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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 7, pp. 3122 - 3134
A series of betulinic acid (BA) derivatives were designed and synthesized by introducing various fused heterocyclic rings at C-2 and C-3 positions. Their... 
SIGNALING PATHWAYS | BISPHOSPHONATES | CHEMISTRY, MEDICINAL | THERAPY | NATURAL-PRODUCTS | GENE-EXPRESSION | ESTROGEN | PARATHYROID-HORMONE | POSTMENOPAUSAL WOMEN | NF-KAPPA-B | OSTEOPOROSIS | Triterpenes - pharmacology | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Tartrate-Resistant Acid Phosphatase | Crystallography, X-Ray | Structure-Activity Relationship | Osteoclasts - cytology | Isoxazoles - chemical synthesis | Pyrimidines - chemistry | Acid Phosphatase - metabolism | Pyrazoles - chemistry | RANK Ligand - pharmacology | Triterpenes - chemistry | Triterpenes - chemical synthesis | Isoenzymes - metabolism | Female | Cathepsin K - antagonists & inhibitors | Bone Density Conservation Agents - chemistry | Pyrazoles - pharmacology | Cell Line | Ovariectomy | Acid Phosphatase - antagonists & inhibitors | Mice, Inbred C57BL | Bone Resorption - drug therapy | Rats | Isoxazoles - chemistry | Pyrimidines - pharmacology | Bone Density Conservation Agents - chemical synthesis | Pyrazines - chemical synthesis | Bone Density Conservation Agents - pharmacology | Isoxazoles - pharmacology | Pyrazines - chemistry | Animals | Cathepsin K - metabolism | Thiazoles - chemical synthesis | Cell Differentiation - drug effects | Bone Resorption - pathology | Thiazoles - chemistry | Cell Proliferation - drug effects | Mice | Thiazoles - pharmacology | Pyrazines - pharmacology | Isoenzymes - antagonists & inhibitors | Osteoclasts - drug effects
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