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Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Nature cell biology, ISSN 1476-4679, 2013, Volume 15, Issue 7, pp. 807 - 817
Journal Article
Journal Article
Nature medicine, ISSN 1546-170X, 2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | CELLS | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | DYSTROPHIC MUSCLE | GROWTH-FACTOR-BETA | HORMONE-RELATED PROTEIN | RYANODINE RECEPTOR | CAMURATI-ENGELMANN-DISEASE | IN-VIVO | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism
Journal Article
The American journal of pathology, ISSN 0002-9440, 2010, Volume 177, Issue 4, pp. 1647 - 1656
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream... 
ADJUVANT CHEMOTHERAPY | INHIBITION | THERAPY | PROTEIN | HUMAN-BREAST-CANCER | PATHWAY | MUTATIONS | PATHOLOGY | RECEPTORS | TRASTUZUMAB RESISTANCE | EXPRESSION | Lung Neoplasms - drug therapy | Receptors, Estrogen - metabolism | Receptor, ErbB-2 - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Immunoenzyme Techniques | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Ductal, Breast - drug therapy | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Survival Rate | Lymphatic Metastasis | Brain Neoplasms - drug therapy | Mutation - genetics | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases | Carcinoma, Lobular - metabolism | Trastuzumab | Bone Neoplasms - mortality | Phosphorylation | Prognosis | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Liver Neoplasms - mortality | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | In Situ Hybridization | Lung Neoplasms - secondary | Adult | Female | Bone Neoplasms - drug therapy | Neoplasm Invasiveness | Liver Neoplasms - drug therapy | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - mortality | Aged | Carcinoma, Lobular - drug therapy | Regular
Journal Article
Breast cancer research : BCR, ISSN 1465-5411, 09/2011, Volume 13, Issue 5, pp. R87 - R87
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2600 - 2610
Journal Article
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2166
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and... 
METHYLATION | 5-METHYLCYTOSINE | DNA | GLIOMA | MULTIDISCIPLINARY SCIENCES | MECHANISMS | RETINOIC ACID RECEPTORS | MUTATIONS | Neoplasms - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Cholangiocarcinoma - metabolism | Bone Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Bone Neoplasms - metabolism | Glioma - metabolism | DNA-Binding Proteins - metabolism | Glioma - genetics | DNA Methylation | Neoplasms - genetics | Glioma - pathology | Trans-Activators - genetics | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Bone Neoplasms - genetics | Bile Duct Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Central Nervous System Neoplasms - metabolism | Bile Duct Neoplasms - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Central Nervous System Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Receptors, Retinoic Acid - metabolism | DNA-Binding Proteins - genetics | Central Nervous System Neoplasms - pathology | Cholangiocarcinoma - pathology | Chondrosarcoma - metabolism | Cholangiocarcinoma - genetics | Isocitrate Dehydrogenase - metabolism | Trans-Activators - metabolism | Glutarates - metabolism | Bile Duct Neoplasms - pathology | Mutation | Neoplasms - pathology | Leukemia, Myeloid, Acute - genetics
Journal Article
BMC cancer, ISSN 1471-2407, 2013, Volume 13, Issue 1, p. 537
Background: Triple Negative subset of (TN) Breast Cancers (BC), a close associate of the basal-like subtype (with limited discordance) is an aggressive form of... 
Breast cancer | Microarray | Wnt | FFPE | Triple negative | TARGET | GENE-EXPRESSION SIGNATURE | ANDROGEN RECEPTOR | REGULATES EXPRESSION | SUBTYPES | T-CELL-FACTOR | BETA-CATENIN | MESENCHYMAL TRANSITION | ONCOLOGY | BONE | BASAL | RNA, Small Interfering - genetics | Cell Proliferation | Prognosis | Follow-Up Studies | Oligonucleotide Array Sequence Analysis | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | Gene Expression Profiling | Wnt Proteins - metabolism | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Bone Neoplasms - metabolism | Neoplasm Recurrence, Local - pathology | Paraffin Embedding | Brain Neoplasms - secondary | Wnt Proteins - genetics | Lung Neoplasms - secondary | Triple Negative Breast Neoplasms - pathology | Biomarkers, Tumor - metabolism | Female | Bone Neoplasms - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Neoplasm Recurrence, Local - metabolism | Signal Transduction | RNA, Messenger - genetics | Brain Neoplasms - genetics | Survival Rate | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Triple Negative Breast Neoplasms - genetics | Triple Negative Breast Neoplasms - metabolism | beta Catenin - antagonists & inhibitors | Neoplasm Recurrence, Local - genetics | Biomarkers, Tumor - genetics | Neoplasm Staging | Cell Movement | Cohort Studies | Research | Metastasis | Biological markers | Oncology, Experimental | Cancer
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2010, Volume 28, Issue 6, pp. 976 - 983
Purpose To evaluate trastuzumab (H) and docetaxel (T) with or without capecitabine (X) as first-line combination therapy for human epidermal growth factor... 
SURVIVAL | COMBINATIONS | MULTICENTER | AMPLIFICATION | THERAPY | EFFICACY | ONCOLOGY | SAFETY | PRETREATED PATIENTS | ANTIBODY | PACLITAXEL | Prognosis | Receptor, ErbB-2 - genetics | Capecitabine | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Bone Neoplasms - secondary | Soft Tissue Neoplasms - drug therapy | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Feasibility Studies | Young Adult | Antibodies, Monoclonal, Humanized | Fluorouracil - administration & dosage | Aged, 80 and over | Adult | Female | Bone Neoplasms - drug therapy | Liver Neoplasms - secondary | Fluorouracil - analogs & derivatives | Soft Tissue Neoplasms - secondary | Deoxycytidine - administration & dosage | Liver Neoplasms - drug therapy | Soft Tissue Neoplasms - metabolism | In Situ Hybridization, Fluorescence | Survival Rate | Treatment Outcome | Breast Neoplasms - drug therapy | Taxoids - administration & dosage | International Agencies | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Liver Neoplasms - metabolism | Aged | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Trastuzumab | Liver Neoplasms | Breast Neoplasms | Life Sciences | Immunology | Taxoids | Fluorouracil | Antineoplastic Combined Chemotherapy Protocols | Antibodies, Monoclonal | Bone Neoplasms | Receptor, erbB-2 | Deoxycytidine | Soft Tissue Neoplasms
Journal Article