - biosynthesis | Factor VIII - therapeutic use | von Willebrand Factor - metabolism | Blood coagulation factors | Gene therapy | Hemophilia | Protein binding | Bioengineering | Pediatrics | Plasma | Animal models | Intravenous administration | Syngeneic grafts | Pathogenesis | Coagulation | Thrombin | Immunity | Bleeding | Infusion | Von Willebrand factor | Immunity (humoral) | Intravenous infusion | Recombinant | Immunoglobulins | Decay rate | Stability | Kidneys | Research & development--R&D | Invasiveness | Cloning | Radioactive half-life | Glycosylation | Coagulation factors | Medicine | Mutagenesis | Immunogenicity | Stem cells | Sheep | Mutation | Blood diseases | Coagulation factor VIII | Kidney transplantation | Cancer | Pharmaceuticals | Index Medicus | Research & development | R&D
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 04/2017, Volume 15, Issue 4, pp. 709 - 720
Background Production of recombinant factor VIII (FVIII) is challenging because of its low expression. It was previously shown that codon-optimization of a... 
coagulation factor VIII | hemophilia A | von Willebrand factor | lentivirus | LRP1 protein, human | B-DOMAIN | RECOMBINANT FACTOR-VIII | VON-WILLEBRAND-FACTOR | MAMMALIAN-CELLS | LRP1 protein