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Annals of Hematology, ISSN 0939-5555, 2/2018, Volume 97, Issue 2, pp. 309 - 317
.... Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone marrow adiposity within the hematopoietic microenvironment. Patients from the “Centre du Sein” at CHUV... 
T-score | Hematology | TBS | Anemia | Bone marrow microenvironment | Oncology | Breast cancer | Graded toxicity of chemotherapy | Osteoporosis | Chemotherapy | Platelet | Medicine & Public Health | Trabecular bone score | Hematopoiesis | Stress hematopoiesis | Osteoblast | Neutrophil | Bone marrow adipocytes | Febrile neutropenia | SCORE TBS | BONE-MINERAL DENSITY | COLONY-STIMULATING FACTOR | POSTMENOPAUSAL WOMEN | HEMATOLOGY | STEM-CELLS | PREMENOPAUSAL WOMEN | COMPLEMENTARY APPROACH | MARROW NICHE | BLOOD-CELL COUNTS | CLINICAL-PRACTICE | Blood Platelets - immunology | Bone Density - immunology | Breast Neoplasms - immunology | Cell Count | Humans | Middle Aged | Adipocytes - drug effects | Antineoplastic Agents - administration & dosage | Hematopoiesis - drug effects | Bone Diseases, Metabolic - drug therapy | Bone Diseases, Metabolic - complications | Bone Marrow Cells - immunology | Osteoporosis - diagnostic imaging | Chemotherapy, Adjuvant | Neutropenia - immunology | Body Mass Index | Osteoporosis - immunology | Lumbar Vertebrae - diagnostic imaging | Neutrophils - drug effects | Bone Marrow Cells - pathology | Lumbar Vertebrae - drug effects | Absorptiometry, Photon | Breast Neoplasms - drug therapy | Hematopoiesis - immunology | Neutropenia - diagnostic imaging | Lumbar Vertebrae - pathology | Blood Platelets - pathology | Osteoporosis - drug therapy | Antineoplastic Agents - adverse effects | Neutropenia - pathology | Adult | Bone Marrow Cells - drug effects | Female | Retrospective Studies | Breast Neoplasms - diagnostic imaging | Blood Platelets - drug effects | Neutropenia - chemically induced | Adipocytes - immunology | Neutrophils - pathology | Bone Diseases, Metabolic - diagnostic imaging | Bone Diseases, Metabolic - immunology | Osteoblasts - drug effects | Neutrophils - immunology | Osteoblasts - immunology | Lumbar Vertebrae - immunology | Adipocytes - pathology | Breast Neoplasms - complications | Osteoblasts - pathology | Bone Density - drug effects | Osteoporosis - complications | Aged | Oncology, Experimental | Adjuvant treatment | Research | Cancer | Neutrophils | Index Medicus | Original
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 361, Issue 8, pp. 745 - 755
.... This study investigated the effects of denosumab on bone mineral density and fractures in men receiving androgen-deprivation therapy for prostate cancer... 
ZOLEDRONIC ACID | FRACTURE | MEDICINE, GENERAL & INTERNAL | PLACEBO | BONE-MINERAL DENSITY | RISK | COMPLICATIONS | RANDOMIZED CONTROLLED-TRIAL | POSTMENOPAUSAL WOMEN | OSTEOPOROSIS | ALENDRONATE | Lumbar Vertebrae - injuries | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Fractures, Bone - epidemiology | Antibodies, Monoclonal - therapeutic use | Male | Osteoporosis - drug therapy | Prostatic Neoplasms - physiopathology | Bone Remodeling - drug effects | Incidence | Antibodies, Monoclonal, Humanized | Spinal Fractures - prevention & control | RANK Ligand - pharmacology | Injections, Subcutaneous | Aged, 80 and over | RANK Ligand - therapeutic use | Gonadotropin-Releasing Hormone - agonists | Lumbar Vertebrae - physiology | Prostatic Neoplasms - drug therapy | RANK Ligand - adverse effects | Osteoporosis - chemically induced | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Prostatic Neoplasms - surgery | Antibodies, Monoclonal - pharmacology | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Lumbar Vertebrae - drug effects | Denosumab | Bone Density Conservation Agents - pharmacology | Orchiectomy | Bone Density - drug effects | Androgen Antagonists - therapeutic use | Aged | Androgen Antagonists - adverse effects | Fractures, Bone - prevention & control | Osteoporosis | Bone density | Prostate cancer | Older people | Men | Index Medicus | Abridged Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 3, p. e92368
.... Germ-free mice have increased bone mass associated with reduced bone resorption indicating that the GM also regulates bone mass. Ovariectomy (ovx... 
C-REACTIVE PROTEIN | TRABECULAR BONE | WOMEN | MINERAL DENSITY | IMMUNE-SYSTEM | MULTIDISCIPLINARY SCIENCES | ESTROGEN-RECEPTOR-ALPHA | OSTEOPROTEGERIN | GUT MICROBIOTA | TNF-ALPHA | T-CELLS | Bone and Bones - pathology | Ovariectomy - adverse effects | T-Lymphocytes, Regulatory - metabolism | RANK Ligand - metabolism | Body Weight - drug effects | Bone and Bones - drug effects | Lactobacillus - drug effects | Bone Marrow - metabolism | Bone and Bones - metabolism | Inflammation Mediators - metabolism | Female | Minerals - metabolism | Bone Marrow - drug effects | Bone Resorption - etiology | Bone Resorption - blood | Cytokines - metabolism | Mice, Inbred C57BL | Bone Resorption - drug therapy | Biomarkers - blood | Probiotics - pharmacology | Lactobacillus - metabolism | Bone Resorption - prevention & control | Organ Size - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Bone Marrow - pathology | Probiotics - therapeutic use | Mice | Osteoprotegerin - metabolism | Transforming Growth Factor beta - metabolism | Probiotics | Ovariectomy | Microbiota (Symbiotic organisms) | Physiological aspects | Bones | T cells | Density | Drinking water | Calcium | Lymphocytes T | Genomes | Arthritis | Immune status | Osteoprotegerin | Bone resorption | Osteoporosis | Microorganisms | Biomedical materials | Microbiota | Lymphocytes | Bone marrow | Bacteria | Tumor necrosis factor-TNF | Biocompatibility | Bone density | Bone loss | Bone (cortical) | Bone composition | Food | Immune system | Calcium (urinary) | Excretion | Gnotobiotics | Cytokines | Nutrition | Immunoregulation | Rheumatology | Inflammation | Tumor necrosis factor-α | IL-1β | Metabolism | Gene expression | Bone mineral content | Medicine | Serum levels | Osteoclastogenesis | Bone mass | Antibiotics | Womens health | Ligands | Endokrinologi och diabetes | Endocrinology and Diabetes
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175329
Teriparatide [human parathyroid hormone (1-34)], which exerts an anabolic effect on bone, is used for the treatment of osteoporosis in patients who are at a high risk for fracture... 
HUMAN PARATHYROID HORMONE(1-34) | MARROW FIBROSIS | OVARIECTOMIZED CYNOMOLGUS MONKEYS | VERTEBRAL FRACTURES | THINNER CORTICES | DISTAL RADIUS | MULTIDISCIPLINARY SCIENCES | TURNOVER MARKERS | POSTMENOPAUSAL WOMEN | FIBROUS DYSPLASIA | MECHANICAL-PROPERTIES | Osteogenesis - physiology | X-Ray Microtomography | Bone and Bones - drug effects | Dose-Response Relationship, Drug | Collagen - drug effects | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Biomechanical Phenomena - drug effects | Bone Resorption - metabolism | Female | Models, Animal | Bone Resorption - chemically induced | Porosity - drug effects | Imaging, Three-Dimensional | Bone and Bones - cytology | Rabbits | Bone Density Conservation Agents - adverse effects | Drug Administration Schedule | Teriparatide - administration & dosage | Teriparatide - blood | Osteogenesis - drug effects | Bone Density Conservation Agents - administration & dosage | Microscopy, Interference | Bone Density Conservation Agents - blood | Collagen - metabolism | Animals | Bone Resorption - pathology | Teriparatide - adverse effects | Microscopy, Fluorescence | Adaptations | Animal models | Spine | Bone (trabecular) | Bisphosphonates | Clinical outcomes | Bone resorption | Proteins | Osteoporosis | Alendronic acid | Bone growth | Computed tomography | Fibrous dysplasia | Bone marrow | Bone dysplasia | Tunneling | Skeleton | Bone density | Bone loss | Bone (cortical) | Drug therapy | Bone strength | Drug dosages | Age | Bone remodelling | Rats | Risk reduction | Endocrine therapy | Pharmacology | Frost | Bone turnover | Metabolism | Bone mass | Fractures | Osteodystrophy | Mice | Bone mineral density | Mutation | Porosity | Pharmacokinetics | Risk management | Kidney transplantation | Bone (cancellous)
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e34647
.... The aim of this study was to determine the effects of Sal B on osteoblast bone formation, angiogenesis and adipogenesis-associated GIO by performing marrow adipogenesis and microcirculation dilation... 
TRABECULAR BONE | CELLS | GLUCOCORTICOIDS | HISTOMORPHOMETRY | MULTIDISCIPLINARY SCIENCES | OSTEOBLASTS | BEAGLE | DIFFERENTIATION | EXPRESSION | OSTEONECROSIS | MILTIORRHIZA | Neovascularization, Physiologic - drug effects | Gene Expression - drug effects | Adipogenesis - drug effects | Benzofurans - administration & dosage | Male | Adipocytes - drug effects | PPAR gamma - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Bone and Bones - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Osteoporosis - metabolism | Bone and Bones - metabolism | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Cell Differentiation | Bone Morphogenetic Proteins - genetics | PPAR gamma - genetics | Prednisone - administration & dosage | Benzofurans - therapeutic use | Osteoporosis - chemically induced | Prednisone - adverse effects | Osteoporosis - prevention & control | Osteoblasts - drug effects | Osteogenesis - drug effects | Stromal Cells - metabolism | Bone and Bones - blood supply | Intercellular Signaling Peptides and Proteins - genetics | Rats | Rats, Sprague-Dawley | beta Catenin - metabolism | beta Catenin - genetics | Animals | Adipocytes - metabolism | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Osteoporosis | Corticosteroids | Bones | Prednisone | Cell differentiation | Density | Steroids | Oxidative stress | Transcription factors | Glucocorticoids | Laboratories | Differentiation (biology) | Stimulation | Adipocytes | Inflammatory diseases | β-catenin | Angiogenesis | Bone histomorphometry | Biomedical materials | Bone growth | Ischemia | Rodents | Bone marrow | Biocompatibility | Inhibition | Bone loss | Bone strength | Osteopenia | Adipogenesis | Cbfa-1 protein | Research & development--R&D | Medical treatment | Pharmacology | Gene expression | Medicine | Studies | Herbal medicine | Osteoblastogenesis | Bone mass | Acids | Stem cells | Dilation | Bone mineral density | In vivo methods and tests | Dkk1 protein | Osteogenesis | Bone (cancellous) | Apoptosis | Herbal medicines | Guanylate cyclase | Osteoblasts | adipogenesis | stromal cells | Bone morphogenetic proteins | Differentiation | Research & development | R&D
Journal Article
Nature medicine, ISSN 1078-8956, 2017, Volume 23, Issue 9, pp. 1072 - 1079
...). Here we investigate a role for senescent cells in age-related bone loss through multiple approaches... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURE | IDENTIFICATION | CELL BIOLOGY | OSTEOCLASTOGENESIS | ACTIVATOR | MASS | ESTROGEN | FRACTURES | DYSFUNCTION | Osteocytes - drug effects | Cancellous Bone - metabolism | beta-Galactosidase | Cellular Senescence - drug effects | Apoptosis - genetics | Cancellous Bone - drug effects | Gene Expression Profiling | Osteoclasts - cytology | Bone and Bones - drug effects | Caspase 8 - genetics | Flow Cytometry | Osteoporosis - metabolism | Bone and Bones - metabolism | Osteoporosis - genetics | Cell Differentiation | Osteoblasts - cytology | Real-Time Polymerase Chain Reaction | Pyrazoles - pharmacology | Cellular Senescence - genetics | Osteoblasts - drug effects | Mice, Transgenic | Absorptiometry, Photon | Cortical Bone - metabolism | Janus Kinases - antagonists & inhibitors | Culture Media, Conditioned | Animals | Cortical Bone - drug effects | Weight-Bearing | Mice | In Vitro Techniques | Osteoclasts - drug effects | Prevention | Osteoporosis | Aging | Physiological aspects | Genetic aspects | Research | Cells | Senescence | Bone (trabecular) | Suicide | Bone resorption | Bone growth | Biomedical materials | Mineralization | Rodents | Computer architecture | Biocompatibility | Inhibition | Conditioning | Bone loss | Bone (cortical) | Suicide genes | Age | Cardiovascular system | Cell survival | Aging (artificial) | Caspase | Pharmacology | Secretome | Inflammation | Insulin | Osteoclastogenesis | Caspase-8 | Bone mass | Cellular biology | Sensitivity enhancement | In vitro methods and tests | Osteogenesis | Disease prevention | Osteoclast | Drug therapy | Osteocyte
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 3143 - 3148
Journal Article
Bone, ISSN 8756-3282, 2015, Volume 83, pp. 127 - 140
Abstract Lycopene supplementation decreases oxidative stress and exhibits beneficial effects on bone health, but the mechanisms through which it alters bone metabolism in vivo remain unclear... 
Orthopedics | Osteoclastogenesis | Oxidative stress | Bone turnover | Ovariectomy | Bone mass and microarchitecture | Lycopene | SYSTEM | RESORPTION | RAT MODEL | SUPPLEMENTATION | WOMEN | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | ESTROGEN-DEFICIENCY | OSTEOCLAST DIFFERENTIATION | Humans | Body Weight - drug effects | Femur - diagnostic imaging | Humerus - physiopathology | X-Ray Microtomography | Biomechanical Phenomena - drug effects | Carotenoids - blood | Hormones - blood | Lumbar Vertebrae - physiopathology | Tibia - physiopathology | Disease Models, Animal | Bone Resorption - physiopathology | Diaphyses - diagnostic imaging | Lumbar Vertebrae - diagnostic imaging | Bone Resorption - drug therapy | Tibia - diagnostic imaging | Lumbar Vertebrae - drug effects | Biomarkers - blood | Absorptiometry, Photon | Osteoporosis, Postmenopausal - drug therapy | Diaphyses - drug effects | Osteoporosis, Postmenopausal - blood | Diaphyses - physiopathology | Minerals - blood | Uterus - pathology | Bone and Bones - pathology | Deoxyguanosine - blood | Rats, Wistar | Uterus - drug effects | Bone Remodeling - drug effects | Carotenoids - pharmacology | Bone and Bones - drug effects | Humerus - drug effects | Carotenoids - therapeutic use | Bone and Bones - diagnostic imaging | Female | Deoxyguanosine - analogs & derivatives | Bone Resorption - blood | Femur - drug effects | Humerus - diagnostic imaging | Femur - physiopathology | Tibia - drug effects | Bone Resorption - diagnostic imaging | Bone Density - drug effects | Bone and Bones - physiopathology | Organ Size - drug effects | Animals | Osteoporosis, Postmenopausal - physiopathology | Enzymes - blood | Osteoporosis | Analysis | Bone densitometry | Physiological aspects | Superoxide | Postmenopausal women
Journal Article
Nature medicine, ISSN 1546-170X, 2012, Volume 18, Issue 7, pp. 1095 - 1101
Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix, maintains bone mass in adulthood... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | PHYSIOLOGY | RESORPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | OSTEOPOROSIS | CELL BIOLOGY | INSULIN-RECEPTOR | OSTEOBLAST PROGENITORS | RELEVANCE | FRACTURES | POSTMENOPAUSAL WOMEN | GROWTH-FACTOR-I | Bone Matrix - metabolism | Immunohistochemistry | Mesenchymal Stromal Cells - enzymology | Bone and Bones - pathology | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Femur - pathology | TOR Serine-Threonine Kinases - metabolism | Cell Count | Humans | Aging - drug effects | Insulin-Like Growth Factor Binding Protein 3 - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Femur - diagnostic imaging | Insulin Receptor Substrate Proteins - metabolism | X-Ray Microtomography | Bone and Bones - drug effects | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Bone Matrix - drug effects | Bone and Bones - metabolism | Insulin-Like Growth Factor I - administration & dosage | Bone Resorption - metabolism | Insulin-Like Growth Factor Binding Protein 3 - administration & dosage | Receptor, IGF Type 1 - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Femur - growth & development | Mesenchymal Stromal Cells - drug effects | Bone Resorption - blood | Osteoblasts - enzymology | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Enzyme Activation - drug effects | Mice, Knockout | Bone Resorption - diagnostic imaging | Osteoblasts - pathology | Organ Size - drug effects | Animals | Cell Differentiation - drug effects | Bone Resorption - pathology | Mice | Mesenchymal Stromal Cells - pathology | Insulin-Like Growth Factor I - metabolism | Aging - metabolism | Physiological aspects | Research | Insulin-like growth factor 1 | Protein kinases | Stem cells | Bone marrow | Insulin-like growth factors
Journal Article