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Cancer Cell, ISSN 1535-6108, 09/2013, Volume 24, Issue 3, pp. 289 - 304
Proteasome inhibitor (PI) resistance mechanisms in multiple myeloma (MM) remain controversial. We report the existence of a progenitor organization in primary... 
BORTEZOMIB RESISTANCE | OVEREXPRESSION | DEXAMETHASONE | BLIMP-1 | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | FACTOR XBP-1 | MECHANISMS | DIFFERENTIATION | CANCER | GENOME | CELL BIOLOGY | eIF-2 Kinase - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Transcription Factors - deficiency | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | Plasma Cells - pathology | DNA-Binding Proteins - metabolism | Multiple Myeloma - drug therapy | Precursor Cells, B-Lymphoid - pathology | Plasma Cells - metabolism | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Bortezomib | Endoribonucleases - metabolism | Proteasome Inhibitors - pharmacology | Signal Transduction | Immunophenotyping | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Multiple Myeloma - metabolism | Regulatory Factor X Transcription Factors | Proteasome Inhibitors - therapeutic use | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Drug Resistance, Neoplasm - genetics | Endoplasmic Reticulum Stress | Mutation | Pyrazines - pharmacology | Multiple Myeloma - genetics | Boronic Acids - pharmacology | Immunoglobulins | Care and treatment | Multiple myeloma | Genetic research | Health aspects | Tumors | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 12455 - 12468
Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate in response to cytotoxic stress. However, the functional... 
PROGRAMMED CELL-DEATH | INHIBITION | BECLIN-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIF-1 | MITOCHONDRIA | DEGRADATION | MEDIATED CLEAVAGE | MACROAUTOPHAGY | CHLOROQUINE | SPHINGOSINE KINASE | Death Domain Receptor Signaling Adaptor Proteins - physiology | Autophagy-Related Proteins | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Protein Multimerization | Caspase 3 - metabolism | Caspase 8 - metabolism | Leukemia, Myeloid, Acute | Autophagy | Heat-Shock Proteins - genetics | Cell Membrane - metabolism | Tumor Cells, Cultured | Pyrazoles - pharmacology | Cell Survival - drug effects | Hydrazines - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Heat-Shock Proteins - metabolism | Cells, Cultured | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Gene Knockout Techniques | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Transport | Cell Membrane - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Animals | Autophagy-Related Protein 5 | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Caspase-8 | Bortezomib | Cell Death | Caspase | Sphingolipid | SKI-I | p62 | Sequestosome 1 | Atg5 | Cell Biology
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 03/2017, Volume 41, pp. 124 - 136
Quercetin, a bioflavonoid contained in several vegetables daily consumed, has been studied for long time for its antiinflammatory and anticancer properties.... 
mTOR/PI3K/AKT | KSHV | PEL | Il-6 | Quercetin | STAT3 | CANCER-CELLS | RAPAMYCIN | mTOR/PI3K/AKF | ACTIVATION | SURVIVIN EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | II-6 | MAJOR HISTOCOMPATIBILITY COMPLEX | KINASE INHIBITOR | KAPPA-B | NUTRITION & DIETETICS | WNT/BETA-CATENIN | GROWTH | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Proteasome Inhibitors - chemistry | Neoplasm Proteins - antagonists & inhibitors | Bortezomib - pharmacology | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Interleukins - metabolism | Drug Agonism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Antineoplastic Agents, Phytogenic - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | B-Lymphocytes - metabolism | STAT3 Transcription Factor - metabolism | Antineoplastic Agents, Phytogenic - adverse effects | Lymphoma, Primary Effusion - metabolism | B-Lymphocytes - cytology | Proteasome Inhibitors - pharmacology | Cells, Cultured | Lymphoma, Primary Effusion - pathology | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Down-Regulation - drug effects | Interleukins - antagonists & inhibitors | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Lymphoma, Primary Effusion - immunology | Signal Transduction - drug effects | Lymphoma, Primary Effusion - drug therapy | Quercetin - adverse effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | STAT3 Transcription Factor - antagonists & inhibitors | Bortezomib - agonists | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Quercetin - metabolism | Cellular proteins | Flavonoids | Flavones | Sarcoma | Bioflavonoids | Lymphomas | B cells | Apoptosis
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 201 - 208
NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified... 
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | CANCER-CELLS | TARGET | APOPTOSIS | OXIDATIVE STRESS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | reactive oxygen species (ROS) | ENDOPLASMIC-RETICULUM STRESS | BORTEZOMIB | FOXM1 | INACTIVATION | proteasome inhibitor | LACTACYSTIN | catalase | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | N-acetyl-l-cysteine (NAC)
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 11/2015, Volume 33, Issue 32, pp. 3750 - 3758
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e46484
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 15, pp. 2975 - 2987
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been... 
CANCER-PATIENTS | DENDRITIC CELLS | T-REGULATORY CELLS | IMMUNOSUPPRESSION | BONE-MARROW | GROWTH | PERIPHERAL-BLOOD | DIFFERENTIATION | IDENTIFICATION | HEMATOLOGY | PROGRESSION | Cell Proliferation | Reactive Oxygen Species - metabolism | Coculture Techniques | Humans | Sialic Acid Binding Ig-like Lectin 3 - immunology | Multiple Myeloma - immunology | Thalidomide - pharmacology | Lewis X Antigen - metabolism | Lipopolysaccharides - immunology | Thalidomide - analogs & derivatives | Flow Cytometry | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Reactive Oxygen Species - immunology | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | HLA-DR Antigens - metabolism | Sialic Acid Binding Ig-like Lectin 3 - metabolism | Cytokines - immunology | Tumor Microenvironment - drug effects | Bortezomib | CD11b Antigen - immunology | Cytokines - metabolism | Cells, Cultured | Lewis X Antigen - immunology | Multiple Myeloma - metabolism | Tumor Microenvironment - immunology | Multiple Myeloma - pathology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | HLA-DR Antigens - immunology | CD11b Antigen - metabolism | Pyrazines - pharmacology | Immunologic Factors - pharmacology | Boronic Acids - pharmacology | Tumor Burden - immunology | Lymphoid Neoplasia
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 25, pp. 2976 - 2987
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 14, Issue 3, pp. 250 - 262
Heat-shock protein 70 (HSP70) isoforms contribute to tumorigenesis through their well-documented antiapoptotic activity and via their role as cochaperones for... 
CHEMBIO | CELLCYCLE | CARCINOMA-CELLS | CANCER-CELLS | HEAT-SHOCK-PROTEIN-70 | 17-ALLYLAMINO | ONCOLOGY | MOLECULAR CHAPERONE | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | 17-DEMETHOXYGELDANAMYCIN | INTERFERENCE | CONFORMATION | STRESS | Neoplasms - metabolism | RNA, Small Interfering - genetics | Apoptosis - drug effects | HSC70 Heat-Shock Proteins - metabolism | Humans | HSP72 Heat-Shock Proteins - genetics | Protease Inhibitors - pharmacology | Ubiquitination | Protein Isoforms - metabolism | Transfection | Neoplasms - genetics | Cell Line | HSC70 Heat-Shock Proteins - genetics | Bortezomib | HCT116 Cells | HSP72 Heat-Shock Proteins - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Lactams, Macrocyclic - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | HSP70 Heat-Shock Proteins - metabolism | Benzoquinones - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Cell Proliferation - drug effects | Apoptosis - physiology | Kinetics | Proteasome Endopeptidase Complex - metabolism | Cell Cycle - drug effects | Neoplasms - pathology | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Protein Isoforms - genetics | Proteins | Oncology, Experimental | Heat shock proteins | Research | Cancer | Tumors | Apoptosis
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2012, Volume 32, Issue 8, pp. 2582 - 2587
Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP), which represses and reversibly regulates the translation of a subset... 
MESSENGER-RNAS | SYNAPSES | PHOSPHORYLATION | FRAGILE-X-SYNDROME | DEPENDENT TRANSLATION | METABOTROPIC GLUTAMATE RECEPTORS | AMPA RECEPTOR | PSD-95 | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | Disks Large Homolog 4 Protein | Okadaic Acid - pharmacology | Enzyme Inhibitors | Protein Biosynthesis | Immunoprecipitation | Embryo, Mammalian | Phosphoprotein Phosphatases - metabolism | Male | Neurons - cytology | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Metabotropic Glutamate - metabolism | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Phosphorylation - genetics | Synapses - metabolism | Transfection | Ubiquitination - drug effects | Female | Membrane Proteins - metabolism | Neurons - metabolism | Phosphorylation - drug effects | Ubiquitination - physiology | Intracellular Signaling Peptides and Proteins - genetics | Dendrites - drug effects | Dendrites - metabolism | Synapses - drug effects | Bortezomib | Membrane Proteins - genetics | Cells, Cultured | Rats | Serine - genetics | Signal Transduction - genetics | Hippocampus - cytology | Mutation - genetics | Rats, Sprague-Dawley | Serine - metabolism | Gene Expression Regulation - drug effects | Leupeptins - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Analysis of Variance | Signal Transduction - drug effects | Fragile X Mental Retardation Protein - genetics | Pyrazines - pharmacology | Boronic Acids - pharmacology | Brief Communications
Journal Article
Cellular Signalling, ISSN 0898-6568, 01/2013, Volume 25, Issue 1, pp. 308 - 318
Generally, both endoplasmic reticulum (ER) stress and mitochondrial dysregulation are a potential therapeutic target of anticancer agents including bortezomib.... 
ER stress | Bortezomib | Autophagy | Mitochondrial dysregulation | Apoptosis | ACTIVATION | MECHANISM | MCL-1 | DEATH | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | RESISTANCE | DEGRADATION | PROTEASOME INHIBITORS | UP-REGULATION | Boronic Acids - toxicity | Reactive Oxygen Species - metabolism | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Proto-Oncogene Protein c-ets-1 - metabolism | Apoptosis - drug effects | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Caspase 3 - chemistry | Humans | Caspase 3 - metabolism | Membrane Potential, Mitochondrial - drug effects | Autophagy - drug effects | Antineoplastic Agents - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Pyrazines - toxicity | RNA Interference | MAP Kinase Kinase Kinase 5 - metabolism | Melanoma - metabolism | Endoplasmic Reticulum Stress - drug effects | HSP70 Heat-Shock Proteins - genetics | Mitochondria - metabolism | Melanoma - pathology | Mitochondria - drug effects | Proteasome Inhibitors - toxicity | HSP70 Heat-Shock Proteins - metabolism | Signal Transduction - drug effects | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Proto-Oncogene Protein c-ets-1 - antagonists & inhibitors | Proto-Oncogene Protein c-ets-1 - genetics | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Cytochrome c | Heat shock proteins | Inositol | Melanoma | Inhibitors | Pathways | Cleavage | Activation | Inhibition | Kinases | Endoplasmic reticulum
Journal Article