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Neuron, ISSN 0896-6273, 01/2015, Volume 85, Issue 2, pp. 296 - 302
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2454 - 2468
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed.... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | NEURITE OUTGROWTH | NITRIC-OXIDE SYNTHASE | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | VASCULAR-PERMEABILITY | ENDOTHELIAL GROWTH-FACTOR | HUMAN GLIOBLASTOMA-MULTIFORME | Membrane Glycoproteins - metabolism | Humans | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Occludin | Brain - metabolism | Inflammation - metabolism | Nitric Oxide Synthase Type III - metabolism | Demyelinating Diseases | Multiple Sclerosis - metabolism | Interleukin-1beta - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Nuclear Proteins - metabolism | Permeability | Blood-Brain Barrier - metabolism | Membrane Glycoproteins - genetics | Membrane Proteins | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Lymphocytes - pathology | Animals | Brain - pathology | Multiple Sclerosis - pathology | Mice | Primary Cell Culture | Vascular Endothelial Growth Factor A - physiology | Astrocytes - metabolism | Physiological aspects | Central nervous system diseases | Research | Blood-brain barrier | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7323, pp. 557 - 561
Journal Article
Journal Article
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 05/2016, Volume 53, Issue 4, pp. 2451 - 2467
Elevated plasma total homocysteine (Hcy) level is associated with an increased risk of Alzheimer's disease (AD). During transsulfuration pathways, Hcy is... 
Cerebrovascular pathology | COGNITIVE PERFORMANCE | NEUROSCIENCES | MATRIX METALLOPROTEINASES | INDUCED MEMORY IMPAIRMENT | RISK-FACTOR | Blood-brain barrier dysfunction | RECEPTOR TRAFFICKING | MATRIX-METALLOPROTEINASE-9 | RAT-BRAIN | Homocysteine | Alzheimer's disease | PLASMA HOMOCYSTEINE | EXPRESSION | Dementia | Memory - drug effects | Glial Fibrillary Acidic Protein - genetics | Cadherins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Blood-Brain Barrier - physiopathology | Claudin-5 - metabolism | Microvessels - pathology | Male | Synapses - pathology | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Matrix Metalloproteinase 9 - metabolism | Cadherins - genetics | Synapses - drug effects | Alzheimer Disease - physiopathology | Hydrogen Sulfide - pharmacology | Cerebrovascular Circulation - drug effects | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Alzheimer Disease - drug therapy | Microvessels - drug effects | Claudin-5 - genetics | Cystathionine beta-Synthase - metabolism | Permeability | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Blood-Brain Barrier - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Hydrogen Sulfide - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Intercellular Adhesion Molecule-1 - genetics | Avoidance Learning - drug effects | Alzheimer Disease - genetics | Dizocilpine Maleate - pharmacology | Hydrogen sulfide | Methyl aspartate | Brain | RNA | Neurons | Intermediate filament proteins | Index Medicus | cerebrovascular pathology | dementia | blood brain barrier dysfunction
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 6/2015, Volume 32, Issue 6, pp. 2003 - 2014
The blood–brain barrier (BBB) essentially restricts therapeutic drugs from entering into the brain. This study tests the hypothesis that brain endothelial cell... 
Biochemistry, general | Biomedical Engineering | Biomedicine | blood–brain barrier | Pharmacy | Medical Law | brain cancer | drug delivery | zebrafish | Pharmacology/Toxicology | exosome | blood-brain barrier | SYSTEM | CELLS | HPLC METHOD | MODEL | CHEMISTRY, MULTIDISCIPLINARY | TRANSPORT | PHARMACOLOGY & PHARMACY | NANOVESICLES | Exosomes - metabolism | Paclitaxel - metabolism | Neoplasm Transplantation | Capillary Permeability | Paclitaxel - pharmacology | Humans | Brain Neoplasms - pathology | Doxorubicin - chemistry | Green Fluorescent Proteins - genetics | Brain Neoplasms - metabolism | Antineoplastic Agents - metabolism | Paclitaxel - chemistry | Endocytosis | Heterografts | Time Factors | Antineoplastic Agents - pharmacology | Doxorubicin - metabolism | Genes, Reporter | Disease Models, Animal | Animals, Genetically Modified | Endothelial Cells - metabolism | Brain Neoplasms - genetics | Technology, Pharmaceutical - methods | Zebrafish | Antineoplastic Agents - chemistry | Brain Neoplasms - drug therapy | Chemistry, Pharmaceutical | Blood-Brain Barrier - metabolism | Particle Size | Animals | Tumor Burden - drug effects | Green Fluorescent Proteins - biosynthesis | Cell Line, Tumor | Cell Proliferation - drug effects | Drug Delivery Systems - methods | Doxorubicin - pharmacology | Drugs | Drug delivery systems | Analysis | Brain cancer | Animal genetic engineering | Health aspects | Membrane proteins | Vehicles | Chemotherapy | Pharmacology | Blood-brain barrier | Index Medicus
Journal Article
Neurochemistry International, ISSN 0197-0186, 2009, Volume 54, Issue 3, pp. 253 - 263
Blood–brain barrier (BBB) characteristics are induced and maintained by cross-talk between brain microvessel endothelial cells and neighbouring elements of the... 
Astrocytes | Pericytes | In vitro BBB model (rat) | Tight junction | Transendothelial electrical resistance | Co-culture | P-Glycoprotein | Drug permeability | Blood–brain barrier | Brain endothelial cells | Blood-brain barrier | DRUG | PERMEABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGIOPOIETIN-1 | INDUCTION | GLIAL-CELLS | NEUROSCIENCES | MESSENGER-RNA | IN-VITRO MODEL | CULTURES | EXPRESSION | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pericytes - ultrastructure | Phosphoproteins - metabolism | Blood-Brain Barrier - ultrastructure | Occludin | Microcirculation - physiology | Endothelial Cells - ultrastructure | Membrane Proteins - metabolism | Capillaries - metabolism | Rhodamine 123 - pharmacokinetics | Tight Junctions - metabolism | Microscopy, Electron, Transmission | Capillaries - ultrastructure | Endothelial Cells - metabolism | Pericytes - metabolism | Cells, Cultured | Rats | Claudin-5 | Cerebral Arteries - ultrastructure | Membrane Potentials - physiology | Blood-Brain Barrier - metabolism | Astrocytes - ultrastructure | Tight Junctions - ultrastructure | Animals | Carrier Proteins - metabolism | Zonula Occludens-1 Protein | Cell Membrane Permeability - physiology | Cerebral Arteries - metabolism | Models, Biological | Cell Membrane Permeability - drug effects | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Astrocytes - metabolism | Proteins | Drug resistance in microorganisms | Brain | Fluorescein | Physiological aspects | Glucose | Universities and colleges | Permeability | Dextrose | Endothelium | Index Medicus
Journal Article