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Circulation, ISSN 0009-7322, 02/2009, Volume 119, Issue 4, pp. 566 - 576
Background-Recent genetic studies have highlighted the role of the bone morphogenetic protein (BMP)/transforming growth factor (TGF)-beta signaling pathways in... 
Pathology | Hypoxia | Hemodynamics | Vessels | Hypertension, pulmonary | FIBROSIS | hypoxia | CARDIAC & CARDIOVASCULAR SYSTEMS | pathology | BMPR2 | hypertension, pulmonary | SMOOTH | PROLIFERATION | MUSCLE-CELLS | hemodynamics | FEATURES | ARTERIAL-HYPERTENSION | II RECEPTOR | PERIPHERAL VASCULAR DISEASE | MUTATIONS | vessels | Monocrotaline | Male | RNA, Messenger - metabolism | Hypertension, Pulmonary - chemically induced | Cell Movement - physiology | Quinolines - pharmacology | Hypoxia - metabolism | Bone Morphogenetic Proteins - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Hypertension, Pulmonary - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Bone Morphogenetic Protein Receptors, Type II - genetics | Rats | Hypertension, Pulmonary - metabolism | Rats, Sprague-Dawley | Bone Morphogenetic Protein Receptors, Type II - metabolism | Disease Progression | Cell Movement - drug effects | Muscle, Smooth, Vascular - pathology | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Hypoxia - pathology | Signal Transduction - physiology | Chronic Disease | Muscle, Smooth, Vascular - enzymology | Transforming Growth Factor beta - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2015, Volume 21, Issue 7, pp. 777 - 785
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 396 - 404
Molecules associated with the transforming growth factor beta (TGF-beta) superfamily, such as bone morphogenic proteins (BMPs) and TGF-beta, are key regulators... 
MEDICINE, RESEARCH & EXPERIMENTAL | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE FIBROSIS | DIABETIC-NEPHROPATHY | CELL BIOLOGY | RENAL FIBROSIS | TO-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | TRANSFORMING GROWTH-FACTOR-BETA-2 | BONE MORPHOGENETIC PROTEIN-7 | EXPRESSION | PROGRESSION | Captopril - pharmacology | Bone Morphogenetic Proteins - agonists | Bone Morphogenetic Protein Receptors - genetics | Peptides - pharmacokinetics | Apoptosis - genetics | Smad3 Protein - metabolism | Structure-Activity Relationship | Peptide Library | Fibrosis - metabolism | Smad3 Protein - genetics | Bone Morphogenetic Proteins - metabolism | Inflammation - metabolism | Kidney - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Regeneration - genetics | Epithelial-Mesenchymal Transition | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Kidney Tubules - metabolism | Diabetic Nephropathies - pathology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Diabetic Nephropathies - metabolism | Bone Morphogenetic Protein Receptors - metabolism | Bone Morphogenetic Protein Receptors, Type I - genetics | Rats | Bone Morphogenetic Protein Receptors, Type I - metabolism | Kidney - injuries | Rats, Sprague-Dawley | Bone Morphogenetic Protein Receptors, Type II - metabolism | Animals | Transforming Growth Factor beta - genetics | Inflammation - genetics | Mice | Transforming Growth Factor beta - metabolism | Physiological aspects | Cellular signal transduction | Research | Kidney diseases | Protein kinases | Risk factors | Signal transduction | Pharmacology | Kinases | Gene expression | Rodents | Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2009, Volume 184, Issue 1, pp. 83 - 99
Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary artery endothelial cell (PAEC) apoptosis and the loss of small... 
Angiogenesis | Cell motility | Receptors | Cell growth | Small interfering RNA | Antibodies | Pseudopodia | Mice | Gene expression regulation | Endothelial cells | SIGNAL-TRANSDUCTION | ACTIVATION | ARTERIAL-HYPERTENSION | II RECEPTOR | KINASE | PLANAR CELL POLARITY | P38 MAPK | C3H10T1/2 CELLS | BMPR-II | ENDOTHELIAL GROWTH-FACTOR | CELL BIOLOGY | Cell Proliferation | Humans | Glycogen Synthase Kinase 3 beta | rhoA GTP-Binding Protein - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Pulmonary Artery - metabolism | Hypertension - genetics | Dishevelled Proteins | Endothelial Cells - physiology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Endothelial Cells - metabolism | Glycogen Synthase Kinase 3 - metabolism | Bone Morphogenetic Protein 2 - physiology | beta Catenin - metabolism | Bone Morphogenetic Protein Receptors, Type II - metabolism | Hypertension - metabolism | Pulmonary Artery - cytology | Neovascularization, Physiologic - physiology | Pulmonary Artery - ultrastructure | Animals | Endothelial Cells - cytology | Smad1 Protein - metabolism | Wnt3 Protein | Bone Morphogenetic Protein Receptors, Type II - physiology | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | rac1 GTP-Binding Protein - metabolism | Apoptosis | Cell Movement | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 7, pp. 5157 - 5165
Bone morphogenetic proteins (BMPs) regulate many mammalian physiologic and pathophysiologic processes. These proteins bind with the kinase receptors BMPR-I and... 
SURVIVAL | FOREBRAIN | REPULSIVE GUIDANCE MOLECULE | DCC | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURONAL DIFFERENTIATION | SPINAL-CORD | EXPRESSION | RGMA | Phosphorylation - physiology | Bone Morphogenetic Protein Receptors, Type II - genetics | Membrane Proteins - genetics | Humans | Bone Morphogenetic Protein Receptors, Type I - genetics | Smad Proteins - genetics | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Bone Morphogenetic Protein Receptors, Type I - metabolism | Bone Morphogenetic Protein Receptors, Type II - metabolism | Bone Morphogenetic Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Osteoblasts - cytology | Osteoblasts - metabolism | Bone Morphogenetic Proteins - genetics | Cell Differentiation - physiology | Enzyme Activation - physiology | Smad Proteins - metabolism | Protein Binding - physiology | Index Medicus | Bone morphogenetic protein 6 | Smad5 protein | Bone morphogenetic protein 4 | Phosphorylation | Smad protein | Transcription factors | Bone morphogenetic protein 2 | Bone morphogenetic protein receptor type II | RhoA protein | Osteoblasts | Bone morphogenetic protein receptor type I | Signal transduction | Osteoblastogenesis | Protein kinase | Bone morphogenetic proteins | Differentiation | Bone morphogenetic protein 7 | Rho | Bone Morphogenetic Protein (BMP) | SMAD Transcription Factor | Signal Transduction | Cell Biology
Journal Article
Circulation Research, ISSN 0009-7330, 05/2008, Volume 102, Issue 10, pp. 1212 - 1221
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3600 - 3613
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE | BONE MORPHOGENETIC PROTEIN | ARTERIAL-HYPERTENSION | HEART-FAILURE | IN-VIVO | APELIN | SMOOTH-MUSCLE-CELLS | TGF-BETA RECEPTOR | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Microvessels - pathology | Male | Cell Hypoxia | Tacrolimus - pharmacology | Hypertension, Pulmonary - drug therapy | Endothelial Cells - physiology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Bone Morphogenetic Protein 4 - physiology | Endothelium, Vascular - physiopathology | Rats | Hypertension, Pulmonary - metabolism | Inhibitor of Differentiation Protein 1 - metabolism | Neointima - metabolism | Rats, Sprague-Dawley | Bone Morphogenetic Protein Receptors, Type II - metabolism | Mice, Knockout | Animals | High-Throughput Screening Assays | Neointima - drug therapy | Neointima - pathology | Tacrolimus Binding Protein 1A - metabolism | Cell Line, Tumor | Inhibitor of Differentiation Protein 1 - genetics | Endothelium, Vascular - pathology | Mice | Hypertension, Pulmonary - pathology | Smad Proteins - metabolism | Pulmonary Artery - pathology | Apoptosis | Endothelial Cells - drug effects | Hypertension | Cell receptors | Physiological aspects | Cellular signal transduction | Research | Properties | Endothelium | Proteins | Medical research | Scholarships & fellowships | Research & development--R&D | Pulmonary arteries | Rodents | Hypoxia | Ligands | Mutation | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2013, Volume 123, Issue 6, pp. 2539 - 2550
Abnormalities in cell-cell communication and growth factor signaling pathways can lead to defects in maternal-fetal interactions during pregnancy, including... 
MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | TROPHOBLAST INVASION | MURINE PREGNANCY | NK CELLS | BONE-FORMATION | II RECEPTOR | IN-VIVO | METRIAL GLAND-CELLS | GENE-EXPRESSION | DIFFERENTIATION | Estradiol - blood | Cell Proliferation | Uterus - metabolism | Trophoblasts - pathology | Fetal Growth Retardation - genetics | Male | Progesterone - blood | Vascular Endothelial Growth Factor A - metabolism | Mice, 129 Strain | Uterus - immunology | Infertility, Female - genetics | Uterus - physiopathology | Female | Cell Differentiation | Angiopoietins - metabolism | Gene Expression | Bone Morphogenetic Protein Receptors, Type II - genetics | Decidua - immunology | Signal Transduction | Mice, Inbred C57BL | Decidua - pathology | Embryo Implantation | Bone Morphogenetic Protein Receptors, Type II - metabolism | Killer Cells, Natural - physiology | Decidua - metabolism | Mice, Knockout | Pregnancy | Placenta - blood supply | Animals | Pregnancy Maintenance | Interleukin-15 - metabolism | Placenta - pathology | Mice | Serine Endopeptidases - metabolism | Bone Morphogenetic Protein Receptors, Type II - physiology | Giant Cells - pathology | Physiological aspects | Bone morphogenetic proteins | Genetic aspects | Cellular signal transduction | Research | Pregnant women | Genotype & phenotype | Fertility | Rodents | Infertility | Cell cycle | Ligands | Smooth muscle | Reproductive system | Laboratory animals | Kinases | Embryos | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article