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1. Full Text Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: A systematic review and meta-analysis
by Fu, Rongwei and Selph, Shelley and McDonagh, Marian and Peterson, Kimberly and Tiwari, Arpita and Chou, Roger and Helfand, Mark
Annals of Internal Medicine, ISSN 0003-4819, 06/2013, Volume 158, Issue 12, pp. 890 - 902
Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used as a bone graft substitute in spinal fusion, which unites (fuses) bones in the... 
SURGERY | MEDICINE, GENERAL & INTERNAL | OFF-LABEL USE | RHBMP-2 | ALLOGRAFT | RETROGRADE EJACULATION | AUTOGRAFT | ANTERIOR CERVICAL DISKECTOMY | LUMBAR INTERBODY FUSION | INTEGRATED ANALYSIS | RADIOGRAPHIC OUTCOMES | Recombinant Proteins - therapeutic use | Spinal Fusion - methods | Off-Label Use | Intervertebral Disc Degeneration - surgery | Drug Industry | Humans | Treatment Outcome | Conflict of Interest | Recombinant Proteins - adverse effects | Incidence | Bone Morphogenetic Protein 2 - adverse effects | Transforming Growth Factor beta - therapeutic use | Bone Morphogenetic Protein 2 - therapeutic use | Ilium - transplantation | Transforming Growth Factor beta - adverse effects | Publication Bias | Publishing - standards | Neoplasms - epidemiology | Care and treatment | Patient outcomes | Bone morphogenetic proteins | Research | Sexual disorders | Health aspects | Spinal fusion
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2. Full Text Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation
by Eun-Joo Jeon and Kwang-Youl Lee and Nam-Sook Choi and Mi-Hye Lee and Hyun-Nam Kim and Yun-Hye Jin and Hyun-Mo Ryoo and Je-Yong Choi and Minoru Yoshida and Norikazu Nishino and Byung-Chul Oh and Kyeong-Sook Lee and Yong Hee Lee and Suk-Chul Bae
Journal of Biological Chemistry, ISSN 0021-9258, 06/2006, Volume 281, Issue 24, pp. 16502 - 16511
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the... 
CLEIDOCRANIAL DYSPLASIA | TRANSCRIPTION FACTOR CBFA1 | OSTEOBLAST DIFFERENTIATION | TGF-BETA | FORMATION IN-VITRO | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED DEGRADATION | HISTONE DEACETYLASE INHIBITORS | EXPRESSION | FUNCTIONAL COOPERATION | GROWTH-FACTOR BETA-1 | Cell Line | Bone Morphogenetic Proteins - physiology | Osteocytes - metabolism | Signal Transduction | Bone Morphogenetic Protein 2 | Humans | Transforming Growth Factor beta - physiology | Ubiquitin - metabolism | Histone Deacetylases - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Bone Morphogenetic Proteins - metabolism | Animals | Bone and Bones - metabolism | Transcription, Genetic | Mice | Osteoblasts - metabolism | Transforming Growth Factor beta - metabolism | Repressor Proteins - metabolism
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3. Full Text A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2
by James, Aaron W and LaChaud, Gregory and Shen, Jia and Asatrian, Greg and Nguyen, Vi and Zhang, Xinli and Ting, Kang and Soo, Chia
Tissue Engineering Part B: Reviews, ISSN 1937-3368, 08/2016, Volume 22, Issue 4, pp. 284 - 297
Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration (FDA)-approved osteoinductive growth factor used as a bone graft... 
Review Articles | MESENCHYMAL PRECURSOR CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | BREAST-CANCER | OFF-LABEL USE | SPINAL-FUSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RETROGRADE EJACULATION | ANTERIOR CERVICAL DISKECTOMY | RECOMBINANT HUMAN BMP-2 | LUMBAR INTERBODY FUSION | OSTEOCLAST DIFFERENTIATION | ENDOTHELIAL GROWTH-FACTOR | Bone Morphogenetic Protein 2 - adverse effects | Bone Resorption | Spinal Fusion | Animals | Humans | Transforming Growth Factor beta | Protein expression | Bones | Tissue engineering | Growth factors | Review
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4. Full Text Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures: A Prospective, Controlled, Randomized Study of Four Hundred and Fifty Patients
by Govender, Shunmugam and Csimma, Cristina and Genant, Harry K and Valentin-Opran, Alexandre and Amit, Yehuda and Arbel, Ron and Aro, Hannu and Atar, Dan and Bishay, Michael and Börner, Martin G and Chiron, Philippe and Choong, Peter and Cinats, John and Courtenay, Brett and Feibel, Robert and Geulette, Bernard and Gravel, Charles and Haas, Norbert and Raschke, M and Hammacher, Eric and van der Velde, D and Hardy, Philippe and Holt, Michael and Josten, Christof and Ketterl, Rupert Ludwig and Lindeque, Bennie and Lob, Günter and Mathevon, Henry and McCoy, Gerald and Marsh, D and Miller, Russell and Munting, Everard and Oevre, Stein and Nordsletten, L and Patel, Amratlal and Pohl, Anthony and Rennie, William and Reynders, Peter and Rommens, Pol Maria and Rondia, Jean and Rossouw, Willem C and Daneel, P J and Ruff, Stephen and Rüter, Axel and Santavirta, Seppo and Schildhauer, Thomas A and Gekle, C and Schnettler, Reinhard and Segal, David and Seiler, Hanns and Snowdowne, Robert B and Stapert, Jouwert and Taglang, Gilbert and Verdonk, Rene and Vogels, Lucas and Weckbach, Arnulf and Wentzensen, Andreas and Wisniewski, Tadeusz and BESTT Study Grp and BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group
The Journal of Bone & Joint Surgery, ISSN 0021-9355, 12/2002, Volume 84, Issue 12, pp. 2123 - 2134
BackgroundThe treatment of open fractures of the tibial shaft is often complicated by delayed union and nonunion. The objective of this study was to evaluate... 
SURGERY | OSTEOBLAST DIFFERENTIATION | SPINAL-FUSION | NONHUMAN PRIMATE | RHBMP-2 | SHAFT FRACTURES | DEVICE | BOVINE COLLAGEN | ORTHOPEDICS | INTRAMEDULLARY NAILS | CANINE | UNION | Fractures, Open - drug therapy | Single-Blind Method | Prospective Studies | Bone Morphogenetic Protein 2 | Humans | Middle Aged | Male | Recombinant Proteins | Tibial Fractures - drug therapy | Transforming Growth Factor beta - therapeutic use | Adolescent | Aged, 80 and over | Adult | Female | Aged | Bone Morphogenetic Proteins - therapeutic use
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5. Full Text Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: A meta-analysis of individual-participant data
by Simmonds, Mark C and Brown, Jennifer V.E and Heirs, Morag K and Higgins, Julian P.T and Mannion, Richard J and Rodgers, Mark A and Stewart, Lesley A
Annals of Internal Medicine, ISSN 0003-4819, 06/2013, Volume 158, Issue 12, pp. 877 - 889
Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned.... 
COST-EFFECTIVENESS ANALYSIS | PROTEIN-2/COMPRESSION RESISTANT MATRIX | MEDICINE, GENERAL & INTERNAL | RANDOMIZED-TRIALS | ABSORBABLE COLLAGEN SPONGE | PATIENT DATA | CLINICAL-TRIALS | ANTERIOR CERVICAL DISKECTOMY | RHBMP-2 FORMULATION | LUMBAR INTERBODY FUSION | RADIOGRAPHIC OUTCOMES | Disability Evaluation | Recombinant Proteins - therapeutic use | Spinal Fusion - methods | Intervertebral Disc Degeneration - surgery | Humans | Treatment Outcome | Recombinant Proteins - adverse effects | Incidence | Bone Morphogenetic Protein 2 - adverse effects | Pain, Postoperative - prevention & control | Time Factors | Transforming Growth Factor beta - therapeutic use | Bone Morphogenetic Protein 2 - therapeutic use | Ilium - transplantation | Transforming Growth Factor beta - adverse effects | Neoplasms - epidemiology | Physiological aspects | Bone morphogenetic proteins | Genetic aspects | Research | Health aspects | Spinal fusion
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6. Full Text Cancer Risk After Use of Recombinant Bone Morphogenetic Protein-2 for Spinal Arthrodesis
by Carragee, Eugene J and Chu, Gilbert and Rohatgi, Rajat and Hurwitz, Eric L and Weiner, Bradley K and Yoon, S Tim and Comer, Garet and Kopjar, Branko
The Journal of Bone & Joint Surgery, ISSN 0021-9355, 09/2013, Volume 95, Issue 17, pp. 1537 - 1545
BACKGROUND:Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a growth factor known to have in vitro effects on the growth and invasiveness of cancer.... 
SURGERY | TGF-BETA | BMP-2 | ORTHOPEDICS | EXPRESSION | GROWTH | Recombinant Proteins - therapeutic use | Spinal Fusion - methods | Spinal Diseases - surgery | Neoplasms - etiology | Follow-Up Studies | Humans | Middle Aged | Bone Transplantation - adverse effects | Male | Recombinant Proteins - adverse effects | Spinal Fusion - adverse effects | Incidence | Randomized Controlled Trials as Topic | Bone Morphogenetic Protein 2 - adverse effects | Lumbar Vertebrae - surgery | Bone Morphogenetic Protein 2 - therapeutic use | Adult | Female | Aged | Bone Transplantation - methods | Neoplasms - epidemiology
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7. Full Text Bone Morphogenetic Protein-2 Induces Proinflammatory Endothelial Phenotype
by Csiszar, Anna and Ahmad, Mansoor and Smith, Kira E and Labinskyy, Nazar and Gao, Qun and Kaley, Gabor and Edwards, John G and Wolin, Michael S and Ungvari, Zoltan
The American Journal of Pathology, ISSN 0002-9440, 2006, Volume 168, Issue 2, pp. 629 - 638
The transforming growth factor-β superfamily member bone morphogenetic protein-2 (BMP-2) is up-regulated in atherosclerotic arteries; however, its effects on... 
OSTEOBLASTIC CELL-DIFFERENTIATION | OXIDATIVE STRESS | NAD(P)H OXIDASE | ACTIVATION | PULMONARY-HYPERTENSION | SUPEROXIDE-PRODUCTION | KINASE | BMP-2 GENE-EXPRESSION | KAPPA-B | PATHOLOGY | CORONARY-ARTERIES | Endothelium, Vascular - cytology | Reactive Oxygen Species - metabolism | Oxidative Stress | Rats, Wistar | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | RNA, Messenger - metabolism | Coronary Vessels - metabolism | Bone Morphogenetic Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Bone Morphogenetic Proteins - genetics | Organ Culture Techniques | Bone Morphogenetic Protein 4 | Mitogen-Activated Protein Kinase 3 - genetics | Acetylcholine - pharmacology | Bone Morphogenetic Protein 2 | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | NADPH Oxidases - antagonists & inhibitors | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation | Rats | Protein Kinase C - antagonists & inhibitors | Cell Adhesion | Blotting, Western | Phenotype | Animals | Transforming Growth Factor beta - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Coronary Vessels - cytology | Endothelium, Vascular - metabolism | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Original Research Paper
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8. Full Text Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2
by Zhang, Ying and Wei, Qiu-Shi and Ding, Wei-Bin and Zhang, Lei-Lei and Wang, Hui-Chao and Zhu, Ying-Jie and He, Wei and Chai, Yu-Na and Liu, You-Wen
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182678
Background and purpose Trauma-induced osteonecrosis of the femoral head (TIONFH) is a major complication of femoral neck fractures. Degeneration and necrosis... 
BMP2 | MARROW | UMBILICAL-CORD | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | STROMAL CELLS | EXPRESSION | CANCER | MESENCHYMAL STEM-CELLS | CLINICAL-SIGNIFICANCE | ADIPOSE-TISSUE | Humans | Middle Aged | Femoral Neck Fractures - complications | Male | Mandibulofacial Dysostosis | Young Adult | RNA Interference | Base Sequence | Bone Morphogenetic Protein 2 - metabolism | HEK293 Cells | Adult | Female | Femoral Neck Fractures - pathology | Femur Head Necrosis - metabolism | Binding Sites | Femur Head Necrosis - etiology | Bone Morphogenetic Protein 2 - genetics | Osteoblasts - physiology | Abnormalities, Multiple | Femoral Neck Fractures - metabolism | Sequence Analysis, DNA | Micrognathism | Femur Head Necrosis - pathology | MicroRNAs - physiology | Limb Deformities, Congenital | Osteogenesis | MicroRNA | Growth | Physiological aspects | Bone morphogenetic proteins | Bones | Genetic aspects | Research | Immunohistochemistry | Cell culture | Alkaline phosphatase | Surgical implants | Transcription factors | Femur | Destruction | Disease | Mesenchyme | Homeostasis | Osteonecrosis | Joint surgery | Necrosis | Proteins | Signal transduction | Cell growth | Pain | Computed tomography | Cell cycle | Gangrene | Bone marrow | Biocompatibility | Degeneration | Inhibition | Bioinformatics | Hip joint | Collapse | Head | Bone morphogenetic protein 2 | MiRNA | Osteopontin | Bone turnover | Gene expression | Metabolism | Bone (subchondral) | Ribonucleic acid--RNA | Patients | Trauma | Hip | Polymerase chain reaction | Hospitals | Fractures | DNA microarrays | MicroRNAs | Stem cells | Bone | Differentiation | Cancer | RNA | Ribonucleic acid
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9. Full Text Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: A prospective, randomized clinical pilot trial 2002 volvo award in clinical studies
by Boden, Scott D and Kang, James and Sandhu, Harvinder and Heller, John G
Spine, ISSN 0362-2436, 12/2002, Volume 27, Issue 23, pp. 2662 - 2673
Study Design. A prospective randomized clinical study was conducted. Objective. To determine whether the dose and carrier that were successful in rhesus... 
Bone morphogenetic protein-2 | Spine fusion | Calcium phosphate | Clinical trial | clinical trial | OSTEOGENIC PROTEIN | NONHUMAN PRIMATE | GRAFT SUBSTITUTE | DEGENERATIVE SPONDYLOLISTHESIS | bone morphogenetic protein-2 | CLINICAL NEUROLOGY | spine fusion | calcium phosphate | ARTHRODESIS | HEALTH SURVEY SF-36 | GROWTH-FACTOR | OUTCOMES | ORTHOPEDICS | PEDICLE SCREW INSTRUMENTATION | OSTEOINDUCTIVE PROTEIN | Recombinant Proteins - therapeutic use | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Bone Transplantation - adverse effects | Male | Spinal Fusion - adverse effects | Lumbosacral Region | Low Back Pain - etiology | Ilium - transplantation | Internal Fixators | Female | Transforming Growth Factor beta | Reoperation | Spinal Fusion - methods | Bone Morphogenetic Protein 2 | Awards and Prizes | Treatment Outcome | Bone Substitutes - administration & dosage | Drug Implants - adverse effects | Pilot Projects | Calcium Phosphates - administration & dosage | Bone Morphogenetic Proteins - therapeutic use | Intervertebral Disc Displacement - surgery
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10. Full Text Reconstruction of Mandibular Continuity Defects With Bone Morphogenetic Protein-2 (rhBMP-2)
by Herford, Alan S., DDS, MD and Boyne, Philip J., DMD, MS, DSc
Journal of Oral and Maxillofacial Surgery, ISSN 0278-2391, 2008, Volume 66, Issue 4, pp. 616 - 624
Purpose Several autogenous bone grafting techniques are available for the restoration of large continuity defects of the mandible. However, these procedures... 
Surgery | INDUCTION | IMPLANTS | GRAFTS | DENTISTRY, ORAL SURGERY & MEDICINE | Age Factors | Humans | Middle Aged | Male | Mandibular Diseases - surgery | Jaw Fixation Techniques | Mandible - surgery | Drug Carriers | Surgical Sponges | Oral Surgical Procedures - methods | Aged, 80 and over | Female | Bone Morphogenetic Proteins - pharmacology | Osteomyelitis - surgery | Bone Regeneration - drug effects | Bone Morphogenetic Proteins - administration & dosage | Bone Morphogenetic Protein 2 | Reconstructive Surgical Procedures - methods | Recombinant Proteins - pharmacology | Recombinant Proteins - administration & dosage | Transforming Growth Factor beta - pharmacology | Collagen | Adolescent | Transforming Growth Factor beta - administration & dosage | Aged | Mandibular Neoplasms - surgery
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11. Full Text Recombinant Human Bone Morphogenetic Protein-2 on an Absorbable Collagen Sponge with an Osteoconductive Bulking Agent in Posterolateral Arthrodesis with Instrumentation: A Prospective Randomized Trial
by Dawson, Edgar and Bae, Hyun W and Burkus, J Kenneth and Stambough, Jeffery L and Glassman, Steven D
The Journal of Bone & Joint Surgery, ISSN 0021-9355, 07/2009, Volume 91, Issue 7, pp. 1604 - 1613
BackgroundRecombinant human bone morphogenetic protein-2 (rhBMP-2) on an absorbable collagen sponge has been shown to be a safe and effective replacement for... 
SURGERY | NONHUMAN PRIMATE | EFFICACY | ILIAC CREST AUTOGRAFT | ALLOGRAFT | LUMBAR SPINE | OP-1 PUTTY RHBMP-7 | SPINE FUSION | GRAFT | RESISTANT MATRIX | ORTHOPEDICS | CLINICAL-OUTCOMES | Spinal Fusion - methods | Bone Morphogenetic Proteins - administration & dosage | Hydroxyapatites - administration & dosage | Lumbar Vertebrae - diagnostic imaging | Bone Morphogenetic Protein 2 | Humans | Middle Aged | Bone Substitutes | Male | Tomography, X-Ray Computed | Recombinant Proteins - administration & dosage | Absorbable Implants | Collagen - administration & dosage | Lumbar Vertebrae - surgery | Bone Transplantation | Transforming Growth Factor beta - administration & dosage | Female | Osteogenesis
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12. Full Text The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2
by Shi, Qin and Li, Yang and Sun, Jie and Zhang, Hua and Chen, Lei and Chen, Bing and Yang, Huilin and Wang, Zhaoxu
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 28, pp. 6644 - 6649
Abstract Bacterial cellulose (BC) is a nanofibrous biological material with attractive physicochemical properties and biocompatibility. Its fiber is similar to... 
Advanced Basic Science | Dentistry | Bone morphogenetic protein-2 | Nanofibrous | Osteogenesis | Bacterial cellulose scaffold | MATRIX | MATERIALS SCIENCE, BIOMATERIALS | COLLAGEN | ENGINEERING, BIOMEDICAL | IN-VIVO DEGRADATION | REGENERATION | MODEL | REPAIR | BINDING | Nanofibers - chemistry | Cell Line | Nanofibers - ultrastructure | Microscopy, Electron, Scanning | Gluconacetobacter xylinus - chemistry | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Tissue Engineering - trends | Bone Morphogenetic Protein 2 - chemistry | Male | Cellulose - administration & dosage | Rats, Sprague-Dawley | Bone and Bones - drug effects | Tissue Scaffolds - chemistry | Cellulose - chemistry | Animals | Bone Morphogenetic Protein 2 - administration & dosage | Nanofibers - administration & dosage | Cellulose - ultrastructure | Mice | Polysaccharides | Phosphatases | Biological products | Tissue engineering | Developmental biology | Cellulose | Bone morphogenetic proteins
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13. Full Text A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE (R) Bone Graft)
by Mckay, WF and Peckham, SM and Badura, JM
INTERNATIONAL ORTHOPAEDICS, ISSN 0341-2695, 12/2007, Volume 31, Issue 6, pp. 729 - 734
The combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) on an absorbable collagen sponge (ACS) carrier has been shown to induce bone... 
AUGMENTATION | SPINE | ORTHOPEDICS | LUMBAR INTERBODY FUSION | RHBMP-2 | TIBIAL FRACTURES | Political corruption | Bone morphogenetic proteins
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14. Full Text Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
by La, Wan-Geun and Jin, Min and Park, Saibom and Yoon, Hee-Hun and Jeong, Gun-Jae and Bhang, Suk Ho and Park, Hoyoung and Char, Kookheon and Kim, Byung-Soo
International Journal of Nanomedicine, ISSN 1176-9114, 05/2014, Volume 9, Issue 1, pp. 107 - 116
In this study, we demonstrate that graphene oxide (GO) can be used for the delivery of bone morphogenetic protein-2 (BMP-2) and substance P (SP), and that this... 
Bone morphogenetic protein-2 | Stem cell recruitment | Bone regeneration | Substance P | Graphene oxides | CELLS | MOLECULAR-DYNAMICS | graphene oxides | DENTAL IMPLANTS | CONTROLLED-RELEASE | NANOSCIENCE & NANOTECHNOLOGY | FACTOR-I | BMP-2 | bone morphogenetic protein-2 | CALCIUM-PHOSPHATE | GROWTH | stem cell recruitment | SURFACE | COATINGS | bone regeneration | PHARMACOLOGY & PHARMACY | substance P | Bone Morphogenetic Protein 2 - pharmacology | Bone Regeneration - drug effects | Mesenchymal Stromal Cells - drug effects | Prostheses and Implants | Bone Morphogenetic Protein 2 - chemistry | Substance P - pharmacology | Skull - chemistry | Mesenchymal Stromal Cells - cytology | Animals | Bone Morphogenetic Protein 2 - pharmacokinetics | Skull - cytology | Skull - injuries | Mice | Graphite - chemistry | Drug Delivery Systems - methods | Skull - drug effects | Substance P - chemistry | Substance P - pharmacokinetics | Drugs | Usage | Drug delivery systems | Graphene | Physiological aspects | Bone morphogenetic proteins | Research | Vehicles
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