International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 11/2009, Volume 41, Issue 11, pp. 2302 - 2314
Bisphenol A, an estrogenic environmental toxicant, has been implicated to have hazardous effects on reproductive health in humans and rodents. However, there...
Testis | Anchoring junction | Bisphenol A | Spermatogenesis | Seminiferous epithelial cycle | Tight junction | Sertoli cells | PERMEABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXICITY | JUNCTIONAL COMPLEX | ENDOCYTOSIS | SERTOLI-CELL | CELL BIOLOGY | SEMINIFEROUS EPITHELIUM | MICROFILAMENTS | CADMIUM CHLORIDE | PROTEINS | Rats, Wistar | Phenols - toxicity | Aging - drug effects | Body Weight - drug effects | Blood-Testis Barrier - pathology | Blood-Testis Barrier - ultrastructure | Immunoblotting | Male | Sertoli Cells - pathology | Sertoli Cells - drug effects | Sertoli Cells - ultrastructure | Cell Membrane - metabolism | Membrane Proteins - metabolism | Cell Death - drug effects | Cell Membrane - drug effects | Tight Junctions - drug effects | Sertoli Cells - metabolism | Tight Junctions - metabolism | Spermatogenesis - drug effects | Permeability - drug effects | Benzhydryl Compounds | Cells, Cultured | Rats | Cell Membrane - ultrastructure | Rats, Sprague-Dawley | Aging - pathology | Tight Junctions - ultrastructure | Organ Size - drug effects | Animals | Models, Biological | Cell Communication - drug effects | Fluorescent Antibody Technique | Blood-Testis Barrier - drug effects | Proteins | Phenols | Bisphenol-A | Analysis | Index Medicus | anchoring junction | spermatogenesis | seminiferous epithelial cycle | bisphenol A | tight junction
Testis | Anchoring junction | Bisphenol A | Spermatogenesis | Seminiferous epithelial cycle | Tight junction | Sertoli cells | PERMEABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXICITY | JUNCTIONAL COMPLEX | ENDOCYTOSIS | SERTOLI-CELL | CELL BIOLOGY | SEMINIFEROUS EPITHELIUM | MICROFILAMENTS | CADMIUM CHLORIDE | PROTEINS | Rats, Wistar | Phenols - toxicity | Aging - drug effects | Body Weight - drug effects | Blood-Testis Barrier - pathology | Blood-Testis Barrier - ultrastructure | Immunoblotting | Male | Sertoli Cells - pathology | Sertoli Cells - drug effects | Sertoli Cells - ultrastructure | Cell Membrane - metabolism | Membrane Proteins - metabolism | Cell Death - drug effects | Cell Membrane - drug effects | Tight Junctions - drug effects | Sertoli Cells - metabolism | Tight Junctions - metabolism | Spermatogenesis - drug effects | Permeability - drug effects | Benzhydryl Compounds | Cells, Cultured | Rats | Cell Membrane - ultrastructure | Rats, Sprague-Dawley | Aging - pathology | Tight Junctions - ultrastructure | Organ Size - drug effects | Animals | Models, Biological | Cell Communication - drug effects | Fluorescent Antibody Technique | Blood-Testis Barrier - drug effects | Proteins | Phenols | Bisphenol-A | Analysis | Index Medicus | anchoring junction | spermatogenesis | seminiferous epithelial cycle | bisphenol A | tight junction
Journal Article
FASEB Journal, ISSN 0892-6638, 04/2016, Volume 30, Issue 4, pp. 1436 - 1452
Earlier studies have shown that rats treated with an acute dose of 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide (adjudin, a male contraceptive under...
Tight junction | Actin microfilaments | Seminiferous epithelial cycle | Spermatogenesis | Gap junction | GAP-JUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERTOLI-CELLS | RAT TESTIS | PROTEIN COMPLEX | CELL BIOLOGY | SEMINIFEROUS EPITHELIUM | ADHESION | BIOLOGY | spermatogenesis | CELL-SPECIFIC KNOCKOUT | seminiferous epithelial cycle | gap junction | F-ACTIN ORGANIZATION | actin microfilaments | tight junction | ECTOPLASMIC SPECIALIZATION | Testis - metabolism | Spermatogenesis - genetics | Gene Expression - drug effects | Immunoblotting | Male | Sertoli Cells - drug effects | Spermatogonia - metabolism | Testis - drug effects | Connexin 43 - genetics | Sertoli Cells - metabolism | Spermatogonia - drug effects | Spermatids - metabolism | Spermatogenesis - drug effects | Hydrazines - pharmacology | Connexin 43 - metabolism | Testis - cytology | Blood-Testis Barrier - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Mice, Knockout | Indazoles - pharmacology | Meiosis - genetics | Animals | Spermatids - drug effects | Blood-Testis Barrier - drug effects | Microscopy, Fluorescence | Index Medicus | Research Communication
Tight junction | Actin microfilaments | Seminiferous epithelial cycle | Spermatogenesis | Gap junction | GAP-JUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERTOLI-CELLS | RAT TESTIS | PROTEIN COMPLEX | CELL BIOLOGY | SEMINIFEROUS EPITHELIUM | ADHESION | BIOLOGY | spermatogenesis | CELL-SPECIFIC KNOCKOUT | seminiferous epithelial cycle | gap junction | F-ACTIN ORGANIZATION | actin microfilaments | tight junction | ECTOPLASMIC SPECIALIZATION | Testis - metabolism | Spermatogenesis - genetics | Gene Expression - drug effects | Immunoblotting | Male | Sertoli Cells - drug effects | Spermatogonia - metabolism | Testis - drug effects | Connexin 43 - genetics | Sertoli Cells - metabolism | Spermatogonia - drug effects | Spermatids - metabolism | Spermatogenesis - drug effects | Hydrazines - pharmacology | Connexin 43 - metabolism | Testis - cytology | Blood-Testis Barrier - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Mice, Knockout | Indazoles - pharmacology | Meiosis - genetics | Animals | Spermatids - drug effects | Blood-Testis Barrier - drug effects | Microscopy, Fluorescence | Index Medicus | Research Communication
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 03/2011, Volume 208, Issue 3, pp. 207 - 223
The blood-testis barrier (BTB), which is created by adjacent Sertoli cells near the basement membrane, serves as a 'gatekeeper' to prohibit harmful substances...
NORMAL HUMAN-TISSUES | BREAST-CANCER | BRAIN-BARRIER | ORGANIC ANION TRANSPORTER | HUMAN LUNG-CANCER | ENDOCRINOLOGY & METABOLISM | MALE GERM-CELLS | CENTRAL-NERVOUS-SYSTEM | MULTIDRUG-RESISTANCE PROTEIN | BINDING-CASSETTE TRANSPORTER | P-GLYCOPROTEIN | Sertoli Cells - metabolism | Spermatogenesis - drug effects | Testis - metabolism | Blood-Testis Barrier - metabolism | Seminiferous Epithelium - drug effects | Humans | Seminiferous Epithelium - metabolism | Membrane Transport Proteins - drug effects | Rats | Male | Spermatozoa - metabolism | Spermatozoa - drug effects | Sertoli Cells - drug effects | Animals | Blood-Testis Barrier - drug effects | Mice | Index Medicus
NORMAL HUMAN-TISSUES | BREAST-CANCER | BRAIN-BARRIER | ORGANIC ANION TRANSPORTER | HUMAN LUNG-CANCER | ENDOCRINOLOGY & METABOLISM | MALE GERM-CELLS | CENTRAL-NERVOUS-SYSTEM | MULTIDRUG-RESISTANCE PROTEIN | BINDING-CASSETTE TRANSPORTER | P-GLYCOPROTEIN | Sertoli Cells - metabolism | Spermatogenesis - drug effects | Testis - metabolism | Blood-Testis Barrier - metabolism | Seminiferous Epithelium - drug effects | Humans | Seminiferous Epithelium - metabolism | Membrane Transport Proteins - drug effects | Rats | Male | Spermatozoa - metabolism | Spermatozoa - drug effects | Sertoli Cells - drug effects | Animals | Blood-Testis Barrier - drug effects | Mice | Index Medicus
Journal Article
Toxicology, ISSN 0300-483X, 2016, Volume 373, pp. 1 - 12
Highlights • PFOS triggers activation of p38/ATF2 in vivo and in vitro. • PFOS perturbs the balance between MMP9 and TIMP1 in mice testes. • Activation of...
Emergency | Activating transcription factor 2 | Perfluorooctane sulfonate | Blood-testis barrier | Matrix metalloproteinase 9 | Tissue inhibitor of metalloproteinase 1 | p38 MAPK signaling pathway | OXIDATIVE STRESS | MOUSE | MALE-MICE | METALLOPROTEINASES | HUMAN SEMEN QUALITY | SERTOLI-CELL | INHIBITION | SERUM-LEVELS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DYSFUNCTION | EXPOSURE | Activating Transcription Factor 2 - drug effects | Immunohistochemistry | Fluorocarbons - toxicity | Sperm Count | Tight Junction Proteins - drug effects | Connexin 43 - drug effects | Body Weight - drug effects | Male | Mice, Inbred ICR | Sertoli Cells - drug effects | Gene Knockdown Techniques | Dose-Response Relationship, Drug | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | MAP Kinase Signaling System - drug effects | Matrix Metalloproteinase 9 - drug effects | Occludin - drug effects | Alkanesulfonic Acids - toxicity | Blood-Testis Barrier - drug effects | Mice | Surface active agents | Index Medicus | Proteins | Pathways | Reproductive disorders | Sulfonates | Permeability | Inhibition | Kinases | Males
Emergency | Activating transcription factor 2 | Perfluorooctane sulfonate | Blood-testis barrier | Matrix metalloproteinase 9 | Tissue inhibitor of metalloproteinase 1 | p38 MAPK signaling pathway | OXIDATIVE STRESS | MOUSE | MALE-MICE | METALLOPROTEINASES | HUMAN SEMEN QUALITY | SERTOLI-CELL | INHIBITION | SERUM-LEVELS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DYSFUNCTION | EXPOSURE | Activating Transcription Factor 2 - drug effects | Immunohistochemistry | Fluorocarbons - toxicity | Sperm Count | Tight Junction Proteins - drug effects | Connexin 43 - drug effects | Body Weight - drug effects | Male | Mice, Inbred ICR | Sertoli Cells - drug effects | Gene Knockdown Techniques | Dose-Response Relationship, Drug | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | MAP Kinase Signaling System - drug effects | Matrix Metalloproteinase 9 - drug effects | Occludin - drug effects | Alkanesulfonic Acids - toxicity | Blood-Testis Barrier - drug effects | Mice | Surface active agents | Index Medicus | Proteins | Pathways | Reproductive disorders | Sulfonates | Permeability | Inhibition | Kinases | Males
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 49, pp. 19623 - 19628
The blood—testis barrier (BTB), one of the tightest blood—tissue barriers in the mammalian body, creates an immune-privileged site for postmeiotic spermatid...
Phosphorylation | Pumps | Small interfering RNA | Antibodies | Cultured cells | Physiological regulation | Epithelium | Automobiles | Sertoli cells | Metrorrhagia | Male contraception | Seminiferous epithelial cycle | Basal ectoplasmic specialization | SPERMATOGENESIS | basal ectoplasmic specialization | RAT | MULTIDISCIPLINARY SCIENCES | MOUSE | MODEL | DEFICIENCY | BRAIN-BARRIER | DRUG TRANSPORTERS | DISRUPTION | male contraception | seminiferous epithelial cycle | TIGHT | Immunoblotting | Male | Protein Transport - drug effects | Phosphoproteins - metabolism | Sertoli Cells - drug effects | Occludin | RNA Interference | Protein Binding - drug effects | Membrane Proteins - metabolism | Sertoli Cells - metabolism | Hydrazines - pharmacology | Blood-Testis Barrier - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Endocytosis - drug effects | Rats | Rats, Sprague-Dawley | Indazoles - pharmacology | Microscopy, Confocal | Animals | Zonula Occludens-1 Protein | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Blood-Testis Barrier - drug effects | Kinetics | Primary Cell Culture | ATP Binding Cassette Transporter, Sub-Family B - genetics | Testis | Measurement | Cell adhesion | Physiological aspects | Glycoproteins | Research | Permeability | Properties | Cells | Biological Sciences
Phosphorylation | Pumps | Small interfering RNA | Antibodies | Cultured cells | Physiological regulation | Epithelium | Automobiles | Sertoli cells | Metrorrhagia | Male contraception | Seminiferous epithelial cycle | Basal ectoplasmic specialization | SPERMATOGENESIS | basal ectoplasmic specialization | RAT | MULTIDISCIPLINARY SCIENCES | MOUSE | MODEL | DEFICIENCY | BRAIN-BARRIER | DRUG TRANSPORTERS | DISRUPTION | male contraception | seminiferous epithelial cycle | TIGHT | Immunoblotting | Male | Protein Transport - drug effects | Phosphoproteins - metabolism | Sertoli Cells - drug effects | Occludin | RNA Interference | Protein Binding - drug effects | Membrane Proteins - metabolism | Sertoli Cells - metabolism | Hydrazines - pharmacology | Blood-Testis Barrier - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Endocytosis - drug effects | Rats | Rats, Sprague-Dawley | Indazoles - pharmacology | Microscopy, Confocal | Animals | Zonula Occludens-1 Protein | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Blood-Testis Barrier - drug effects | Kinetics | Primary Cell Culture | ATP Binding Cassette Transporter, Sub-Family B - genetics | Testis | Measurement | Cell adhesion | Physiological aspects | Glycoproteins | Research | Permeability | Properties | Cells | Biological Sciences
Journal Article
Archives of Toxicology, ISSN 0340-5761, 4/2016, Volume 90, Issue 4, pp. 971 - 983
Perfluorooctanoic acid (PFOA) is correlated with male reproductive dysfunction in animals and humans, but the underlying mechanisms for this remain unknown. To...
Biomedicine | Environmental Health | Perfluorooctanoic acid | Occupational Medicine/Industrial Medicine | Male infertility | JNK | Transforming growth factor β3 | Pharmacology/Toxicology | Biomedicine general | p38 MAPK inhibitor | NATIONAL BIRTH COHORT | HUMAN SEMEN QUALITY | TIGHT JUNCTION | SERTOLI-CELL | FACTOR-ALPHA | PROTEIN COMPLEX | TUMOR-NECROSIS-FACTOR | Transforming growth factor beta 3 | REPRODUCTIVE DYSFUNCTION | INTERFERON-GAMMA | PERFLUORINATED CHEMICALS | TOXICOLOGY | Tumor Necrosis Factor-alpha - metabolism | Fluorocarbons - toxicity | Caprylates - toxicity | Male | Sertoli Cells - drug effects | Testis - drug effects | Pregnancy | Animals | Signal Transduction - drug effects | Testis - immunology | Fertility - drug effects | Female | Blood-Testis Barrier - drug effects | Mice, Inbred BALB C | p38 Mitogen-Activated Protein Kinases - metabolism | Blood-Testis Barrier - physiology | Index Medicus
Biomedicine | Environmental Health | Perfluorooctanoic acid | Occupational Medicine/Industrial Medicine | Male infertility | JNK | Transforming growth factor β3 | Pharmacology/Toxicology | Biomedicine general | p38 MAPK inhibitor | NATIONAL BIRTH COHORT | HUMAN SEMEN QUALITY | TIGHT JUNCTION | SERTOLI-CELL | FACTOR-ALPHA | PROTEIN COMPLEX | TUMOR-NECROSIS-FACTOR | Transforming growth factor beta 3 | REPRODUCTIVE DYSFUNCTION | INTERFERON-GAMMA | PERFLUORINATED CHEMICALS | TOXICOLOGY | Tumor Necrosis Factor-alpha - metabolism | Fluorocarbons - toxicity | Caprylates - toxicity | Male | Sertoli Cells - drug effects | Testis - drug effects | Pregnancy | Animals | Signal Transduction - drug effects | Testis - immunology | Fertility - drug effects | Female | Blood-Testis Barrier - drug effects | Mice, Inbred BALB C | p38 Mitogen-Activated Protein Kinases - metabolism | Blood-Testis Barrier - physiology | Index Medicus
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 2011, Volume 43, Issue 4, pp. 651 - 665
During spermatogenesis, extensive junction restructuring takes place at the blood–testis barrier (BTB) and the Sertoli cell–spermatid interface known as the...
Testis | Apical ectoplasmic specialization | c-Yes | Spermatogenesis | Seminiferous epithelial cycle | Cell adhesion | Blood–testis barrier | Blood-testis barrier | TUBULOBULBAR COMPLEXES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN COMPLEX | CELL BIOLOGY | IN-VITRO | ADHERENS JUNCTION DYNAMICS | GERM-CELLS | GROWTH | CONTRACEPTIVE DEVELOPMENT | SERTOLI TIGHT JUNCTION | SRC FAMILY KINASES | Seminiferous Epithelium - drug effects | Male | Adherens Junctions - metabolism | Sertoli Cells - drug effects | Actin Cytoskeleton - drug effects | Sertoli Cells - cytology | Spermatids - cytology | Indoles - pharmacology | Sertoli Cells - metabolism | Transforming Growth Factor beta3 - pharmacology | Spermatids - metabolism | Spermatogenesis - drug effects | Hydrazines - pharmacology | Actin Cytoskeleton - metabolism | Proto-Oncogene Proteins c-yes - metabolism | Blood-Testis Barrier - metabolism | Endocytosis - drug effects | Gene Expression Regulation, Developmental - drug effects | Seminiferous Epithelium - metabolism | Rats | Cell Adhesion - drug effects | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Clathrin - metabolism | Indazoles - pharmacology | Animals | Adherens Junctions - drug effects | Seminiferous Epithelium - cytology | Spermatids - drug effects | Blood-Testis Barrier - drug effects | Proteins | Phosphorylation | Inhibitors | Filaments | Barriers | Company structure | Kinases | Epithelium | blood-testis barrier | cell adhesion | spermatogenesis | seminiferous epithelial cycle | apical ectoplasmic specialization
Testis | Apical ectoplasmic specialization | c-Yes | Spermatogenesis | Seminiferous epithelial cycle | Cell adhesion | Blood–testis barrier | Blood-testis barrier | TUBULOBULBAR COMPLEXES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN COMPLEX | CELL BIOLOGY | IN-VITRO | ADHERENS JUNCTION DYNAMICS | GERM-CELLS | GROWTH | CONTRACEPTIVE DEVELOPMENT | SERTOLI TIGHT JUNCTION | SRC FAMILY KINASES | Seminiferous Epithelium - drug effects | Male | Adherens Junctions - metabolism | Sertoli Cells - drug effects | Actin Cytoskeleton - drug effects | Sertoli Cells - cytology | Spermatids - cytology | Indoles - pharmacology | Sertoli Cells - metabolism | Transforming Growth Factor beta3 - pharmacology | Spermatids - metabolism | Spermatogenesis - drug effects | Hydrazines - pharmacology | Actin Cytoskeleton - metabolism | Proto-Oncogene Proteins c-yes - metabolism | Blood-Testis Barrier - metabolism | Endocytosis - drug effects | Gene Expression Regulation, Developmental - drug effects | Seminiferous Epithelium - metabolism | Rats | Cell Adhesion - drug effects | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Clathrin - metabolism | Indazoles - pharmacology | Animals | Adherens Junctions - drug effects | Seminiferous Epithelium - cytology | Spermatids - drug effects | Blood-Testis Barrier - drug effects | Proteins | Phosphorylation | Inhibitors | Filaments | Barriers | Company structure | Kinases | Epithelium | blood-testis barrier | cell adhesion | spermatogenesis | seminiferous epithelial cycle | apical ectoplasmic specialization
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 08/2016, Volume 94, pp. 103 - 111
Fluoride and sulfur dioxide (SO ), two well-known environmental toxicants, have been implicated to have adverse effects on male reproductive health in humans...
Testis | Sperm quality | Fluoride | Blood-testis barrier | Sulfur dioxide | PROTEIN | FOOD SCIENCE & TECHNOLOGY | KINASE | RATS | POLLUTION | SO2 | DYNAMICS | TOXICOLOGY | Reproduction - drug effects | Microscopy, Electron, Transmission | Animals | Sodium Fluoride - toxicity | Sulfur Dioxide - toxicity | Blood-Testis Barrier - ultrastructure | Male | Blood-Testis Barrier - drug effects | Mice | Proteins | Contraceptives | RNA | Air pollution | Fluorides | Cells | Index Medicus
Testis | Sperm quality | Fluoride | Blood-testis barrier | Sulfur dioxide | PROTEIN | FOOD SCIENCE & TECHNOLOGY | KINASE | RATS | POLLUTION | SO2 | DYNAMICS | TOXICOLOGY | Reproduction - drug effects | Microscopy, Electron, Transmission | Animals | Sodium Fluoride - toxicity | Sulfur Dioxide - toxicity | Blood-Testis Barrier - ultrastructure | Male | Blood-Testis Barrier - drug effects | Mice | Proteins | Contraceptives | RNA | Air pollution | Fluorides | Cells | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 238, Issue 3, pp. 240 - 249
Cadmium (Cd) is an environmental toxicant and an endocrine disruptor in humans and rodents. Several organs (e.g., kidney, liver) are affected by Cd and recent...
Testis | Cadmium | Germ cells | Spermatogenesis | Seminiferous epithelial cycle | Infertility | Cell adhesion | Blood–testis barrier | Environmental toxicant | Sertoli cells | Cancer | Blood-testis barrier | OXIDATIVE STRESS | JUNCTION DYNAMICS | PRIMARY RAT SERTOLI | MALE CONTRACEPTIVE DEVELOPMENT | E-CADHERIN | METALLOTHIONEIN GENE-EXPRESSION | MOUSE TESTES | INTERSTITIAL-CELLS | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Metallothionein - metabolism | Spermatogenesis - drug effects | Testis - metabolism | Endocrine Disruptors - metabolism | Cadmium - toxicity | Blood-Testis Barrier - metabolism | Humans | Male | Cadmium - metabolism | Environmental Pollutants - metabolism | Testis - drug effects | Endocrine Disruptors - toxicity | Animals | Testis - pathology | Signal Transduction - drug effects | Cation Transport Proteins - metabolism | Blood-Testis Barrier - drug effects | Environmental Pollutants - toxicity | Infertility, Male - chemically induced | Protein kinases | Heavy metals | Index Medicus | HUMAN POPULATIONS | HEAVY METALS | METALLOTHIONEIN | RODENTS | ZINC IONS | NEOPLASMS | CALCIUM IONS | SPERMATOZOA | TESTES | TOXICITY | 60 APPLIED LIFE SCIENCES | KIDNEYS | MERCURY | CADMIUM | LIVER | MEN | BLOOD | LEAD | blood-testis barrier | cell adhesion | spermatogenesis | cadmium | seminiferous epithelial cycle | cancer | testis | infertility | germ cells
Testis | Cadmium | Germ cells | Spermatogenesis | Seminiferous epithelial cycle | Infertility | Cell adhesion | Blood–testis barrier | Environmental toxicant | Sertoli cells | Cancer | Blood-testis barrier | OXIDATIVE STRESS | JUNCTION DYNAMICS | PRIMARY RAT SERTOLI | MALE CONTRACEPTIVE DEVELOPMENT | E-CADHERIN | METALLOTHIONEIN GENE-EXPRESSION | MOUSE TESTES | INTERSTITIAL-CELLS | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Metallothionein - metabolism | Spermatogenesis - drug effects | Testis - metabolism | Endocrine Disruptors - metabolism | Cadmium - toxicity | Blood-Testis Barrier - metabolism | Humans | Male | Cadmium - metabolism | Environmental Pollutants - metabolism | Testis - drug effects | Endocrine Disruptors - toxicity | Animals | Testis - pathology | Signal Transduction - drug effects | Cation Transport Proteins - metabolism | Blood-Testis Barrier - drug effects | Environmental Pollutants - toxicity | Infertility, Male - chemically induced | Protein kinases | Heavy metals | Index Medicus | HUMAN POPULATIONS | HEAVY METALS | METALLOTHIONEIN | RODENTS | ZINC IONS | NEOPLASMS | CALCIUM IONS | SPERMATOZOA | TESTES | TOXICITY | 60 APPLIED LIFE SCIENCES | KIDNEYS | MERCURY | CADMIUM | LIVER | MEN | BLOOD | LEAD | blood-testis barrier | cell adhesion | spermatogenesis | cadmium | seminiferous epithelial cycle | cancer | testis | infertility | germ cells
Journal Article
Endocrinology, ISSN 0013-7227, 10/2012, Volume 153, Issue 10, pp. 5036 - 5048
During spermatogenesis, preleptotene spermatocytes residing near the basement membrane of the seminiferous tubule must traverse the blood-testis barrier (BTB)...
MAMMALIAN TARGET | SPERMATOGENESIS | SEMINIFEROUS EPITHELIUM | IN-VITRO | RAT | SERTOLI-CELL MONOLAYERS | CADMIUM CHLORIDE | GROWTH | ENDOCRINOLOGY & METABOLISM | 2-COMPARTMENT CULTURE | TRANSEPITHELIAL ELECTRICAL-RESISTANCE | Sertoli Cells - metabolism | Tight Junctions - metabolism | Spermatogenesis - drug effects | Hydrazines - pharmacology | Blood-Testis Barrier - metabolism | Actins - metabolism | Rats | Male | Protein Transport - physiology | Permeability | Rats, Sprague-Dawley | Sertoli Cells - drug effects | Indazoles - pharmacology | Spermatogenesis - physiology | Animals | Signal Transduction - drug effects | Ribosomal Protein S6 - metabolism | Signal Transduction - physiology | Blood-Testis Barrier - drug effects | Tight Junctions - drug effects | Reproduction-Development
MAMMALIAN TARGET | SPERMATOGENESIS | SEMINIFEROUS EPITHELIUM | IN-VITRO | RAT | SERTOLI-CELL MONOLAYERS | CADMIUM CHLORIDE | GROWTH | ENDOCRINOLOGY & METABOLISM | 2-COMPARTMENT CULTURE | TRANSEPITHELIAL ELECTRICAL-RESISTANCE | Sertoli Cells - metabolism | Tight Junctions - metabolism | Spermatogenesis - drug effects | Hydrazines - pharmacology | Blood-Testis Barrier - metabolism | Actins - metabolism | Rats | Male | Protein Transport - physiology | Permeability | Rats, Sprague-Dawley | Sertoli Cells - drug effects | Indazoles - pharmacology | Spermatogenesis - physiology | Animals | Signal Transduction - drug effects | Ribosomal Protein S6 - metabolism | Signal Transduction - physiology | Blood-Testis Barrier - drug effects | Tight Junctions - drug effects | Reproduction-Development
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 324 - 335
Poor antiretroviral drug (ARV) penetration in the testes could be due, in part, to the presence of ATP-binding cassette (ABC) membrane-associated drug efflux...
Testis - metabolism | Receptors, Steroid - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Humans | Male | Receptors, Steroid - antagonists & inhibitors | Neoplasm Proteins - metabolism | Receptors, Steroid - agonists | Sertoli Cells - drug effects | Testis - drug effects | RNA Interference | Seminiferous Tubules - metabolism | Multidrug Resistance-Associated Proteins - genetics | ATP Binding Cassette Transporter, Subfamily B - genetics | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Sertoli Cells - metabolism | Cell Line | Blood-Testis Barrier - metabolism | Mice, Inbred C57BL | ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics | Anti-Retroviral Agents - pharmacology | Recombinant Proteins - chemistry | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | ATP Binding Cassette Transporter, Subfamily B - metabolism | Anti-Retroviral Agents - metabolism | Orchiectomy | Gene Expression Regulation - drug effects | Animals | Receptors, Steroid - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Ligands | Blood-Testis Barrier - drug effects | Mice | Pregnane X Receptor | Seminiferous Tubules - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Testis - metabolism | Receptors, Steroid - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Humans | Male | Receptors, Steroid - antagonists & inhibitors | Neoplasm Proteins - metabolism | Receptors, Steroid - agonists | Sertoli Cells - drug effects | Testis - drug effects | RNA Interference | Seminiferous Tubules - metabolism | Multidrug Resistance-Associated Proteins - genetics | ATP Binding Cassette Transporter, Subfamily B - genetics | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Sertoli Cells - metabolism | Cell Line | Blood-Testis Barrier - metabolism | Mice, Inbred C57BL | ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics | Anti-Retroviral Agents - pharmacology | Recombinant Proteins - chemistry | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | ATP Binding Cassette Transporter, Subfamily B - metabolism | Anti-Retroviral Agents - metabolism | Orchiectomy | Gene Expression Regulation - drug effects | Animals | Receptors, Steroid - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Ligands | Blood-Testis Barrier - drug effects | Mice | Pregnane X Receptor | Seminiferous Tubules - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Toxicology Letters, ISSN 0378-4274, 01/2017, Volume 266, pp. 1 - 12
Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is required for spermatogenesis. Exposure to particulate matter (PM) is...
Testis | Fine particulate matter | Blood-testis barrier | Male infertility | SPERMATOGENESIS | OXIDATIVE STRESS | CELL-ADHESION | SEMEN QUALITY | TIGHT JUNCTION STRANDS | SEMINIFEROUS EPITHELIUM | AIR-POLLUTION | IN-VIVO | CIGARETTE-SMOKE | TOXICOLOGY | HUMAN-SPERM | Immunohistochemistry | Particulate Matter - toxicity | Cells, Cultured | Rats | Male | Rats, Sprague-Dawley | Sertoli Cells - drug effects | Epididymis - physiology | Sertoli Cells - physiology | Animals | Blood-Testis Barrier - drug effects | Epididymis - drug effects | Infertility, Male - chemically induced | Apoptosis | Polyvinylidene fluoride | Horticultural industry | Analysis | Leukemia | Air pollution | Superoxide | DNA binding proteins | Index Medicus | Spermatogenesis | Barriers | Markers | Sod | Exposure | Males | Injuries
Testis | Fine particulate matter | Blood-testis barrier | Male infertility | SPERMATOGENESIS | OXIDATIVE STRESS | CELL-ADHESION | SEMEN QUALITY | TIGHT JUNCTION STRANDS | SEMINIFEROUS EPITHELIUM | AIR-POLLUTION | IN-VIVO | CIGARETTE-SMOKE | TOXICOLOGY | HUMAN-SPERM | Immunohistochemistry | Particulate Matter - toxicity | Cells, Cultured | Rats | Male | Rats, Sprague-Dawley | Sertoli Cells - drug effects | Epididymis - physiology | Sertoli Cells - physiology | Animals | Blood-Testis Barrier - drug effects | Epididymis - drug effects | Infertility, Male - chemically induced | Apoptosis | Polyvinylidene fluoride | Horticultural industry | Analysis | Leukemia | Air pollution | Superoxide | DNA binding proteins | Index Medicus | Spermatogenesis | Barriers | Markers | Sod | Exposure | Males | Injuries
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2009, Volume 23, Issue 8, pp. 2555 - 2567
In the seminiferous epithelium, Eps8 is localized to actin-based cell junctions at the blood-testis barrier (BTB) and the apical ectoplasmic specialization...
Germ cells | Actin | Spermatogenesis | Actin dynamics | Sertoli cells | KINASE PATHWAY | JUNCTION DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE TESTES | RAT TESTIS | SERTOLI-CELL | CELL BIOLOGY | actin | IN-VIVO | BIOLOGY | spermatogenesis | actin dynamics | TISSUE INHIBITOR | ADHERENS JUNCTIONS | germ cells | ECTOPLASMIC SPECIALIZATION | Seminiferous Epithelium - drug effects | Actins - metabolism |
Germ cells | Actin | Spermatogenesis | Actin dynamics | Sertoli cells | KINASE PATHWAY | JUNCTION DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE TESTES | RAT TESTIS | SERTOLI-CELL | CELL BIOLOGY | actin | IN-VIVO | BIOLOGY | spermatogenesis | actin dynamics | TISSUE INHIBITOR | ADHERENS JUNCTIONS | germ cells | ECTOPLASMIC SPECIALIZATION | Seminiferous Epithelium - drug effects | Actins - metabolism |