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Nature cell biology, ISSN 1476-4679, 07/2018, Volume 20, Issue 8, pp. 954 - 965
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Index Medicus | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Journal of thoracic oncology, ISSN 1556-0864, 03/2013, Volume 8, Issue 3, pp. 346 - 351
Journal Article
European urology, ISSN 0302-2838, 02/2014, Volume 65, Issue 2, pp. 270 - 273
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2010, Volume 28, Issue 6, pp. 976 - 983
...) as first-line combination therapy for human epidermal growth factor receptor 2 (HER2) -positive advanced breast cancer... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Prognosis | Receptor, ErbB-2 - genetics | Capecitabine | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Bone Neoplasms - secondary | Soft Tissue Neoplasms - drug therapy | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Feasibility Studies | Young Adult | Antibodies, Monoclonal, Humanized | Fluorouracil - administration & dosage | Aged, 80 and over | Adult | Female | Bone Neoplasms - drug therapy | Liver Neoplasms - secondary | Fluorouracil - analogs & derivatives | Soft Tissue Neoplasms - secondary | Deoxycytidine - administration & dosage | Liver Neoplasms - drug therapy | Soft Tissue Neoplasms - metabolism | In Situ Hybridization, Fluorescence | Survival Rate | Treatment Outcome | Breast Neoplasms - drug therapy | Taxoids - administration & dosage | International Agencies | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Liver Neoplasms - metabolism | Aged | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Trastuzumab | Index Medicus | Liver Neoplasms | Breast Neoplasms | Life Sciences | Immunology | Taxoids | Fluorouracil | Antineoplastic Combined Chemotherapy Protocols | Antibodies, Monoclonal | Bone Neoplasms | Receptor, erbB-2 | Deoxycytidine | Soft Tissue Neoplasms
Journal Article
BMC cancer, ISSN 1471-2407, 09/2006, Volume 6, Issue 1, pp. 225 - 225
Background: HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. We therefore tested the activity of the combination of Trastuzumab... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Cyclophosphamide - administration & dosage | Humans | Middle Aged | Neoplasm Proteins - immunology | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Cyclophosphamide - adverse effects | Bone Neoplasms - blood supply | Leukopenia - chemically induced | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Liver Neoplasms - secondary | Combined Modality Therapy | Lung Neoplasms - therapy | Lymphatic Metastasis | Breast Neoplasms - blood supply | Brain Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Remission Induction | Methotrexate - adverse effects | Breast Neoplasms - genetics | Brain Neoplasms - therapy | Immunization, Passive | Methotrexate - administration & dosage | Trastuzumab | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Bone Neoplasms - therapy | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Brain Neoplasms - blood supply | Liver Neoplasms - therapy | Ventricular Dysfunction, Left - chemically induced | Breast Neoplasms - therapy | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | Lung Neoplasms - secondary | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Bone Neoplasms - drug therapy | Neutropenia - chemically induced | Lung Neoplasms - blood supply | Drug Administration Schedule | Liver Neoplasms - drug therapy | Treatment Outcome | Gene Amplification | Liver Neoplasms - blood supply | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Genes, erbB-2 | Aged | Index Medicus
Journal Article
Clinical Lung Cancer, ISSN 1525-7304, 2011, Volume 12, Issue 6, pp. 380 - 386
Micro-Abstract We evaluated EGFR and KRAS mutations between 37 paired primary tumors and corresponding metastases in lung adenocarcinoma. A substantial... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Lung adenocarcinoma | Metastasis | Mutation | Epidermal growth factor receptor | Pleura | Life Sciences & Biomedicine | Oncology | Science & Technology | Adrenal Gland Neoplasms - drug therapy | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Pleural Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Prognosis | Humans | Middle Aged | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Pleural Neoplasms - drug therapy | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Polymerase Chain Reaction | Aged, 80 and over | Adrenal Gland Neoplasms - secondary | Adult | Female | Adenocarcinoma - genetics | Bone Neoplasms - genetics | Bone Neoplasms - drug therapy | Liver Neoplasms - secondary | Lung Neoplasms - genetics | Pleural Neoplasms - secondary | Liver Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Liver Neoplasms - drug therapy | Brain Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Brain Neoplasms - drug therapy | Mutation - genetics | Adenocarcinoma - drug therapy | Aged | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA, Neoplasm - genetics | Neoplasm Staging | Adrenal Gland Neoplasms - genetics | Index Medicus
Journal Article
Journal Article
Journal of thoracic oncology, ISSN 1556-0864, 07/2011, Volume 6, Issue 7, pp. 1236 - 1241
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2010, Volume 102, Issue 1, pp. 220 - 226
Journal Article