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1. Full Text Non-mulberry silk fibroin grafted poly (Є-caprolactone)/nano hydroxyapatite nanofibrous scaffold for dual growth factor delivery to promote bone regeneration
by Bhattacharjee, Promita and Naskar, Deboki and Maiti, Tapas K and Bhattacharya, Debasis and Kundu, Subhas C
Journal of Colloid And Interface Science, ISSN 0021-9797, 06/2016, Volume 472, pp. 16 - 33
This study aims at developing biodegradable, mineralized, nanofibrous scaffolds for use in bone regeneration. Scaffolds are loaded with combinations of bone... 
Nonmulberry silk fibroin | Poly (Є-caprolactone) | Bone tissue engineering | Aminolysis | Growth factor | Poly (Ie-caprolactone) | Bone Morphogenetic Protein 2 - pharmacology | Nanofibers - chemistry | Bone Regeneration - drug effects | Cell Line | Nanofibers - ultrastructure | Fibroins - chemistry | Bombyx - chemistry | Humans | Osteoblasts - drug effects | Osteogenesis - drug effects | Delayed-Action Preparations - chemistry | Durapatite - chemistry | Drug Delivery Systems | Tissue Scaffolds - chemistry | Polyesters - chemistry | Transforming Growth Factor beta - pharmacology | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Transforming Growth Factor beta - administration & dosage | Osteoblasts - cytology | Osteoblasts - metabolism | Tissue Engineering | Silk | Restaurants | Bone morphogenetic proteins | Transforming growth factors | Cell differentiation | Tissue engineering | Biomedical materials | Electrospinning | Bones | In vitro testing | Nanostructure | Scaffolds | Grafting | Growth factors
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2. Full Text Silk fibroin sponges with cell growth‐promoting activity induced by genetically fused basic fibroblast growth factor
by Kambe, Yusuke and Kojima, Katsura and Tamada, Yasushi and Tomita, Naohide and Kameda, Tsunenori
Journal of Biomedical Materials Research Part A, ISSN 1549-3296, 01/2016, Volume 104, Issue 1, pp. 82 - 93
Transgenic silkworm technology has enabled the biological properties of silk fibroin protein to be altered by fusion to recombinant bioactive proteins.... 
transgenic technology | cell proliferation | scaffold | basic fibroblast growth factor | silk fibroin | TRANSGENIC SILKWORMS | MATERIALS SCIENCE, BIOMATERIALS | CHONDROCYTES | ENGINEERING, BIOMEDICAL | STABILIZATION | REGENERATION | QUANTIFICATION | ADHESIVE FORCE | BOMBYX-MORI SILK | POROUS 3-D STRUCTURE | BIOMATERIALS | PROTEINS | NIH 3T3 Cells | Rabbits | Chondrocytes - cytology | Cartilage, Articular - cytology | Electrophoresis, Polyacrylamide Gel | Humans | Cells, Cultured | Fibroblast Growth Factor 2 - pharmacology | Fibroins - pharmacology | Genetic Vectors - metabolism | Blotting, Western | Bombyx | Chondrocytes - drug effects | Animals | Genetic Engineering | Fibroblasts - drug effects | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Porifera - chemistry | Silk | Fibroblast growth factors | Genetic engineering | Tissue engineering | Genetically modified organisms | Proteins | Silk fibroin | Transgenic | Fibroblasts | Sponges | Biological | Silkworms | Recombinant
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3. Full Text Insulin-like growth factor (IGF)-like peptide and 20-hydroxyecdysone regulate the growth and development of the male genital disk through different mechanisms in the silkmoth, Bombyx mori
by Fujinaga, Daiki and Kohmura, Yusuke and Okamoto, Naoki and Kataoka, Hiroshi and Mizoguchi, Akira
Insect Biochemistry and Molecular Biology, ISSN 0965-1748, 08/2017, Volume 87, pp. 35 - 44
It is well established that ecdysteroids play pivotal roles in the regulation of insect molting and metamorphosis. However, the mechanisms by which... 
Bombyx mori | Adult development | Genital disk | Cell signaling pathway | IGF-like peptide | 20-hydroxyecdysone | PROTHORACICOTROPIC HORMONE | MANDUCA-SEXTA | WING IMAGINAL DISKS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | SILKWORM | ENTOMOLOGY | DROSOPHILA | ECDYSONE | PROGRAMMED CELL-DEATH | PROTEIN-COUPLED RECEPTOR | Bombyx - growth & development | Ecdysterone - pharmacology | Signal Transduction | Tissue Culture Techniques | Male | Bombyx - drug effects | Somatomedins - pharmacology | Animals | Peptides - metabolism | Genitalia, Male - growth & development | Genitalia, Male - drug effects | Female | Hemolymph - chemistry | Insect Proteins - metabolism | Cellular signal transduction | Ecdysone | Peptides | Analysis
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4. Full Text Enhancing Mechanical Properties of Silk Fibroin Hydrogel through Restricting the Growth of β‑Sheet Domains
by Su, Dihan and Yao, Meng and Liu, Jie and Zhong, Yiming and Chen, Xin and Shao, Zhengzhong
ACS Applied Materials & Interfaces, ISSN 1944-8244, 05/2017, Volume 9, Issue 20, pp. 17489 - 17498
Usually, regenerated silk fibroin (RSF) hydrogels cross-linked by chemical agents such as horseradish peroxide (HRP)/H2O2 perform elastic properties, while... 
Research | tough hydrogel | double networks | nanofibrils | regenerated silk fibroin | restricted network | BOMBYX-MORI-SILK | HIGH-STRENGTH | MATERIALS SCIENCE, MULTIDISCIPLINARY | CROSS-LINKING | NANOSCIENCE & NANOTECHNOLOGY | PROTEIN-BASED HYDROGELS | FIBERS | SPECTROSCOPY | ROBUST | FTIR | DOUBLE-NETWORK HYDROGELS | TOUGH | Fibroins - chemistry | Silk | Hydrogels | Protein Conformation, beta-Strand | Hydrogen Peroxide
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5. Full Text Application of insulin signaling to predict insect growth rate in Maruca vitrata (Lepidoptera: Crambidae)
by Al Baki, Md Abdullah and Al Baki, Md. Abdullah and Jung, Jin Kyo and Maharjan, Rameswor and Yi, Hwijong and Ahn, Jeong Joon and Ahn, Jeong Joon and Gu, Xiaojun and Gu, Xiaojun and Kim, Yonggyun and Kim, Yonggyun
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, p. e0204935
Insect growth is influenced by two major environmental factors: temperature and nutrient. These environmental factors are internally mediated by... 
PROTHORACICOTROPIC HORMONE | AMINO-ACID-SEQUENCE | BOMBYX-MORI | PEPTIDES | EVOLUTION | LEGUME POD BORER | MULTIDISCIPLINARY SCIENCES | SECRETION | IDENTIFICATION | EXPRESSION | DROSOPHILA | Metamorphosis | Lepidoptera | Research | TOR protein | Larvae | Temperature | Populations | Growth rate | Peptides | Genes | AKT protein | Kinases | Growth models | Proteins | Rural development | Temperature effects | Forkhead protein | Nutrients | Growth factors | Insect migration | Legumes | Crop science | Threonine | RNA-mediated interference | Rapamycin | Environmental factors | Regression analysis | Metabolism | Gene expression | Ribonucleic acid--RNA | Insulin | Weight | Environmental conditions | Nutrition research | Insects | Protein kinase | Growth patterns | Larval development | RNA | Ribonucleic acid
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6. Full Text Genetically engineered bi-functional silk material with improved cell proliferation and anti-inflammatory activity for medical application
by Wang, Feng and Wang, Fan and Wang, Riyuan and Wang, Yuancheng and Xu, Sheng and Chen, Wenjing and Hou, Kai and Tian, Chi and Yu, Ling and Lu, Zhisong and Zhao, Ping and Xia, Qingyou
Acta Biomaterialia, ISSN 1742-7061, 03/2019, Volume 86, pp. 148 - 157
Functional silk is a promising material for future medical applications. These include fabrication of diverse silk fiber and silk protein-regenerated... 
Binary-functional silk | Genetic engineering | Human basic fibroblast growth factor | Human transforming growth factor-β1 | Silkworm | H-CHAIN | MATERIALS SCIENCE, BIOMATERIALS | SECRETES RECOMBINANT PROTEINS | ENGINEERING, BIOMEDICAL | FIBROBLAST-GROWTH-FACTOR | TRANSGENIC SILKWORM | MONOCLONAL-ANTIBODY | SERICIN LAYER | FIBROIN | BOMBYX-MORI | GENE | Human transforming growth factor-beta 1 | EXPRESSION | Proteins | Silk | Biological products | Anti-inflammatory drugs | Genetically modified organisms | Growth factors | Fibers | Cell proliferation | Fibroblast growth factor | Smad protein | Hydrogels | Toxicity | Transforming growth factor | Genes | Macrophages | Biomaterials | Lipopolysaccharides | Fabrication | Biomedical materials | Cell growth | Sutures | Biocompatibility | Chemical composition | Fibroblast growth factor 2 | Reconstruction | Antiinflammatory agents | Wound healing | Tissue engineering | Extracellular signal-regulated kinase | Mechanical properties | Inflammation | Mechanical tests | Silkworms | Regeneration | Medical materials | Index Medicus
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7. Full Text The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, Bombyx mori
by Zeng, Baosheng and Huang, Yuping and Xu, Jun and Shiotsuki, Takahiro and Bai, Hua and Palli, Subba Reddy and Huang, Yongping and Tan, Anjiang
Journal of Biological Chemistry, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11659 - 11669
Forkhead box O (FOXO) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many... 
LIFE-SPAN | FAT-BODY | CELLS | INSULIN-RECEPTOR | DROSOPHILA-MELANOGASTER | PATHWAY | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIZE | METAMORPHOSIS | ESTERASE | Ecdysterone - pharmacology | Hydrolysis - drug effects | Juvenile Hormones - chemistry | Male | Promoter Regions, Genetic - drug effects | Bombyx - metabolism | Enzyme Induction - drug effects | Female | Carboxylic Ester Hydrolases - genetics | Insect Proteins - metabolism | Metamorphosis, Biological - drug effects | Forkhead Box Protein O1 - metabolism | Molting - drug effects | Bombyx - growth & development | Animals, Genetically Modified | Juvenile Hormones - metabolism | Gene Expression Regulation, Developmental - drug effects | Methoprene - pharmacology | Insect Proteins - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Bombyx - drug effects | Epoxide Hydrolases - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Response Elements - drug effects | Animals | CRISPR-Cas Systems | Epoxide Hydrolases - metabolism | Mutation | Forkhead Box Protein O1 - genetics | Carboxylic Ester Hydrolases - metabolism | FOXO | CRISPR | development | juvenile hormone (JH) | insulin | JHE | Bombyx mori | Cas9 | Developmental Biology
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8. Full Text Dual growth factor loaded nonmulberry silk fibroin/carbon nanofiber composite 3D scaffolds for in vitro and in vivo bone regeneration
by Naskar, Deboki and Ghosh, Ananta K and Mandal, Mahitosh and Das, Piyali and Nandi, Samit K and Kundu, Subhas C
Biomaterials, ISSN 0142-9612, 2017, Volume 136, pp. 67 - 85
Abstract In recent years the potential application of nanocomposite biomaterials in tissue engineering field is gaining importance because of the combined... 
Advanced Basic Science | Dentistry | Carbon nanofiber | Nonmulberry silk fibroin | Bone tissue engineering | Composite sponge | Growth factors TGF-β1 BMP-2 | Compressive modulus | DEFECTS | MATERIALS SCIENCE, BIOMATERIALS | COLLAGEN | Growth factors TGF-beta 1 BMP-2 | ENGINEERING, BIOMEDICAL | OSTEOGENESIS | HYDROXYAPATITE | CARBON NANOTUBES | DELIVERY | REPAIR | RABBITS | BIOMATERIALS | DIFFERENTIATION | Bone Morphogenetic Protein 2 - pharmacology | Nanofibers - chemistry | Bone Regeneration - drug effects | Cell Line | Mesenchymal Stromal Cells - drug effects | Rabbits | Fibroins - chemistry | Transforming Growth Factor beta1 - administration & dosage | Tissue Engineering - methods | Humans | Osteoblasts - drug effects | Delayed-Action Preparations - chemistry | Male | Materials Testing | Recombinant Proteins - pharmacology | Bombyx | Recombinant Proteins - administration & dosage | Tissue Scaffolds - chemistry | Mesenchymal Stromal Cells - cytology | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Female | Osteoblasts - cytology | Transforming Growth Factor beta1 - pharmacology | Silk | Biological products | Tissue engineering | Analysis | Stem cells | Bone morphogenetic proteins | Transforming growth factors
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9. Full Text Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold
by Farokhi, Mehdi and Mottaghitalab, Fatemeh and Ai, Jafar and Shokrgozar, Mohammad Ali
International Journal of Pharmaceutics, ISSN 0378-5173, 09/2013, Volume 454, Issue 1, pp. 216 - 225
To exploit the therapeutic potential of growth factors in tissue regeneration, it is necessary to design a porous scaffold in order to concurrently accommodate... 
Bone tissue engineering | Silk/calcium phosphate/PLGA | PDGF | VEGF | Controlled release | MOLECULAR-WEIGHT | ANGIOGENESIS | MICROSPHERES | HYALURONIC-ACID | SILK FIBROIN CONFORMATION | IN-VITRO | BOMBYX-MORI SILK | BETA-TCP | BONE REGENERATION | PHARMACOLOGY & PHARMACY | DRUG-DELIVERY SYSTEMS | Neovascularization, Physiologic - drug effects | Proto-Oncogene Proteins c-sis - chemistry | Humans | Vascular Endothelial Growth Factor A - metabolism | Spectroscopy, Fourier Transform Infrared | Drug Carriers | Tissue Scaffolds | Vascular Endothelial Growth Factor A - chemistry | Time Factors | X-Ray Diffraction | Spectrum Analysis, Raman | Proto-Oncogene Proteins c-sis - pharmacology | Vascular Endothelial Growth Factor A - pharmacology | Rabbits | Microscopy, Electron, Scanning | Lactic Acid - chemistry | Tissue Engineering - methods | Proto-Oncogene Proteins c-sis - metabolism | Osteoblasts - drug effects | Osteogenesis - drug effects | Cells, Cultured | Freeze Drying | Solubility | Calcium Phosphates - chemistry | Technology, Pharmaceutical - methods | Chemistry, Pharmaceutical | Animals | Nanocomposites | Polyglycolic Acid - chemistry | Porosity | Osteoblasts - metabolism | Powder Diffraction | Delayed-Action Preparations | Silk - chemistry | Endothelial growth factors | Tissue engineering | Platelet-derived growth factor
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10. Full Text Human corneal endothelial cell growth on a silk fibroin membrane
by Madden, Peter W and Lai, Jonathan N.X and George, Karina A and Giovenco, Talia and Harkin, Damien G and Chirila, Traian V
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 17, pp. 4076 - 4084
Abstract Tissue engineering of the cornea could overcome shortages of donor corneas for transplantation and improve quality. Our aim was to grow an endothelial... 
Advanced Basic Science | Dentistry | Cell culture | Silk | Cornea | Fibroin | Collagen | Endothelium | MATERIALS SCIENCE, BIOMATERIALS | FIBROBLAST CELLS | ENGINEERING, BIOMEDICAL | RABBIT MODEL | BASEMENT-MEMBRANES | ADULT HUMAN | PROLIFERATIVE CAPACITY | TRANSPLANTATION | LENS CAPSULE | BIOMATERIALS | DESCEMETS-MEMBRANE | Cell Line | Endothelium, Corneal - cytology | Fibroins - chemistry | Animals | Tissue Engineering - methods | Endothelial Cells - cytology | Cell Count | Cell Division | Humans | Collagen - chemistry | Laminin - chemistry | Bombyx
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11. Full Text Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering
by Wang, Xiaoqin and Wenk, Esther and Zhang, Xiaohui and Meinel, Lorenz and Vunjak-Novakovic, Gordana and Kaplan, David L
Journal of Controlled Release, ISSN 0168-3659, 2009, Volume 134, Issue 2, pp. 81 - 90
Temporally and spatially controlled delivery of growth factors in polymeric scaffolds is crucial for engineering composite tissue structures, such as... 
rhBMP-2 | Silk | Gradient | Polylactic-co-glycolic acid | Fibroin | Alginate | rhIGF-I | Scaffold | BONE MORPHOGENETIC PROTEIN-2 | CONTROLLED-RELEASE | CHONDROGENIC DIFFERENTIATION | FACTOR-I | SUSTAINED DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | MESENCHYMAL STEM-CELLS | rhIGF-1 | BIPHASIC SCAFFOLD | BOMBYX-MORI SILK | PHARMACOLOGY & PHARMACY | SILK-BASED BIOMATERIALS | POLY(ETHYLENE OXIDE) | Cartilage - growth & development | Chondrogenesis - drug effects | Lactic Acid - chemistry | Humans | Osteogenesis - drug effects | Cells, Cultured | Silk - administration & dosage | Hexuronic Acids - chemistry | Tissue Scaffolds | Microspheres | Bone Morphogenetic Protein 2 - administration & dosage | Mesenchymal Stromal Cells | Cell Differentiation - drug effects | Alginates - chemistry | Polyglycolic Acid - chemistry | Insulin-Like Growth Factor I - administration & dosage | Glucuronic Acid - chemistry | Drug Delivery Systems - methods | Lactic Acid - administration & dosage | Polyglycolic Acid - administration & dosage | Silk - chemistry | Tissue Engineering | Bone morphogenetic proteins | Polymers | Enzyme-linked immunosorbent assay | Stem cells | Environmental engineering | silk | alginate | polylactic-co-glycolic acid | fibroin | scaffold | gradient
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12. Full Text Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics
by Lovett, Michael L and Wang, Xiaoqin and Yucel, Tuna and York, Lyndsey and Keirstead, Marc and Haggerty, Linda and Kaplan, David L
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 09/2015, Volume 95, Issue Pt B, pp. 271 - 278
Silk hydrogels were formulated with anti-vascular endothelial growth factor (anti-VEGF) therapeutics for sustained ocular drug delivery. Using silk fibroin as... 
Biodegradation | Silk fibroin | Hydrogel | Sustained drug delivery | Controlled release | Bevacizumab | PROTEIN | FIBROIN HYDROGELS | DRUG-DELIVERY | STABILIZATION | MACULAR DEGENERATION | RELEASE | IN-VITRO | BOMBYX-MORI | PHARMACOLOGY & PHARMACY | BIOMATERIALS | Administration, Ophthalmic | Rabbits | Bevacizumab - pharmacology | Fibroins - chemistry | Bevacizumab - administration & dosage | Hydrogels | Intravitreal Injections | Angiogenesis Inhibitors - pharmacology | Bevacizumab - pharmacokinetics | Angiogenesis Inhibitors - pharmacokinetics | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Drug Delivery Systems | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Animals | Time Factors | Drug Liberation | Delayed-Action Preparations | Silk - chemistry | Silk | Endothelial growth factors | Therapeutics | Homeopathy | Materia medica and therapeutics
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