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1. Full Text Targeting Osteocytes to Attenuate Early Breast Cancer Bone Metastasis by Theranostic Upconversion Nanoparticles with Responsive Plumbagin Release
by Qiao, Han and Cui, Zhaowen and Yang, Shengbing and Ji, Dingkun and Wang, Yugang and Yang, Ying and Han, Xiuguo and Fan, Qiming and Qin, An and Wang, Tingyu and He, Xiao-Peng and Bu, Wenbo and Tang, Tingting
ACS nano, ISSN 1936-0851, 07/2017, Volume 11, Issue 7, pp. 7259 - 7273
ATP competitiveness | plumbagin | zoledronic acid | breast cancer bone metasatasis | osteocyte-targeting | theranostic | upconversion nanoparticle | Physical Sciences | Chemistry | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology - Other Topics | Chemistry, Multidisciplinary | Chemistry, Physical | Science & Technology | Osteocytes - drug effects | Luminescent Agents - chemistry | Nanoparticles - chemistry | Zoledronic Acid - therapeutic use | Humans | Bone Neoplasms - secondary | Delayed-Action Preparations - chemistry | Bone Neoplasms - pathology | Drug Delivery Systems | Antineoplastic Agents, Phytogenic - administration & dosage | Theranostic Nanomedicine - methods | Female | Naphthoquinones - administration & dosage | Bone Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - therapeutic use | Optical Imaging - methods | Bone Neoplasms - diagnostic imaging | Silicon Dioxide - chemistry | Nanoparticles - ultrastructure | Naphthoquinones - therapeutic use | Bone Density Conservation Agents - therapeutic use | Bone Density Conservation Agents - administration & dosage | Zoledronic Acid - administration & dosage | Gadolinium - chemistry | Animals | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Osteocytes - pathology | Mice | Index Medicus
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2. Biotransformations of prenylated hop flavonoids for drug discovery and production
by Bartmańska, Agnieszka and Tronina, Tomasz and Popłoński, Jarosław and Huszcza, Ewa
Current drug metabolism, ISSN 1389-2002, 2013, Volume 14, Issue 10, pp. 1083 - 1097
8-prenylnaringenin | Isoxanthohumol | Hop flavonoids | Xanthohumol | Model system | Biotransformation | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Prenylation | Antioxidants - chemistry | Anti-Infective Agents - metabolism | Gram-Positive Bacteria - drug effects | Anti-Infective Agents - pharmacology | Antioxidants - metabolism | Humans | Phytoestrogens - chemistry | Phytoestrogens - pharmacokinetics | Flowers - chemistry | Gram-Negative Bacteria - metabolism | Fungi - metabolism | Anti-Obesity Agents - pharmacokinetics | Anti-Infective Agents - chemistry | Antineoplastic Agents, Phytogenic - metabolism | Flavonoids - pharmacology | Bone Density Conservation Agents - metabolism | Humulus - chemistry | Antineoplastic Agents, Phytogenic - pharmacokinetics | Phytoestrogens - pharmacology | Anti-Obesity Agents - metabolism | Bone Density Conservation Agents - chemistry | Bone Density Conservation Agents - pharmacokinetics | Fungi - drug effects | Antineoplastic Agents, Phytogenic - chemistry | Antioxidants - pharmacology | Drug Discovery | Flavonoids - pharmacokinetics | Bone Density Conservation Agents - pharmacology | Gram-Positive Bacteria - metabolism | Gram-Negative Bacteria - drug effects | Anti-Obesity Agents - chemistry | Animals | Anti-Infective Agents - pharmacokinetics | Flavonoids - metabolism | Phytoestrogens - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Antioxidants - pharmacokinetics | Anti-Obesity Agents - pharmacology | Flavonoids - chemistry
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3. Full Text Fracture Risk and Zoledronic Acid Therapy in Men with Osteoporosis
by Boonen, Steven and Reginster, Jean-Yves and Kaufman, Jean-Marc and Lippuner, Kurt and Zanchetta, Jose and Langdahl, Bente and Rizzoli, Rene and Lipschitz, Stanley and Dimai, Hans Peter and Witvrouw, Richard and Eriksen, Erik and Brixen, Kim and Russo, Luis and Claessens, Frank and Papanastasiou, Philemon and Antunez, Oscar and Su, Guoqin and Bucci-Rechtweg, Christina and Hruska, Josef and Incera, Elodie and Vanderschueren, Dirk and Orwoll, Eric
The New England journal of medicine, ISSN 0028-4793, 11/2012, Volume 367, Issue 18, pp. 1714 - 1723
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Osteoporosis. Osteomalacia. Paget disease | Biological and medical sciences | General aspects | Medical sciences | Diseases of the osteoarticular system | Humans | Middle Aged | Male | Osteoporosis - drug therapy | Risk | Osteoporosis - etiology | Spinal Fractures - prevention & control | Aged, 80 and over | Diphosphonates - therapeutic use | Imidazoles - therapeutic use | Testosterone - blood | Diphosphonates - adverse effects | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Imidazoles - adverse effects | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Logistic Models | Imidazoles - pharmacology | Bone Density Conservation Agents - pharmacology | Bone Density - drug effects | Analysis of Variance | Hypogonadism - complications | Aged | Diphosphonates - pharmacology | Drugs | Dose-response relationship (Biochemistry) | Osteoporosis | Men | Zoledronic acid | Dosage and administration | Product/Service Evaluations | Drug therapy | Health aspects | Risk factors | Vertebrae | Intravenous administration | Calcium | Clinical trials | Bone turnover | Hypogonadism | Serum levels | Testosterone | Fractures | Vitamin D | Older people | Bone mineral density | Bone density | Supplementation | Index Medicus | Abridged Index Medicus
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4. Full Text Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling
by Hattersley, Gary and Dean, Thomas and Corbin, Braden A and Bahar, Hila and Gardella, Thomas J
Endocrinology (Philadelphia), ISSN 0013-7227, 01/2016, Volume 157, Issue 1, pp. 141 - 149
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Peptide Fragments - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - chemistry | HEK293 Cells | Cell Membrane - metabolism | Bone Density Conservation Agents - metabolism | Cyclic AMP - metabolism | Binding Sites - drug effects | Cell Membrane - drug effects | Bone Density Conservation Agents - chemistry | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Second Messenger Systems - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Parathyroid Hormone-Related Protein - chemistry | Parathyroid Hormone-Related Protein - metabolism | Bone Density Conservation Agents - pharmacology | Parathyroid Hormone-Related Protein - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Peptide Fragments - chemistry | MAP Kinase Signaling System - drug effects | Receptor, Parathyroid Hormone, Type 1 - genetics | Genes, Reporter - drug effects | Ligands | Protein Conformation | Kinetics | GTP-Binding Proteins - metabolism | Index Medicus | Abridged Index Medicus | Original Research
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5. Full Text A new double emulsion solvent diffusion technique for encapsulating hydrophilic molecules in PLGA nanoparticles
by Cohen-Sela, Einat and Chorny, Michael and Koroukhov, Nickolay and Danenberg, Haim D and Golomb, Gershon
Journal of controlled release, ISSN 0168-3659, 2009, Volume 133, Issue 2, pp. 90 - 95
Nanoparticles formulation | Hydrophilic | PLGA | Macrophages restenosis | Double emulsion | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Sonication | Carotid Stenosis - prevention & control | Nanoparticles - chemistry | Monocytes - cytology | Acetates - chemistry | Biological Availability | Male | Monocytes - metabolism | Secondary Prevention | Drug Carriers - chemistry | Alendronate - therapeutic use | Alendronate - pharmacokinetics | Carotid Stenosis - surgery | Cell Line | Rabbits | Lactic Acid - chemistry | Drug Compounding - methods | Emulsions - chemistry | Bone Density Conservation Agents - therapeutic use | Rats | Drug Carriers - chemical synthesis | Bone Density Conservation Agents - administration & dosage | Carotid Stenosis - pathology | Macrophages - cytology | Bone Density Conservation Agents - pharmacology | Monocytes - drug effects | Particle Size | Macrophages - metabolism | Animals | Polyglycolic Acid - chemistry | Macrophages - drug effects | Cell Proliferation - drug effects | Nanoparticles - administration & dosage | Surface-Active Agents - chemistry | Alendronate - administration & dosage | Hydrogen-Ion Concentration | Nanoparticles | Surface active agents | Organic solvents | Analysis | Esters | Macrophages | Methods | Nanotechnology | Index Medicus
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6. Full Text Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
by Varela, Ignacio and Osorio, Fernando G and Cobo, Juan and Suárez, María F and Freije, José M P and López-Otín, Carlos and Pereira, Sandrine and Cadiñanos, Juan and Ugalde, Alejandro P and de Carlos, Félix and Navarro, Claire L and Foray, Nicolas and Cau, Pierre and Lévy, Nicolas
Nature medicine, ISSN 1078-8956, 07/2008, Volume 14, Issue 7, pp. 767 - 772
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Immunohistochemistry | Pravastatin - pharmacology | Prenylation - drug effects | Humans | Enzyme Inhibitors - pharmacology | Bone Density Conservation Agents - therapeutic use | Imidazoles - pharmacology | Bone Density Conservation Agents - pharmacology | Mice, Knockout | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Diphosphonates - therapeutic use | Models, Animal | Farnesyltranstransferase - antagonists & inhibitors | Mice | Aging, Premature - drug therapy | Imidazoles - therapeutic use | Drug Therapy, Combination | Pravastatin - therapeutic use | Diphosphonates - pharmacology | Diphosphonates | Progeria | Aging | Research | Drug therapy | Health aspects | Risk factors | Statins | Medical research | Inhibitor drugs | Rodents | Index Medicus | Prenylation | Enzyme Inhibitors | Biochemistry, Molecular Biology | Pravastatin | Aging, Premature | Farnesyltranstransferase | Life Sciences | Imidazoles | Bone Density Conservation Agents | Hydroxymethylglutaryl-CoA Reductase Inhibitors
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7. Full Text The key role of the scaffold on the efficiency of dendrimer nanodrugs
by Caminade, Anne-Marie and Fruchon, Severine and Turrin, Cedric-Olivier and Poupot, Mary and Ouali, Armelle and Maraval, Alexandrine and Garzoni, Matteo and Maly, Marek and Furer, Victor L and Kovalenko, Valeri and Majoral, Jean-Pierre and Pavan, Giovanni M and Poupot, Remy
Nature communications, ISSN 2041-1723, 07/2015, Volume 6, Issue 1, pp. 7722 - 7722
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Polylysine - pharmacology | Silanes - chemistry | Nanoparticles - chemistry | Biocompatible Materials - chemistry | Humans | Aza Compounds - chemistry | Polylysine - chemistry | Aza Compounds - pharmacology | Biocompatible Materials - pharmacology | Polypropylenes - pharmacology | Molecular Dynamics Simulation | Bone Density Conservation Agents - pharmacology | Monocytes - drug effects | Flow Cytometry | Diphosphonates - chemistry | Dendrimers - chemistry | Polypropylenes - chemistry | Molecular Structure | Dendrimers - pharmacology | Silanes - pharmacology | Diphosphonates - pharmacology | Bone Density Conservation Agents - chemistry | Index Medicus | Chemical Sciences | Coordination chemistry
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8. Full Text Preparation of calcium phosphate nanocapsules including simvastatin/deoxycholic acid assembly, and their therapeutic effect in osteoporosis model mice
by Ito, Tomoko and Takemasa, Manami and Makino, Kimiko and Otsuka, Makoto
Journal of pharmacy and pharmacology, ISSN 0022-3573, 04/2013, Volume 65, Issue 4, pp. 494 - 502
simvastatin | deoxycholic acid | micelles | osteoporosis | calcium phosphate | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Simvastatin - therapeutic use | Surface-Active Agents - adverse effects | Simvastatin - adverse effects | Humans | Deoxycholic Acid - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Nanocapsules - adverse effects | Nanocapsules - chemistry | Bone and Bones - drug effects | Deoxycholic Acid - adverse effects | Micelles | Surface Properties | Calcium Phosphates - adverse effects | Drug Compounding | Female | Deoxycholic Acid - administration & dosage | Hypolipidemic Agents - chemistry | Bone Density Conservation Agents - chemistry | Disease Models, Animal | Cell Line | Hypolipidemic Agents - adverse effects | Bone Density Conservation Agents - adverse effects | Simvastatin - chemistry | Simvastatin - administration & dosage | Bone Density Conservation Agents - therapeutic use | Calcium Phosphates - chemistry | Deoxycholic Acid - therapeutic use | Bone Density Conservation Agents - administration & dosage | Random Allocation | Mice, Inbred Strains | Osteoporosis, Postmenopausal - drug therapy | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Hypolipidemic Agents - administration & dosage | Hypolipidemic Agents - therapeutic use | Mice | Surface-Active Agents - chemistry | Drug Delivery Systems - adverse effects | Osteoporosis | Calcium phosphate | Health aspects | Analysis | Simvastatin | Deoxycholic acid | Calcium | Medical treatment | Index Medicus
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9. Full Text Modulation of Alendronate release from a calcium phosphate bone cement: An in vitro osteoblast-osteoclast co-culture study
by Dolci, Luisa Stella and Panzavolta, Silvia and Torricelli, Paola and Albertini, Beatrice and Sicuro, Laura and Fini, Milena and Bigi, Adriana and Passerini, Nadia
International journal of pharmaceutics, ISSN 0378-5173, 01/2019, Volume 554, pp. 245 - 255
Osteoblast osteoclast cell cultures | Spray congealing | Calcium phosphate bone cements | Sodium Alendronate | Solid Lipid Microparticles | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cell Survival - drug effects | Chemistry, Pharmaceutical - methods | Coculture Techniques | Humans | Osteoblasts - drug effects | Calcium Phosphates - chemistry | Lipids | Bone Density Conservation Agents - administration & dosage | Osteoclasts - cytology | Alendronate - chemistry | Bone Density Conservation Agents - pharmacology | Microspheres | Cell Differentiation - drug effects | Alendronate - pharmacology | Drug Liberation | Osteoblasts - cytology | Bone Cements - chemistry | Delayed-Action Preparations | Biomimetic Materials - chemistry | Osteoclasts - drug effects | Alendronate - administration & dosage | Bone Density Conservation Agents - chemistry | Index Medicus
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10. Full Text Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates
by Kimmel, D.B
11/2007, Volume 86, Issue 11, 12
Osteoporosis | Bone metastasis | Osteoclast | Bone remodeling | Half-life | Farnesyl pyrophosphase synthase | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Bone Density Conservation Agents - pharmacokinetics | Humans | Bone Density Conservation Agents - therapeutic use | Bone Neoplasms - secondary | Diphosphonates - pharmacokinetics | Half-Life | Nitrogen | Bone Remodeling - drug effects | Osteoporosis, Postmenopausal - drug therapy | Bone Density Conservation Agents - pharmacology | Geranyltranstransferase - antagonists & inhibitors | Multiple Myeloma - drug therapy | Bone and Bones - metabolism | Diphosphonates - chemistry | Diphosphonates - therapeutic use | Female | Hypercalcemia - drug therapy | Molecular Structure | Bone Neoplasms - drug therapy | Diphosphonates - pharmacology | Osteoclasts - drug effects | Bone Density Conservation Agents - chemistry | Index Medicus | Dentistry
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