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1. Full Text Controlled release of bone morphogenetic protein (BMP)-2 from nanocomplex incorporated on hydroxyapatite-formed titanium surface
by Bae, Soon Eon and Choi, Jiyeon and Joung, Yoon Ki and Park, Kwideok and Han, Dong Keun
Journal of Controlled Release, ISSN 0168-3659, 06/2012, Volume 160, Issue 3, pp. 676 - 684
Both osteoconductivity and osteoinductivity are equally very important aspects in a new bone formation and ultimately for bone regeneration. The purpose of... 
Titanium | Apatite | Bone | Bone morphogenic protein-2 | Nanocomplex | CALCIUM-PHOSPHATE COATINGS | DEXTRAN | IMPLANTS | BMP-2 | HEPARIN | CHEMISTRY, MULTIDISCIPLINARY | ADHESION | PRECALCIFICATION | ENHANCEMENT | SIMULATED BODY-FLUID | PHARMACOLOGY & PHARMACY | ALLOY | Cell Line | Gene Expression | Cell Proliferation | Nanoparticles - chemistry | Calcium - metabolism | Osteoblasts - drug effects | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Titanium - chemistry | Recombinant Proteins - chemistry | Titanium - administration & dosage | Bone Morphogenetic Protein 2 - chemistry | Durapatite - chemistry | Recombinant Proteins - administration & dosage | Particle Size | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Collagen Type I - genetics | Durapatite - administration & dosage | Mice | Nanoparticles - administration & dosage | Osteoblasts - metabolism | Delayed-Action Preparations | Hydrogen-Ion Concentration | Phosphates | Phosphate minerals | Phosphatases | Phosphate rock | Hydroxylapatite | Bone morphogenetic proteins | Gene expression | Index Medicus
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2. Full Text Bone morphogenetic proteins - 7 and - 2 in the treatment of delayed osseous union secondary to bacterial osteitis in a rat model
by Helbig, Lars and Omlor, Georg W and Ivanova, Adriana and Guehring, Thorsten and Sonntag, Robert and Kretzer, J. Philippe and Minkwitz, Susann and Wildemann, Britt and Schmidmaier, Gerhard
BMC Musculoskeletal Disorders, ISSN 1471-2474, 07/2018, Volume 19, Issue 1, pp. 261 - 261
Background: Bone infections due to trauma and subsequent delayed or impaired fracture healing represent a great challenge in orthopedics and trauma surgery.... 
Animal model | Bone morphogenetic protein 2 | Delayed osseous union | Rat | Biomechanical testing | Osteitis | Micro-CT | Bone morphogenetic protein 7 | IMPLANT-RELATED OSTEOMYELITIS | GRAFTS | HUMAN OSTEOGENIC PROTEIN-1 | RHEUMATOLOGY | BMP-2 | TIBIAL SHAFT FRACTURES | FEMUR | STAPHYLOCOCCUS-AUREUS | COMPLICATIONS | GROWTH-FACTOR | ORTHOPEDICS | STABILIZED SEGMENTAL DEFECT | Staphylococcal Infections - drug therapy | Rats | Treatment Outcome | Random Allocation | Osteitis - diagnostic imaging | Rats, Sprague-Dawley | Staphylococcal Infections - diagnostic imaging | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Time Factors | Fracture Healing - physiology | Female | Fractures, Bone - diagnostic imaging | Osteitis - drug therapy | Staphylococcus aureus - drug effects | Bone Morphogenetic Protein 7 - administration & dosage | Fractures, Bone - drug therapy | Disease Models, Animal | Care and treatment | Bacterial infections | Analysis | Rattus | Bone morphogenetic proteins | Models | Research | Health aspects | Callus | Chronic infection | Infections | Nonunion | Defects | Proteins | Inoculation | Bone biomaterials | Computed tomography | Tibia | Surgery | Rodents | Bones | Bacteria | Statistical analysis | Mechanical properties | Bone healing | Trauma | Biomechanics | Fractures | Antibiotics | Orthopedics | Index Medicus
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3. Full Text Delivery of a Therapeutic Protein for Bone Regeneration from a Substrate Coated with Graphene Oxide
by La, Wan‐Geun and Park, Saibom and Yoon, Hee‐Hun and Jeong, Gun‐Jae and Lee, Tae‐Jin and Bhang, Suk Ho and Han, Jeong Yeon and Char, Kookheon and Kim, Byung‐Soo
Small, ISSN 1613-6810, 12/2013, Volume 9, Issue 23, pp. 4051 - 4060
The therapeutic efficacy of drugs often depends on the drug delivery carrier. For efficient delivery of therapeutic proteins, delivery carriers should enable... 
graphene oxide | bone formation | titanium implant | bone morphogenetic protein‐2 | bone morphogenetic protein-2 | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | RELEASE | ADSORPTION | HEPARIN | BMP-2 | CHEMISTRY, MULTIDISCIPLINARY | GROWTH | COATINGS | SYSTEMS | DIFFERENTIATION | MORPHOGENETIC PROTEIN-2 | SURFACES | Bone Regeneration - drug effects | Titanium - adverse effects | Bone Marrow Cells - cytology | Coated Materials, Biocompatible - adverse effects | Humans | Osteogenesis - drug effects | Titanium - chemistry | Coated Materials, Biocompatible - chemistry | Prostheses and Implants | Mesenchymal Stromal Cells - cytology | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Bone Morphogenetic Protein 2 - therapeutic use | Mice | Graphite - chemistry | Graphite - adverse effects | Drugs | Drug delivery systems | Graphene | Analysis | Stem cells | Graphite | Bone morphogenetic proteins | Health aspects | Biopharmaceutics | Vehicles | Proteins | Bone marrow | Drug dosages | Biological activity | Index Medicus | Carriers | Surgical implants | Bones | Oxides | Titanium base alloys
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4. Full Text Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein‐2: histologic observations
by Wikesjö, Ulf M. E and Qahash, Mohammed and Polimeni, Giuseppe and Susin, Cristiano and Shanaman, Richard H and Rohrer, Michael D and Wozney, John M and Hall, Jan
Journal of Clinical Periodontology, ISSN 0303-6979, 11/2008, Volume 35, Issue 11, pp. 1001 - 1010
Background: Studies using ectopic rodent, orthotopic canine, and non‐human primate models show that bone morphogenetic proteins (BMPs) coated onto titanium... 
seroma | dental/oral implants | tissue engineering | titanium | alveolar augmentation | dogs | rhBMP‐2 | bone morphogenetic protein | osseointegration | titanium porous oxide | rhBMP-2 | Osseointegration | Bone morphogenetic protein | Seroma | Tissue engineering | Dogs | Dental/oral implants | Titanium | Alveolar augmentation | Titanium porous oxide | oral implants | TITANIUM IMPLANTS | RAT | TISSUE REGENERATION | MODEL | BMP-2 | DELIVERY | dental | DENTISTRY, ORAL SURGERY & MEDICINE | GRINDING TECHNIQUE | Bone Morphogenetic Protein 2 - pharmacology | Humans | Coated Materials, Biocompatible - pharmacology | Male | Recombinant Proteins - adverse effects | Bone Morphogenetic Protein 2 - adverse effects | Dose-Response Relationship, Drug | Bone Morphogenetic Protein 2 - administration & dosage | Surface Properties | Transforming Growth Factor beta - adverse effects | Bone Morphogenetic Proteins - pharmacology | Seroma - chemically induced | Osseointegration - drug effects | Alveolar Ridge Augmentation - methods | Bone Morphogenetic Proteins - administration & dosage | Implants, Experimental | Coated Materials, Biocompatible - adverse effects | Alveolar Bone Loss - chemically induced | Random Allocation | Recombinant Proteins - pharmacology | Recombinant Proteins - administration & dosage | Bone Morphogenetic Proteins - adverse effects | Transforming Growth Factor beta - pharmacology | Animals | Transforming Growth Factor beta - administration & dosage | Alveolar Ridge Augmentation - adverse effects | Dental Implants | Bone morphogenetic proteins | Implant dentures | Index Medicus | Dentistry
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5. Full Text Enhanced Capability of Bone Morphogenetic Protein 2–loaded Mesoporous Calcium Silicate Scaffolds to Induce Odontogenic Differentiation of Human Dental Pulp Cells
by Huang, Kuo-Hao and Chen, Yi-Wen and Wang, Chen-Ying and Lin, Chun-Pin and Lin, Yen-Hong and Wu, Yuan-Haw Andrew and Shie, Ming-You
Journal of Endodontics, ISSN 0099-2399, 11/2018, Volume 44, Issue 11, pp. 1677 - 1685
Calcium silicate bioceramics have been broadly used as reparative or grafting materials with good bioactivity and biocompatibility in dental application. It... 
dental pulp cell | mesoporous calcium silicate | odontogenesis | bone morphogenetic protein 2 | 3D-printed scaffold | STEM-CELLS | CEMENT | OSTEOGENESIS PROPERTIES | POROUS SCAFFOLDS | PERIODONTAL-LIGAMENT CELLS | DELIVERY | MINERAL TRIOXIDE AGGREGATE | IN-VITRO | SIGNALING PATHWAY | CLINICAL-APPLICATIONS | DENTISTRY, ORAL SURGERY & MEDICINE | Bone Morphogenetic Protein 2 - pharmacology | Cell Proliferation - genetics | Calcium Compounds | Odontogenesis - drug effects | Humans | Cells, Cultured | Dental Pulp - cytology | Odontogenesis - genetics | Silicates | Cell Adhesion - drug effects | Stimulation, Chemical | Drug Delivery Systems | Tissue Scaffolds | Up-Regulation - drug effects | Cell Differentiation - genetics | Bone Morphogenetic Protein 2 - administration & dosage | Cell Differentiation - drug effects | Dental Pulp - physiology | Cell Proliferation - drug effects | Regenerative Endodontics | Printing, Three-Dimensional | Drugs | Yuan (China) | Medical colleges | Drug delivery systems | Biological products | Phosphatases | Ceramics | Vehicles | Analysis | Bone morphogenetic proteins | Research institutes | Ceramic materials | 3D printing | Dentistry
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6. Full Text Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds
by Lee, Sungsoo S and Huang, Brian J and Kaltz, Stuart R and Sur, Shantanu and Newcomb, Christina J and Stock, Stuart R and Shah, Ramille N and Stupp, Samuel I
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 2, pp. 452 - 459
Abstract Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive cytokine that plays a critical role during bone regeneration and repair. In the... 
Advanced Basic Science | Dentistry | Heparan sulfate | Peptide amphiphile | Heparin | Regenerative medicine | Bone regeneration | BMP-2 (bone morphogenetic protein-2) | MATERIALS SCIENCE, BIOMATERIALS | ORTHOPEDIC TRAUMA | ENGINEERING, BIOMEDICAL | DRUG-RELEASE | DELIVERY | REPAIR | MORPHOGENETIC PROTEIN | TIBIAL FRACTURES | GROWTH-FACTOR | INFLAMMATORY RESPONSE | PEPTIDE-AMPHIPHILE NANOFIBERS | Bone Morphogenetic Protein 2 - pharmacology | Nanofibers - chemistry | Bone Regeneration - drug effects | Nanofibers - ultrastructure | Heparin - metabolism | Peptides - chemistry | Rats, Inbred Lew | Rats | Collagen - chemistry | Male | Heparitin Sulfate - metabolism | Tissue Scaffolds - chemistry | Biomimetic Materials - metabolism | Collagen - metabolism | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Peptides - metabolism | Biomimetic Materials - chemistry | Fibronectins | Biological products | Glycosaminoglycans | Peptides | Analysis | Collagen | Bone morphogenetic proteins | Anticoagulants (Medicine) | Sulfates | Index Medicus | Heparan Sulfate | Bone Regeneration | Peptide Amphiphile | Regenerative Medicine
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7. Full Text Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo
by Suliman, Salwa and Xing, Zhe and Wu, Xujun and Xue, Ying and Pedersen, Torbjorn O and Sun, Yang and Døskeland, Anne P and Nickel, Joachim and Waag, Thilo and Lygre, Henning and Finne-Wistrand, Anna and Steinmüller-Nethl, Doris and Krueger, Anke and Mustafa, Kamal and Fiber- och polymerteknologi and KTH and Skolan för kemivetenskap (CHE)
Journal of Controlled Release, ISSN 0168-3659, 01/2015, Volume 197, pp. 148 - 157
A low dose of 1 μg rhBMP-2 was immobilised by four different functionalising techniques on recently developed poly( -lactide)-co-(ε-caprolactone)... 
Copolymer scaffold | Nanodiamond | Drug delivery | Functionalization | Tissue engineering | Growth factor | FACTOR DELIVERY | REGENERATION | OSTEOGENIC DIFFERENTIATION | MODEL | BMP-2 | CHEMISTRY, MULTIDISCIPLINARY | NANOCRYSTALLINE DIAMOND | RHBMP-2 | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR | MARROW STROMAL CELLS | Bone Morphogenetic Protein 2 - genetics | Bone Regeneration - drug effects | Signal Transduction | Humans | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Bone Morphogenetic Protein 2 - chemistry | Male | Rats, Sprague-Dawley | Tissue Scaffolds | Microspheres | Polyesters - chemistry | Mesenchymal Stromal Cells - cytology | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Cell Differentiation - drug effects | Bone Morphogenetic Protein 2 - metabolism | Cell Proliferation - drug effects | Bone morphogenetic proteins | Analysis | Methods | Stem cells | Gene expression | Mass spectrometry | Index Medicus | Naturvetenskap | Kemi | Natural Sciences | Chemical Sciences
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8. Full Text Comparison of micro- vs. nanostructured colloidal gelatin gels for sustained delivery of osteogenic proteins: Bone morphogenetic protein-2 and alkaline phosphatase
by Wang, Huanan and Boerman, Otto C and Sariibrahimoglu, Kemal and Li, Yubao and Jansen, John A and Leeuwenburgh, Sander C.G
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 33, pp. 8695 - 8703
Abstract Colloidal gels have recently emerged as a promising new class of materials for regenerative medicine by employing micro- and nanospheres as building... 
Advanced Basic Science | Dentistry | Controlled delivery | Nanosphere | Self-healing | Microsphere | Gelatin | Colloidal gels | CELLS | HYDROGELS | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | CONTROLLED-RELEASE | MICROPARTICLES | IN-VITRO | MATRICES | GROWTH-FACTOR | SCAFFOLDS | CHARGED DEXTRAN MICROSPHERES | Microspheres | Bone Morphogenetic Protein 2 - administration & dosage | Nanospheres | Alkaline Phosphatase - administration & dosage | Alkaline Phosphatase - chemistry | Nanostructures - chemistry | Bone Morphogenetic Protein 2 - chemistry | Gelatin - chemistry | Drugs | Drug delivery systems | Crosslinked polymers | Biological products | Phosphatases | Bone morphogenetic proteins | Comparative analysis | Biomedical engineering | Vehicles | Index Medicus
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9. Full Text Local Administration of Bone Morphogenetic Protein-2 and Bisphosphonate During Non-Weight-Bearing Treatment of Ischemic Osteonecrosis of the Femoral Head: An Experimental Investigation in Immature Pigs
by Kim, Harry K.W and Aruwajoye, Olumide and Du, Justin and Kamiya, Nobuhiro
The Journal of Bone and Joint Surgery, ISSN 0021-9355, 09/2014, Volume 96, Issue 18, pp. 1515 - 1524
BACKGROUND:Non-weight-bearing decreases the femoral head deformity but increases bone resorption without increasing bone formation in an experimental animal... 
DEFORMITY | EPIPHYSIS | SURGERY | RESORPTION | NECROSIS | CALVE-PERTHES DISEASE | RETENTION | IBANDRONATE | MODEL | CONTAINMENT TREATMENT | ORTHOPEDICS | Bone Morphogenetic Protein 2 - pharmacology | Legg-Calve-Perthes Disease - drug therapy | Osteogenesis - physiology | Legg-Calve-Perthes Disease - physiopathology | Male | Diphosphonates - administration & dosage | Bone Density Conservation Agents - administration & dosage | Ischemia - physiopathology | Bone Density Conservation Agents - pharmacology | Weight-Bearing - physiology | Femur Head - blood supply | Radiography | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Swine | Legg-Calve-Perthes Disease - diagnostic imaging | Drug Therapy, Combination | Administration, Topical | Diphosphonates - pharmacology | Index Medicus | Abridged Index Medicus
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10. Full Text The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2
by Shi, Qin and Li, Yang and Sun, Jie and Zhang, Hua and Chen, Lei and Chen, Bing and Yang, Huilin and Wang, Zhaoxu
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 28, pp. 6644 - 6649
Abstract Bacterial cellulose (BC) is a nanofibrous biological material with attractive physicochemical properties and biocompatibility. Its fiber is similar to... 
Advanced Basic Science | Dentistry | Bone morphogenetic protein-2 | Nanofibrous | Osteogenesis | Bacterial cellulose scaffold | MATRIX | MATERIALS SCIENCE, BIOMATERIALS | COLLAGEN | ENGINEERING, BIOMEDICAL | IN-VIVO DEGRADATION | REGENERATION | MODEL | REPAIR | BINDING | Nanofibers - chemistry | Cell Line | Nanofibers - ultrastructure | Microscopy, Electron, Scanning | Gluconacetobacter xylinus - chemistry | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Tissue Engineering - trends | Bone Morphogenetic Protein 2 - chemistry | Male | Cellulose - administration & dosage | Rats, Sprague-Dawley | Bone and Bones - drug effects | Tissue Scaffolds - chemistry | Cellulose - chemistry | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Nanofibers - administration & dosage | Cellulose - ultrastructure | Mice | Polysaccharides | Phosphatases | Biological products | Tissue engineering | Developmental biology | Cellulose | Bone morphogenetic proteins | Index Medicus
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11. Full Text Cartilage repair by local delivery of transforming growth factor‐β1 or bone morphogenetic protein‐2 from a novel, segmented polyurethane/polylactic‐co‐glycolic bilayered scaffold
by Reyes, Ricardo and Delgado, Araceli and Solis, Raul and Sanchez, Esther and Hernandez, Antonio and Roman, Julio San and Evora, Carmen
Journal of Biomedical Materials Research Part A, ISSN 1549-3296, 04/2014, Volume 102, Issue 4, pp. 1110 - 1120
This study aimed to analyze the in vitro and in vivo release kinetics and evaluate the grades of repair induced by either the release of 50 ng of transforming... 
osteochondral repair | controlled release | TGF‐β1 | BMP‐2 | SPU‐PLGA scaffold | B