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Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
International journal of radiation oncology, biology, physics, ISSN 0360-3016, 2012, Volume 83, Issue 3, pp. 878 - 886
Purpose To analyze the long-term survival and tumor control outcomes after stereotactic body radiotherapy (SBRT) for metastases limited in number and extent.... 
Radiology | Hematology, Oncology and Palliative Medicine | Stereotactic body radiotherapy | Breast cancer | Oligometastases | Survival | Metastases | ACR PRACTICE GUIDELINES | PHASE I/II TRIAL | HEPATIC RESECTION | CELL LUNG-CANCER | LIVER METASTASES | ONCOLOGY ASTRO | ONCOLOGY | COLORECTAL-CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | AMERICAN SOCIETY | RADIATION-THERAPY SBRT | TUMOR VOLUME | Bone Neoplasms - mortality | Sarcoma - secondary | Prospective Studies | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Carcinoma, Squamous Cell - surgery | Liver Neoplasms - mortality | Radiosurgery - adverse effects | Brain Neoplasms - surgery | Esophageal Neoplasms - pathology | Brain Neoplasms - secondary | Carcinoma, Squamous Cell - mortality | Lung Neoplasms - secondary | Sarcoma - mortality | Aged, 80 and over | Adult | Female | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Radiosurgery - methods | Colorectal Neoplasms - mortality | Neoplasm Metastasis - radiotherapy | Liver Neoplasms - surgery | Lymphatic Metastasis | Bone Neoplasms - surgery | Adenocarcinoma - secondary | Head and Neck Neoplasms - pathology | Breast Neoplasms - pathology | Sarcoma - surgery | Breast Neoplasms - mortality | Carcinoma, Squamous Cell - secondary | Lung Neoplasms - surgery | Aged | Head and Neck Neoplasms - mortality | Colorectal Neoplasms - pathology | Adenocarcinoma - mortality | Adenocarcinoma - surgery | Radiotherapy | Nuclear radiation | Analysis | Radiation | MULTIVARIATE ANALYSIS | PATIENTS | MAMMARY GLANDS | NEOPLASMS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | DEATH | REGRESSION ANALYSIS | RADIOTHERAPY | HAZARDS | SKELETON
Journal Article
European journal of cancer (1990), ISSN 0959-8049, 2016, Volume 68, pp. 156 - 162
Abstract Purpose To assess preliminary safety and efficacy results of the anti-programmed cell death ligand-1 (anti-PD-L1) durvalumab in combination with... 
Hematology, Oncology and Palliative Medicine | Immunoradiotherapy | Phase 2 | Phase 1 | Radiotherapy | Anti-PD-L1 | ABSCOPAL | ONCOLOGY | MECHANISMS | PATIENT | RADIATION-THERAPY | Lymphatic Metastasis - radiotherapy | Bone Neoplasms - therapy | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Carcinoma, Transitional Cell - secondary | Radiosurgery | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Transitional Cell - therapy | Liver Neoplasms - therapy | Eye Neoplasms - therapy | Chemoradiotherapy | Small Cell Lung Carcinoma - secondary | Breast Neoplasms - therapy | Brain Neoplasms - secondary | Neoplasms - therapy | Squamous Cell Carcinoma of Head and Neck | Urinary Bladder Neoplasms - pathology | Aged, 80 and over | Adult | Female | Liver Neoplasms - secondary | Colonic Neoplasms - therapy | Eye Neoplasms - pathology | Head and Neck Neoplasms - therapy | Kaplan-Meier Estimate | Carcinoma, Squamous Cell - therapy | Survival Rate | Lung Neoplasms - therapy | Adenocarcinoma - secondary | Melanoma - secondary | Head and Neck Neoplasms - pathology | Disease-Free Survival | B7-H1 Antigen - antagonists & inhibitors | Adenocarcinoma - therapy | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Urinary Bladder Neoplasms - therapy | Brain Neoplasms - therapy | Radiotherapy, Conformal | Aged | Small Cell Lung Carcinoma - therapy | Melanoma - therapy | Biochemistry | Apoptosis
Journal Article
Nature cell biology, ISSN 1476-4679, 2013, Volume 15, Issue 7, pp. 807 - 817
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2016, Volume 22, Issue 4, pp. 676 - 681
Abstract We wanted to determine whether allogeneic hematopoietic stem cell transplantation (HSCT) may result in long-term survival in patients with solid... 
Hematology, Oncology and Palliative Medicine | Pancreatic adenocarcinoma | Allogeneic hematopoietic stem cell transplantation | Colon carcinoma | Renal carcinoma | Cholangiocarcinoma | DONOR | BONE-MARROW | GRAFT | IMMUNOLOGY | VERSUS-HOST-DISEASE | TRANSPLANTATION | BREAST-CANCER | PRIMARY LIVER-CANCER | LEUKEMIA | HEMATOLOGY | COLON-CARCINOMA | MARROW TRANSPLANTATION | BLOOD | Adenocarcinoma - pathology | Follow-Up Studies | Breast Neoplasms - immunology | Humans | Middle Aged | Kidney Neoplasms - immunology | Male | Graft vs Host Disease - immunology | Cyclophosphamide - therapeutic use | Transplantation, Homologous | Prostatic Neoplasms - immunology | Prostatic Neoplasms - therapy | Breast Neoplasms - therapy | Bile Duct Neoplasms - immunology | Neoplasm Metastasis | Graft vs Host Disease - mortality | Colonic Neoplasms - immunology | Adult | Female | Pancreatic Neoplasms - mortality | Transplantation Conditioning - methods | Graft vs Host Disease - diagnosis | Kidney Neoplasms - therapy | Colonic Neoplasms - therapy | Prostatic Neoplasms - pathology | Colonic Neoplasms - mortality | Adenocarcinoma - immunology | Pancreatic Neoplasms - pathology | Hematopoietic Stem Cell Transplantation | Vidarabine - analogs & derivatives | Vidarabine - therapeutic use | Kidney Neoplasms - mortality | Myeloablative Agonists | Prostatic Neoplasms - mortality | Graft vs Host Disease - pathology | Bile Duct Neoplasms - therapy | Adenocarcinoma - therapy | Breast Neoplasms - pathology | Bile Duct Neoplasms - mortality | Colonic Neoplasms - pathology | Pancreatic Neoplasms - immunology | Survival Analysis | Breast Neoplasms - mortality | Kidney Neoplasms - pathology | Aged | Bile Duct Neoplasms - pathology | Adenocarcinoma - mortality | Pancreatic Neoplasms - therapy | Liver cancer | Colon cancer | Pancreatic cancer | Liver | Mortality | Stem cells | Transplantation | Metastasis | Health aspects | Prostate cancer | Risk factors | Hematopoietic stem cells | College teachers
Journal Article
Modern pathology, ISSN 1530-0285, 2011, Volume 24, Issue 12, pp. 1560 - 1570
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2019, Volume 20, Issue 23, p. 6047
The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast,... 
multimodal pain treatment | nociceptive pain | BIOCHEMISTRY & MOLECULAR BIOLOGY | METASTASES | CELL GLUTAMATE RELEASE | CLINICAL-FEATURES | CHEMISTRY, MULTIDISCIPLINARY | RAT MODEL | NERVE GROWTH-FACTOR | BREAST-CANCER | neuropathic pain | cancer-induced bone pain | SYSTEM X(C)(-) | PROSTATE-CANCER | DISEASE | DOUBLE-BLIND | Bone Neoplasms - therapy | Humans | Gamma Rays - therapeutic use | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Prostatic Neoplasms - physiopathology | Lung Neoplasms - physiopathology | Neuralgia - pathology | Breast Neoplasms - physiopathology | Prostatic Neoplasms - therapy | Breast Neoplasms - therapy | Cancer Pain - pathology | Kidney Neoplasms - physiopathology | Musculoskeletal Pain - pathology | Musculoskeletal Pain - therapy | Bone Neoplasms - physiopathology | Diphosphonates - therapeutic use | Female | Musculoskeletal Pain - physiopathology | Neuralgia - psychology | Quality of Life - psychology | Neuralgia - physiopathology | Kidney Neoplasms - psychology | Kidney Neoplasms - therapy | Analgesics - therapeutic use | Bone Neoplasms - psychology | Prostatic Neoplasms - pathology | Cancer Pain - physiopathology | Pain Management - methods | Lung Neoplasms - therapy | Prostatic Neoplasms - psychology | Musculoskeletal Pain - psychology | Cancer Pain - therapy | Breast Neoplasms - pathology | Breast Neoplasms - psychology | Kidney Neoplasms - pathology | Cancer Pain - psychology | Lung Neoplasms - psychology | Neuralgia - therapy
Journal Article
Journal Article
European urology, ISSN 0302-2838, 2014, Volume 65, Issue 2, pp. 270 - 273
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2600 - 2610
Journal Article
Nature medicine, ISSN 1546-170X, 2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | CELLS | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | DYSTROPHIC MUSCLE | GROWTH-FACTOR-BETA | HORMONE-RELATED PROTEIN | RYANODINE RECEPTOR | CAMURATI-ENGELMANN-DISEASE | IN-VIVO | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism
Journal Article