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Circulation, ISSN 0009-7322, 08/2019, Volume 140, Issue 8, pp. e382 - e482
Supplemental Digital Content is available in the text. 
CARDIAC & CARDIOVASCULAR SYSTEMS | myocardial infarction | syncope | AHA Scientific Statements | sinus arrest | intraoperative | electrocardiogram | EXPERT CONSENSUS STATEMENT | shared decision-making | PERIPHERAL VASCULAR DISEASE | QUALITY-OF-LIFE | spinal cord injuries | sick sinus syndrome | cardiac resynchronization therapy | theophylline | ablation | heart block | sarcoidosis | COMPLETE ATRIOVENTRICULAR-BLOCK | pacing | glucagon | beta-adrenergic agonist | quality of life | digoxin antibodies Fab fragments | pacemaker | right bundle branch block | aminophylline | CARDIOVASCULAR-MAGNETIC-RESONANCE | bradyarrhythmia | isoproterenol | sinus node dysfunction | myotonic dystrophy | preoperative | Holter monitoring | AV block | lamin A-C | congenital heart disease | ACUTE MYOCARDIAL-INFARCTION | cardiac sinus pause | muscular dystrophies | atropine | bundle branch block | ambulatory electrocardiography | left bundle branch block | PERMANENT PACEMAKER IMPLANTATION | BUNDLE-BRANCH-BLOCK | atrioventricular block | transcatheter aortic valve replacement | cardiac surgery | TERM-FOLLOW-UP | AORTIC-VALVE-REPLACEMENT | bradycardia | cardiac pacing | sinus bradycardia syndrome | Cardiac Conduction System Disease - complications | Cardiac Conduction System Disease - diagnosis | Bradycardia - diagnosis | Humans | Bradycardia - therapy | Arrhythmias, Cardiac - etiology | Heart Diseases - congenital | Bradycardia - complications | Epilepsy - complications | Cardiac Conduction System Disease - therapy | Bradycardia - epidemiology | Myocardial Infarction - complications | Cardiac Conduction System Disease - epidemiology | Heart Diseases - complications | Electrocardiography | Quality of Life | Electrophysiological Phenomena | Adrenergic beta-Antagonists - therapeutic use
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 4, pp. 1798 - 1808
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 361, Issue 22, pp. 2123 - 2134
Journal Article
Circulation research, ISSN 0009-7330, 10/2017, Volume 121, Issue 9, pp. 1058 - 1068
RATIONALE:Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic... 
INTRONIC MICRORNAS | HEART-FAILURE | sinoatrial node | DOWN-REGULATION | athletes | micro-RNAs | sinus bradycardia | O-GLCNAC TRANSFERASE | HIGH VAGAL TONE | ATRIAL-FIBRILLATION | ion channel remodeling | HOST GENES | ENDURANCE EXERCISE | exercise training | CARDIOMYOCYTE DIFFERENTIATION | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | RECEPTOR | PROLIFERATION | MICRORNAS | TBX5 | PERIPHERAL VASCULAR DISEASE | HEART-RATE | HEMATOLOGY | EXPRESSION | REVEALS | Gene Targeting - methods | Bradycardia - genetics | Humans | Physical Conditioning, Animal - methods | Male | MicroRNAs - metabolism | Gene Knockdown Techniques - methods | Potassium Channels - metabolism | Young Adult | Bradycardia - metabolism | Muscle Proteins - metabolism | Adult | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Mice, Inbred C57BL | Sinoatrial Node - physiopathology | Bradycardia - physiopathology | Physical Conditioning, Animal - physiology | Potassium Channels - genetics | Muscle Proteins - genetics | Animals | Adolescent | Sinoatrial Node - metabolism | Exercise - physiology | Mice | MicroRNAs - genetics | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics | Bradycardia | Exercise | Physiological aspects | Ion channels | Research | Nucleotide sequencing | Athletes | Health aspects | Risk factors | DNA sequencing | Cardiac arrhythmia | Animal models | Physical training | Reverse transcription | Polymerase chain reaction | Heart rate | Sinuses | Sinus | Computer applications | miRNA | Fitness training programs | Nkx2.5 protein | Hyperpolarization | Ion channels (cyclic nucleotide-gated) | 10063 | 10032 | 10035 | Molecular Medicine | 10001 | 10003
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2019, Volume 139, Issue 18, pp. 2157 - 2169
BACKGROUND:Bradyarrhythmia is a common clinical manifestation. Although the majority of cases are acquired, genetic analysis of families with bradyarrhythmia... 
ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | ZEBRAFISH | KIR3.4 | VIVO | ACETYLCHOLINE | bradyarrhythmia | inward rectifier potassium channel | GATED K+ CHANNEL | I-KACH | GENETIC-VARIATION | atrial fibrillation | genetic research | PERIPHERAL VASCULAR DISEASE | molecular targeted therapy | HEART-RATE | Atrioventricular Block - genetics | Bradycardia - genetics | Humans | Genetic Diseases, Inborn - genetics | Male | Genetic Diseases, Inborn - pathology | Mutation, Missense | Atrial Fibrillation - physiopathology | Atrioventricular Block - pathology | Bradycardia - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Female | Genetic Diseases, Inborn - metabolism | Benzopyrans - pharmacology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Atrial Fibrillation - pathology | Atrioventricular Block - physiopathology | Atrioventricular Block - metabolism | Animals, Genetically Modified | Xenopus laevis | Bradycardia - physiopathology | Zebrafish | Atrial Fibrillation - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Atrial Fibrillation - metabolism | Animals | Bradycardia - pathology | Genetic Diseases, Inborn - physiopathology | Electrophysiologic Techniques, Cardiac | Amino Acid Substitution | Bradycardia | Care and treatment | Gene mutations | Atrial fibrillation | Genetic aspects | Potassium channels | Health aspects | Identification and classification | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 08/2019, Volume 140, Issue 8, pp. e333 - e381
Supplemental Digital Content is available in the text. 
CARDIAC & CARDIOVASCULAR SYSTEMS | myocardial infarction | syncope | AHA Scientific Statements | sinus arrest | intraoperative | electrocardiogram | ALCOHOL SEPTAL ABLATION | EXPERT CONSENSUS STATEMENT | shared decision-making | PERIPHERAL VASCULAR DISEASE | spinal cord injuries | sick sinus syndrome | cardiac resynchronization therapy | theophylline | ablation | heart block | sarcoidosis | pacing | BUNDLE-BRANCH BLOCK | glucagon | beta-adrenergic agonist | IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS | quality of life | digoxin antibodies Fab fragments | pacemaker | DEGREE ATRIOVENTRICULAR-BLOCK | right bundle branch block | aminophylline | bradyarrhythmia | isoproterenol | sinus node dysfunction | myotonic dystrophy | preoperative | Holter monitoring | AV block | lamin A-C | congenital heart disease | ACUTE MYOCARDIAL-INFARCTION | cardiac sinus pause | muscular dystrophies | atropine | bundle branch block | ambulatory electrocardiography | left bundle branch block | PERMANENT PACEMAKER IMPLANTATION | atrioventricular block | transcatheter aortic valve replacement | cardiac surgery | TERM-FOLLOW-UP | AORTIC-VALVE-REPLACEMENT | bradycardia | cardiac pacing | sinus bradycardia syndrome | Bronchodilator Agents - therapeutic use | Bradycardia - genetics | Cardiac Conduction System Disease - diagnosis | Bradycardia - diagnosis | Humans | Bradycardia - therapy | Calcium Channel Blockers - therapeutic use | Genetic Testing - methods | Cardiac Conduction System Disease - therapy | Cardiotonic Agents - therapeutic use | Algorithms | Cardiac Conduction System Disease - genetics | Adrenergic beta-Agonists - therapeutic use | Electrocardiography - methods
Journal Article